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  • 1
    Language: English
    Description: NcRNA represent most of primary transcripts RNA in higher eukaryotes and tune gene expression via diverse mechanisms. They adopt 3D structures composed at 70% by WC bp forming A-form helices linked by RNA motifs. We identified the pk-turn,...
    Keywords: Life Sciences ; Biochemistry, Molecular Biology ; Branching Reaction ; Lcrz Ribozyme ; RNA Structure ; Crystallography ; Saxs ; Twintron ; Cristallographie ; Ribozymes ; Structure Arn ; Ribozyme Lcrz ; Gir1 ; Réaction de Branchement
    Source: Hyper Article en Ligne (CCSd)
    Source: Hyper Article en Ligne Open Access (CCSd)
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  • 2
    Description: Adolessente loop In hoe risiko om slagoffers van seksuele misbruik te word. Seksuele misbruik het In merkwaardige impak op adolessente. Tesame met die hoe eise wat die stormagtige adolessensieperiode aan In persoon stel is vroee intervensie veral noodsaaklik. Dit word geredelik aanvaar dat vroee intervensie ernstige versteurings in volwassensheid mag verhoed. Adolessente kom egter oor die algemeen nie vanself na vore vir die nodige hulpverlening nie. Die doel van die ondersoek was om ondersoek in te stel na die noodsaaklikheid van In bewusmakingsprogram vir adolessente rakende seksuele misbruik. Die doel was verder om aanbevelings aan die hand te doen vir die ontwerp van In effektiewe bewusmakingsprogram. Die navorsing het In gekombineerde kwantitatiewe en kwalitatiewe benadering gevolg. 214 adolessente en 10 onderwysers van twee hoerskole is by die ondersoek betrek. Albei groepe deelnemers het vraelyste voltooi. Adolessente het kwantitatiewe vraelyste voltooi terwyl onderwysers In kwalitatiewe skedule voltooi het. Uit laasgenoemde is verskeie temas ge'identifiseer en bespreek. Die studie was verkennend sowel as beskrywend van aard. Dit is vanuit die bevindings duidelik dat daar die noodsaaklikheid bestaan van In bewusmakingsprogram aan adolessente rakende seksuele misbruik. Aanbevelings rakende die inhoud en ontwerp van so In program is vanuit die studie gedoen. Thesis (M.A. (MW))--North-West University, Potchefstroom Campus, 2011.
    Keywords: Bewusmakingsprogram ; Adolessente ; Seksuele Misbruik ; Awareness Program ; Adolescents ; Sexual Abuse
    Source: Networked Digital Library of Theses and Dissertations
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  • 3
    Dissertation
    Dissertation
    Uppsala universitet, Företagsekonomiska institutionen ; Uppsala universitet, Företagsekonomiska institutionen
    Language: English
    Description: The power of digital technology serves developers of new services as an access funnel to the vast amount of customer behavioural information. The utilization of this information is forecasted to differentiate the winners from the losers in the market and benefit the new service development process. This study explores the phenomenon of customer information in new service development empirically by looking at the industry at the forefront, the gaming industry. By conducting three case studies with leading Swedish game developers, it challenges the previous research assumptions that acquired and disseminated customer information is implicitly used. This study has made significant contributions by investigating the broader context of customer information use and differentiating among three types of use. The findings show that behavioural information is used to backup own decisions or to enhance the developers understanding, but is not directly applied to the decision task. Despite the great potential, this advanced type of customer information is only used in the post-launch stages of new service development, for service iterations. To further validate the findings and explore information use in new service development more in-depth, future research generating contextual detailed realtime data is needed.
    Keywords: Customer Information ; Customer Information Use ; New Service Development ; Behavioural Data ; Digital Services ; Gaming Industry ; Social Sciences ; Samhällsvetenskap ; Economics And Business ; Ekonomi Och Näringsliv
    Source: Networked Digital Library of Theses and Dissertations
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  • 4
    Language: German
    Description: Liberalization of the European energy markets – until then traditionally based on monopolies and the domain of the Member States – was first pushed forward in the context of the internal market of the European Union. With the decision of the European Court in the 90ies („Courbeau“, „Amelo“, the so called „energy monopoly decisions“) the liberalization slowed down considerably. These decisions regarding the exemption in Article 86.2 of the EC-Treaty as well as the implementation of Article 16 EC-Treaty showed a different attitude towards those markets which have been a public service domain in the Member States. The goal of this thesis is to examine if and to what extent these Directives show a more critical attitude towards the primacy of competition and if and to what extent a new concept of public services guarantees has been established on a European level. The developments of the text and judicial interpretation of the EC-Treaty will be followed by a in-depth analysis of the individual provision regarding public services guarantees in the Directive. The main question is if the new provisions in the Directive display just a parallel to the new attitude towards Article 86.2 and Article 16 of the EC-Treaty or if the changes bring the public service idea in the energy sector to a new level in European law.
    Keywords: 340 Recht ; 340 Law ; Ddc:340 ; Public Service Energy Directive
    Source: Freie Universitat Berlin
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  • 5
    Language: English
    Description: The power of digital technology serves developers of new services as an access funnel to the vast amount of customer behavioural information. The utilization of this information is forecasted to differentiate the winners from the losers in the market and benefit the new service development process. This study explores the phenomenon of customer information in new service development empirically by looking at the industry at the forefront, the gaming industry. By conducting three case studies with leading Swedish game developers, it challenges the previous research assumptions that acquired and disseminated customer information is implicitly used. This study has made significant contributions by investigating the broader context of customer information use and differentiating among three types of use. The findings show that behavioural information is used to backup own decisions or to enhance the developers understanding, but is not directly applied to the decision task. Despite the great potential, this advanced type of customer information is only used in the post-launch stages of new service development, for service iterations. To further validate the findings and explore information use in new service development more in-depth, future research generating contextual detailed realtime data is needed.
    Keywords: Customer Information ; Customer Information Use ; New Service Development ; Behavioural Data ; Digital Services ; Gaming Industry ; Social Sciences ; Samhällsvetenskap ; Social Sciences ; Economics And Business ; Samhällsvetenskap ; Ekonomi Och Näringsliv ; Masterprogram I Företagande Och Ledning ; Master Programme In Business And Management
    Source: Uppsala University Library
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  • 6
    Dissertation
    Dissertation
    Université de Strasbourg
    Language: English
    Description: NcRNA represent most of primary transcripts RNA in higher eukaryotes and tune gene expression via diverse mechanisms. They adopt 3D structures composed at 70% by WC bp forming A-form helices linked by RNA motifs. We identified the pk-turn, a new RNA motif related to k-turns that allow for the formation of a bend of 60° between stems P16 and P17 from the bacterial RNaseP. Yet it features different sequence and structural requirements than k-turns. The 2nd ribozyme which got my attention is the LCrz inserted in GIR2, a group I intron. This twintron is observed in the pre-rRNA 18S of the small subunit of the eukaryoteD. iris. LCrz catalyzes a reaction equivalent to the first step of splicing by group II introns, but in a structural context related to group I introns. We solved the 2.5 Å crystal structure of the LCrz and confirmed the unexpected shape by means of SAXS experiments. This work emphasizes the relationship between structure and function in the evolution of ribozymes.
    Keywords: Life Sciences/Biochemistry ; Molecular Biology ; Sciences Du Vivant/Biochimie ; Biologie Moléculaire ; Ribozymes ; Rna Structure ; Lcrz Ribozyme ; Gir1 ; Branching Reaction ; Crystallography ; Saxs ; Twintron
    Source: Networked Digital Library of Theses and Dissertations
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  • 7
    Dissertation
    Dissertation
    ScholarWorks
    Language: English
    Description: Health care reform has caused consumers to learn more about what it means to have health insurance and its costs. Patient engagement, a critical component of health care reform, reflects provider and consumer attention to shared decision making between patient and physician. The problem addressed in this study is that although researchers have studied patient engagement, there has been insufficient exploration of the relationship between financial literacy and patient engagement, which could negatively impact health outcomes not only for patients or consumers but for society as a whole. The purpose of this quantitative research was to determine if a relationship exists between patient financial literacy and patient engagement, as measured by the patient activation measure. The potential effects of increased patient financial responsibility due to high deductible health plans, measured via an item inquiring about participantsâ?? deductible, as well as shared decision making between physician and patient were also evaluated as potential moderators between financial literacy and patient engagement. Theories used to provide conceptual context include Shimâ??s cultural health capital theory and Bourbeauâ??s (2008) self-management model. Two hierarchical linear multiple regression models were used to test the research hypotheses. While the research did not find a significant relationship between patient financial literacy and patient engagement, it did confirm the importance of mental health status and patient-physician shared decision making as important predictors of patient engagement. These findings provide a better understanding of financial literacy and specific financial behaviors in the context of healthcare environment today.
    Keywords: Financial Literacy ; Patient Activation ; Patient Engagement ; Patient Financial Responsibility ; Self Management ; Shared Decision Making ; Health And Medical Administration ; Medicine And Health Sciences ; Public Health Education And Promotion
    Source: Networked Digital Library of Theses and Dissertations
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  • 8
    Language: German
    Description: Berlin, Freie Universiẗat, Diss., 2007. Dateiformat: zip, Dateien im PDF-Format.
    Source: Networked Digital Library of Theses and Dissertations
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  • 9
    Language: German
    Description: Berlin, Freie Univ., Diss., 2007.
    Source: Networked Digital Library of Theses and Dissertations
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  • 10
    Language: English
    Description: Les ARNnc sont impliqués dans la régulation de l’expression des gènes via divers mécanismes. Ils adoptent des structures 3D composées à 70% de pb WC formant des hélices de types A liées entre elles par des jonctions modulaires ayant des caractéristiques géométriques spécifiques. Nous avons identifié un nouveau motif 3D d’ARN apparenté au kturn, le pk-turn. Le pk-turn, situé dans la RNase P bactérienne permet, comme le k-turn, la formation d’un angle de 60° entre les hélices P16 & P17 avec cependant des exigences de séquences et de structure différentes. Le 2nd ribozyme qui a focalisé mon attention est le LCrz observé dans l’intron siamois (GIR2/LCrz) identifié dans le pré-ARNr 18S de la petite sous unité du ribosome eucaryote du myxomycète D. iridis. LCrz catalyse une réaction de branchement, équivalente à la première étape de l’épissage par les introns de groupe II, dans un contexte structural proche des introns du groupe I. Nous avons résolu la structure cristallographique du LCrz à une résolution de 2.5Å révélant un repliement inattendu. Cette structure a été confirmée par des expériences de SAXS. Ce travail nous permet de souligner la relation entre structure et fonction dans l'évolution des ribozymes. NcRNA represent most of primary transcripts RNA in higher eukaryotes and tune gene expression via diverse mechanisms. They adopt 3D structures composed at 70% by WC bp forming A-form helices linked by RNA motifs. We identified the pk-turn, a new RNA motif related to k-turns that allow for the formation of a bend of 60° between stems P16 and P17 from the bacterial RNaseP. Yet it features different sequence and structural requirements than k-turns. The 2nd ribozyme which got my attention is the LCrz inserted in GIR2, a group I intron. This twintron is observed in the pre-rRNA 18S of the small subunit of the eukaryoteD. iris. LCrz catalyzes a reaction equivalent to the first step of splicing by group II introns, but in a structural context related to group I introns. We solved the 2.5 Å crystal structure of the LCrz and confirmed the unexpected shape by means of SAXS experiments. This work emphasizes the relationship between structure and function in the evolution of ribozymes.
    Keywords: Ribozymes ; Structure Arn ; Ribozyme Lcrz ; Gir1 ; Réaction De Branchement ; Cristallographie ; Saxs ; Twintron ; Ribozymes ; Rna Structure ; Lcrz Ribozyme ; Gir1 ; Branching Reaction ; Crystallography ; Saxs ; Twintron ; 572.8
    Source: Networked Digital Library of Theses and Dissertations
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