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  • 1
    In: Genes, Chromosomes and Cancer, July 2015, Vol.54(7), pp.433-443
    Description: The novel CKLF‐like Marvel Transmembrane Domain‐containing gene family (CMTM) consists of 8 members (). As little is known about the oncogenic impact of these genes, we aimed to systematically investigate the relevance of CMTMs to glioblastoma pathogenesis. We performed mRNA expression analyses and survival correlations in glioblastoma patients. Moreover, we analyzed the impact of RNAi‐based silencing and overexpression of CMTM family genes on tumor cell proliferation and invasion in vitro. CMTMs appeared to be widely regulated in the group of glioblastomas relative to non‐neoplastic brain (NB) tissue (significant upregulation for , , and and significant downregulation for and ). For , and , we found aberrant expression levels in individual tumors. Functionally, , , and promoted tumor cell invasion, while additionally enhanced cell proliferation. In a large clinically annotated dataset, higher and expression was significantly correlated with shorter overall survival. Our data thus suggest and as priority targets in glioblastomas. Using a human phosphokinase protein expression profiling assay, we can provide first insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation. © 2015 Wiley Periodicals, Inc.
    Keywords: Genetic Research – Investigations ; Stem Cells – Investigations ; Genes – Investigations ; RNA – Investigations ; Glioblastomas – Investigations;
    ISSN: 1045-2257
    E-ISSN: 1098-2264
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  • 2
    Language: English
    In: Social Psychiatry and Psychiatric Epidemiology, 2005, Vol.40(11), pp.855-864
    Description: Byline: Matthias C. Angermeyer (1), Peter Breier (2), Sandra Dietrich (1), Denis Kenzine (1), Herbert Matschinger (1) Keywords: public attitudes; treatment; help seeking; transcultural psychiatry; schizophrenia; major depression Abstract: Aim In order to examine whether there is a relationship between the state of mental health care and the acceptance of psychiatry, public attitudes toward psychiatric treatment in three countries where the reform of mental health care has progressed to a different degree will be compared. Methods Population surveys on public beliefs about mental illness and attitudes toward psychiatric treatment were conducted in Bratislava, Slovak Republic, and Novosibirsk, Russia. The data were compared with those from a population survey that had recently been carried out in Germany. In all three surveys, the same sampling procedure and fully structured interview were applied. Results Although respondents from all three countries were equally inclined to seek help from mental health professionals, those from Bratislava and Novosibirsk tended to recommend more frequently to address other medical or nonmedical professionals or members of the lay support system. In all three countries, psychotherapy was the most favored treatment modality, followed by psychotropic medication. Although natural remedies were more frequently recommended in Bratislava and Novosibirsk, meditation/yoga was more popular among the German public. Across all three countries, the endorsement of a brain disease as cause was associated with a greater willingness to seek help from medical professionals (psychiatrist, GP). Respondents who adopted biological causes tended to recommend psychotropic medication more frequently. Conclusion In countries with less developed mental health care systems, there appears to be a tendency of the public toward more frequently relying on helping sources outside the mental health sector and on traditional "alternative" treatment methods. However, it is our prognosis that with the progress of reforms observed, differences may further decrease. Author Affiliation: (1) Dept. of Psychiatry, University of Leipzig, Johannisallee 20, 04317, Leipzig, Germany (2) Dept. of Psychiatry, University Hospital, Ruzinov, Slovak Republic Article History: Registration Date: 06/06/2005 Accepted Date: 25/05/2005 Online Date: 12/10/2005
    Keywords: public attitudes ; treatment ; help seeking ; transcultural psychiatry ; schizophrenia ; major depression
    ISSN: 0933-7954
    E-ISSN: 1433-9285
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  • 3
    Language: English
    In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 01 February 2004, Vol.38(3), pp.329-34
    Description: From October 1999 through January 2000, an Escherichia coli clonal group (designated "CgA") was isolated from the urine of nearly one-half of all women with urinary tract infections (UTIs) caused by trimethoprim-sulfamethoxazole (TMP-SMZ)-resistant E. coli in a California community. This study describes the prevalence of pyelonephritis caused by CgA in the same community. E. coli isolates were characterized by enterobacterial repetitive intergenic consensus (ERIC2) polymerase chain reaction (PCR), serogrouping, and pulsed-field gel electrophoresis. Fourteen (11%) of 130 women with UTIs received a diagnosis of pyelonephritis. CgA was associated with 4 (57%) of the 7 pyelonephritis cases caused by TMP-SMZ-resistant E. coli and was associated with none of the cases caused by TMP-SMZ-susceptible E. coli (P〈.02). Six (86%) of these TMP-SMZ-resistant E. coli isolates belonged to 2 distinct ERIC2 PCR-defined clonal groups, whereas all of the TMP-SMZ-susceptible E. coli strains had unique fingerprints (P〈.001). The prevalence of antimicrobial-resistant pyelonephritis in a community may be affected by a limited number of E. coli clonal groups.
    Keywords: Drug Resistance, Multiple, Bacterial ; Escherichia Coli -- Drug Effects ; Escherichia Coli Infections -- Microbiology ; Pyelonephritis -- Microbiology ; Trimethoprim, Sulfamethoxazole Drug Combination -- Pharmacology
    ISSN: 10584838
    E-ISSN: 1537-6591
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 4
    Language: English
    In: Computers in Biology and Medicine, 01 February 2013, Vol.43(2), pp.144-153
    Description: We propose an automatic system for the classification of coronary artery disease (CAD) based on entropy measures of MCG recordings. Ten patients with coronary artery narrowing≥or≤50% were categorized by a multilayer perceptron (MLP) neural network based on Linear Discriminant Analysis (LDA). Best results were obtained with MCG at rest: 99% sensitivity, 97% specificity, 98% accuracy, 96% and 99% positive and negative predictive values for single heartbeats. At patient level, these results correspond to a correct classification of all patients. The classifier's suitability to detect CAD-induced changes on the MCG at rest was validated with surrogate data.
    Keywords: Automatic Classification System ; Magnetocardiography ; Entropy ; Coronary Artery Disease ; Early Diagnosis ; Medicine
    ISSN: 0010-4825
    E-ISSN: 1879-0534
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  • 5
    Language: English
    In: Journal of Oral and Maxillofacial Surgery, August 2012, Vol.70(8), pp.1781-1788
    Description: Animal studies of excisional biopsies have shown less thermal damage when a carbon dioxide (CO ) laser (10.6 μm) is used in a char-free (CF) mode than in a continuous-wave (CW) mode. The authors' aim was to evaluate and compare clinical and histopathologic findings of excisional biopsies performed with CW and CF CO laser (10.6 μm) modes. This prospective randomized controlled clinical trial included 60 patients with similar fibrous hyperplasias of the buccal plane willing to undergo excisional CO laser biopsy. Patients were randomly allocated to the CW (5 W) or CF (140 Hz, 400 μs, 33 mJ) group. Duration of surgery, intra- and postoperative complications, and the width (micrometers) of the histopathologic collateral thermal damage zone were registered as primary outcome variables. Secondary outcome variables were pain (patients filled in a visual analog scale [VAS]) and analgesic intake (recorded by patients). The study group consisted of 36 women and 24 men with a median age of 50.5 years. Median durations of surgery were 74.5 seconds in the CW group and 83.5 seconds in the CF group. Intraoperative venous bleeding occurred in 16.7% of patients in the CW group and in 13.3% of patients in the CF group. Median areas of histopathologic collateral damage zones were similar in the CW group (166.5 μm) and the CF group (162.5 μm). There was no statistically significant difference between the VAS values of the 2 groups. Analgesic intake was recorded by 16.7% of patients in the CW group and by 6.7% of patients in the CF group ( = .23, not significant). No statistically significant correlation was found between areas of thermal damage zones and postoperative VAS scores. In contrast to previous animal studies, no significant difference was found in the widths of thermal damage zones between the CW and CF groups. The VAS values and analgesic intake were low in the 2 groups. The 2 CO laser modes are appropriate for the excision of intraoral mucosal lesions. A safety border of at least 1 mm is recommended regardless of the laser mode used.
    Keywords: Dentistry
    ISSN: 0278-2391
    E-ISSN: 1531-5053
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  • 6
    Language: English
    In: Foodborne pathogens and disease, 2007, Vol.4(4), pp.419-31
    Description: The increasing incidence of community-acquired urinary tract infections (UTIs) caused by antimicrobial resistant Escherichia coli, and observations of potential outbreaks of UTI-causing E. coli, suggest that food may be an important source of E. coli in women who develop UTI. We sought to determine if acquisition of and infection with a UTI-causing, antimicrobial resistant E. coli isolate is associated with a woman's dietary habits, specifically her preparation and consumption of retail meat products. Between April 2003 and June 2004, a case-control study was conducted. The dietary habits of women with UTI caused by an antimicrobial resistant E. coli (cases) and women with UTI caused by fully susceptible E. coli (controls) were compared. Broth microdilution was used to perform antimicrobial resistance testing. All E. coli isolates were genotyped by the pulsed-field gel electrophoresis (PFGE) method. Ninety-nine women met study criteria. Women who were infected with multidrug-resistant E. coli reported more frequent chicken consumption (adjusted OR = 3.7, 95% CI 1.1, 12.4). Women with UTI caused by an ampicillin- or cephalosporin-resistant E. coli isolate reported more frequent consumption of pork (adjusted OR = 3.2, 95% CI 1.0, 10.3 and adjusted OR = 4.0, 95% CI 1.0, 15.5, respectively). Frequent alcohol consumption was associated with antimicrobial resistant UTI. This study provides epidemiologic evidence that antimicrobial resistant, UTI-causing E. coli could have a food reservoir, possibly in poultry or pork.
    Keywords: Feeding Behavior ; Escherichia Coli -- Drug Effects ; Escherichia Coli Infections -- Drug Therapy ; Meat -- Microbiology ; Urinary Tract Infections -- Drug Therapy
    ISSN: 1535-3141
    E-ISSN: 15567125
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  • 7
    Language: English
    In: American Heart Journal, 1983, Vol.105(5), pp.722-726
    Description: The antiarrhythmic efficacy of oral acebutolol, a new cardioselective beta-blocking agent, was assessed in a randomized double-blind, placebo-controlled study. Twenty-five patients with greater than or equal to 30 ventricular ectopic beats (VEB) per hour on three control ambulatory monitorings were studied. Mean VEB reduction from the control period was 35% with placebo and 45% and 50% with the use of acebutolol 200 mg and 400 mg, respectively. Eleven patients had greater than or equal to 70% reduction in VEB with acebutolol and nine of them had greater than or equal to 90 VEB reduction. Among these 11 patients, the mean VEB suppression was 51% after placebo but significantly higher following the two doses of acebutolol at 71% (p less than 0.05) and 86% (p less than 0.01). The mean reduction of paired VEB compared to placebo was 71% (p less than 0.05) and 75% (p less than 0.01) following 200 mg and 400 mg of acebutolol and only 49% after placebo. Complete suppression of paroxysmal ventricular tachycardia was also noted in five patients. Mean PR interval only increased slightly when patients took 400 mg of acebutolol, but there was no significant change in either the QRS or QTc intervals. A significant decrease in heart rate from that during control periods was noted after acebutolol. No significant adverse reactions were noted during the study. Acebutolol appears to be an effective and well-tolerated antiarrhythmic agent in the treatment of VEB and higher grades of ventricular ectopy.
    Keywords: Medicine
    ISSN: 0002-8703
    E-ISSN: 1097-6744
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  • 8
    Language: English
    In: New England Journal of Medicine, 06/11/1970, Vol.282(24), pp.1334-1336
    Keywords: Lung ; Radionuclide Imaging ; Ventilation-Perfusion Ratio ; Pulmonary Embolism -- Diagnosis;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 9
    Language: English
    In: American Journal of Industrial Medicine, September 2004, Vol.46(3), pp.297-303
    Description: BACKGROUND: The objective of this study was to investigate risk factors associated with persistent or recurrent upper extremity and neck pain among engineering graduate students.METHODS: A random sample of 206 Electrical Engineering and Computer Science (EECS) graduate students at a large public university completed an online questionnaire.RESULTS: Approximately 60% of respondents reported upper extremity or neck pain attributed to computer use and reported a mean pain severity score of 4.5 (+/-2.2; scale 0-10). In a final logistic regression model, female gender, years of computer use, and hours of computer use per week were significantly associated with pain.CONCLUSIONS: The high prevalence of upper extremity pain reported by graduate students suggests a public health need to identify interventions that will reduce symptom severity and prevent impairment.
    Keywords: Musculoskeletal ; Pain ; Graduate Students ; Computer ; Ergonomics
    ISSN: 0271-3586
    E-ISSN: 1097-0274
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  • 10
    Language: English
    In: Neuron, 2005, Vol.46(6), pp.957-969
    Description: Placebo analgesia and reward processing share several features. For instance, expectations have a strong influence on the subsequent emotional experience of both. Recent imaging data indicate similarities in the underlying neuronal network. We hypothesized that placebo analgesia is a special case of reward processing and that placebo treatment could modulate emotional perception in the same way as does pain perception. The behavioral part of this study indicates that placebo treatment has an effect on how subjects perceive unpleasant pictures. Furthermore, event-related fMRI demonstrated that the same modulatory network, including the rostral anterior cingulate cortex and the lateral orbitofrontal cortex, is involved in both emotional placebo and placebo analgesia. These effects were correlated with the reported placebo effect and were predicted by the amount of treatment expectation induced on a previous day. Thus, the placebo effect may be considered to be a general process of modulation induced by the subjects’ expectations.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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