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  • 1
    In: HLA, October 2018, Vol.92(4), pp.253-254
    Description: A new allele, now named , was discovered during testing of a registry donor for possible stem cell transplantation.
    Keywords: C*02:138 ; Hla ; Ngs
    ISSN: 2059-2302
    ISSN: 00012815
    E-ISSN: 2059-2310
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  • 2
    In: British Journal of Dermatology, February 2001, Vol.144(2), pp.422-424
    Keywords: Acitretin–Therapeutic Use ; Adult–Therapeutic Use ; Follow-Up Studies–Drug Therapy ; Humans–Drug Therapy ; Keratolytic Agents–Drug Therapy ; Keratosis–Drug Therapy ; Lichenoid Eruptions–Drug Therapy ; Male–Drug Therapy ; Keratolytic Agents ; Acitretin;
    ISSN: 0007-0963
    E-ISSN: 1365-2133
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  • 3
    Language: English
    In: The Journal of family practice, September 1994, Vol.39(3), pp.262-70
    Description: Many conventional health education materials, such as pamphlets and booklets, are designed to reach as wide an audience as possible; they are therefore often lengthy and contain information irrelevant to many consumers. Computer technologies allow sophisticated tailoring of messages targeted to individual patients and free of irrelevant information. In two studies in North Carolina (study 1, N = 51; study 2, N = 197), adult cigarette smokers were identified from a cohort of family practice patients. Cigarette consumption, interest in quitting smoking, perceived benefits and barriers to quitting, and other characteristics relevant to smoking cessation were collected. Based on this information, smoking cessation letters were tailored by computer to individuals. Smokers were randomly assigned to experimental (tailored health letters) or comparison groups (generic health letter in study 1, no health letter in study 2). Smoking status was assessed again at 4 months (study 1) or 6 months (study 2). Both studies found statistically significant positive effects of tailored health letters among moderate to light smokers. In study 1, 30.7% reported quitting after 6 months vs 7.1% in the control group (P 〈 .05); in study 2, 19.1% vs 7.3% (P 〈 .05). Results from both studies indicate positive effects of computer-tailored smoking messages among moderate to light smokers. These findings are consistent with the focus of our computer-tailored program on psychological and behavioral factors related to smoking cessation. Smoking cessation outcomes may be enhanced by combining tailored messages with nicotine replacement therapies to treat physical dependency. Methods of tailoring health messages and incorporating the results into family practice are described.
    Keywords: Correspondence As Topic ; Family Practice ; Smoking Cessation ; Word Processing ; Health Education -- Methods
    ISSN: 0094-3509
    E-ISSN: 15337294
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  • 4
    Language: English
    In: Journal of pharmaceutical sciences, March 1986, Vol.75(3), pp.256-8
    Description: [14C]Polyhexyl cyanoacrylate nanoparticles (PHCA), with diameters between 200 and 300 nm, were injected intravenously into nude mice bearing a human osteosarcoma. The distribution in liver, spleen, lung, heart, kidney, GI tract, gonads, brain, muscle, as well as in serum and transplanted tumor fragments was investigated by liquid scintillation counting. The peak levels in all organs with the exception of tumor and spleen were reached within 24 h. The highest levels were found in the organs of the reticuloendothelial system, liver, spleen, and lungs. The radioactivity in the other organs was found to be low, approximately 2%. In the tumor and the spleen the highest levels of radioactivity were found at approximately 7 d. At this stage the level of radioactivity in the tumor was 40 times higher than that in muscle. However, the amount of isotope detected in the tumor was still generally less than 1% of the injected dose. The concentration of radioactivity in the tumor was found to be quite variable. Higher levels of radioactivity were correlated with a low amount of tumor necrosis indicating the importance of viable tumor tissue for the accumulation of the radiolabel in this particular animal model.
    Keywords: Bone Neoplasms -- Metabolism ; Cyanoacrylates -- Metabolism ; Osteosarcoma -- Metabolism
    ISSN: 0022-3549
    E-ISSN: 15206017
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  • 5
    In: British Journal of Dermatology, September 2006, Vol.155(3), pp.600-607
    Description: In previous studies, distinct immunological abnormalities have been reported in localized scleroderma (LS). Several pro‐inflammatory cytokines have been demonstrated at increased levels in sera of patients with LS in parallel with disease activity. Human ‐defensins (hBDs) are peptides with antimicrobial activity, but have been also shown to be implicated in tissue injury, scarring and wound healing. hBD expression in LS, a condition resembling pathological scarring due to excessive stimulation of matrix synthesis and fibroblast activation, has so far not been investigated. Ultraviolet (UV) A1 phototherapy, the most recent advance in the treatment of LS, targets T‐cell dermal inflammatory infiltrates via induction of various cytokines and soluble factors besides well‐known effects on collagen metabolism. We sought to investigate the effects of UVA1 on the expression and modulation of hBDs and several pro‐inflammatory cytokines in LS. UVA1 phototherapy was performed five times weekly for 8 weeks resulting in a total of 40 treatment sessions (single dose 20 J cm, cumulative dose 800 J cm). hBD‐1, hBD‐2 and hBD‐3 mRNA as well as tumour necrosis factor‐, transforming growth factor‐, interleukin (IL) ‐2, IL‐4, IL‐6 and IL‐8 mRNA expression were determined by quantitative real‐time reverse transcription‐polymerase chain reaction in lesional and unaffected skin of patients with LS. Skin status markedly improved in all 14 patients, resulting in a significant reduction of the clinical score from baseline to the end of treatment. hBD‐1, hBD‐2 and hBD‐3 mRNA levels were higher in lesional skin compared with unaffected skin and skin from healthy volunteers. Following UVA1 phototherapy, hBD‐1 mRNA decreased in lesional, but not in unaffected skin. hBD‐3 mRNA levels significantly decreased after UVA1 in lesional skin, whereas an increase of hBD‐3 was observed in unaffected skin. IL‐6 and IL‐8 mRNA levels were significantly elevated in lesional skin and significantly decreased after UVA1 irradiation, whereas mRNA for both cytokines remained unchanged in irradiated unaffected skin. The decrease of hBD‐1, hBD‐3, IL‐6 and IL‐8 mRNA paralleled the extent of disease and response to UVA1 phototherapy. hBDs and IL‐6 and IL‐8, cytokines with pivotal importance in sclerotic skin diseases, are downregulated by UVA1 in the lesional skin of patients with LS. Their pathogenetic relevance with respect to clinical improvement needs further investigation.
    Keywords: Human Beta Defensins ; Interleukin‐6 ; Interleukin‐8 ; Localized Scleroderma ; Ultraviolet‐A1 Irradiation
    ISSN: 0007-0963
    E-ISSN: 1365-2133
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  • 6
    Language: English
    In: Dermatology (Basel, Switzerland), 2000, Vol.201(1), pp.76-7
    Description: Abstract Sorry, there is no abstract. Read the first few lines of the text instead! Mucinosis follicularis, first described in the thirties as a follicular skin disease with intra- and perifollicular deposits of mucin [ 1 , 2 ], is a chronic type of inflammatory dermatosis involving the sebaceous glands and outer root sheaths. Even though it is characterised clinically by a variety of unspecific skin affections, mucinosis follicularis reveals distinct characteristic histological features [ 3 , 4 , 5 ]. The age of onset, distribution, number and morphology of lesions are important prognostic signs. Copyright © 2000 S. Karger AG, Basel
    Keywords: Ultraviolet Therapy ; Mucinosis, Follicular -- Therapy
    ISSN: 1018-8665
    E-ISSN: 14219832
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  • 7
    Language: English
    In: European journal of dermatology : EJD, December 2000, Vol.10(8), pp.635-6
    Keywords: Lymphoid Tissue -- Pathology ; Pseudolymphoma -- Pathology ; Skin Diseases -- Pathology
    ISSN: 1167-1122
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 8
    Language: English
    In: Clinical chemistry and laboratory medicine, January 1999, Vol.37(1), pp.21-8
    Description: This paper describes a new enzyme-linked ligand sorbent assay (ELLSA) to quantify free apolipoprotein(a) (apo(a)). The new test immobilizes free apo(a) utilizing a specific peptide that carries the amino acid sequence of a non-covalent apo(a) binding site on apoB3375-3405 (ligand-peptide). The ligand-peptide coupled to Sepharose was used in affinity chromatography to separate free apo(a) from whole serum. Isolated free apo(a) consisted of full length apo(a) and smaller apo(a). Additionally, free apo(a) levels determined by ELLSA as well as by electroimmunodiffusion correlated moderately well. Significantly increased serum concentrations of free apo(a) were found in coronary artery disease. The mean value of free apo(a) was three times higher in patients than in controls while the lipoprotein(a) (Lpla)) concentration was doubled. Utilizing receiver operating characteristic diagrams, it was shown that the free apo(a)-ELLSA had a better diagnostic test performance in atherosclerotic risk assessment than the Lp(a)-test: specificity free apo(a)-ELLSA 0.77, Lp(a)-test 0.81 [with (a:a)-enzyme immunoassay (EIA)] to 0.83 [with (a:B)-EIA]; sensitivity free apo(a)-ELLSA 0.57, Lp(a)-test 0.36 to 0.40. In conclusion, the new free apo(a)-ELLSA allows for the specific quantification of free apo(a). This provides an interesting indicator for atherosclerotic risk assessment.
    Keywords: Lipoprotein(a) ; Apolipoproteins -- Blood ; Coronary Disease -- Blood ; Enzyme-Linked Immunosorbent Assay -- Methods
    ISSN: 1434-6621
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  • 9
    Language: English
    In: Psychopharmacology, 1982, Vol.76(3), pp.236-239
    Description: Twenty-nine inpatients with primary affective disorder were treated with 150 mg amitriptyline (AT) daily for 28 days. Pretreatment urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was measured in two or three 24-h urine samples. Plasma levels of AT and nortriptyline (NT) were determined after 14, 21, and 28 days of treatment. MHPG excretion was significantly correlated with clinical response to treatment. Responders defined by two different methods showed higher pretreatment MHPG excretion than nonresponders. Correspondingly, high MHPG excretors (median split) showed significantly more improvement than low excretors. These relationships were even more apparent when possibly incomplete urine samples (creatinine excretion below 1000 mg/24 h) were excluded. The high and low MHPG subgroups did not significantly differ from each other in their plasma levels of AT, NT, or AT plus NT. A significant rank correlation between clinical response and plasma levels of AT and/or NT did not exist, but there was a trend towards lower levels in responders.
    Keywords: Methoxy-4-hydroxyphenylglycol ; MHPG ; Amitriptyline ; Plasma drug level ; Drug response
    ISSN: 0033-3158
    E-ISSN: 1432-2072
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  • 10
    Language: English
    In: The Journal of family practice, July 1994, Vol.39(1), pp.26-32
    Description: The physician can be an important part of a comprehensive strategy to assist persons with alcohol problems. This study was designed to contribute to the development of physician-initiated brief interventions for patients with alcohol problems by incorporating into an existing screening instrument questions that solicit information relevant to behavior change strategies. Adult patients from 12 family practices in North Carolina (N = 2716) completed a self-administered questionnaire assessing alcohol consumption and other health-related behaviors. Alcohol problems were assessed using the four-item CAGE (Have you ever felt you should cut down on your drinking? Have people annoyed you by criticizing your drinking? Have you ever felt bad or guilty about your drinking? Have you ever had a drink first thing in the morning to steady your nerves, or to get rid of a hangover?). For this study, CAGE was adapted to address only the past 12 months. Patient interest in reducing the amount of alcohol consumed was measured using the Transtheoretical Model developed by Prochaska and colleagues. Patients were also asked about their motives for and barriers to reducing consumption. Five percent of all patients and 9% of patients who reported drinking alcohol gave positive responses on at least two CAGE items. Patients with three or four positive CAGE responses were 74% more likely to report an interest in reducing alcohol consumption than were those with one or two. Intrinsic reasons were the most important motives for reducing consumption. No pattern was found in barriers. We found that in the management of patients with alcohol-related problems, there are many clinical opportunities for patient counseling and referral in the family practice setting. Individually tailored brief interventions that take into consideration the patient's interest in, motives for, and barriers to reducing alcohol consumption are likely to be successful for the family practice physician.
    Keywords: Alcohol Drinking ; Counseling ; Alcoholism -- Diagnosis
    ISSN: 0094-3509
    E-ISSN: 15337294
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