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Berlin Brandenburg

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  • Anatomy & Physiology
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  • 1
    Language: English
    In: The Journal of biological chemistry, 11 November 2016, Vol.291(46), pp.24215-24230
    Description: Protein phosphatases play vital roles in phosphorylation-mediated cellular signaling. Although there are 11 serine/threonine protein kinases in Mycobacterium tuberculosis, only one serine/threonine phosphatase, PstP, has been identified. Although PstP has been biochemically characterized and multiple in vitro substrates have been identified, its physiological role has not yet been elucidated. In this study, we have investigated the impact of PstP on cell growth and survival of the pathogen in the host. Overexpression of PstP led to elongated cells and partially compromised survival. We find that depletion of PstP is detrimental to cell survival, eventually leading to cell death. PstP depletion results in elongated multiseptate cells, suggesting a role for PstP in regulating cell division events. Complementation experiments performed with PstP deletion mutants revealed marginally compromised survival, suggesting that all of the domains, including the extracellular domain, are necessary for complete rescue. On the other hand, the catalytic activity of PstP is absolutely essential for the in vitro growth. Mice infection experiments establish a definitive role for PstP in pathogen survival within the host. Depletion of PstP from established infections causes pathogen clearance, indicating that the continued presence of PstP is necessary for pathogen survival. Taken together, our data suggest an important role for PstP in establishing and maintaining infection, possibly via the modulation of cell division events.
    Keywords: Mycobacterium Tuberculosis ; Pstp ; Cell Division ; Cell Signaling ; Mycobacteria ; Phosphatase ; Phosphorylation ; Protein Serine/Threonine Phosphatase (Psp) ; Microbial Viability ; Bacterial Proteins -- Metabolism ; Cell Division -- Physiology ; Mycobacterium Tuberculosis -- Enzymology ; Phosphoprotein Phosphatases -- Metabolism ; Tuberculosis -- Enzymology
    ISSN: 00219258
    E-ISSN: 1083-351X
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  • 2
    Language: English
    In: Journal of Materials Science, 2018, Vol.53(1), pp.185-201
    Description: Over the past decade, incorporation of nanomaterials into agricultural practices like nanofertilizers and nanopesticides has gained a lot of attention. Progress and application of fertilizers in nanoforms are one of the effective options for considerable improvement of the agricultural yield worldwide. Zinc oxide nanoparticles (ZnO NPs) are considered as a biosafe material for biological species. Earlier studies have shown the potential of ZnO NPs in stimulation of seed germination and plant growth as well as disease suppression and plant protection by its antimicrobial activity. However, both positive and negative effects of ZnO NPs on plant growth and metabolism at various developmental periods have been documented. Uptake, translocation and accumulation of ZnO NPs by plants depend upon the features of NPs as well as the anatomy of the host plant. This review summarizes the applications of ZnO NPs as nanofertilizer in crop production and also attempts to examine and record the possible mechanism of antimicrobial activity of ZnO NPs. Biological synthesis of ZnO NPs and their uptake, translocation and biotransformation in plants via various routes have also been examined.
    Keywords: Materials Science ; Materials Science, General ; Characterization and Evaluation of Materials ; Polymer Sciences ; Continuum Mechanics and Mechanics of Materials ; Crystallography and Scattering Methods ; Classical Mechanics ; Engineering;
    ISSN: 0022-2461
    E-ISSN: 1573-4803
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  • 3
    In: PLoS ONE, 2017, Vol.12(5)
    Description: One hundred and sixty two genotypes of different Lens species were screened for salinity tolerance in hydroponics at 40, 80 and 120 mM sodium chloride (NaCl) for 30 d. The germination, seedling growth, biomass accumulation, seedling survivability, salinity scores, root and shoot anatomy, sodium ion (Na + ), chloride ion (Cl - ) and potassium ion (K + ) concentrations, proline and antioxidant activities were measured to evaluate the performance of all the genotypes. The results were compared in respect of physiological (Na + , K + and Cl - ) and seed yield components obtained from field trials for salinity stress conducted during two years. Expression of salt tolerance in hydroponics was found to be reliable indicator for similarity in salt tolerance between genotypes and was evident in saline soil based comparisons. Impressive genotypic variation for salinity tolerance was observed among the genotypes screened under hydroponic and saline field conditions. Plant concentrations of Na + and Cl - at 120 mM NaCl were found significantly correlated with germination, root and shoot length, fresh and dry weight of roots and shoots, seedling survivability, salinity scores and K + under controlled conditions and ranked the genotypes along with their seed yield in the field. Root and shoot anatomy of tolerant line (PDL-1) and wild accession (ILWL-137) showed restricted uptake of Na + and Cl - due to thick layer of their epidermis and endodermis as compared to sensitive cultigen (L-4076). All the genotypes were scanned using SSR markers for genetic diversity, which generated high polymorphism. On the basis of cluster analysis and population structure the contrasting genotypes were grouped into different classes. These markers may further be tested to explore their potential in marker-assisted selection.
    Keywords: Research Article ; Physical Sciences ; Physical Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Ecology And Environmental Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Physical Sciences ; Physical Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences
    E-ISSN: 1932-6203
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  • 4
    Article
    Article
    British Medical Journal Publishing Group
    Language: English
    In: BMJ, 1 March 2003, Vol.326(7387), p.468
    Description: To many he is nothing more than a fedora-wearing ringmaster of a circus of cadavers. To others he is an accomplished anatomist who, through his invention of plastination (where body parts are preserved by saturating them with polymer resin), has brought an understanding of the human body to lay people.
    Keywords: Other Anaesthesia
    ISSN: 0959-8138
    ISSN: 09598138
    E-ISSN: 1468-5833
    E-ISSN: 14685833
    E-ISSN: 17561833
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  • 5
    Article
    Article
    BMJ Publishing Group Ltd.
    Language: English
    In: British Journal of Ophthalmology June 2014, Vol.98(Suppl 1), p.i1
    Description: The treatment of chorioretinal vascular conditions has improved significant with the advent of anti-vascular endothelial growth factor inhibitors (VEGF). Diseases such as age related macular degeneration (AMD), diabetic retinopathy, retinal vein occlusion, and retinopathy of prematurity are all being treated by delivering intravitreal therapy to knock down VEGF.1–4 As ophthalmologists, we are now fortunate to have many anti-VEGF options to choose from which include off label therapy with bevacizumab, and on label therapy with ranibizumab, aflibercept, and pegaptanib. In addition, we have learned how to best track the need for retreatment by clinical exam and optical coherence tomography findings and are able to effectively treat patients on an as needed basis.
    Keywords: Anatomy
    ISSN: 0007-1161
    ISSN: 00071161
    E-ISSN: 1468-2079
    E-ISSN: 14682079
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  • 6
    Language: English
    In: Journal of Community Health, 2016, Vol.41(3), pp.619-625
    Description: In disadvantaged populations, including Hispanics, there is a deficit in understanding of cancer risk factors, symptoms, prevention, and treatment. The objective of this study was to assess ovarian cancer knowledge in a population of Hispanic women in Arizona, identify deficiencies, and to evaluate the utility of an educational program developed specifically for this community’s needs. A de novo questionnaire about ovarian cancer was distributed to Hispanic women enrolled in family literacy programs at Mesa Public Schools. Following this assessment, a video educational program was developed, with emphasis on areas of greatest knowledge deficits, and post-intervention assessment administered. Chi square, Wilcoxon rank sum, and Kruskal–Wallis tests were used for analysis. 167 questionnaires were completed in the pretest group and 102 in the post-intervention group. Between groups, there were no differences in age ( p  = 0.49), education ( p  = 0.68), or annual income ( p  = 0.26). In the pretest group, 45 % of questions were answered correctly versus 84 % in the post-test group ( p  〈 0.01). 24.2 % of the initial respondents correctly identified ovarian cancer symptoms versus 85.6 of post-test respondents ( p  〈 0.01). With the program, there was an increase in the number of correct post-test responses for each question and symptom ( p  〈 0.01), except those about hereditary risk of ovarian cancer ( p  = 0.62) and pelvic anatomy ( p  = 0.16). Following identification of an ovarian cancer knowledge deficit in this cohort of Hispanic women, an educational tool targeting specific deficiencies successfully increased cancer knowledge and awareness of symptoms. Similar efforts in this and other minority populations should be continued.
    Keywords: Ovarian cancer ; Education ; Hispanic ; Prevention
    ISSN: 0094-5145
    E-ISSN: 1573-3610
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  • 7
    Language: English
    In: Anatomical Sciences Education, January 2010, Vol.3(1), pp.50-51
    Description: Peer‐assisted learning as is reverberating in medical institutions around the world. Anatomy classroom activities are challenging and different, and the stressful environment of dissection rooms poses a greater challenge than what can be addressed through peer‐assisted learning. It is here that “near‐peer role modeling” is not only likely to be more useful, both to the students as well as their near‐peer teachers, but also holds the answer to the worsening faculty shortage in anatomy education. Anat Sci Educ 3:50–51, 2010. © 2010 American Association of Anatomists.
    Keywords: Peer‐Assisted Learning ; Near‐Peer Role Modeling ; Peer Teaching ; Gross Anatomy ; Basic Sciences Education ; Mentoring
    ISSN: 1935-9772
    E-ISSN: 1935-9780
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  • 8
    Article
    Article
    BMJ Publishing Group Ltd.
    Language: English
    In: British Journal of Ophthalmology June 2014, Vol.98(6), p.716
    Description: One ending is also another beginning. Always think in terms of beginnings, not endings. hsd
    Keywords: Anatomy
    ISSN: 0007-1161
    ISSN: 00071161
    E-ISSN: 1468-2079
    E-ISSN: 14682079
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  • 9
    Language: English
    In: Surgical and Radiologic Anatomy, 2011, Vol.33(9), pp.827-831
    Description: Emissary veins are valveless veins which pass through the cranial apertures and connect the dural venous sinuses and the extracranial veins. The clinical importance of emissary veins is increasingly being appreciated. Some emissary veins like the petrosquamosal sinus and mastoid emissary vein may cause significant bleeding during middle ear and skull base surgeries. A dilated mastoid emissary vein or condylar emissary vein can sometimes be a rare cause of tinnitus. Radiological identification of these venous channels has been described in recent years and assumes significance in light of their clinical importance. We describe the CT and MRI findings of a rare case that had persistence of multiple emissary veins and presented clinically with tinnitus. The radiological findings included a dilated left mastoid emissary vein, bilateral petrosquamosal sinuses, posterior condylar veins, occipital emissary veins and an intrapetrous venule. The left petrosquamosal sinus had an unusual origin from the dilated mastoid emissary vein. The patient also had major anomalies of posterior fossa venous sinuses which are discussed. A relevant review of literature is included.
    Keywords: Petrosquamosal sinus ; Mastoid emissary vein ; Condylar emissary veins ; Objective tinnitus ; Anomalous venous drainage
    ISSN: 0930-1038
    E-ISSN: 1279-8517
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  • 10
    Book
    Book
    India: Elsevier Health Science
    Language: English
    ISBN: 8131215695
    ISBN: 9788131215692
    Source: Dawsonera
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