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  • 1
    Language: German
    Description: Biological ageing processes lead to continuing loss of the physical and psychological abilities to adapt to life processes. The age depending functional impairment of several organ systems is mainly expressed in decreased adaption capacity and reduced reserve capacity. Malnutrition plays a central role. This work shows how malnutrition assessment and other assessment methods can be combined und a new diagnostic tool in the clinical daily routine can be established. The main points of this work are: Characterization of factors which can identify malnutrition, combination of geriatric assessment tools, development and evaluation of determination proceedings for the energy need of geriatric patients, Standardized recording of the GFR (glomerular filtration rate) considering the body composition of geriatric patients, detection of nutritional risk factors for cognitive decline and support of the orophacial therapy with standardized nutrition therapy proceedings. Malnutrition touches not only the general performance weakness with increased inactivity and risk of falling but also presents a risk factor in wound healing. Our work shows how different assessment and screening tools can useful be combined in the daily routine in acute geriatrics with regard to the risk management for malnutrition and decubitus. A significant match in the risk scaling could be found and with that the clear clinical relationship could be established. How can the scientific data be implemented in the clinical daily routine? 1. The seven most important items for the risk management of malnutrition have been integrated in the routine assessment of the different therapist groups. 2. The measurement of the body composition by means of BIA is routinely done together with the electrocardiogram at hospital admission. 3. During determination of the nutritional therapy the energy need of patients is calculated by means of the Mifflin-St. Jeor formula together with the respective activity level. 4. The LBM is included in the standardized calculation of the energy needs and in the GFR direct after hospital admission. 5. Folic acid is supplemented mainly in all patients with malnutrition and cognitive impairment. 6. Patients with neurological dysphagia mainly receive dysphagia diagnostics by a speech therapist within 10 days after admission to determine the need of a PEG placement. Wether these actions confirm the current international studies or the situation for geriatric patients concerning reduction of complications, shorter hospital stay, preservation or restoration of greatest possible ability in everyday tasks is objective of further research.
    Keywords: 610 Medizin Und Gesundheit ; 610 Medical Sciences; Medicine ; Ddc:610 ; Malnutrition ; Assessment ; Ageing
    Source: Freie Universitat Berlin
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  • 2
    Language: German
    Description: Techn. Univ., Diss.--Braunschweig, 1997.
    Source: Networked Digital Library of Theses and Dissertations
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  • 3
    Language: English
    Description: University, Diss., 2006--Heidelberg.
    Source: Networked Digital Library of Theses and Dissertations
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  • 4
    Dissertation
    Dissertation
    University of Cape Town ; Faculty of Science ; Department of Biological Sciences
    Language: English
    Description: Includes bibliographical references. Runoff and spray-drift-related pesticide input are important sources of non pointsource pesticide pollution in surface waters but few studies have directly compared these routes in a risk assessment scenario. Accordingly a risk assessment approach was instituted to determine differences between runoff...
    Keywords: Zoology
    Source: Networked Digital Library of Theses and Dissertations
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  • 5
    Language: German
    Description: Mikrofiche-Ausg.: 2 Mikrofiches : 24x ; Thesis (doctoral)--Technische Universität Berlin, 1994 ; 157 Bl. : graph. Darst
    Keywords: Gestein -- Deformation -- Elastische Spannung -- Wellenausbreitung -- Nichtlineare Elastizitätstheorie
    Source: Center for Research Libraries
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  • 6
    Language: German
    Description: Mikroreprod. e. Ms. 142 Bl. : graph. Darst ; Thesis (doctoral)--Technische Universität Berlin, 1986 ; 2 Mikrofiches. : 24x
    Source: Center for Research Libraries
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  • 7
    Language: German
    Description: In the course of this study Pex7p, Pex14p and Pex8p were identified as new interaction partners of Pex8p, by means of two-hybrid-analysis. Interactions of further peroxines of the docking-machinery, to peroxines of the zincfinger-class and of other functional groups were not identified. The region of interaction of Pex8p and Pex5p, Pex8p and Pex14p was narrowed down to amino acids 146-586 of Pex8p. It was not possible to narrow down the region of interaction of Pex8p to Pex7p. Pex7p needs a full length Pex8-protein for interaction. For interaction with Pex8p (146-586 aa) Pex5p requires the amino acids 1-312. The TRP-domains of Pex5p are not required for the interaction between Pex5p and Pex8p. The interaction between Pex8p and Pex14p is influenced by peroxines of the "cargo-receptor-binding-group", the "docking-machinery-group", and the "receptor-translocation-group", and is therefore indirect. The interactions between Pex8p and Pex5p, as well as between Pex8p and Pex7p are not mediated by peroxines of the investigated functional groups and are therefore likely to be direct. By means of mutationanalysis of Pex8p, three mutations were identified, which prevent interactions between Pex8p and Pex5p, Pex7p and Pex14p in different ways. Mutation Pex8pM-A(S231P) prevents the interaction to Pex5p, Pex7p and Pex14p. Mutation Pex8pM-C(A238V) prevents the interaction to Pex5p and Pex14p. Mutation Pex8pM-D(T327P) prevents the interaction to Pex7p and Pex14p. Therefore, both receptors seem to be necessary for interaction between Pex8p and Pex14p. The Pex8p-mutant can be complemented by all mutated Pex8-proteins. Moreover, fluorescently labelled cargoproteins are imported into peroxisomes in complemented pex8D-cells. On the basis of the mutationanalysis of Pex8p it is likely, that Pex8p induces the release of the cargo-receptorcomplex due to changes of the receptor conformation. In spite of the presence of a PTS-signal in Pex8p, the targeting of Pex8p to the peroxisomal membrane is independent of the PTS-receptors. This is further supported by extraction analysis of the protein from peroxisomal membranes. In the absence of Pex5p, Pex8p can be degraded by Proteinase K. Therefore Pex5p does not influence the targeting of Pex8p but indirectly influences its approachability to the cytosolic components.
    Keywords: 570 Life Sciences ; Ddc:570 ; 570 Biowissenschaften; Biologie ; Saccharomyces ; Peroxisome ; Protein ; Import ; Pex8
    Source: Freie Universitat Berlin
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  • 8
    Language: German
    Description: Thesis (doctoral)--Johann Wolfgang Goethe-Universität zu Frankfurt am Main, 1990 ; VIII, 108 S : graph. Darst ; 21 cm
    Source: Center for Research Libraries
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  • 9
    Language: German
    Description: Thesis (doctoral)--Albert-Ludwigs-Universität Freiburg im Breisgau, 1993 ; 44 leaves
    Source: Center for Research Libraries
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  • 10
    Language: German
    Description: The objective of the present work was the investigation and demonstration of the potential of sol-gel alumina layers as corrosion protection of commercial power plant steels under oxyfuel conditions. The starting points of this work were modified Yoldas-sols which were developed in the BAM-department 5.6. These sols were suitable for the spin-coating method only. The application of coatings on tubes by spin-coating is impossible. Therefore, the chemical composition of the modified Yoldas-sol had to be adapted to the dip- and spray-coating techniques. Exclusively the sol with the composition s-0.52-6-1.5 with a nitrate/aluminium ratio of 0.52; a solid content of 6 wt.% and a PVP (binder) content of 1.5 wt.% could fulfill the necessary criteria: long-term stability; formation of a dense, crack-free and well adhered layer on polished metal surfaces; as well as high protective abilities against corrosion in H2O-CO2-O2-SO2. The commercial power plant steel X20CrMoV12-1 (X20) and the steel X12Cr13 were successfully coated with the sol s-0.52-6-1.5 by means of the dip-coating method. An at least 400 nm thick alumina layer (δ-Al2O3) is necessary to ensure the corrosion protection of these steels. The corrosion of the coated samples compared to that of the uncoated ones was significantly reduced, even after 1000 h of exposure in a H2O-CO2-O2-SO2 atmosphere at 600°C. Sulfur and carbon were not detected at the substrate surface or beneath the coating. Hence the transport of the flue gas components SO2 and CO2 into as well as through the alumina layer could be hindered. The diffusion of the alloying elements (Cr, Mn, Si) into the alumina layer resulted in the formation of mixed oxides like δ-(Al,Cr)2O3. Formation of such phases considerably contributed to the corrosion protection. The long-term stability of the sol s-0.52-6-1.5 and the high protective abilities of the alumina layer on commercial power plant steels provide a good basis for an industrial application.
    Keywords: Ddc:550 ; 550 Earth Sciences ; 550 Geowissenschaften ; Alumina ; Coating ; Oxyfuel ; Steel ; High-Temperature Corrosion ; Tem
    Source: Freie Universitat Berlin
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