In:
Cancer Medicine, Wiley, Vol. 5, No. 10 ( 2016-10), p. 2740-2755
Abstract:
Categorization of primary cutaneous B‐cell lymphomas ( PCBCL ) other than marginal zone ( MZL ) represents a diagnostic challenge with relevant prognostic implications. The 2008 WHO lymphoma classification recognizes only primary cutaneous follicular center cell lymphoma ( PCFCCL ) and primary cutaneous diffuse large B‐cell lymphoma, leg type ( PCDLBCL ‐ LT ), whereas the previous 2005 WHO / EORTC classification also included an intermediate form, namely PCDLBCL , other. We conducted a retrospective, multicentric, consensus‐based revision of the clinicopathologic characteristics of 161 cases of PCBCL other than MZL . Upon the histologic features that are listed in the WHO classification, 96 cases were classified as PCFCCL and 25 as PCDLBCL ‐ LT ; 40 further cases did not fit in the former subgroups in terms of cytology and/or architecture, thus were classified as PCDLBCL , not otherwise specified ( PCDLBCL ‐ NOS ). We assigned all the cases a histogenetic profile, based on the immunohistochemical detection of CD 10, BCL 6, and MUM 1, and a “double hit score” upon positivity for BCL 2 and MYC . PCDLBCL ‐ NOS had a clinical presentation more similar to PCFCCL , whereas the histology was more consistent with the picture of a diffuse large B‐cell lymphoma, as predominantly composed of centroblasts but with intermixed a reactive infiltrate of small lymphocytes. Its behavior was intermediate between the other two forms, particularly when considering only cases with a “non‐germinal B‐cell” profile, whereas “germinal center” cases resembled PCFCCL . Our data confirmed the aggressive behavior of PCDLBC ‐ LT , which often coexpressed MYC and BCL 2. The impact of single factors on 5‐year survival was documented, particularly histogenetic profile in PCDLBCL and BCL 2 translocation in PCFCCL . Our study confirms that a further group— PCDLBCL ‐ NOS —exists, which can be recognized through a careful combination of histopathologic criteria coupled with adequate clinical information.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2016.5.issue-10
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2659751-2
Bookmarklink