In:
European Journal of Clinical Investigation, Wiley, Vol. 11, No. 4 ( 1981-08), p. 279-283
Abstract:
Abstract. recovery from acute hypoglycaemia induced by the injection of insulin has been examined in six human subjects under control conditions, under nonselective beta blockade (propranolol) and under selective beta] blockade (metoprolol). The normal blood glucose recovery was biphasic with an initial rapid and a slower subsequent phase of recovery. The early recovery mechanism was unaffected by either form of beta blockade, but with propranolol the late phase of recovery was significantly prolonged. Rises in blood lactate and plasma free fatty acids following hypoglycaemia were markedly reduced by propranolol but to a much lesser degree with metoprolol. The counterregulatory hormonal responses of glucagon, cortisol and growth hormone were augmented appropriately for the prolonged hypoglycaemia ass ociated with propranolol. Non‐selective beta adrenergic blockade with propranolol is associated with an impairment of the late phase of blood glucose recovery from hypoglycaemia. The possible mechanisms of this impairment are discussed.
Type of Medium:
Online Resource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.1981.11.issue-4
DOI:
10.1111/j.1365-2362.1981.tb02117.x
Language:
English
Publisher:
Wiley
Publication Date:
1981
detail.hit.zdb_id:
2004971-7
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