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  • Conference Proceeding  (10)
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  • Conference Proceeding  (10)
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  • 1
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America 21 , 7659-7664., 2014
    Description: The lariat-capping (LC) ribozyme is a natural ribozyme isolated from eukaryotic microorganisms. Despite apparent structural similarity to group I introns, the LC ribozyme catalyzes cleavage by a 2',5' branching reaction, leaving the 3' product with a 3-nt lariat cap that functionally substitutes for a conventional mRNA cap in the downstream pre-mRNA encoding a homing endonuclease. We describe the crystal structures of the precleavage and postcleavage LC ribozymes, which suggest that structural features inherited from group I ribozymes have undergone speciation due to profound changes in molecular selection pressure, ultimately giving rise to an original branching ribozyme family. The structures elucidate the role of key elements that regulate the activity of the LC ribozyme by conformational switching and suggest a mechanism by which the signal for branching is transmitted to the catalytic core. The structures also show how conserved interactions twist residues, forming the lariat to join chemical groups involved in branching.
    Keywords: Arn ; Ribozyme ; Rna Structure;Rna Catalysis;Gir1;Crystallography;Saxs
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 2
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America 21 , 7659-7664., 2014
    Description: The lariat-capping (LC) ribozyme is a natural ribozyme isolated from eukaryotic microorganisms. Despite apparent structural similarity to group I introns, the LC ribozyme catalyzes cleavage by a 2',5' branching reaction, leaving the 3' product with a 3-nt lariat cap that functionally substitutes for a conventional mRNA cap in the downstream pre-mRNA encoding a homing endonuclease. We describe the crystal structures of the precleavage and postcleavage LC ribozymes, which suggest that structural features inherited from group I ribozymes have undergone speciation due to profound changes in molecular selection pressure, ultimately giving rise to an original branching ribozyme family. The structures elucidate the role of key elements that regulate the activity of the LC ribozyme by conformational switching and suggest a mechanism by which the signal for branching is transmitted to the catalytic core. The structures also show how conserved interactions twist residues, forming the lariat to join chemical groups involved in branching.
    Keywords: Arn ; Ribozyme ; Rna Structure;Rna Catalysis;Gir1;Crystallography;Saxs
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 3
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 2009, Vol.106(10), pp.4012-4017
    Description: Synapse loss correlates with a cognitive decline in Alzheimer's disease (AD), but whether this is caused by fibrillar deposits known as senile plaques or soluble oligomeric forms of amyloid β (Aβ) is controversial. By using array tomography, a technique that combines ultrathin sectioning of tissue with immunofluorescence, allowing precise quantification of small structures, such as synapses, we have tested the hypothesis that oligomeric Aβ surrounding plaques contributes to synapse loss in a mouse model of AD. We find that senile plaques are surrounded by a halo of oligomeric Aβ. Analysis of 〉14,000 synapses (represented by PSD95-stained excitatory synapses) shows that there is a 60% loss of excitatory synapses in the halo of oligomeric Aβ surrounding plaques and that the density increases to reach almost control levels in volumes further than 50 μm from a plaque in an approximately linear fashion (linear regression, r² = 0.9; P 〈 0.0001). Further, in transgenic cortex, microdeposits of oligomeric Aβ associate with a subset of excitatory synapses, which are significantly smaller than those not in contact with oligomeric Aβ. The proportion of excitatory synapses associated with Aβ correlates with decreasing density (correlation, -0.588; P 〈 0.0001). These data show that senile plaques are a potential reservoir of oligomeric Aβ, which colocalizes with the postsynaptic density and is associated with spine collapse, reconciling the apparently competing schools of thought of "plaque" vs. "oligomeric Aβ" as the synaptotoxic species in the brain of AD patients. ; p. 4012-4017.
    Keywords: Tomography ; Cortex ; Patients ; Alzheimer Disease ; Animal Models ; Genetically Modified Organisms ; Synapse ; Fluorescent Antibody Technique ; Brain ; Amyloid ; Linear Models
    ISSN: 0027-8424
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 4
    Language: English
    In: International European Forum on System Dynamics and Innovation in Food Networks〉2010 International European Forum, February 8-12, 2010, Innsbruck-Igls, Austria, October 2010
    Description: Usually, marketing communication efforts in the agrifood sector address the end consumers and concentrate on products that are processed and ready for consumption, thus quality efforts often concentrate on the final product. Moreover, there’s...
    Keywords: Agribusiness ; Agricultural and Food Policy ; Farm Management ; Food Consumption/Nutrition/Food Safety ; Production Economics ; Research Methods/ Statistical Methods ; Prototyping ; Quality Communication System ; Region of Origin
    Source: AgEcon Search: Research in Agricultural and Applied Economics
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  • 5
    Language: English
    In: Proceedings of the 15th ACM Symposium on applied perception, 10 August 2018, pp.1-8
    Description: A method is presented for perceptually characterizing appearance non-uniformities that result from 3D printing. In contrast to physical measurements, the model is designed to take into account the human visual system and variations in observer conditions such as lighting, point of...
    Keywords: 3d Printing ; Appearance Uniformity ; Neural Networks ; Spatially-Varying Appearance Perception
    ISBN: 9781450358941
    ISBN: 1450358942
    Source: ACM Digital Library (Association for Computing Machinery)
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  • 6
    Language: English
    In: 2010
    Description: Usually, marketing communication efforts in the agrifood sector address the end consumers and concentrate onproducts that are processed and ready for consumption, thus quality efforts often concentrate on the final product.Moreover, there’s a widespread view that agricultural commodities like wheat aren’t suitable neither forproduct focused marketing nor branding. However, recent developments in the in agrifood sector challenge thisview. The increasing use of biotechnology, the globalisation of markets and changing consumer demands forquality, food safety and process attributes require improved communication concepts and information sharingalong whole production chains. This paper considers the development of a quality communication system tosupport a regional wheat brand and prerequisites for quality management efforts.
    Keywords: Farm Management ; Region Of Origin ; Agricultural And Food Policy ; Research Methods/ Statistical Methods ; Production Economics ; Food Consumption/Nutrition/Food Safety ; Agribusiness ; Prototyping ; Quality Communication System
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 7
    Language: English
    In: MRS Proceedings, 2010, Vol.1268
    Description: Pulsed-laser-deposited ZnO thin films were exposed to a 1.5 MeV helium ion beam to study the changes in radiative and non-radiative recombination. The authors first measured photoluminescence (PL) spectra at 4.2 K excited with the 325 nm line of a HeCd laser. The as-deposited films showed a donor-bound exciton peak at 3.3567 eV attributed to Zn interstitials. After irradiation the donor-bound-exciton dominated PL spectra shifted to acceptor-bound behaviour with a signal at 3.3519 eV, tentatively attributed to Li or Na acceptors. In contrast to the approximately 30 % decrease of the PL signal near the band edge, the authors observed a strong concomitant enhancement of the green/orange PL band, located between 2.1 eV and 2.8 eV, by a factor of over 4. Candidates for those transitions are Li impurities and/or vacancies. For comparison, the steady-state photocurrent decreased strongly in the irradiated region, which can also be attributed to increased non-radiative recombination through oxygen-related defects.
    Keywords: Zinkoxid ; Halbleiterdünnschicht ; Ionenbestrahlung ; Heliumion ; Laserstrahlbearbeitung ; Photolumineszenzspektrum ; Angeregter Zustand ; Optisches Pumpen ; Exciton ; Akzeptor (Fremdatom) ; Donator (Fremdatom) ; Lithiumzusatz ; Natriumzusatz ; Verunreinigung ; Gitterlücke ; Photostrom ; Photoleitfähigkeit ; Rutherford-Rückstreuspektrometrie ; Xps-Spektroskopie ; Engineering;
    ISBN: 9781605112459
    ISSN: 0272-9172
    E-ISSN: 1946-4274
    Source: CrossRef
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  • 8
    Language: English
    In: The Search FOR Other Worlds: Fourteenth Astrophysics Conference, College Park, Maryland (USA) (13-14 October 2003):
    In: AIP Conference Proceedings, 24 June 2004, Vol.713(1), pp.193-196
    Description: We plan to take advantage of the unprecedented combination of low thermal background and high resolution provided by the 6.5m MMT’s adaptive secondary mirror, to target the 3–5 micron atmospheric window where giant planets are expected to be anomalously bright. We are in the process of building a 3–5 micron coronograph that is predicted to be sensitive to planets as close as 0.4 arcsec to the parent star. We expect to be able to detect giant planets down to 5 times Jupiter’s mass for a 1 Gyr old system at 10 pc. We plan to carry out a survey which is complementary to the radial velocity detections of planets and constructed to characterize the prevalence and distribution of giant planets around nearby, Sun‐like stars.
    Keywords: Astronomy and Astrophysics
    ISBN: 0-7354-0190-X
    ISSN: 0094-243X
    E-ISSN: 1551-7616
    Source: © 2004 American Institute of Physics (AIP)〈img src=http://exlibris-pub.s3.amazonaws.com/AIP_edited.gif style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Proceedings of SPIE, 30 September 2004, Vol.5492(1), pp.1561-1571
    Description: We plan to take advantage of the unprecedented combination of low thermal background and high resolution provided by the 6.5m MMT's adaptive secondary mirror, to target the 3-5 micron atmospheric window where giant exoplanets are expected to be anomalously bright. We are in the process of building a 3-5 micron camera that we will use to carry out a survey to characterize the prevalence and distribution of giant planets around nearby, Sun-like stars. Sensitivity estimates show that for a 1 Gyr old G0V primary at 10 pc, we expect to detect 5 M and 15 M exoplanets at angular separations greater than 0.45-2.1" and 0.2-1.2" respectively. Monte Carlo simulations based on these sensitivity estimates and a sample of 80 young (〈1 Gyr), nearby (〈20 pc) M0V-F0V stars, predict the detection of 15±3 exoplanets with masses of 4-15 M and separations of 17-50 AU. Construction of the camera is currently underway and on-telescope testing is expected in the Fall 2004-Winter 2005.
    Keywords: Engineering
    ISSN: 0277-786X
    Source: SPIE Digital Library - Journals
    Source: SPIE Digital Library - Proceedings
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  • 10
    Language: English
    In: European Palaeobotany and Palynology Conference EPPC 2018
    Keywords: Life Sciences ; Biodiversity ; Systematics, Phylogenetics and Taxonomy ; Life Sciences ; Ecology, Environment ; Ecosystems ; Life Sciences ; Vegetal Biology ; Botanics ; Environmental Sciences ; Biodiversity and Ecology ; Devonian ; Archaeopterid ; Environmental Sciences
    Source: Hyper Article en Ligne (CCSd)
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