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  • 1
    Dissertation
    Dissertation
    Royal Holloway, University of London
    Language: English
    Description: The success of the First Crusade by the Christian armies caught the interest and arrested the imagination of contemporaries, stimulating the production of a large number of historical narratives. Four eyewitness accounts, as well as letters written by the crusaders to the West, were taken up by later authors, re-worked and re-fashioned into new narratives; a process which continued throughout the twelfth century and beyond. This thesis sets out to explore why contemporaries continued to write about the First Crusade in light of medieval attitudes towards the past, how authors constructed their narratives and how the crusade and the crusaders were remembered throughout the twelfth and thirteenth centuries. It will analyse the development in the way the First Crusade was recorded and investigate the social, religious, intellectual and political influences dictating change: How, why and under what circumstances was the story re- told? What changed in the re-telling? What ideas and concepts were the authors trying to communicate and what was their meaning for contemporaries? The thesis will also aim to place these texts not only in their historical but also in their literary contexts, analyse the literary traditions from which authors were writing, and consider the impact the crusade had on medieval literature. The focus will be on Latin histories of the First Crusade, especially those written in England and France, which produced the greatest number of narratives. Those written in the Levant, the subject of these histories, will also be discussed, as well as texts written in the Empire and in Italy.
    Keywords: 907.2 ; Crusades ; Medieval Literature ; Medieval History
    Source: The British Library
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  • 2
    Language: English
    Description: Cerebellar ataxia affects 68% of adult patients with mitochondrial disease and is associated with progressive loss of co-ordination, impaired balance, and speech difficulties. In these patients, the cerebellum shows numerous neuropathological changes, and a prominent feature is the appearance of axonal...
    Keywords: 616.07
    Source: The British Library
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  • 3
    Description: Cerebellar ataxia affects 68% of adult patients with mitochondrial disease and is associated with progressive loss of co-ordination, impaired balance, and speech difficulties. In these patients, the cerebellum shows numerous neuropathological changes, and a prominent feature is the appearance of axonal torpedoes which represent swollen axons from Purkinje cells. Axonal torpedoes occur in the proximal portion of the Purkinje cell axon projecting into the granular cell layer and are mainly comprised of hyper phosphorylated neurofilament H. Although they have been reported in mitochondrial disease, their significance and contribution to disease is not known. Immunohistochemistry and immunofluorescence was used to characterise and quantify axonal torpedoes in the cerebellums of ten patients with mitochondrial disease and fourteen controls. A triple immunofluorescent assay was developed to reliably quantify the level of respiratory chain protein expression in axonal torpedoes compared to Purkinje cell bodies and their axons. A major limitation of current immunofluorescent techniques is the ability to use very thin brain sections (5μm) due to the intrinsic properties of the tissue causing scattering of light emitted from the fluorophores reducing the resolution of the image. To overcome this limitation, I have optimised the novel clearing technique known as CLARITY (Clear, Lipid-exchanged, Acrylamide-hybridized Rigid, Imaging/immunostaining compatible, Tissue hYdrogel) to use on both mouse and human cerebellar sections from both control individuals and patients. The optimisation of CLARITY has allowed for the use of 250μm thick cerebellar sections to further characterise the morphology of axonal torpedoes in 3D volume as well as determining the degree of axonal changes between patients and controls on a global scale. This study provides a detailed characterisation of axonal pathology that occurs in the cerebellum of patients with mitochondrial disease. The success in optimising the clearing method that produces quality staining of neuronal structures in thick (250μm) cerebellar tissue from both mouse and human tissue will allow for further investigation of changes in the vascular, dendritic or axonal networks in 3D volume on a global scale.
    Source: Networked Digital Library of Theses and Dissertations
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  • 4
    Dissertation
    Dissertation
    University of Bristol
    Language: English
    Source: The British Library
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  • 5
    Dissertation
    Dissertation
    Royal Holloway, University of London
    Description: The success of the First Crusade by the Christian armies caught the interest and arrested the imagination of contemporaries, stimulating the production of a large number of historical narratives. Four eyewitness accounts, as well as letters written by the crusaders to the West, were taken up by later authors, re-worked and re-fashioned into new narratives; a process which continued throughout the twelfth century and beyond. This thesis sets out to explore why contemporaries continued to write about the First Crusade in light of medieval attitudes towards the past, how authors constructed their narratives and how the crusade and the crusaders were remembered throughout the twelfth and thirteenth centuries. It will analyse the development in the way the First Crusade was recorded and investigate the social, religious, intellectual and political influences dictating change: How, why and under what circumstances was the story re- told? What changed in the re-telling? What ideas and concepts were the authors trying to communicate and what was their meaning for contemporaries? The thesis will also aim to place these texts not only in their historical but also in their literary contexts, analyse the literary traditions from which authors were writing, and consider the impact the crusade had on medieval literature. The focus will be on Latin histories of the First Crusade, especially those written in England and France, which produced the greatest number of narratives. Those written in the Levant, the subject of these histories, will also be discussed, as well as texts written in the Empire and in Italy.
    Keywords: 907.2 ; Crusades ; Medieval Literature ; Medieval History
    Source: Networked Digital Library of Theses and Dissertations
    Library Location Call Number Volume/Issue/Year Availability
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  • 6
    Dissertation
    Dissertation
    University of Bristol
    Source: Networked Digital Library of Theses and Dissertations
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  • 7
    Description: I draw on an in-depth longitudinal analysis of the adoption of an American organizational form, namely 'Academic Health Science Centre' (or 'AHSC'), in the field of the British health care from 1989 to 2009 to examine translation processes of foreign organizational forms. I draw upon two institutional approaches that have been traditionally treated separately - institutional translation and theorization - to examine how the translation was successful, given the significantly different institutional contexts of the two countries. I found that the adoption of the new and foreign organizational form as in the present case study unfolds over three phases - activation, dormancy, and reactivation. I also found that translation and theorization operated in configurations that underpinned the three phases of the process. In addition, my empirical data also supported that translation is actually not a planned and purposeful process, as extant research implies. Rather, translation is embedded within complexity and randomness, which can be conceptualized by using the garbage can model. I thus argue that successful translation depends on the presence of various elements: strategic actors with motivation, opportunity, and capacity to promote the organizational form; existence of powerful problems; and field receptivity that facilitates the organizational form. These findings contribute to two literatures. The first contribution is to the translation literature by providing more nuanced view of translation and a new insight into how translation actually works by drawing on the garbage can model. More importantly, they highlight the temporal dimension in the translation process. The second contribution is to the theorization literature by highlighting strategies underlying theorization that contributes to legitimacy of foreign organizational forms.
    Keywords: 658.4
    Source: Networked Digital Library of Theses and Dissertations
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  • 8
    Language: English
    Description: Magnetic Resonance Imaging (MRI) was first applied back in the 1970s and is a medical imaging technique for anatomical and physiological processes of the body. It is characterized by high sensitivity and distinctive diagnostic ability on soft tissues....
    Source: The British Library
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  • 9
    Description: The work undertaken in this thesis uses finite element analysis to investigate the most critical causes of acetabular cup implant failure. To enable accurate conclusions from finite element analysis, three studies have been carried out to strengthen understanding and confidence in finite element model outcomes. Two of these are sensitivity studies, which inform the required level of model definition to enable repeatable results. The third study is an in vitro experimental validation of finite element strains, displacements and cup-bone micromotions; therefore validating the use of the finite element model to predict physical situations. Metal on metal press-fit acetabular cups are the worst performing acetabular cup type with severe failure consequences compared to cups made from more inert materials such as polyethylene or ceramic. The cause of failure of these cup types is widely acknowledged to be multi-factorial, therefore creating a complex scenario for analysis through clinical studies. A factorial analysis has been carried out using finite element analysis to investigate the relative influence of five input factors associated with acetabular cup implantation on output parameters indicating potential failure of the implantation. The factorial analysis concluded that the most significant influences on failure are cup positioning and the interference fit between the acetabular bone and implanted cup; and that these influences have a higher potential to cause failure than the design of the implant used, within the boundaries of the implant design parameters investigated here. Errors in these aspects of surgery may result in acetabular cup failure. It is therefore paramount to reduce errors in the surgical process to enable accurate levels of positioning and interference fit. Time and resources may therefore be best spent developing surgical instrumentation which can increase the accuracy of the implant positioning and fit, and ascertaining the optimal levels of both, rather than designing new implants.
    Keywords: 617
    Source: Networked Digital Library of Theses and Dissertations
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  • 10
    Language: English
    Keywords: 572.8 ; Genetics
    Source: The British Library
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