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  • 1
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    Online Resource
    Long-term follow-up of cats in complete remission after treatment of feline infectious peritonitis with oral GS-441524
    SAGE Publications ; 2023
    In:  Journal of Feline Medicine and Surgery Vol. 25, No. 8 ( 2023-08)
    Details
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 25, No. 8 ( 2023-08)
    Abstract: Feline infectious peritonitis (FIP), a common disease in cats caused by feline coronavirus (FCoV), is usually fatal once clinical signs appear. Successful treatment of FIP with oral GS-441524 for 84 days was demonstrated recently by this research group. The aim of this study was to evaluate the long-term outcome in these cats. Methods A total of 18 successfully treated cats were followed for up to 1 year after treatment initiation (9 months after completion of the antiviral treatment). Follow-up examinations were performed at 12-week intervals, including physical examination, haematology, serum biochemistry, abdominal and thoracic ultrasound, FCoV ribonucleic acid (RNA) loads in blood and faeces by reverse transciptase-quantitative PCR and anti-FCoV antibody titres by indirect immunofluorescence assay. Results Follow-up data were available from 18 cats in week 24, from 15 cats in week 36 and from 14 cats in week 48 (after the start of treatment), respectively. Laboratory parameters remained stable after the end of the treatment, with undetectable blood viral loads (in all but one cat on one occasion). Recurrence of faecal FCoV shedding was detected in five cats. In four cats, an intermediate short-term rise in anti-FCoV antibody titres was detected. In total, 12 cats showed abdominal lymphadenomegaly during the follow-up period; four of them continuously during the treatment and follow-up period. Two cats developed mild neurological signs, compatible with feline hyperaesthesia syndrome, in weeks 36 and 48, respectively; however, FCoV RNA remained undetectable in blood and faeces, and no increase in anti-FCoV antibody titres was observed in these two cats, and the signs resolved. Conclusions and relevance Treatment with GS-441524 proved to be effective against FIP in both the short term as well as the long term, with no confirmed relapse during the 1-year follow-up period. Whether delayed neurological signs could be a long-term adverse effect of the treatment or associated with a ‘long FIP syndrome’ needs to be further evaluated.
    Type of Medium: Online Resource
    ISSN: 1098-612X , 1532-2750
    URL: Article
    DOI: 10.1177/1098612X231183250
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2049047-1
    SSG: 22
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  • 2
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    Online Resource
    Cooling Effects Occur in Hepatic Microwave Ablation At Low Vascular Flow Rates and in Close Proximity to Liver Vessels – Ex Vivo
    SAGE Publications ; 2022
    In:  Surgical Innovation Vol. 29, No. 6 ( 2022-12), p. 705-715
    Details
    In: Surgical Innovation, SAGE Publications, Vol. 29, No. 6 ( 2022-12), p. 705-715
    Abstract: Background. The impact of vascular cooling effects in hepatic microwave ablation (MWA) is controversially discussed. The objective of this study was a systematic assessment of vascular cooling effects in hepatic MWA ex vivo. Methods. Microwave ablations were performed in fresh porcine liver ex vivo with a temperature-controlled MWA generator (902-928 MHz) and a non-cooled 14-G-antenna. Energy input was set to 9.0 kJ. Hepatic vessels were simulated by glass tubes. Three different vessel diameters (3.0, 5.0, 8.0 mm) and vessel to antenna distances (5, 10, 20 mm) were examined. Vessels were perfused with saline solution at nine different flow rates (0-500 mL/min). Vascular cooling effects were assessed at the largest cross-sectional ablation area. A quantitative and semi-quantitative/morphologic analysis was carried out. Results. 228 ablations were performed. Vascular cooling effects were observed at close (5 mm) and medium (10 mm) antenna to vessel distances ( P 〈 .05). Vascular cooling effects occurred around vessels with flow rates ≥1.0 mL/min ( P 〈 .05) and a vessel diameter ≥3 mm ( P 〈 .05). Higher flow rates did not result in more distinct cooling effects ( P 〉 .05). No cooling effects were measured at large (20 mm) antenna to vessel distances ( P 〉 .05). Conclusion. Vascular cooling effects occur in hepatic MWA and should be considered in treatment planning. The vascular cooling effect was mainly affected by antenna to vessel distance. Vessel diameter and vascular flow rate played a minor role in vascular cooling effects.
    Type of Medium: Online Resource
    ISSN: 1553-3506 , 1553-3514
    URL: Article
    DOI: 10.1177/15533506221074619
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2233576-6
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  • 3
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    Online Resource
    Can You Feel it? – Correlation Between Intraoperatively Perceived Bone Quality and Objectively Measured Bone Mineral Density
    SAGE Publications ; 2022
    In:  Global Spine Journal
    Details
    In: Global Spine Journal, SAGE Publications
    Abstract: clinical study. Objectives Loosening of pedicle screws is a frequent complication in patients with osteoporosis. The indication for additional stabilization, such as cement augmentation, is more often based on the subjective intraoperative feeling of the surgeon than on a preoperative bone mineral density (BMD) measurement. Aim was to evaluate the correlation of the intraoperative perceived bone quality in comparison to the objectively measured BMD. Methods A total of 62 patients undergoing dorsal stabilization using pedicle screws at a level-1 trauma center were analyzed. The preoperative CT scan measured each instrumented vertebra's pedicle size and BMD. During the surgery, the perceived screw stability was graded by the respective surgeon for each screw. Results 204 vertebral bodies were evaluated. Looking at all implanted screws a significant correlation between the measured BMD and the perceived screw stability was found (Resident r = .450; R 2 = .202; P 〈 .001/Attending r = .364; R 2 = .133; P 〈 .001), but there was no significant correlation in the osteoporotic patients (Resident P = .148 / Attending P = .907). The evaluation of the screws implanted in osteoporotic vertebrae showed that the surgeons considered a total of 31% of these screws to be sufficiently stable. Conclusions There was no significant correlation between the measured BMD and the perceived pedicle screw stability in the group with osteopenic / osteoporotic bone ( 〈 100 mg/cm³). The results indicate that it is not possible to reliably determine the bone quality and the resulting screw stability in patients with reduced BMD. The preoperative measurement of the BMD should become a crucial part of preoperative planning.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682221120398
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2648287-3
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  • 4
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    Online Resource
    Cervical Disc Arthroplasties Fail to Maintain Physiological Kinematics Under Lateral Eccentric Loads
    SAGE Publications ; 2023
    In:  Global Spine Journal
    Details
    In: Global Spine Journal, SAGE Publications
    Abstract: In vitro human cadaveric biomechanical analysis. Objectives Optimization of prostheses for cervical disc arthroplasties (CDA) reduces the risk of complications. The instantaneous helical axis (IHA) is a superior parameter for examining the kinematics of functional spinal units. There is no comprehensive study about the IHA after CDA considering all 3 motion dimensions. Methods Ten human functional spinal units C4-5 (83.2 ± 7.9 yrs.) were examined with an established measuring apparatus in intact conditions (IC), and after CDA, with 2 different types of prostheses during axial rotation, lateral bending, and flexion/extension. Eccentric preloads simulated strains. The IHA orientation and its position at the point of rest (IHA 0 -position) were analyzed. Results The results confirmed the existing data for IHA in IC. Lateral preloads showed structural alterations of kinematics after CDA: During axial rotation and lateral bending, the shift of the IHA 0 -position was corresponding with the lateral preloads’ applied site in IC, while after CDAs, it was vice versa. During lateral bending, the lateral IHA orientation was inclined, corresponding with the lateral preloads’ applied site in the IC and oppositely after the CDAs. During flexion/extension, the lateral IHA orientation was nearly vertical in the IC, while after CDA, it inclined, corresponding with the lateral preloads’ applied site. The axial IHA orientation rotated to the lateral preloads’ corresponding site in the IC; after CDA, it was vice versa. Conclusion Both CDAs failed to maintain physiological IHA characteristics under lateral preloads, revealing a new aspect for improving prostheses’ design and optimizing their kinematics.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682231193642
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 5
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    Embodied Language Learning and Cognitive Bootstrapping: Methods and Design Principles
    SAGE Publications ; 2016
    In:  International Journal of Advanced Robotic Systems Vol. 13, No. 3 ( 2016-05-01), p. 105-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 13, No. 3 ( 2016-05-01), p. 105-
    Abstract: Co-development of action, conceptualization and social interaction mutually scaffold and support each other within a virtuous feedback cycle in the development of human language in children. Within this framework, the purpose of this article is to bring together diverse but complementary accounts of research methods that jointly contribute to our understanding of cognitive development and in particular, language acquisition in robots. Thus, we include research pertaining to developmental robotics, cognitive science, psychology, linguistics and neuroscience, as well as practical computer science and engineering. The different studies are not at this stage all connected into a cohesive whole; rather, they are presented to illuminate the need for multiple different approaches that complement each other in the pursuit of understanding cognitive development in robots. Extensive experiments involving the humanoid robot iCub are reported, while human learning relevant to developmental robotics has also contributed useful results. Disparate approaches are brought together via common underlying design principles. Without claiming to model human language acquisition directly, we are nonetheless inspired by analogous development in humans and consequently, our investigations include the parallel co-development of action, conceptualization and social interaction. Though these different approaches need to ultimately be integrated into a coherent, unified body of knowledge, progress is currently also being made by pursuing individual methods.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.5772/63462
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2202393-8
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