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  • 1
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    Effect of COVID-19-related lockdown on ophthalmic practice in Italy: A report from 39 institutional centers
    SAGE Publications ; 2022
    In:  European Journal of Ophthalmology Vol. 32, No. 1 ( 2022-01), p. 695-703
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 32, No. 1 ( 2022-01), p. 695-703
    Kurzfassung: To compare the number of eye surgical procedures performed in Italy in the 2 months following the beginning of lockdown (study period) because of COVID-19 epidemic with those performed in the two earlier months of the same year (intra-year control) and in the period of 2019 corresponding to the lockdown (inter-year control). Methods: Retrospective analysis of surgical procedures carried out at 39 Academic hospitals. A distinction was made between elective and urgent procedures. Intravitreal injections were also considered. Percentages for all surgical procedures and incidence rate ratios (IRR) for rhegmatogenous retinal detachment (RRD) events were calculated. A p value 〈 0.05 was considered significant. Results: A total of 20,886 versus 55,259 and 56,640 patients underwent surgery during the lockdown versus intra-and inter-year control periods, respectively. During the lockdown, only 70% of patients for whom an operation/intravitreal injection was recommended, finally underwent surgery; the remaining patients did not attend because afraid of getting infected at the hospital (23%), taking public transportation (6.5%), or unavailable swabs (0.5%). Elective surgeries were reduced by 96.2% and 96.4%, urgent surgeries by 49.7% and 50.2%, and intravitreal injections by 48.5% and 48.6% in the lockdown period in comparison to intra-year and inter-year control periods, respectively. IRRs for RRDs during lockdown dropped significantly in comparison with intra- and inter-year control periods (CI: 0.65–0.80 and 0.61–0.75, respectively, p  〈  0.001 for both). Conclusion: This study provides a quantitative analysis of the reduction of eye surgical procedures performed in Italy because of the COVID-19 epidemic.
    Materialart: Online-Ressource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/11206721211002442
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 1475018-1
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  • 2
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    5-Fluorouracil plus Folinic Acid with or without Ifosfamide in Advanced Colorectal Cancer: A Phase II Randomized Trial
    SAGE Publications ; 2000
    In:  Tumori Journal Vol. 86, No. 3 ( 2000-05), p. 211-214
    Details
    In: Tumori Journal, SAGE Publications, Vol. 86, No. 3 ( 2000-05), p. 211-214
    Kurzfassung: This phase II trial evaluated the biomodulation of 5-fluorouracil (5-FU) plus folinic acid (FA) with or without ifosfamide (IFO) in chemotherapy-naive patients with colorectal cancer. Patients and methods Forty-eight patients were randomized to receive: FA (25 mg/m 2 iv bolus days 1 to 3), followed by 5-FU (750 mg/m 2 iv bolus days 1 to 3), arm A; or FA (25 mg/m 2 iv bolus days 1 to 3), followed by 5-FU (750 mg/m 2 iv bolus days 1 to 3) plus IFO (2,000 mg/m 2 in 1000 mL 5% dextrose in a 2-hr infusion, days 1 to 3), arm B. Mesna was added during and after IFO to prevent hemorrhagic cystitis. Treatment was repeated every 21 days in both arms. Results Forty-five patients were assessable for response: in arm A, 5 patients achieved a partial response (overall response, 25%), and in arm B, 2 patients achieved a complete and 1 a partial response (overall response, 12%). Time to failure was 3.5 months (range, 1–38) in patients treated with 5-FU plus FA, and 3 months (range, 1–21) in patients treated with the IFO combination. The median survival time was 13.5 months (range, 1–49 months) in arm A and 16 months (range, 1–43 months) in arm B. Diarrhea, stomatitis and vomiting were the most common nonhematologic toxicities in both arms. The most notable hematologic toxicity was leukopenia; 15% and 20% of patients experienced grade 4 in arm A and arm B, respectively. Conclusions IFO does not increase the activity of the 5-FU plus FA combination in advanced colorectal cancer.
    Materialart: Online-Ressource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089160008600307
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2000
    ZDB Id: 280962-X
    ZDB Id: 2267832-3
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  • 3
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    Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study
    SAGE Publications ; 2013
    In:  Multiple Sclerosis Journal Vol. 19, No. 11 ( 2013-10), p. 1508-1517
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 19, No. 11 ( 2013-10), p. 1508-1517
    Kurzfassung: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). Objectives: The CoSMo study evaluated the association between CCSVI and MS. Methods: The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. Results: The study involved 35 MS centers across Italy and included 1874 subjects aged 18–55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72–3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53–4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47–2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers. Conclusions: CCSVI is not associated with MS.
    Materialart: Online-Ressource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458513501231
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2008225-3
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  • 4
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    The microbiological profile of patients with Fournier’s gangrene: A retrospective multi-institutional cohort study
    SAGE Publications ; 2022
    In:  Urologia Journal Vol. 89, No. 3 ( 2022-08), p. 437-443
    Details
    In: Urologia Journal, SAGE Publications, Vol. 89, No. 3 ( 2022-08), p. 437-443
    Kurzfassung: To evaluate the role of the microbiological profile and of disease-related factors in the management of patients affected with Fournier’s gangrene (FG). Patients and methods: Data regarding patients admitted for FG at nine Italian Hospitals (March 2007–June 2018) were collected. Patients were stratified according to the number of microorganisms documented: Group A – one microorganism; Group B – two microorganisms; Group C – more than three microorganisms. Baseline blood tests, dedicated scoring systems, predisposing risk factors, disease’s features, management and post-operative course were analyzed. UpSet technique for visualizing set intersections in a matrix layout and Cuzick’s nonparametric test for trend across ordered groups were used. Results: Eighty-one patients were available for the analysis: 18 included in Group A, 32 in Group B, 31 in Group C. The most common microorganism isolated was Escherichia coli. In Group B-C, Escherichia coli was often associated to Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Statistically significant positive association was highlighted among the number of pathogens (Group A vs B vs C) and serum C-reactive Protein ( p 〈 0.001), procalcitonin ( p = 0.02) and creatinine ( p = 0.03). Scoring systems were associated with the number of microorganisms detected ( p 〈 0.02). A significant association between the number of microorganisms and the use of VAC therapy and need of a fecal diversion was found ( p 〈 0.02). The number of microorganisms was positively associated with the length of stay (LOS) ( p = 0.02). Ten weeks after initial debridement, wound closure was achieved in 11 (91.7%), 22 (84.6%) and 20 (80%) patients in Group A, B, and C, respectively, with no differences in overall survival. Conclusion: Polymicrobial infections in FG are positively associated with inflammatory scores, the need for fecal diversion and the LOS. This results may help the counseling and the clinical management of this rare niche of patients.
    Materialart: Online-Ressource
    ISSN: 0391-5603 , 1724-6075
    URL: Article
    DOI: 10.1177/03915603211018441
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2557852-2
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  • 5
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    Influence of Surgical Experience in the Learning Curve of a New Approach in Hip Replacement: Anterior Mini-Invasive Vs. Standard Lateral
    SAGE Publications ; 2012
    In:  HIP International Vol. 22, No. 5 ( 2012-09), p. 555-561
    Details
    In: HIP International, SAGE Publications, Vol. 22, No. 5 ( 2012-09), p. 555-561
    Kurzfassung: There is conflicting evidence regarding the potential benefit of minimally invasive surgery for total hip arthroplasty (THA), especially during the ‘learning curve’ of individual surgeons. Sixty patients who underwent THA between January and December 2010 were evaluated. The aim was to assess the anterior mini-invasive (MI) approach performed in 30 patients during the learning curve of a single experienced hip surgeon compared with the results of 30 patients operated upon through a standard lateral approach by the same surgeon. Operation and hospitalisation times, blood loss, number of transfusions, peri-operative complications and femoral/acetabular component placement were monitored. Harris Hip Score (HHS) and Hip Disability and Osteoarthritis Outcome Score (HOOS) were analysed before and 12 months after surgery. Pain Visual Analogue Scale (VAS) was also recorded 1 week and 1 month after surgery. Hospitalisation, blood loss, number of transfusions and VAS score 1 week postoperatively were significantly lower and operative time was significantly longer in the anterior MI approach. Similar functional outcomes 1 year after surgery, component positioning and complication rates were observed in both groups. The results suggest that anterior MI approach is a safe procedure during the learning curve of an experienced hip surgeon.
    Materialart: Online-Ressource
    ISSN: 1120-7000 , 1724-6067
    URL: Article
    DOI: 10.5301/HIP.2012.9710
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2012
    ZDB Id: 1475775-8
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  • 6
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    Coordinating of multi-echelon supply chains through the generalized (R, S) policy
    SAGE Publications ; 2020
    In:  SIMULATION Vol. 96, No. 9 ( 2020-09), p. 767-778
    Details
    In: SIMULATION, SAGE Publications, Vol. 96, No. 9 ( 2020-09), p. 767-778
    Kurzfassung: Numerous studies have confirmed the negative impact of the lack of coordination on supply chain performance. In particular, the lack of coordination leads to the bullwhip effect, which has severe impacts on supply chain stability. This paper evaluates a proposed coordination mechanism that allows a decentralized information sharing in multi-echelon supply chains. The proposed mechanism “Info-Smooth” utilizes the ordering rule of the generalized (R, S) policy in which a replenishment order can be transferred to upstream echelons including two pieces of information (demand forecast and inventory balance). As the generalized (R, S) can allow order smoothing, Info-Smooth combines the power of both information sharing and order smoothing. A simulation modeling methodology is employed to investigate the effectiveness of Info-Smooth in a multi-echelon supply chain. The factorial design results have shown that Info-Smooth is successful in mitigating the bullwhip effect whilst keeping acceptable inventory stability, compared to the traditional supply chain model.
    Materialart: Online-Ressource
    ISSN: 0037-5497 , 1741-3133
    URL: Article
    DOI: 10.1177/0037549720920708
    RVK:
    SA 7910
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2072208-4
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  • 7
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    Exploring the Bullwhip Effect and Inventory Stability in a Seasonal Supply Chain
    SAGE Publications ; 2013
    In:  International Journal of Engineering Business Management Vol. 5 ( 2013-01-01), p. 23-
    Details
    In: International Journal of Engineering Business Management, SAGE Publications, Vol. 5 ( 2013-01-01), p. 23-
    Kurzfassung: The bullwhip effect is defined as the distortion of demand information as one moves upstream in the supply chain, causing severe inefficiencies in the whole supply chain. Although extensive research has been conducted to study the causes of the bullwhip effect and seek mitigation solutions with respect to several demand processes, less attention has been devoted to the impact of seasonal demand in multi-echelon supply chains. This paper considers a simulation approach to study the effect of demand seasonality on the bullwhip effect and inventory stability in a four-echelon supply chain that adopts a base stock ordering policy with a moving average method. The results show that high seasonality levels reduce the bullwhip effect ratio, inventory variance ratio, and average fill rate to a great extent; especially when the demand noise is low. In contrast, all the performance measures become less sensitive to the seasonality level when the noise is high. This performance indicates that using the ratios to measure seasonal supply chain dynamics is misleading, and that it is better to directly use the variance (without dividing by the demand variance) as the estimates for the bullwhip effect and inventory performance. The results also show that the supply chain performances are highly sensitive to forecasting and safety stock parameters, regardless of the seasonality level. Furthermore, the impact of information sharing quantification shows that all the performance measures are improved regardless of demand seasonality. With information sharing, the bullwhip effect and inventory variance ratios are consistent with average fill rate results.
    Materialart: Online-Ressource
    ISSN: 1847-9790 , 1847-9790
    URL: Article
    DOI: 10.5772/56833
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2597501-8
    SSG: 3,2
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  • 8
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    Fluid Dynamic Characterization of a Polymeric Heart Valve Prototype (Poli-Valve) Tested under Continuous and Pulsatile Flow Conditions
    SAGE Publications ; 2015
    In:  The International Journal of Artificial Organs Vol. 38, No. 11 ( 2015-11), p. 600-606
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 38, No. 11 ( 2015-11), p. 600-606
    Kurzfassung: Only mechanical and biological heart valve prostheses are currently commercially available. The former show longer durability but require anticoagulant therapy; the latter display better fluid dynamic behavior but do not have adequate durability. New Polymeric Heart Valves (PHVs) could potentially combine the hemodynamic properties of biological valves with the durability of mechanical valves. This work presents a hydrodynamic evaluation of 2 groups of newly developed supra-annular, trileaflet prosthetic heart valves made from styrenic block copolymers (SBC): Poli-Valves. Methods 2 types of Poli-Valves made of SBC and differing in polystyrene fraction content were tested under continuous and pulsatile flow conditions as prescribed by ISO 5840 Standard. A pulse duplicator designed ad hoc allowed the valve prototypes to be tested at different flow rates and frequencies. Pressure and flow were recorded; pressure drops, effective orifice area (EOA), and regurgitant volume were computed to assess the behavior of the valve. Results Both types of Poli-Valves met the minimum requirements in terms of regurgitation and EOA as specified by the ISO 5840 Standard. Results were compared with 5 mechanical heart valves (MHVs) and 5 tissue heart valves (THVs), currently available on the market. Conclusions Based on these results, PHVs based on styrenic block copolymers, as are Poli-Valves, can be considered a promising alternative for heart valve replacement in the near future.
    Materialart: Online-Ressource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.5301/ijao.5000452
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2015
    ZDB Id: 1474999-3
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  • 9
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    De Quervain Disease in Volleyball Players
    SAGE Publications ; 2005
    In:  The American Journal of Sports Medicine Vol. 33, No. 3 ( 2005-03), p. 424-427
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 33, No. 3 ( 2005-03), p. 424-427
    Kurzfassung: Chronic inflammatory tendon diseases in athletes are frequent, and they often result from modifications in normal kinematics of a tendon associated with a patient's anatomical determinants. De Quervain stenosing tenosynovitis is an inflammatory disease of tendons of the first dorsal compartment of the wrist. There is no literature about this disease concerning professional volleyball players. Hypothesis Limited, multiple trauma on the dorsal radial portion of the wrist, associated with long training times, can be involved in the pathogenetic process of de Quervain disease in professional volleyball players. Study Design Case series; Level of evidence, 4. Materials and Methods The authors studied 45 consecutively enrolled volleyball players (27 professional, 18 nonprofessional) satisfying clinical criteria for the diagnosis of de Quervain stenosing tenosynovitis. All patients were evaluated by questionnaire and physical examination. They were divided into group A (mild) and group B (severe) based on the severity of the symptoms and physical findings; they were followed for a mean of 37 months. Results Total training quantity (mean weekly training time multiplied by mean sports activity duration) in group A was 74, whereas it was 155 in group B (P 〈 . 01). No neuropathies were found in group A, whereas they were found in 3 patients in group B. Fifty percent of surgical patients had a longitudinal fibrous septum, whereas 54% showed multiple tendon sheaths making up the abductor pollicis longus tendon. Conclusions This study shows that increased training time and consequent microtrauma associated with professional volleyball activity can increase the likelihood of de Quervain disease.
    Materialart: Online-Ressource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546504268134
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2005
    ZDB Id: 2063945-4
    SSG: 31
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  • 10
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    Infants Born to Mothers With Anti-SSA/Ro Autoantibodies: Neonatal Outcome and Follow-up
    SAGE Publications ; 2008
    In:  Clinical Pediatrics Vol. 47, No. 3 ( 2008-04), p. 231-236
    Details
    In: Clinical Pediatrics, SAGE Publications, Vol. 47, No. 3 ( 2008-04), p. 231-236
    Kurzfassung: Neonatal lupus syndrome is considered a model of passively acquired autoimmune disease. The first 10 newborns born to mothers with connective tissue disease and positive for anti-SSA/Ro antibodies enrolled in a follow-up program to evaluate the incidence of cardiac, hepatobiliary, hematologic, echoencephalographic, and cutaneous manifestations until 9 months of age are described in this study. No congenital heart block was observed, but only transient rhythm alterations were observed. In all, 1 infant showed typical neonatal lupus syndrome skin lesions at 3 months of age. During the neonatal period, echoencephalographic alterations were found more frequently, whereas at follow-up, hepatic and hematologic alterations were more often observed. In all, 1 baby showed persistent neutropenia. A standard program that enrolls all infants born to mothers with anti-SSA/Ro autoantibodies, who are at risk of developing neonatal lupus syndrome, should also include tests performed some time after birth, as a number of clinical manifestations might appear at a late stage.
    Materialart: Online-Ressource
    ISSN: 0009-9228 , 1938-2707
    URL: Article
    DOI: 10.1177/0009922807307264
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2008
    ZDB Id: 2066146-0
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