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  • Anthozoa
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  • 1
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 01 July 2016, Vol.26(13), pp.3060-3063
    Description: Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian sp. afforded two new sterols, 11-acetoxy-24 -methyl-3 ,5 ,6 -trihydroxy-9,11-secocholest-7-en-9-one ( ) and 5 ,6 -epoxy-(22 ,24 )-ergosta-8,22-diene-3 ,7 -diol ( ). The structures of sterols and were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both and were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
    Keywords: Pinnigorgia ; Gorgonian ; Sterol ; Anti-Inflammatory Activity ; Inos ; Cox-2 ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 2
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 01 May 2016, Vol.26(9), pp.2344-2348
    Description: Bioassay-guided fractionation of an ethanolic extract of spp. collected in Taiwan has resulted in the isolation of one new ecdysone, zoanthone A ( ), along with thirteen known compounds ( – ). The structures of these compounds were determined by spectroscopic methods, especially 2D NMR analyses. The in vitro antiviral activities of all isolated ecdysones ( – ) against dengue virus type 2 (DENV-2) were evaluated using DENV infectious system. New compound ( ) exhibited potent antiviral activity (EC = 19.61 ± 2.46 μM) with a selectivity index (CC /EC ) value of 36.7. The structure–activity relationships of isolated ecdysones against DENV-2 were concluded. Molecular docking information of and NS5 polymerase was performed either.
    Keywords: Ecdysone ; Zoanthus ; Dengue Virus Type 2 ; Structure–Activity Relationships ; Molecular Docking ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 3
    In: Organic & Biomolecular Chemistry, 2011, Vol.9(9), pp.3272-3278
    Description: Seven new polyoxygenated steroids, hirsutosterols A–G ( 1–7 ), were isolated from the Formosan soft coral Cladiella hirsuta . Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configurations of 1 and 5 were determined by Mosher's method. Sterols 4–6 possess hydroxy groups at C-9 and C-11 and might be oxidatively cleaved to the corresponding 9,11-secosterols. Hirsutosterol A ( 1 ) was found to exhibit a stronger cytotoxicity against a limited panel of cancer cell lines.
    Keywords: Anthozoa -- Chemistry ; Oxygen -- Chemistry ; Steroids -- Chemistry;
    ISSN: 1477-0520
    E-ISSN: 1477-0539
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  • 4
    Language: English
    In: Marine Drugs, 01 December 2017, Vol.15(12), p.382
    Description: In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol. The chemical constituents of these 68 secondary metabolites, and their names, structures, and bioactivities, along with studies of their biological activities, are summarized in this review. Based on the literature, many of these compounds possess bioactivities, including anti-inflammation properties, cytotoxicity, and ichthyotoxicity, suggesting that they may have the potential to be developed into biomedical agents for treatment.
    Keywords: Pachyclavularia ; Octocoral ; Cembrane ; Briarane ; Briarellin ; Secosterol ; Bioactivity ; Pharmacy, Therapeutics, & Pharmacology
    E-ISSN: 1660-3397
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  • 5
    Language: English
    In: Marine Drugs, 01 January 2013, Vol.11(1), pp.136-145
    Description: Three new steroidal carboxylic acids, paraminabic acids A–C (1–3) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC50 values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.
    Keywords: Paraminabea Acronocephala ; Paraminabic Acid ; Soft Coral ; Cytotoxicity ; Anti-Inflammatory Activity ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1660-3397
    E-ISSN: 1660-3397
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  • 6
    Language: English
    In: Natural product communications, August 2013, Vol.8(8), pp.1037-40
    Description: Three natural clovane-related sesquiterpenoids, 2beta-acetoxyclovan-9alpha-ol (1), 9alpha-acetoxyclovan-2beta-ol (2) and clovan-2beta,9beta-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
    Keywords: Anthozoa -- Chemistry ; Anti-Inflammatory Agents, Non-Steroidal -- Isolation & Purification ; Sesquiterpenes -- Isolation & Purification
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 7
    Language: English
    In: Natural product communications, June 2015, Vol.10(6), pp.835-8
    Description: Two new natural caryophyllane-type sesquiterpenoids, 1 and 2, were isolated from the gorgonian coral Rumphella antipathies. Standard spectroscopic techniques were used to determine the structures of caryophyllanes 1 and 2.
    Keywords: Anthozoa -- Chemistry ; Polysaccharides -- Chemistry ; Sesquiterpenes -- Chemistry
    ISSN: 1934-578X
    E-ISSN: 15559475
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  • 8
    Language: English
    In: Marine Drugs, 01 November 2016, Vol.14(12), p.218
    Description: Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
    Keywords: 9,11-Secosterol ; Gorgonian ; Pinnigorgia ; Anti-Inflammatory ; Superoxide Anion ; Elastase ; Pharmacy, Therapeutics, & Pharmacology
    E-ISSN: 1660-3397
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  • 9
    In: Organic & Biomolecular Chemistry, 2011, Vol.9(3), pp.834-844
    Description: New eunicellin-base diterpenoids, klysimplexins I–T ( 1–12 ), were isolated from a cultured soft coral Klyxum simplex . Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute stereochemistry of 4 was determined by Mosher's method. Compounds 9 and 12 have been shown to exhibit cytotoxicity toward a limited panel of cancer cell lines. Compounds 2–6 , 10 and 11 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compounds 10 and 11 also could effectively reduce the level of COX-2 protein.
    Keywords: Chemistry;
    ISSN: 1477-0520
    E-ISSN: 1477-0539
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  • 10
    Language: English
    In: Marine drugs, 09 August 2016, Vol.14(8)
    Description: Two new cubitanoids, nanoculones A and B (1 and 2), and three new cembranoids, nanolobols A-C (3-5), as well as six known compounds, calyculone I (6), sinulariuol A (7), sinulariols C, D, H, and J (8-11), were isolated from the soft coral Sinularia nanolobata, collected off the coast of the eastern region of Taiwan. Their structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of compounds 1-11 was evaluated. The nitric oxide (NO) inhibitory activity of selected compounds was further measured by assay of lipopolysaccharide (LPS)-stimulated NO production in activated RAW264.7 cells. The results showed that none of 1-11 exhibited cytotoxicity against the tested cancer cell lines, whereas compound 8 was found to significantly reduce NO production.
    Keywords: Sinularia ; Cubitane ; Nanoculones A and B ; Nanolobols A–C ; Anthozoa -- Chemistry ; Antineoplastic Agents -- Chemistry ; Diterpenes -- Pharmacology ; Nitric Oxide -- Metabolism
    E-ISSN: 1660-3397
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