Format:
Online-Ressource (X, 391 p. 47 illus., 42 illus. in color, digital)
ISBN:
9783642287114
Series Statement:
Current Topics in Behavioral Neurosciences 11
Content:
This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease.¡ These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age.¡ New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer's disease, which collectively affect a large segment of the population.¡ These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences. ¡ The Authors of this volume are leaders in the development of PET and MRI methods as well as clinical and translational researchers skilled in their use in patients with brain disorders. Individual chapters of this volume focus on the use of specific methodologies, covering the full range of PET chemistry based approaches as well as MRI methods from structural and diffusion tensor based imaging, to functional MRI of functional brain circuitry, to pharmacological MRI and MRI spectroscopic molecular imaging.¡
Content:
This volume highlights the remarkable new developments in brain imaging, including those applying the techniques of magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that facilitate the non-invasive study of the living human brain
Note:
Description based upon print version of record
,
Brain Imaging in Behavioral Neuroscience; Preface; Contents; 169 Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction; Abstract; 1…Background; 2…The Role of Dopamine in Acute Reward to Drugs and Food; 3…Imaging DA in Response to Drugs and to Conditioned Cues in Addiction; 4…The Impact of Dysfunction in Inhibitory Control; 5…Involvement of Motivation Circuits; 6…Involvement of Interoceptive Circuitry; 7…The Circuitry of Aversion; 8…Pathological Drug and Food Reward: An Updated Working Model; Acknowledgments; References
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168 Nonhuman Primate Models of Addiction and PET Imaging: Dopamine System DysregulationAbstract; 1…Introduction; 1.1 Positron Emission Tomography and Dopamine Neurotransmission; 1.2 Nonhuman Primates as Research Subjects; 1.3 Animal Models; 2…Models of Cocaine Addiction and DA Receptor Function; 2.1 Models of Vulnerability; 2.2 Models of Maintenance; 2.3 Models of Abstinence and Relapse; 3…Functional Sequelae of Cocaine Administration; 3.1 Blood Flow and Metabolic Responses to Cocaine-Related Stimuli; 3.2 Models of Cognitive Decline; 4…Summary; Acknowledgments; References
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6.1 Status of DA Markers in ADHD6.2 Synaptic DA Transmission in ADHD; 6.3 Potential Confounding Factors Underlying Inconsistencies Across PET/SPECT Findings in ADHD; 7…Neuroanatomical Correlates of ADHD; 7.1 Continuity of Morphological Abnormalities Across the Lifespan; 7.2 Evidence for Abnormal Structural Connectivity in ADHD; 8…Conclusions; References; 206 Experimental Protocols for Behavioral Imaging: Seeing Animal Models of Drug Abuse in a New Light; Abstract; 1…Behavioral Neuroimaging in Animal Models of Addiction; 2…Behavioral Imaging Modalities: Strengths and Weaknesses
,
Abstract
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167 PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory DisordersAbstract; 1…Introduction; 2…Visualization of Fibrillar Protein Assemblies; 3…Imaging Biomarkers for Immune Responses to Neuropathologies; 4…Neurochemical Profiling and Neuronal Viability; 5…Conclusion; Acknowledgments; References; 200 Neural and Behavioral Endophenotypes in ADHD; Abstract; 1…Introduction; 2…Genetics; 3…Cognitive Markers of ADHD; 4…Pharmacological Treatment; 5…Cognitive Effects of Psychostimulants: Implications for our Understanding of ADHD; 6…Molecular Neuroimaging Studies in ADHD
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3…''Snapshot'' Imaging Protocols4…Behavioral Imaging of Metabolic Function with FDG; 5…Behavioral Imaging of Dopaminergic Function with [11C]-Raclopride; 6…Technical Issues; 6.1 Route of Radiotracer Administration; 6.2 Effects of Anesthesia on Functional Imaging with ''Snapshot'' Protocols; 6.3 The Use of Anesthesia for Behavioral Imaging Studies in Animals; 6.4 Defining the Baseline State; 7…Convergence or Divergence of Behavioral and Imaging Data, of Human and Animal Data; 8…Conclusions; Acknowledgments; References; 165 Molecular Imaging and the Neuropathologies of Parkinson's Disease
Additional Edition:
ISBN 9783642287107
Additional Edition:
Buchausg. u.d.T. Brain imaging in behavioral neuroscience Berlin : Springer, 2012 ISBN 9783642287107
Additional Edition:
ISBN 3642287107
Language:
English
Subjects:
Biology
Keywords:
Neuropsychiatrie
;
Neuropathologie
;
Positronen-Emissions-Tomografie
;
Kernspintomografie
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-28711-4
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