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  • Genetics
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  • 1
    Language: English
    In: Journal of bacteriology, February 2017, Vol.199(3), pp.e00691-16
    Description: The L-arabinose-inducible araBAD promoter (P) allows tightly controlled and tunable expression of genes of interest in a broad range of bacterial species. It has been successfully used to study bacterial sRNA regulation, where P drives expression of target mRNA translational fusions. Here we report that in Escherichia coli, Spot 42 sRNA can regulate P promoter activity by affecting arabinose uptake. We demonstrate that Spot 42 sRNA represses araF, a gene encoding the AraF subunit of the high-affinity low-capacity arabinose transporter AraFGH, through direct base pairing interactions. We further show that endogenous Spot 42 sRNA is sufficient to repress araF expression under various growth conditions. Finally, we demonstrate this posttranscriptional repression has a biological consequence, decreasing the induction of P at low levels of arabinose. This problem can be circumvented using strategies reported previously for avoiding all-or-none induction behavior, that is through constitutive expression of the low-affinity high-capacity arabinose transporter AraE or induction with higher concentration of inducers. This work adds araF to the set of Spot 42-regulated genes, in agreement with previous studies suggesting that Spot 42, itself negatively regulated by cAMP-CRP complex, reinforces the catabolite repression network. The bacterial arabinose inducible system is widely used for titratable control of gene expression. We demonstrate here that a post-transcriptional mechanism mediated by the Spot 42 sRNA contributes to the functionality of the P system at subsaturating inducer concentrations by affecting inducer uptake. Our finding extends the inputs into the known transcriptional control for the P system, and has implications for improving its usage for tunable gene expression.
    Keywords: Gene Expression ; Translation ; Promoters ; Growth Conditions ; Cyclic Amp ; Catabolite Repression ; Arabinose ; Transcription ; Post-Transcription ; Bacteriology ; Escherichia Coli ; Cell Biology ; RNA;
    ISSN: 00219193
    E-ISSN: 1098-5530
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  • 2
    Conference Proceeding
    Conference Proceeding
    Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory
    Language: English
    In: Meeting on Molecular Genetics of Bacteria & Phages (1995 : Cold Spring Harbor Laboratory), 1995
    Description: arranged by Susan Gottesman ... [et al.]. Includes bibliographical references and index. ; xlix, 307 p. : ill. ; 22 cm.
    Keywords: Bacterial Genetics ; Genetics ; Bacteriophages ; Congresses ; Molecular Genetics ; Prokaryotes ; Genetic Regulation
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 3
    In: Journal of Child Psychology and Psychiatry, October 1996, Vol.37(7), pp.785-801
    Description: The diagnostic boundaries of the behavioural phenotype for autism were examined in 28 MZ pairs and 20 DZ same‐sex twin pairs, where one or both twins had autism. In the non‐autistic cotwin (i.e. In twin pairs discordant for autism) it was common to find language impairments in childhood and social deficits persisting into adulthood. Concordance for this broader phenotype was much greater in MZ pairs than DZ pairs, indicating a strong genetic component. Behavioural and cognitive manifestations of autism were compared both within and between MZ twin pairs. The variation was as great within MZ twin pairs as between pairs, suggesting that it does not index genetic heterogeneity (although aetiological heterogeneity probably exists). Current diagnostic practices need re‐evaluation.
    Keywords: Autism ; Twins ; Broader Phenotype ; Genetics
    ISSN: 0021-9630
    E-ISSN: 1469-7610
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  • 4
    Language: English
    In: 1992, p.;
    Description: arranged by Susan Gottesman, Peter Model, Miriam Susskind. Spine title: Molecular genetics of bacteria and phages 1992. Includes bibliographical references and index. ; xxix, 169 p. ; 22 cm.
    Keywords: Bacterial Genetics ; Genetics ; Bacteriophages ; Congresses ; Molecular Genetics ; Prokaryotes ; Genetic Regulation
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 5
    Language: English
    In: 1993, p.;
    Description: arranged by Susan Gottesman, Peter Model, Jeffrey Roberts. Spine title: Molecular genetics of bacteria & phages, 1993. Includes bibliographical references and index. ; xxix, 156 p. ; 22 cm.
    Keywords: Bacterial Genetics ; Genetics ; Bacteriophages ; Congresses ; Molecular Genetics ; Prokaryotes ; Genetic Regulation
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 6
    Language: English
    In: Personality and Individual Differences, 2010, Vol.49(4), pp.324-330
    Description: A subset of members of the Hathaway and Monachesi (1953, 1961, 1963) normative adolescent MMPI dataset was examined to find MMPI scales that predict the future onset of schizophrenia or adult psychopathy. The sample consisted of 23 individuals who later developed schizophrenia, 30 individuals who later developed psychopathy, and their matched controls. Results suggested that nine MMPI scales could reliably distinguish between schizophrenia and no schizophrenia; an additional nine scales could distinguish between adult psychopathy and no psychopathy. These 18 scales could also be used to discriminate those individuals who later developed schizophrenia from those individuals who later developed psychopathy. The results support the hypothesis that latent personality characteristics can function as endophenotypes for some adult psychopathologies.
    Keywords: Schizophrenia ; Psychopathy ; Mmpi ; Personality ; Genetics ; Endophenotype ; Psychology
    ISSN: 0191-8869
    E-ISSN: 1873-3549
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  • 7
    Language: English
    In: Behavior Genetics, 2016, Vol.46(2), pp.193-204
    Description: We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region.
    Keywords: Schizophrenia ; Genetics ; Twins ; Endophenotype ; Affective psychoses ; ICD-10 ; Denmark
    ISSN: 0001-8244
    E-ISSN: 1573-3297
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  • 8
    Language: English
    In: Behavior Genetics, 2007, Vol.37(2), pp.362-375
    Description: The prevalence of marriage varies across the lifespan, as does its importance to reproduction and the nurturance of children. We examined genetic and environmental influences on self-reported marriage at each decade from 20 through 70 years of age, using data collected for the Duke Dementia Study, a followed-up subset of the World War II Veteran Twin Registry. Genetic influences best fit a common factor model, supplemented by another, age-specific, genetic factor at age 30. Broad heritability increased from age 20 through 40, and then decreased to zero by ages 60 and 70. A longitudinal Cholesky model best described environmental influences on marriage across the lifespan. Shared environmental factors showed their greatest influence at age 20, no influence at 30 or 40 years, and then, reappeared with influence at 60 and 70. Variance due to error and unique environmental influences increased steadily to age 50 years and then declined slightly.
    Keywords: Marriage ; Divorce ; Individual differences ; Lifespan ; Genetics ; Heritability ; Twins ; Endophenotypes ; Natural selection ; World War II veteran ; Adult development ; Pair bonding
    ISSN: 0001-8244
    E-ISSN: 1573-3297
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  • 9
    Language: English
    In: Biological Psychiatry, 15 April 2015, Vol.77(8), pp.749-763
    Description: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged ≥45 years. Replication of suggestive associations ( 〈 5 × 10 ) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. rs4420638, near , was associated with poorer delayed recall performance in discovery ( = 5.57 × 10 ) and replication cohorts ( = 5.65 × 10 ). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [ ] = 3.11 × 10 , and rs6813517 [ ], = 2.58 × 10 ) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with and , both related to ubiquitin metabolism. This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.
    Keywords: Alzheimer Disease ; Dementia ; Epidemiology ; Genetics ; Population-Based ; Verbal Declarative Memory ; Medicine ; Biology ; Chemistry
    ISSN: 0006-3223
    E-ISSN: 1873-2402
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  • 10
    Language: English
    In: Monda, K. L., G. K. Chen, K. C. Taylor, C. Palmer, T. L. Edwards, L. A. Lange, M. C. Ng, et al. 2013. “A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry.” Nature genetics 45 (6): 690-696. doi:10.1038/ng.2608. http://dx.doi.org/10.1038/ng.2608.
    Description: Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of 〉3.2 million SNPs with BMI in 39,144 men and women of African ancestry, and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one novel locus at 5q33 (GALNT10, rs7708584, p=3.4×10−11) and another at 7p15 when combined with data from the Giant consortium (MIR148A/NFE2L3, rs10261878, p=1.2×10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African ancestry sample (KLHL32, rs974417, p=6.9×10−8). Thirty-two of the 36 previously established BMI variants displayed directionally consistent effect estimates in our GWAS (binomial p=9.7×10−7), of which five reached genome-wide significance. These findings provide strong support for shared BMI loci across populations as well as for the utility of studying ancestrally diverse populations.
    Keywords: African Americans–Genetics ; Body Mass Index–Ethnology ; Case-Control Studies–Genetics ; Gene Frequency–Genetics ; Genetic Loci–Genetics ; Genetic Predisposition to Disease–Genetics ; Genome-Wide Association Study–Genetics ; Humans–Genetics ; Linkage Disequilibrium–Genetics ; Obesity–Genetics ; Obesity–Genetics ; Polymorphism, Single Nucleotide–Genetics ; Genetics ; African Americans ; Statistical Methods ; Genealogy ; Body Mass Index ; Genomes ; Women ; Meta-Analysis;
    ISSN: 1061-4036
    E-ISSN: 15461718
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