Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Biology
Language
Year
  • 1
    Language: English
    In: Science (New York, N.Y.), 12 April 2013, Vol.340(6129), pp.163-5
    Description: [Index to Australopithecus sediba special section][1] The site of Malapa, South Africa, has yielded perhaps the richest assemblage of early hominin fossils on the continent of Africa. The fossil remains of Au. sediba were discovered in August of 2008, and the species was named in 2010 ([ 1 ][2])
    Keywords: Fossils ; Bone and Bones -- Anatomy & Histology ; Hominidae -- Anatomy & Histology
    ISSN: 00368075
    E-ISSN: 1095-9203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Science (New York, N.Y.), 15 September 2017, Vol.357(6356), pp.1146-1149
    Description: Propagation of patterns of gene expression through the cell cycle requires prompt restoration of epigenetic marks after the twofold dilution caused by DNA replication. Here we show that the transcriptional repressive mark H3K27me3 (histone H3 lysine 27 trimethylation) is restored in replicating plant cells through DNA replication-coupled modification of histone variant H3.1. Plants evolved a mechanism for efficient K27 trimethylation on H3.1, which is essential for inheritance of the silencing memory from mother to daughter cells. We illustrate how this mechanism establishes H3K27me3-mediated silencing during the developmental transition to flowering. Our study reveals a mechanism responsible for transmission of H3K27me3 in plant cells through cell divisions, enabling H3K27me3 to function as an epigenetic mark.
    Keywords: DNA Replication ; Gene Silencing ; Histones -- Metabolism ; Plants -- Genetics
    ISSN: 00368075
    E-ISSN: 1095-9203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Biochemical and Biophysical Research Communications, 17 June 2011, Vol.409(4), pp.610-615
    Description: ► TUDCA inhibits the expression of ER stress markers in intestinal epithelial cells. ► TUDCA prohibits the activation of the unfolded protein response in these cells. ► UDCA but not taurine mediates the inhibitory effects of TUDCA. ► The hydrophobic parts of TUDCA prohibit the aggregation of denatured proteins. Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to exhibit beneficial effects in various diseases associated with ER stress mechanisms by prohibiting the unfolded protein response (UPR). In a structure–function analysis, we tested the potential of the conjugated bile salt sodium tauroursodeoxycholate (TUDCA), naturally present in the small bowel, to resolve ER stress in intestinal epithelial cells. TUDCA efficiently inhibited the expression of UPR dependent genes like GRP78 triggered by the ER stressor tunicamycin in the small intestinal epithelial cell line Mode-K. TUDCA inhibited upstream signaling events in all three branches of the UPR cascade and diminished binding of UPR activated transcription factors to the promoter. A structure–function analysis revealed that UDCA but not its conjugation partner taurine, known as a chemical chaperone, is responsible for the inhibition of GRP78 induction and that UDCA is 10 times more effective than its taurine conjugate. This inhibitory effect was confirmed in a cell free assay, where TUDCA and UDCA but not taurine effectively inhibited the aggregation of thermally denatured BSA. We conclude that TUDCA and UDCA are potent anti-aggregants for the resolution of ER stress in intestinal epithelial cells and should be considered as a potential drug target to resolve ER stress mechanisms underlying the pathology of IBD.
    Keywords: Inflammatory Bowel Disease ; Endoplasmic Reticulum Stress ; Unfolded Protein Response ; Chemical Chaperone ; Tauroursodeoxycholic Acid ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Biophysical Journal, 27 January 2015, Vol.108(2), pp.3a-4a
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bpj.2014.11.034 Byline: James Berger Author Affiliation: Department of Biophysics and Biochemistry, Johns Hopkins University, Baltimore, MD, USA Article Note: (miscellaneous) 16-Subg
    Keywords: Biology
    ISSN: 0006-3495
    E-ISSN: 1542-0086
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: Spanish
    In: Conservation Biology, October 2012, Vol.26(5), pp.769-777
    Description: Alces alcesp p p Ovibos moschatus
    Keywords: Conservation Policy ; Moose ; Muskoxen ; Orphans ; Overwinter Survival ; Photogrammetry ; Alce ; Buey Almizclero ; Fotogrametría ; Huérfanos ; Políticas De Conservación ; Supervivencia A La Hibernación
    ISSN: 0888-8892
    E-ISSN: 1523-1739
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Science (New York, N.Y.), 06 April 2007, Vol.316(5821), pp.49
    Keywords: Access to Information ; Disease Outbreaks ; Health Planning ; Periodicals As Topic ; Influenza, Human -- Epidemiology
    ISSN: 00368075
    E-ISSN: 1095-9203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Science (New York, N.Y.), 09 September 2011, Vol.333(6048), pp.1411-7
    Description: Hand bones from a single individual with a clear taxonomic affiliation are scarce in the hominin fossil record, which has hampered understanding the evolution of manipulative abilities in hominins. Here we describe and analyze a nearly complete wrist and hand of an adult female [Malapa Hominin 2 (MH2)] Australopithecus sediba from Malapa, South Africa (1.977 million years ago). The hand presents a suite of Australopithecus-like features, such as a strong flexor apparatus associated with arboreal locomotion, and Homo-like features, such as a long thumb and short fingers associated with precision gripping and possibly stone tool production. Comparisons to other fossil hominins suggest that there were at least two distinct hand morphotypes around the Plio-Pleistocene transition. The MH2 fossils suggest that Au. sediba may represent a basal condition associated with early stone tool use and production.
    Keywords: Biological Evolution ; Fossils ; Hand -- Anatomy & Histology ; Hand Bones -- Anatomy & Histology ; Hominidae -- Anatomy & Histology
    ISSN: 00368075
    E-ISSN: 1095-9203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Biochemical and Biophysical Research Communications, 13 July 2012, Vol.423(4), pp.785-788
    Description: ► Report of an unbiased quantification of the birefringence of muscle of fish larvae. ► Quantification method readily identifies level of overall muscle damage. ► Compare zebrafish muscle mutants for level of phenotype severity. ► Proposed tool to survey treatments that aim to ameliorate muscular dystrophy. Muscular dystrophies are a group of genetic disorders that progressively weaken and degenerate muscle. Many zebrafish models for human muscular dystrophies have been generated and analysed, including dystrophin-deficient zebrafish mutants that model Duchenne Muscular Dystrophy. Under polarised light the zebrafish muscle can be detected as a bright area in an otherwise dark background. This light effect, called birefringence, results from the diffraction of polarised light through the pseudo-crystalline array of the muscle sarcomeres. Muscle damage, as seen in zebrafish models for muscular dystrophies, can readily be detected by a reduction in the birefringence. Therefore, birefringence is a very sensitive indicator of overall muscle integrity within larval zebrafish. Unbiased documentation of the birefringence followed by densitometric measurement enables the quantification of the birefringence of zebrafish larvae. Thereby, the overall level of muscle integrity can be detected, allowing the identification and categorisation of zebrafish muscle mutants. In addition, we propose that the establish protocol can be used to analyse treatments aimed at ameliorating dystrophic zebrafish models.
    Keywords: Muscle ; Zebrafish ; Muscular Dystrophy ; Birefringence ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Article
    Article
    Language: English
    In: Current Biology, 21 November 2016, Vol.26(22), pp.R1170-R1171
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cub.2016.09.022 Byline: Frederic Berger Abstract: Interview with Frederic Berger, who studies chromatin and evolution at GMI Vienna. Author Affiliation: Gregor Mendel Institute for Molecular Plant Biology, Vienna, Austria
    Keywords: Biology
    ISSN: 0960-9822
    E-ISSN: 1879-0445
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Current Biology, 22 July 2013, Vol.23(14), pp.1367-1372
    Description: Multisensory interactions are the norm in perception, and an abundance of research on the interaction and integration of the senses has demonstrated the importance of combining sensory information from different modalities on our perception of the external world [ ]. However, although research on mental imagery has revealed a great deal of functional and neuroanatomical overlap between imagery and perception, this line of research has primarily focused on similarities within a particular modality [ ] and has yet to address whether imagery is capable of leading to multisensory integration. Here, we devised novel versions of classic multisensory paradigms to systematically examine whether imagery is capable of integrating with perceptual stimuli to induce multisensory illusions. We found that imagining an auditory stimulus at the moment two moving objects met promoted an illusory bounce percept, as in the classic cross-bounce illusion; an imagined visual stimulus led to the translocation of sound toward the imagined stimulus, as in the classic ventriloquist illusion; and auditory imagery of speech stimuli led to a promotion of an illusory speech percept in a modified version of the McGurk illusion. Our findings provide support for perceptually based theories of imagery and suggest that neuronal signals produced by imagined stimuli can integrate with signals generated by real stimuli of a different sensory modality to create robust multisensory percepts. These findings advance our understanding of the relationship between imagery and perception and provide new opportunities for investigating how the brain distinguishes between endogenous and exogenous sensory events.
    Keywords: Biology
    ISSN: 0960-9822
    E-ISSN: 1879-0445
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages