In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3244-3244
Abstract:
A method for assessment of bone based on comprehensive analysis of waveforms of ultrasound signals propagating in the bone is presented. A set of ultrasound propagation parameters, which are differentially sensitive to bone material properties, structure, and cortical thickness, are evaluated. The parameters include various features of different modes of acoustics waves, such as bulk, surface, and guided ultrasonic waves in a wide range of carrier frequencies. Data processing algorithms were developed for obtaining axial profiles of waveform parameters. Such profiles are capable of revealing axial heterogeneity of long bones and spatially nonuniform pathological processes, such as osteoporosis. The examination procedure may include either one long bone in the skeleton, like the tibia, radius of the forearm, etc., or several bones in sequence to provide a more comprehensive assessment of the skeletal system. Specifically, for tibia assessment, a multi-parametric linear classifier based on a DEXA evaluation of skeleton conditions has been developed. Preliminary results of the pilot clinical studies involving 149 patients have demonstrated early stages of osteoporosis detection sensitivity of 80% and specificity of 67% based on DEXA data as the gold standard. [Work was supported by NIH and NASA grants.]
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2006
detail.hit.zdb_id:
1461063-2
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