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  • 1
    Book
    Book
    San Diego [u.a.] : Acad. Press
    UID:
    b3kat_BV013950815
    Format: XXIII, 834 S. , Ill., graph. Darst.
    Edition: Concise ed.
    ISBN: 0125139209
    Language: English
    Subjects: Engineering , Chemistry/Pharmacy , Physics
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    Keywords: Nanostrukturiertes Material ; Nanotechnologie ; Aufsatzsammlung
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  • 2
    Book
    Book
    San Diego [u.a.] : Academic Press
    UID:
    b3kat_BV013614943
    Format: XXIII, 970 S. , Ill., graph. Darst.
    ISBN: 0125139047
    Language: English
    Subjects: Chemistry/Pharmacy , Physics
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    Keywords: Werkstoff ; Elektronik ; Supramolekulare Struktur
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  • 3
    Book
    Book
    San Diego, Calif. [u.a.] : Academic Pr.
    UID:
    gbv_122329279
    Format: XXII, 499 S , graph. Darst , 24 cm
    Edition: 2. ed.
    ISBN: 0126463816
    Series Statement: Food science and technology
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Chemistry/Pharmacy
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    Keywords: Einführung
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  • 4
    Online Resource
    Online Resource
    Singapore : Springer Singapore | Singapore : Imprint: Springer
    UID:
    gbv_1737524945
    Format: 1 Online-Ressource(XIII, 306 p. 80 illus., 54 illus. in color.)
    Edition: 1st ed. 2020.
    ISBN: 9789811568152
    Series Statement: Springer eBook Collection
    Content: 1 Computational Approaches in Drug Discovery and Design -- 2 Molecular Modeling of Proteins: Methods, Recent Advances and Future Prospects -- 3 Cavity/Binding Site Prediction Approaches, and their Applications -- 4 Role of ADMET Tools in Current Scenario; Application and Limitations -- 5 Database Resources for Drug Discovery -- 6 Molecular Docking and Structure-Based Drug Design -- 7 Molecular Dynamics Simulation of Protein and Protein-Ligand Complexes -- 8 Computational Approaches for Drug Target Identification -- 9 Computational Screening Techniques for Lead Design and Development -- 10 Advances in Pharmacophore Modeling and its Role in Drug Designing -- 11 In Silico Designing of Vaccines: Methods, Tools and Their Limitations -- 12 Machine learning Approaches to Rational Drug Design. .
    Content: This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
    Additional Edition: ISBN 9789811568145
    Additional Edition: ISBN 9789811568169
    Additional Edition: ISBN 9789811568176
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9789811568145
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9789811568169
    Additional Edition: Erscheint auch als Druck-Ausgabe Computer-aided drug design Singapore : Springer, 2020 ISBN 9789811568176
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
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  • 5
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg
    UID:
    gbv_165108940X
    Format: Online-Ressource (XIII, 483p. 90 illus, digital)
    ISBN: 9783642237898
    Series Statement: Environmental Science and Engineering
    Content: Our interest in the microbial biodegradation of xenobiotics has increased many folds in recent years to find out sustainable ways for environmental cleanup. Bioremediation and biotransformation processes harness the naturally occurring ability of microbes to degrade, transform or accumulate a wide range of organic pollutants. Major methodological breakthroughs in recent years through detailed genomic, metagenomic, proteomic, bioinformatic and other high-throughput analyses of environmentally relevant microorganisms have provided us unprecedented insights into key biodegradative pathways and the ability of organisms to adapt to changing environmental conditions. The degradation of a wide spectrum of organic pollutants and wastes discharged into the¡environment by anthropogenic activities¡is an emerging need today to promote sustainable development of our society with low environmental impact. Microbial processes play a major role in the removal of recalcitrant compounds taking advantage of the astonishing catabolic versatility of microorganisms to degrade or transform such compounds. New breakthroughs in sequencing, genomics, proteomics, bioinformatics and imaging are generating vital information which opens a new era providing new insights of metabolic and regulatory networks, as well as clues to the evolution of degradation pathways and to the molecular adaptation strategies to changing environmental conditions. Functional genomic and metagenomic approaches are increasing our understanding of the relative importance of different pathways and regulatory networks to carbon flux in particular environments and for particular compounds. New approaches will certainly accelerate the development of bioremediation technologies and biotransformation processes in coming years for natural attenuation of contaminated environments
    Note: Description based upon print version of record , Microbial Degradation of Xenobiotics; Preface; Contents; Contributors; 1 Microbial Degradation of Polychlorophenols; 1.1…Introduction; 1.1.1 Sources of Polychlorophenols; 1.1.2 Toxicity of Polychlorophenols; 1.2…Microbial Degradation of Polychlorophenols; 1.2.1 Pentachlorophenol Degradation by Aerobic Bacteria; 1.2.2 2,4,6-Trichlorophenol Degradation by Aerobic Bacteria; 1.2.3 2,4,5-Trichlorophenol Degradation by Aerobic Bacteria; 1.2.4 Anaerobic Degradation of Polychlorophenols; 1.2.5 Fungal Degradation of Polychlorophenols; 1.3…Biochemistry of Polychlorophenol Degradation , 1.3.1 Pentachlorophenol Metabolic Pathway of S. Chlorophenolicum L-11.3.1.1 Pentachlorophenol 4-Monooxygenase (PcpB); 1.3.1.2 Tetrachloroquinone Reductase (PcpD); 1.3.1.3 Tetrachloroquinol Reductive Dehalogenase (PcpC); 1.3.1.4 2,6-Dichloroquinol 1,2-Dioxygenase (PcpA); 1.3.1.5 2-Chloromaleylacetate Reductase (PcpE); 1.3.1.6 3-Oxoadipate:succinyl-CoA Transferase and 3-Oxoadipyl-CoA Thiolase; 1.3.1.7 Glutathionyl-(chloro)quinol Reductase (PcpF); 1.3.1.8 PcpF Homologs are GS-(chloro)quinol Reductases; 1.3.2 2,4,6-Trichlorophenol Metabolic Pathway of C. Necator JMP134 , 1.3.2.1 The tcp Gene Cluster1.3.2.2 2,4,6-Trichlorophenol 4-Monooxygenase (TcpA); 1.3.2.3 NADH:FAD Oxidoreductase (TcpX); 1.3.2.4 Quinone Reductase (TcpB); 1.3.2.5 6-Chlorohydroxyquinol 1,2-Dioxygenase (TcpC); 1.3.2.6 Chloromaleylacetate Reductase (TcpD); 1.3.2.7 beta -Barrel Outer Membrane Protein (TcpY); 1.3.2.8 The Presence of tcp Genes in Other Bacteria; 1.3.3 2,4,5-Trichlorophenol Metabolic Pathway of B. Cepacia AC1100; 1.3.3.1 2,4,5-Trichlorophenoxyactate Oxygenase (TftAB); 1.3.3.2 2,4,5-Trichlorophenol 4-Monooxygenase (TftCD); 1.3.3.3 5-Chlorohydroxyquinol Dehydrochlorinase (TftG) , 1.3.3.4 Quinone Reductase (TftX)1.3.3.5 Hydroxyquinol 1,2-Dioxygenase (TftH); 1.3.3.6 Maleylacetate Reductase (TftE); 1.4…Dechlorination Mechanisms; 1.5…Gene Organization, Regulation and Evolution of the Polychlorophenol Degradation Pathways; 1.6…Conclusions; Acknowledgments; References; 2 Degradation of Chloro-organic Pollutants by White Rot Fungi; 2.1…Introduction; 2.2…Enzymology; 2.2.1 Extracellular Peroxidases and Laccases; 2.2.2 Induction of Hydroxyl Radicals; 2.2.3 Cytochrome P450 System; 2.2.4 Phase II Conjugation Reactions , 2.3…Biodegradation of Chloro-organic Compounds by White Rot Fungi2.3.1 Chlorinated Alkanes and Alkenes; 2.3.2 Polychlorinated Biphenyls; 2.3.3 Phenoxyalkanoic Herbicides; 2.3.4 Triazine Herbicides; 2.3.5 Chlorinated Dioxins; 2.3.6 Chlorobenzenes; 2.3.7 Chlorinated Insecticides; 2.3.8 Chlorinated Pharmaceutical and Personal Care Products; 2.4…Conclusions; Acknowledgments; References; 3 Microbial Styrene Degradation: From Basics to Biotechnology; 3.1…Introduction; 3.2…Physico-Chemical Properties, Toxicological Aspects, Industrial Usage, and Environmental Fate of Styrene , 3.3…Degradation Pathways
    Additional Edition: ISBN 9783642237881
    Additional Edition: Buchausg. u.d.T. Microbial degradation of xenobiotics Berlin : Springer, 2012 ISBN 3642237886
    Additional Edition: ISBN 9783642237881
    Language: English
    Subjects: Chemistry/Pharmacy
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    Keywords: Xenobiotikum ; Bioremediation ; Xenobiotikum ; Bioremediation ; Aufsatzsammlung ; Aufsatzsammlung
    URL: Volltext  (lizenzpflichtig)
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