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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2673, No. 11 ( 2019-11), p. 59-70
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2673, No. 11 ( 2019-11), p. 59-70
    Abstract: A central issue in urban inequity has to do with distributive justice in the costs and benefits associated with urban transport, and whether certain population groups are systematically disadvantaged about mobility, accessibility, affordability, and externalities, the preponderant factors in transport poverty. This article proposes a methodology for analyzing how investment in transport infrastructure and non-housing construction, mobility levels (trip distances, times, and speeds) and the associated trip costs (monetary, accidents, pollution, and energy consumption) are distributed across the different socioeconomic quintiles of a city. The methodology was applied to the real-world case of Santiago de Chile. The results showed that compared with the lowest income quintile, people in the highest income quintile made 1.2 times more trips at an average speed 1.6 times higher. In relation to costs, the richest quintile generated 6.7 times as much pollution and used 7 times as much energy but consumed a significantly lower share of their income (10% vs. 45%). In addition, the top quintile was the beneficiary of 2.5 times more investment in both transport infrastructure and new construction space for commercial activities and services over the period considered. Finally, private car use in the top quintile was 5.3 times greater. This transport mode accounts for 6.8 times more of the accident rate than public transport, bicycles, or walking combined. This clearly inequitable scenario points to the needs for progressive policies that target lower income groups and promote a more rational use of cars in view of their negative impacts on the city.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2403378-9
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  • 2
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 30, No. 9 ( 2011-09), p. 1382-1391
    Abstract: Paullinia cupana Mart. var. Sorbilis, commonly known as Guaraná, is a Brazilian plant frequently cited for its antioxidant properties and different pharmacological activities on the central nervous system. The potential beneficial uses of Guaraná in neurodegenerative disorders, such as in Parkinson's disease (PD), the pathogenesis of which is associated with mitochondrial dysfunction and oxidative stress, has not yet been assessed. Therefore, the main aim of the present study was to evaluate if an extract of commercial powdered seeds of Guaraná could protect human dopaminergic neuroblastoma SH-SY5Y cell line against rotenone-induced cytotoxicity. Two concentration of Guaraná dimethylsulfoxide extract (0.312 and 0.625 mg/mL) were added to SH-SY5Y cells treated with 300 nM rotenone for 48 h, and the cytoprotective effects were assessed by means of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, measuring lactate dehydrogenase (LDH) levels, and analyzing nuclear integrity with Hoechst33258 stain. Results showed that the addition of Guaraná extract significantly increased the cell viability of SH-SY5Y cells treated with rotenone, in a dose-dependent manner. On the other hand, LDH levels were significantly reduced by addition of 0.312 mg/mL of Guaraná, but unexpectedly, no changes were observed with the higher concentration. Moreover, chromatin condensation and nuclear fragmentation were significantly reduced by addition of any of both concentrations of the extract. The results obtained in this work could provide relevant information about the mechanisms underlying the degeneration of dopaminergic neurons in PD and precede in vivo experiments. Further studies are needed to investigate which active constituent is responsible for the cytoprotective effect produced by Paullinia cupana.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 1483723-7
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