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  • 1
    Online Resource
    Online Resource
    CUDA-enabled hierarchical ward clustering of protein structures based on the nearest neighbour chain algorithm
    SAGE Publications ; 2016
    In:  The International Journal of High Performance Computing Applications Vol. 30, No. 2 ( 2016-05), p. 200-211
    Details
    In: The International Journal of High Performance Computing Applications, SAGE Publications, Vol. 30, No. 2 ( 2016-05), p. 200-211
    Abstract: Clustering of molecular systems according to their three-dimensional structure is an important step in many bioinformatics workflows. In applications such as docking or structure prediction, many algorithms initially generate large numbers of candidate poses (or decoys), which are then clustered to allow for subsequent computationally expensive evaluations of reasonable representatives. Since the number of such candidates can easily range from thousands to millions, performing the clustering on standard central processing units (CPUs) is highly time consuming. In this paper, we analyse and evaluate different approaches to parallelize the nearest neighbour chain algorithm to perform hierarchical Ward clustering of protein structures, using both atom-based root mean square deviation (RMSD) and rigid-body RMSD molecular distances on a graphics processing unit (GPU). This leads to a speedup of around one order of magnitude of our CUDA implementation on a GeForce Titan GPU compared to a multi-threaded CPU implementation on a Core-i7 2700. Furthermore, the runtimes compare favourably with ClusCo, another state-of-the-art CUDA-enabled protein structure clustering method, while achieving similar accuracy on the iTasser benchmark dataset. Our implementation has also been incorporated into the Biochemical Algorithms library to allow easy integration into biologists’ workflows.
    Type of Medium: Online Resource
    ISSN: 1094-3420 , 1741-2846
    URL: Article
    DOI: 10.1177/1094342015597988
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2017480-9
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  • 2
    Online Resource
    Online Resource
    Gas Exchange during Gas and Liquid Ventilation
    SAGE Publications ; 1996
    In:  Journal of Intensive Care Medicine Vol. 11, No. 6 ( 1996-11), p. 313-325
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 11, No. 6 ( 1996-11), p. 313-325
    Abstract: Liquid Ventilation with perfluorochemicals (PFC) violates many of our long-held assumptions about how the lung functions. However, the technique has been so successful in animal models of lung disease that it is currently being tested in clinical trials for the treatment of infant and acute (“adult”) respiratory distress syndrome in newborns, children, and adults. A common feature of both infant and acute respiratory distress syndromes is an inability of the lung's surfactant system to adequately lower surface tension, leading to regions of atelectasis. Liquid ventilation with PFC appears to ameliorate the disease process by lowering interfacial tension in the lung, opening regions of atelectasis, and improving gas exchange. To understand how gas exchange is successful during liquid ventilation requires careful re-evaluation of the assumptions underlying our current models of gas exchange physiology during normal gas ventilation. These assumptions must then be examined in light of the alterations in pulmonary physiology during liquid ventilation.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/088506669601100603
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1996
    detail.hit.zdb_id: 2001472-7
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  • 3
    Online Resource
    Online Resource
    Working Memory Training and Semantic Structuring Improves Remembering Future Events, Not Past Events
    SAGE Publications ; 2015
    In:  Neurorehabilitation and Neural Repair Vol. 29, No. 1 ( 2015-01), p. 33-40
    Details
    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 29, No. 1 ( 2015-01), p. 33-40
    Abstract: Objectives. Memory training in combination with practice in semantic structuring and word fluency has been shown to improve memory performance. This study investigated the efficacy of a working memory training combined with exercises in semantic structuring and word fluency and examined whether training effects generalize to other cognitive tasks. Methods. In this double-blind randomized control study, 36 patients with memory impairments following brain damage were allocated to either the experimental or the active control condition, with both groups receiving 9 hours of therapy. The experimental group received a computer-based working memory training and exercises in word fluency and semantic structuring. The control group received the standard memory therapy provided in the rehabilitation center. Patients were tested on a neuropsychological test battery before and after therapy, resulting in composite scores for working memory; immediate, delayed, and prospective memory; word fluency; and attention. Results. The experimental group improved significantly in working memory and word fluency. The training effects also generalized to prospective memory tasks. No specific effect on episodic memory could be demonstrated. Conclusion. Combined treatment of working memory training with exercises in semantic structuring is an effective method for cognitive rehabilitation of organic memory impairment.
    Type of Medium: Online Resource
    ISSN: 1545-9683 , 1552-6844
    URL: Article
    DOI: 10.1177/1545968314527352
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2100545-X
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  • 4
    Online Resource
    Online Resource
    Adaptive Cueing Treatment of Neglect in Stroke Patients Leads to Improvements in Activities of Daily Living: A Randomized Controlled, Crossover Trial
    SAGE Publications ; 2018
    In:  Neurorehabilitation and Neural Repair Vol. 32, No. 11 ( 2018-11), p. 988-998
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    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 32, No. 11 ( 2018-11), p. 988-998
    Abstract: Background. Visuospatial neglect is a disabling syndrome with serious consequences for activities in daily life. This study investigated the effect of adaptive cueing during a reading task as a possible treatment for neglect by including (1) a task relevant for the patient’s daily life, (2) a fading out procedure to stimulate independent orientation to the left by self-cueing, and (3) a clear definition of neglect severity for the adaptive treatment protocol. Methods. A randomized controlled crossover design was used, including 26 patients from an early rehabilitation unit with left-sided visuospatial neglect after stroke or hemorrhage. They were examined twice at baseline (T1, T2), after 15 daily sessions in 1 condition (T3), and again after 15 daily sessions in the other condition (T4). The intervention condition included a daily reading task combined with endogenous and exogenous cues provided by a therapist, which were continuously reduced after a patient had reached a defined level of performance. The control condition consisted of a neuropsychological treatment of the same length, not targeting visuospatial attention. Results. Significant improvements were shown after intervention on scores for reading (word and text reading), daily life activities (Catherine Bergego Scale), Line Bisection, and the Clock Drawing Task. Conclusion. This study shows that adaptive cueing in a reading task can improve neglect symptoms by using an intensive intervention lasting 3 weeks.
    Type of Medium: Online Resource
    ISSN: 1545-9683 , 1552-6844
    URL: Article
    DOI: 10.1177/1545968318807054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2100545-X
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  • 5
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    Online Resource
    Justice and Impoverished Women: The Ethical Implications of Work-Based Welfare
    SAGE Publications ; 2009
    In:  Policy, Politics, & Nursing Practice Vol. 10, No. 4 ( 2009-11), p. 295-302
    Details
    In: Policy, Politics, & Nursing Practice, SAGE Publications, Vol. 10, No. 4 ( 2009-11), p. 295-302
    Abstract: Current U.S. welfare policy, Temporary Assistance for Needy Families, requires impoverished people to work in order to receive welfare, and it limits cash support to 5 years. Most of the people who have used this program are single-parent women, and a disturbing number have been terminated at 5 years, not having made a successful transition to work. The purpose of this longitudinal study was to explore the barriers to success and the social justice of the program from the perspective of single-parent women who were terminated. In all, 41 women were recruited through community-based purposive sampling, and the primary research methods were a qualitative, narrative interview approach and narrative analysis. Data from the semistructured interview guide are reported here. Findings describe health and socioeconomic burdens, and barriers that lie within the social policy. The study has ethical implications for nursing advocacy, and it informs nursing interventions for impoverished women and their families.
    Type of Medium: Online Resource
    ISSN: 1527-1544 , 1552-7468
    URL: Article
    DOI: 10.1177/1527154409359328
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2070898-1
    SSG: 2
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  • 6
    Online Resource
    Online Resource
    Maternal Perception of Lactogenesis Time: A Clinical Report
    SAGE Publications ; 1999
    In:  Journal of Human Lactation Vol. 15, No. 4 ( 1999-12), p. 317-323
    Details
    In: Journal of Human Lactation, SAGE Publications, Vol. 15, No. 4 ( 1999-12), p. 317-323
    Abstract: A study evaluating the time between delivery and the surge in milk production (lactogenesis time) determined whether lactogenesis time (LT) is affected by parity, factors in pregnancy and delivery, and especially cesarean section. Forty-six primiparous mothers and 81 multiparous mothers reported the time of sensation of milk production after delivery. The mean LT in the entire sample was 50 ± 15 hours. The mean LT in 46 primiparous mothers was 59 ± 14 hours, and in 81 multiparous mothers 45 ± 12 hours (by student t test,p 〈 0.01). Mean LT did not decrease as parity increased in the multiparous mothers. By multivariate analysis, mean LT was 44 hours in multiparous mothers who delivered vaginally without medication, 11 hours longer if primiparous, 6 hours longer if delivery by cesarean section, and 13 hours longer if sedative or pain medication were given during labor.
    Type of Medium: Online Resource
    ISSN: 0890-3344 , 1552-5732
    URL: Article
    DOI: 10.1177/089033449901500409
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
    detail.hit.zdb_id: 2092674-1
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  • 7
    Online Resource
    Online Resource
    Web-Based Tailored Lifestyle Programs: Exploration of the Target Group's Interests and Implications for Practice
    SAGE Publications ; 2008
    In:  Health Promotion Practice Vol. 9, No. 1 ( 2008-01), p. 82-92
    Details
    In: Health Promotion Practice, SAGE Publications, Vol. 9, No. 1 ( 2008-01), p. 82-92
    Abstract: An important challenge in Web-based health promotion is to increase the reach of the target audience by taking the target groups' desires into consideration. Data from 505 members of a Dutch Internet panel (representative for Dutch Internet users) were used to asses the target group's interests and needs. 28% participated in Web-based tailored lifestyle programs, 57% expressed an interest in such programs, and 15% expressed no interest. Interest in Web-based programs was predominantly caused by a general interest in lifestyle and online tests. Participation in Web-based tailored lifestyle programs should not take more than 17 minutes per occasion. 84% were interested in follow-up testing after the initial participation. Responders were particularly interested in physical activity and nutrition. Hardly anyone was willing to pay for participation. The results from this study support the use of Web-based tailored lifestyle programs in behavior change efforts.
    Type of Medium: Online Resource
    ISSN: 1524-8399 , 1552-6372
    URL: Article
    DOI: 10.1177/1524839906289515
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2036801-X
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  • 8
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    Online Resource
    A Lower-Class Advantage in Face Memory
    SAGE Publications ; 2022
    In:  Personality and Social Psychology Bulletin
    Details
    In: Personality and Social Psychology Bulletin, SAGE Publications
    Abstract: People remember what they deem important. In line with research suggesting that lower-class (vs. higher class) individuals spontaneously appraise other people as more relevant, we show that social class is associated with the habitual use of face memory. We find that lower-class (vs. higher class) participants exhibit better incidental memory for faces (i.e., spontaneous memory for faces they had not been instructed to memorize; Studies 1 and 2). No social-class differences emerge for faces participants are instructed to learn (Study 2), suggesting that this pattern reflects class-based relevance appraisals rather than memory ability. Study 3 extends our findings to eyewitness identification. Lower-class (vs. higher-class) participants’ eyewitness accuracy is less impacted by the explicit relevance of a target (clearly relevant thief vs. incidental bystander). Integrative data analysis shows a robust negative association between social class and spontaneous face memory. Preregistration (Studies 1 and 3) and cross-cultural replication (Study 2) further strengthen the results.
    Type of Medium: Online Resource
    ISSN: 0146-1672 , 1552-7433
    URL: Article
    DOI: 10.1177/01461672221125599
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2047603-6
    SSG: 5,2
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  • 9
    Online Resource
    Online Resource
    Citation Award MNRS Abstract: Perspectives of HIV-Infected Women Who Have Significant Adherence Difficulties
    SAGE Publications ; 2008
    In:  Western Journal of Nursing Research Vol. 30, No. 1 ( 2008-02), p. 149-149
    Details
    In: Western Journal of Nursing Research, SAGE Publications, Vol. 30, No. 1 ( 2008-02), p. 149-149
    Type of Medium: Online Resource
    ISSN: 0193-9459 , 1552-8456
    URL: Article
    DOI: 10.1177/0193945907308663
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2067773-X
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  • 10
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    Online Resource
    The relationship between music performance anxiety, subjective performance quality and post-event rumination among music students
    SAGE Publications ; 2018
    In:  Psychology of Music Vol. 46, No. 1 ( 2018-01), p. 136-152
    Details
    In: Psychology of Music, SAGE Publications, Vol. 46, No. 1 ( 2018-01), p. 136-152
    Abstract: According to cognitive models, the negative perception of one’s performance and the post-event rumination (PER) occurring after stressful social events maintain social anxiety. These aspects have hardly been studied in music performance anxiety (MPA), a specific form of social anxiety. The first aim of this study was to analyze the development of negative and positive PER over two days following a soloist concert, depending on the usual MPA level. The second aim was to investigate if subjective performance quality serves as mediator between MPA and PER. Negative and positive PER were assessed 10 minutes, one day and two days after a concert in 72 music students with different levels of usual MPA. Subjective performance quality was measured 10 minutes after the study concert. An increasing usual MPA level was associated with more negative and less positive PER. Both decreased over time. Negative PER decreased less rapidly in high-anxious than in low-anxious musicians and positive PER decreased more rapidly in low-anxious than in high-anxious musicians. Subjective performance quality mediated the relationship between MPA and PER. These findings extend previous knowledge in social anxiety to the field of MPA and have implications for interventions aiming at reducing MPA.
    Type of Medium: Online Resource
    ISSN: 0305-7356 , 1741-3087
    URL: Article
    DOI: 10.1177/0305735617706539
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2110840-7
    SSG: 5,2
    SSG: 9,2
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