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  • 1
    Language: English
    In: Emergency Radiology, 2012, Vol.19(3), pp.211-215
    Description: The purpose of this study is to determine how often CT is repeated to obtain chest/abdomen/pelvis data outside the reconstructed field of view (FOV) on a prior spine CT. Radiology records of 1,239 consecutive thoracic and lumbar spine CT exams of 1,025 patients from January 1, 2006 to December 31, 2008 were retrospectively reviewed to identify patients who subsequently had CT studies of the chest, abdomen, and/or pelvis. The CT data were also evaluated for contrast enhancement, slice thickness, radiation dose, and reason for subsequent CT exam. Over 3 years, 290 of the 1,239 (24%) spine CT exams were followed by CT of the same anatomic region to evaluate extraspinal anatomy. The use or nonuse of contrast in these follow-up studies was the same as the preceding spine study in 91 cases, which were repeated on the same day ( n  = 37), within 7 days ( n  = 19), within 8–30 days ( n  = 15), or after 30 days ( n  = 20). Fourteen of 25 (56%) T spine CTs and 34 of 52 (65%) L spine CTs without contrast were followed by a chest CT or abdomen/pelvis CT without contrast within 7 days, respectively. Among 31 pediatric exams, 6 of 31 (19%) spine CTs were followed by a CT of the same anatomic region, all within 7 days. Reconstructing full FOV images of spine CT scans in addition to the standard coned down spine FOV may reduce redundant CT imaging and radiation dose.
    Keywords: Lumbar ; Thoracic ; Spine CT ; Redundant imaging
    ISSN: 1070-3004
    E-ISSN: 1438-1435
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  • 2
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(11), p.e110773
    Description: Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was to assess whether BDNF promoter methylation in peripheral blood was able to predict the risk of AD. A total of...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 3
    Language: English
    In: Scientific reports, 23 August 2018, Vol.8(1), pp.12698
    Description: This clinical retrospective study explored factors associated with distal tibiofibular syndesmosis ossification (TFSO) after ankle fracture fixation. Between August 2012 and January 2015, 172 patients with ankle fractures (121 men) with an average age of 46.6 years (range, 22-71 years) were treated surgically...
    Keywords: Fracture Fixation, Internal ; Ankle Fractures -- Surgery ; Ankle Joint -- Pathology ; Osteogenesis -- Physiology
    E-ISSN: 2045-2322
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  • 4
    Language: English
    In: AJR. American journal of roentgenology, February 2011, Vol.196(2), pp.W138-43
    Description: Our objective was to determine the incidence of immediate adverse events for gadolinium-based contrast agents. All gadolinium-based contrast agent adverse events reported to radiology quality assurance committees were graded according to American College of Radiology criteria and divided by the total number of injections to determine incidence during the past 10 years. For each event, an age- and examination-matched control patient was identified to compare sex, weight, creatinine, eosinophil count, allergic history and gadolinium-based contrast agent dose differences. The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database was analyzed to compare local experience to national trends. Abdominal MRI had the highest rates of adverse events, 0.013% compared with brain (0.0045%, p 〈 0.001) or spine (0.0034%, p 〈 0.001). Adverse events were more likely in women, with a female to male ratio of 3.3, and in patients with history of prior allergic reactions (p 〈 0.001). Immediate adverse events rates were 0.2, 0.5, 1.2, and 3.3 per 1,000 injections for gadodiamide, gadopentetate dimeglumine, gadobenate dimeglumine, and gadoteridol, respectively. Gadobenate dimeglumine had more severe patient reactions, including three patients who arrested (defined as the patient becoming unresponsive and the code team being called), one of whom died. From 2004 to 2009, the FDA received reports on 40 gadolinium-based contrast agent U.S. deaths unrelated to nephrogenic systemic fibrosis, with an incidence per million doses of 0.15, 0.19, 0.97, 2.7, and 0.7 for gadodiamide, gadoversetimide, gadopentetate dimeglumine, gadobenate dimeglumine, and gadoteridol, respectively. This limited retrospective analysis shows that gadolinium-based contrast agents are very safe, with only rare reports of death, and raises the possibility that nonionic linear gadolinium-based contrast agents and gadopentetate dimeglumine may have fewer severe immediate adverse events compared with gadobenate dimeglumine.
    Keywords: Anaphylaxis -- Chemically Induced ; Contrast Media -- Adverse Effects ; Drug Hypersensitivity -- Epidemiology ; Gadolinium -- Adverse Effects
    ISSN: 0361803X
    E-ISSN: 1546-3141
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  • 5
    In: American Journal of Epidemiology, 2003, Vol.157(11), pp.1007-1014
    Description: Previous epidemiologic studies have generated inconsistent results regarding the associations between fat intakes and risk of Parkinsons disease. The authors investigated these associations in two large, prospective US cohorts. They documented 191 incident cases of Parkinsons disease in men (19861998) and 168 in women (19801998) during the follow-up. Overall, intakes of total fat or major types of fat were not significantly associated with the risk. The relative risks comparing the highest quintile of animal fat intake with the lowest were 1.42 for men (95 confidence interval (CI): 0.91, 2.20; p for trend 0.1) and 0.65 for women (95 CI: 0.36, 1.16; p for trend 0.3). For men, but not women, replacement of polyunsaturated fat with saturated fat was associated with a significantly increased risk (5 of energy intake, relative risk (RR) 1.83, 95 CI: 1.10, 3.03). Of the individual polyunsaturated fatty acids, arachidonic acid tended to be inversely associated with the risk (pooled RR between extreme quintiles 0.65, 95 CI: 0.46, 0.91; p for trend 0.05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinsons disease, but a possible adverse effect of saturated fat for men could not be excluded.
    Keywords: Dietary Fats -- Adverse Effects ; Parkinson Disease -- Etiology;
    ISSN: 0002-9262
    E-ISSN: 1476-6256
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  • 6
    Language: English
    In: Clinica Chimica Acta, September 2018, Vol.484, pp.246-252
    Description: We examined the independent and cumulative associations of resting heart rate and pulse pressure with metabolic syndrome in Chinese rural population based on epidemiological research. A total of 38,708 participants were derived from the Henan Rural Cohort study. Restricted cubic splines and logistic regression model were used to estimate the odds ratios and 95% confidence intervals of metabolic syndrome risk in relation to resting heart rate and pulse pressure. After adjusting for potential confounders, the odds ratio (95% confidence intervals) of resting heart rate and pulse pressure in the highest quartile with the risk of metabolic syndrome were 1.59 (1.48–1.70) and1.81 (1.67–1.95), respectively. Simultaneously, the cumulative effect analysis indicated that the adjusted the odd ratio of resting heart rate and pulse pressure in the highest quartile was 2.89 (2.40–3.47). Furthermore, there was a significantly additive interaction between resting heart rate and pulse pressure on the risk of metabolic syndrome. Increased resting heart rate and pulse pressure are associated with the higher risk of metabolic syndrome as well as the influences of resting heart rate with pulse pressure might cumulatively increase the risk of metabolic syndrome. However, the potential clinical application remains to be determined.
    Keywords: Metabolic Syndrome ; Resting Heart Rate ; Pulse Pressure ; Rural Population ; Medicine ; Chemistry
    ISSN: 0009-8981
    E-ISSN: 1873-3492
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  • 7
    Language: English
    In: Complementary Therapies in Medicine, October 2014, Vol.22(5), pp.858-863
    Description: To investigate the effect of auricular stimulation in cavum conchae on the glycemic control for patients with type 2 diabetes mellitus. Seventy-one cases were treated with auricular electrical stimulator in the cavum choncha for 30 min, once daily for consecutive 3 months. The changes on the fasting plasma glucose (FBG), 2-h postprandial blood glucose after a 75 g oral glucose load (P BG), glycated hemoglobin (HbA1c), blood urea nitrogen (BUN), serum creatinine (SCr), total cholesterol (TC) and aspartate transaminase (AST) were compared before and after the treatment. The level of the HbA1c was significantly decreased ( 〈 0.05), and there were also statistically significant decreases in BUN, SCr, TC and AST after the treatment ( 〈 0.05). A few patients ( = 7) reduced the dose of the hypoglycemic agents in response to repeated hypoglycemia during the treatment. The stimulation in the cavum conchae of patients with types 2 diabetes mellitus may help decrease HbA1c, BUN, SCr, TC and AST, and may be an effective treatment for type 2 diabetes mellitus.
    Keywords: Diabetes ; Auricular Therapy ; Cavum Conchae ; Fbg ; Hba1c ; Medicine
    ISSN: 0965-2299
    E-ISSN: 1873-6963
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  • 8
    Language: English
    In: Clinica Chimica Acta, May 2018, Vol.480, pp.119-125
    Description: We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) in Chinese rural adults. A total of 16,577 subjects (6354 men and 10,223 women) were from the RuralDiab study. SUA concentration was measured by the enzymatic colorimetric method. A meta-analysis including 12 eligible studies focused on SUA and MetS was preformed to confirm the findings of the cross-sectional study. After adjustment for age, educational level, and other covariates, the odds ratio (ORs) for MetS increased smoothly with the increasing SUA concentration in both sexes ( for no-linear trend 〉 0.05). The adjusted ORs of MetS comparing the fourth and firstly quartiles were 3.11 [95% CI: 2.58–3.74] in men and 3.64 [95% CI: 3.22–4.11] in women (  〈 0.001). In continuous analysis, each 1 mg/dl increment in SUA concentration was significantly associated with a 41% increased risk of MetS in men and 62% in women. The meta-analysis validated the positive association between SUA and MetS (pooled OR: Men, 1.80 [95% CI: 1.57–2.07]; Women, 2.46 [95% CI: 1.95–3.12]). SUA concentration was positively with the prevalence of MetS in Chinese rural population, and more studies are needed to explore the mechanisms of the relationship. Previous studies have explored the association between serum uric acid and metabolic syndrome, but evidence on the strength and consistency of the association remains uncertain and limited, especially in rural population. In addition, the epidemiological research and meta-analysis on the association have not been reported. The results of this study showed that serum uric acid was significantly associated with metabolic syndrome and its components in Chinese rural population. Furthermore, the findings demonstrated that the significant associations varied across sex. In addition, the results of epidemiological research were similar with the meta-analysis, which demonstrates the credible of the results of the epidemiology research.
    Keywords: Serum Uric Acid ; Metabolic Syndrome ; Rural Population ; Meta-Analysis ; Medicine ; Chemistry
    ISSN: 0009-8981
    E-ISSN: 1873-3492
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  • 9
    Language: English
    In: Lipids in Health and Disease, 01 May 2018, Vol.17(1), pp.1-12
    Description: Abstract Background The prevalence of dyslipidemia continue to increase in recent decades in China, however, little is known about the recent prevalence, awareness, treatment, control, and potential risk factors of dyslipidemia in the rural areas of China. Methods A total of 39,207 participants...
    Keywords: Dyslipidemia ; Prevalence ; Awareness ; Treatment ; Control ; Risk Factors ; Medicine ; Anatomy & Physiology
    E-ISSN: 1476-511X
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  • 10
    Language: English
    In: The Journal of nutrition, January 2013, Vol.143(1), pp.53-8
    Description: Thiamine has been hypothesized to play an important role in mental health; however, few studies have investigated the association between thiamine nutritional status and depression in the general population. Concentrations of free thiamine and its phosphate esters [thiamine monophosphate (TMP) and thiamine diphosphate (TDP)] in erythrocytes were measured by HPLC among 1587 Chinese men and women aged 50-70 y. The presence of depressive symptoms was defined as a Center for Epidemiological Studies Depression Scale score of ≥16. The median erythrocyte concentration (nmol/L) was 3.73 for free thiamine, 3.74 for TMP, and 169 for TDP. The overall prevalence of depressive symptoms was 11.3%. Lower concentrations of all 3 erythrocyte thiamine biomarkers were monotonically associated with a higher prevalence of depressive symptoms: the multivariable adjusted ORs comparing the lowest with the highest quartiles were 2.97 (95% CI = 1.87, 4.72; P-trend 〈 0.001) for free thiamine, 3.46 (95% CI = 1.99, 6.02; P-trend 〈 0.001) for TMP, and 1.98 (95% CI = 1.22, 3.21; P-trend = 0.002) for TDP. In conclusion, poorer thiamine nutritional status and higher odds of depressive symptoms were associated among older Chinese adults. This finding should be further investigated in prospective or interventional studies.
    Keywords: Aging ; Nutritional Status ; Depression -- Etiology ; Thiamine -- Administration & Dosage ; Thiamine Deficiency -- Physiopathology
    ISSN: 00223166
    E-ISSN: 1541-6100
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