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  • 1
    In: Pigment Cell & Melanoma Research, September 2015, Vol.28(5), pp.488-489
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12389/abstract Byline: Peter Dietrich, Anja Katrin Bosserhoff ***** No abstract is available for this article. ***** Article Note: Coverage on: Shoshan E, Mobley AK, Braeuer RR, Kamiya T, Huang L, Vasquez ME, Salameh A, Lee HJ, Kim SJ, Ivan C, Velazquez-Torres G, Nip KM, Zhu K, Brooks D, Jones SJ, Birol I, Mosqueda M, Wen YY, Eterovic AK, Sood AK, Hwu P, Gershenwald JE, Robertson AG, Calin GA, Markel G, Fidler IJ, Bar-Eli M. (2015) Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nat. Cell Biol. 17(3), 311-321. doi: 10.1038/ncb3110.
    Keywords: Melanoma ; Microrna;
    ISSN: 1755-1471
    E-ISSN: 1755-148X
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  • 2
    Language: English
    In: Journal of Epidemiology and Community Health, 27 February 2013, Vol.67(2), p.194
    Description: To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment.
    Keywords: Activity ; Elderly ; Walking ; Cardiovascular ; Biomarker ; Epidemiology ; Methodology ; Physical Activity ; Ageing ; Cancer: Breast ; Coronary Heart Disease ; Diabetes ; Epidemiology ; Renal ; Press Releases
    ISSN: 0143-005X
    ISSN: 0143005X
    E-ISSN: 1470-2738
    E-ISSN: 14702738
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  • 3
    Language: English
    In: PLoS ONE, 2012, Vol.7(6), p.e39909
    Description: The current vaccine against tuberculosis (TB), BCG, has failed to control TB worldwide and the protective efficacy is moreover limited to 10–15 years. A vaccine that could efficiently boost a BCG-induced immune response and thus prolong protective immunity would therefore have a significant impact on the global TB-burden. ; In the present study we show that the fusion protein HyVac4 (H4), consisting of the mycobacterial antigens Ag85B and TB10.4, given in the adjuvant IC31® or DDA/MPL effectively boosted and prolonged immunity induced by BCG, leading to improved protection against infection with virulent (M.tb). Increased protection correlated with an increased percentage of TB10.4 specific IFNγ/TNFα/IL-2 or TNFα/IL-2 producing CD4 T cells at the site of infection. Moreover, this vaccine strategy did not compromise the use of ESAT-6 as an accurate correlate of disease development/vaccine efficacy. Indeed both CD4 and CD8 ESAT-6 specific T cells showed significant correlation with bacterial levels. ; H4-IC31® can efficiently boost BCG-primed immunity leading to an increased protective anti-M.tb immune response dominated by IFNγ/TNFα/IL-2 or TNFα/IL2 producing CD4 T cells. H4 in the CD4 T cell inducing adjuvant IC31® is presently in clinical trials.
    Keywords: Research Article ; Biology ; Medicine ; Immunology ; Microbiology
    E-ISSN: 1932-6203
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  • 4
    In: Genes, Chromosomes and Cancer, July 2015, Vol.54(7), pp.433-443
    Description: The novel CKLF‐like Marvel Transmembrane Domain‐containing gene family (CMTM) consists of 8 members (). As little is known about the oncogenic impact of these genes, we aimed to systematically investigate the relevance of CMTMs to glioblastoma pathogenesis. We performed mRNA expression analyses and survival correlations in glioblastoma patients. Moreover, we analyzed the impact of RNAi‐based silencing and overexpression of CMTM family genes on tumor cell proliferation and invasion in vitro. CMTMs appeared to be widely regulated in the group of glioblastomas relative to non‐neoplastic brain (NB) tissue (significant upregulation for , , and and significant downregulation for and ). For , and , we found aberrant expression levels in individual tumors. Functionally, , , and promoted tumor cell invasion, while additionally enhanced cell proliferation. In a large clinically annotated dataset, higher and expression was significantly correlated with shorter overall survival. Our data thus suggest and as priority targets in glioblastomas. Using a human phosphokinase protein expression profiling assay, we can provide first insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation. © 2015 Wiley Periodicals, Inc.
    Keywords: Genetic Research – Investigations ; Stem Cells – Investigations ; Genes – Investigations ; RNA – Investigations ; Glioblastomas – Investigations;
    ISSN: 1045-2257
    E-ISSN: 1098-2264
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  • 5
    Language: English
    In: Social Psychiatry and Psychiatric Epidemiology, 2005, Vol.40(11), pp.855-864
    Description: Byline: Matthias C. Angermeyer (1), Peter Breier (2), Sandra Dietrich (1), Denis Kenzine (1), Herbert Matschinger (1) Keywords: public attitudes; treatment; help seeking; transcultural psychiatry; schizophrenia; major depression Abstract: Aim In order to examine whether there is a relationship between the state of mental health care and the acceptance of psychiatry, public attitudes toward psychiatric treatment in three countries where the reform of mental health care has progressed to a different degree will be compared. Methods Population surveys on public beliefs about mental illness and attitudes toward psychiatric treatment were conducted in Bratislava, Slovak Republic, and Novosibirsk, Russia. The data were compared with those from a population survey that had recently been carried out in Germany. In all three surveys, the same sampling procedure and fully structured interview were applied. Results Although respondents from all three countries were equally inclined to seek help from mental health professionals, those from Bratislava and Novosibirsk tended to recommend more frequently to address other medical or nonmedical professionals or members of the lay support system. In all three countries, psychotherapy was the most favored treatment modality, followed by psychotropic medication. Although natural remedies were more frequently recommended in Bratislava and Novosibirsk, meditation/yoga was more popular among the German public. Across all three countries, the endorsement of a brain disease as cause was associated with a greater willingness to seek help from medical professionals (psychiatrist, GP). Respondents who adopted biological causes tended to recommend psychotropic medication more frequently. Conclusion In countries with less developed mental health care systems, there appears to be a tendency of the public toward more frequently relying on helping sources outside the mental health sector and on traditional "alternative" treatment methods. However, it is our prognosis that with the progress of reforms observed, differences may further decrease. Author Affiliation: (1) Dept. of Psychiatry, University of Leipzig, Johannisallee 20, 04317, Leipzig, Germany (2) Dept. of Psychiatry, University Hospital, Ruzinov, Slovak Republic Article History: Registration Date: 06/06/2005 Accepted Date: 25/05/2005 Online Date: 12/10/2005
    Keywords: public attitudes ; treatment ; help seeking ; transcultural psychiatry ; schizophrenia ; major depression
    ISSN: 0933-7954
    E-ISSN: 1433-9285
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  • 6
    Language: English
    In: PLoS ONE, 2009, Vol.4(4), p.e5139
    Description: Although CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consisting of both CD4 and CD8 T cells. ; To compare CD4 and CD8 responses against Ag85B-TB10.4 (H4), H4 was delivered as a subunit vaccine in cationic liposomes (CAF01), expressed in Ad5 (Ad-H4) or as a heterologous prime boost vaccination. H4/CAF01 induced primarily CD4 T cells and Ad-H4 gave predominantly a CD8 T cell response. In contrast, the heterologous prime boost combination resulted in augmentation of both the CD4 and CD8 response. The majority (〉40%) of the CD4 T cells induced by the heterologous prime boost protocol were polyfunctional, and expressed IFN-γ, IL-2, and TNF-α, whereas most of the CD8 T cells expressed IFN-γ and TNF-α and possessed strong cytotoxic potential. The heterologous prime boost protocol also gave an increase in protective efficacy against challenge compared to H4/CAF01 and Ad-H4. Both the H4 specific CD4 and CD8 T cells were recruited to the site of infection, at the onset of infection. However, compared to CD8 T cells, CD4 T cells showed more extensive recruitment and were the main T cell subset proliferating at the site of infection. ; Heterologous prime boost based on H4, produced an additive effect on the priming of CD4 and CD8 cells and in terms of the protective capacity of the vaccine, and therefore represent an interesting new vaccine strategy against . However, CD4 and CD8 T cells respond very differently to live challenge, in a manner which supports the consensus that CD4 T cells do play the major role during the early stages of an infection.
    Keywords: Research Article ; Immunology ; Infectious Diseases ; Immunology -- Immune Response ; Immunology -- Immunity To Infections ; Infectious Diseases -- Bacterial Infections
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: PLoS ONE, 2009, Vol.4(6), p.e5930
    Description: Previously we have shown that Ag85B-TB10.4 is a highly efficient vaccine against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic liposomes. Another Th1 inducing adjuvant, which has shown a very promising profile in both preclinical and clinical trials, is IC31®. In this study, we examined the potential of Ag85B-TB10.4 delivered in the adjuvant IC31® for the ability to induce protection against infection with Mycobacterium tuberculosis . In addition, we examined if the antigen dose could influence the phenotype of the induced T cells. ; We found that vaccination with the combination of Ag85B-TB10.4 and IC31® resulted in high numbers of polyfunctional CD4 T cells co-expressing IL-2, IFN-γ and TNF-α. This correlated with protection against subsequent challenge with in the mouse TB model. Importantly, our results also showed that both the vaccine induced T cell response, and the protective efficacy, was highly dependent on the antigen dose. Thus, whereas antigen doses of 5 and 15 µg did not induce significant protection against , reducing the dose to 0.5 µg selectively increased the number of polyfunctional T cells and induced a strong protection against infection with . The influence of antigen dose was also observed in the guinea pig model of aerosol infection with In this model a 2.5 fold increase in the antigen dose reduced the protection against infection with to the level observed in non-vaccinated animals. ; Small changes in the antigen dose can greatly influence the induction of specific T cell subpopulations and the dose is therefore a crucial factor when testing new vaccines. However, the adjuvant IC31® can, with the optimal dose of Ag85B-TB10.4, induce strong protection against . This vaccine has now entered clinical trials.
    Keywords: Research Article ; Immunology ; Infectious Diseases ; Immunology -- Immune Response ; Infectious Diseases -- Bacterial Infections
    E-ISSN: 1932-6203
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  • 8
    Language: English
    In: The Canadian journal of urology, June 2018, Vol.25(3), pp.9334-9339
    Description: Classic surgical teaching advocates for closure of the mesenteric defect (MD) after bowel anastomosis but the necessity is controversial. We sought to evaluate the necessity of MD closure at the time of harvest of ileum for genitourinary reconstructive surgery (GURS) by analyzing the incidence of early and late gastrointestinal adverse events (GIAE) in patients with and without MD closure. A retrospective review was conducted on patients undergoing urologic reconstruction with ileum to identify incidence of ileus, small bowel obstruction (SBO), gastrointestinal (GI) fistula and stoma complications. Patient and procedure variables were analyzed to identify risk factors for GIAE. A total of 288 patients met inclusion criteria and 93% of GURS was for urinary diversion following cystectomy. MD was closed in 194 cases (67%). Median follow up was 19 months. Early (〈 30 day) GIAE rates were 16.5% (n = 32) and 21.3% (n = 20) in the closure and non-closure groups, respectively (p = 0.22). The rate of early ileus/SBO requiring nasogastric tube decompression or laparotomy were similar after closure (15.0%) and non-closure (21.3%) (p = .18). The late GIAE rates were 5.7% (n = 11) and 6.4% (n = 6) in the closure and non-closure cohorts, respectively (p = 0.56). The rate of late SBO were similar and no cases of early or late SBO in either cohort were due to internal herniation. On multivariate analysis, increasing BMI was associated with both early and late GIAE. After harvesting ileum for urologic reconstruction, the MD can safely be left open as we found no association between non-closure and early or late GIAE..
    Keywords: Cystectomy -- Methods ; Ileum -- Transplantation ; Mesentery -- Surgery ; Reconstructive Surgical Procedures -- Methods ; Urinary Diversion -- Methods
    ISSN: 1195-9479
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 9
    In: Anesthesia & Analgesia, 2004, Vol.99(5), pp.1521-1527
    Description: Surgical procedures on the vertebral column may result in spinal cord damage, leading to neurological deficits that demand immediate therapeutical intervention. We designed this study to determine which anesthetic regimen allows a rapid wake-up test during and after surgery to detect neurological deficits. Fifty-four patients were randomly allocated to the following groups: group PR (propofol/remifentanil): target-controlled infusion with propofol (plasma concentration, 2–4 μg/mL) and remifentanil 0.2–0.5 μg · kg · min; group PS (propofol/sufentanil): propofol (2–4 μg/mL) and repetitive boluses of 0.1–0.2 μg/kg of sufentanil adjusted to patients requirements; and group DR (desflurane/remifentanil): desflurane/air 3.0–4.0 vol% combined with remifentanil 0.2–0.5 μg · kg · min. Group PS required significantly longer times for the onset of breathing (8.9 ± 1.6 min), elevation of the head (17.0 ± 3.8 min), and motion of the feet (17.0 ± 7.4 min) than group PR (6.9 ± 2.6 min, 9.3 ± 2.2 min, and 9.4 ± 2.4 min, respectively) or group DR (5.4 ± 0.8 min, 6.1 ± 1.0 min, and 6.2 ± 1.0 min, respectively). The anesthetic regimen with desflurane and remifentanil allowed faster awakening during and after surgery that permitted immediate neurological examination after spinal surgery compared with propofol/remifentanil.
    Keywords: Anesthesia Recovery Period ; Anesthesia, General ; Anesthesia, Inhalation ; Anesthesia, Intravenous ; Arousal -- Physiology ; Isoflurane -- Analogs & Derivatives ; Monitoring, Intraoperative -- Methods ; Spine -- Surgery;
    ISSN: 0003-2999
    E-ISSN: 15267598
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  • 10
    Language: English
    In: Oncogene, January 2019, Vol.38(5), pp.609-621
    Description: Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.
    Keywords: Tumor Microenvironment ; Bone Morphogenetic Protein 6 -- Metabolism ; Melanoma -- Metabolism ; Neoplasm Proteins -- Metabolism ; Neoplasms, Experimental -- Metabolism ; Skin Neoplasms -- Metabolism
    ISSN: 09509232
    E-ISSN: 1476-5594
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