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  • 1
    Online Resource
    Online Resource
    Totowa, NJ : Humana Press
    UID:
    b3kat_BV036726393
    Format: 1 Online-Ressource
    Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008
    ISBN: 9781592598519
    Series Statement: Cancer drug discovery and development
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-1-58829-172-1
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Krebs ; Apoptosis
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  • 2
    UID:
    gbv_50106608X
    Format: XI, 198 S. , Ill., graph. Darst.
    ISBN: 1573315435 , 1573315443
    Series Statement: Annals of the New York Academy of Sciences 1059
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Therapieresistenz ; Tumorwachstum ; Metastase ; Tumor ; Maligne Transformation ; Arzneimittelresistenz ; Konferenzschrift
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  • 3
    Book
    Book
    Totowa, NJ : Humana Press
    UID:
    gbv_362742561
    Format: XIX, 657 S. , Ill., graph. Darst. , 26 cm
    ISBN: 0896039870 , 1592593291
    Series Statement: Tumor suppressor genes Vol. 2
    Note: Literaturangaben
    Language: English
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  • 4
    Book
    Book
    Totowa, NJ : Humana Press
    UID:
    gbv_362742383
    Format: XIX, 504 S. , Ill., graph. Darst. , 26 cm
    ISBN: 0896039862 , 1592593283
    Series Statement: Tumor suppressor genes Vol. 1
    Note: Literaturangaben
    Language: English
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  • 5
    Book
    Book
    New York [u.a.] : Springer
    UID:
    b3kat_BV040795667
    Format: VIII, 446 S. , Ill., graph. Darst.
    ISBN: 9781461461753 , 9781461461760
    Series Statement: Advances in experimental medicine and biology 779
    Language: English
    Subjects: Biology
    RVK:
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  • 6
    Book
    Book
    Totowa, NJ : Humana Press
    UID:
    gbv_353046647
    Format: 26 cm
    Series Statement: Methods in molecular biology ...
    Note: Erschienen: 1 - 2
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Krebs ; Tumorsuppressor-Gen
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  • 7
    Online Resource
    Online Resource
    New York, NY : Springer
    UID:
    gbv_1652022880
    Format: Online-Ressource (VIII, 446 p. 22 illus., 21 illus. in color, digital)
    ISBN: 9781461461760 , 1283945894 , 9781283945899
    Series Statement: Advances in Experimental Medicine and Biology 779
    Content: ​​​The topic of ‘Impact of genetic targets on cancer therapy’ has reviews that each focuses on a specific tumor type, review recent knowledge about molecular pathogenesis in general and especially as it impacts response to therapy. The topic is aimed to provide a forum for publication of original peer-reviewed short communications, full-length research and review articles on new research findings and developments in cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to build a comprehensive knowledge on genetic targets on different cancer therapies. Each chapter also includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells
    Note: Description based upon print version of record , Impact of Genetic Targetson Cancer Therapy; Forward; Contents; Novel Antineoplastics Targeting Genetic Changes in Colorectal Cancer; Introduction; Overview of Genetic Alterations in Colorectal Cancer; Targeting Cell Death Pathways; Agonistic TRAIL Death Receptor Antibodies; Bcl-2; Targeting Growth Factor Signaling; The EGFR Family; IGF Receptors; Hepatocyte Growth Factor (HGF); Mutant BRAF; MEK; Akt; Mammalian Target of Rapamycin (mTOR); Protein Kinase C (PKC); Targeting Angiogenesis; VEGF Receptors; Other Receptors That Mediate Angiogenesis; Multi-Targeted Agents; Sorafenib; Sunitinib , DasatinibHarnessing the Immune System; Epithelial Cell Adhesion Molecule (EpCAM); Toll-Like Receptor 9 (TLR9); A33; Other Approaches; Wnt and Hedgehog Signaling Pathways; COX-2; Heat Shock Protein 90 (Hsp90); Virotherapy; Colorectal Cancer Stem Cells (CRCSCs); Stem Cell Signaling in CRC; Stem Cell Microenvironment in CRC; References; Update on Clinical Trials: Genetic Targets in Breast Cancer; Cell Membrane Signaling; Growth Factor Receptors EGFR and HER2- neu as Molecular Targets in Breast Cancer; IGF in Breast Cancer; Impact of the Tumor Microenvironment and Cancer Stem Cells , Cancer Stem Cells and Stem Cell Niche in Breast CancerAngiogenic Targets; Intracellular Signaling and Genetic, Epigenetic Targets; Intracellular Signaling; Ras, Raf, mTOR; Post-Translational Modi fi cation: Histone Deacytelase Inhibitors (HDACIs); MicroRNAs and the Molecular Pathogenesis of Breast Cancer; Telomerase Inhibitors in Breast Cancer; PARP in Breast Cancer; Hormone Receptor Positive but Resistant to Hormone Therapy; Mechanisms of Hormone Resistance; Conclusion; References; Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer; Introduction , Targeting Epidermal Growth Factor Receptor (EGFR) Family PathwayTargeting Angiogenesis Pathway; Other Potential Targets; Conclusions; References; Impact of Genetic Targets on Cancer Therapy: Hepatocellular Cancer; Introduction; Pathogenesis and Genetics for HCC; Hepatitis Virus Infections and HCC; Sorafenib and Targeted Therapy for HCC; Types of Targeted Therapies; Tyrosine Kinase Inhibitors TKIs; Monoclonal Antibodies (mABs); Enzyme Inhibitors; Miscellaneous Agents; Combination Therapy and Future Directions; Cancer Stem Cells and New Targets in HCC; Conclusion; References , Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular PhenotypeIntroduction; Genetic Alterations Involved in Pathogenesis of Pancreatic Adenocarcinoma; Genetic Alterations as Therapeutic Targets; Receptor Tyrosine Kinases and Ligands; Epidermal Growth Factor (EGF); Insulin-Like Growth Factor-1 (IGF-1); Hepatocyte Growth Factor (HGF); Signal Transducers; RAS; MEK; AKT; Mammalian Target of Rapamycin (mTOR); Heat Shock Protein (Hsp90); Nuclear Targets; Histone Deacetylases (HDACs); Polo-Like Kinase 1 (Plk1); Ribonucleotide Reductase (RR) , Peroxisome Proliferator-Activated Receptor g (PPAR g) , ​​​Novel antineoplastics targeting genetic changes in colorectal cancer -- Update on Clinical Trials: Genetic Targets in Breast Cancer -- Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer -- Impact of Genetic Targets on Cancer Therapy: Liver Cancer -- Targeting the molecular phenotype of pancreatic cancer toward the goal of patient-tailored therapy -- Impact of genetic markers on treatment of Non-small cell lung cancer -- Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma -- Tyrosine Kinase Targeted Treatment of Chronic Myelogenous Leukemia and Other Myeloproliferative Neoplasms -- Targeted Therapy of Multiple Myeloma -- Current and Future Trials of Targeted Therapies in Cutaneous Melanoma -- Current Approaches to Epigenetic therapy for the treatment of Mantle Cell Lymphoma -- Impact of Genetic Targets on Primary Brain Tumor Therapy: What’s Ready for Prime Time? -- Rational therapy for renal cell carcinoma based on its genetic targets -- Molecular and Genetic Markers of Follicular-Cell Thyroid Cancer: Etiology and Diagnostic and Therapeutic Opportunities -- Genetic Targets in Pediatric Acute Lymphoblastic Leukemia -- Emerging molecular therapies for the treatment of Acute Lymphoblastic Leukemia -- Impact of Genetic Targets on Prostate Cancer Therapy -- Small-Cell Lung Cancer: An Update on Targeted Therapies -- Impact of Genetic Targets on Cancer Therapy in Acute Myelogenous Leukemia -- Index.
    Additional Edition: ISBN 9781461461753
    Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-46175-3
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 8
    UID:
    gbv_1868818411
    ISSN: 1476-5403
    In: Cell death and differentiation, Houndmills, Basingstoke : Nature Publishing Group, 1997, 30(2023), 5, Seite 1097-1154, 1476-5403
    In: volume:30
    In: year:2023
    In: number:5
    In: pages:1097-1154
    Language: English
    Author information: Simon, Hans-Uwe 1958-
    Author information: Galluzzi, Lorenzo 1980-
    Author information: Aaronson, Stuart A. 1942-
    Author information: Conrad, Marcus 1970-
    Author information: Debatin, Klaus-Michael 1952-
    Author information: Gronemeyer, Hinrich 1951-
    Author information: Kroemer, Guido 1961-
    Author information: Robinson, Nirmal 1976-
    Author information: Kashkar, Hamid 1968-
    Author information: Pagano, Michele 1961-
    Author information: Häcker, Georg 1964-
    Author information: Borner, Christoph
    Author information: Rajalingam, Krishnaraj 1977-
    Author information: Vandenabeele, Peter
    Author information: García-Sáez, Ana J.
    Author information: Adam, Dieter
    Author information: Lavrik, Inna N.
    Author information: Madeo, Frank 1967-
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