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  • 1
    Language: English
    In: British Journal of Clinical Pharmacology, 03/1980, Vol.9(3), pp.300P-301P
    Keywords: Pharmacy, Therapeutics, & Pharmacology;
    ISSN: British Journal of Clinical Pharmacology
    E-ISSN: 03065251
    E-ISSN: 13652125
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  • 2
    Language: English
    In: International Journal of Cardiology, 1/1986, Vol.10(1), pp.65-69
    Description: We have studied the relationship between age, daily dose, plasma concentration and clinical efficacy of disopyramide in a group of paediatric patients. Twelve children with ventricular and 3 with supraventricular arrhythmias were treated with oral disopyramide. The initial dose was 3-6 mg/kg per day. This was adjusted until a pre-dose plasma concentration greater than 2 mg/I was achieved. Seven patients were judged to have responded to the treatment on clinical criteria. No symptoms or signs of toxicity were observed. In some of the children the dose of disopyramide required to achieve a plasma concentration greater than 2 mg/l was greatly in excess of the normal adult dose. Generally the youngest children required the highest dose, but the variation was wide. The dose could not be predicted from the age, the body weight or the surface area of the patient. In children high doses of disopyramide may be needed to achieve effective plasma concentrations of the drug; such doses are not associated with adverse effects. Measurement of the plasma concentration is necessary to guard against premature termination of therapy.
    Keywords: Arrhythmias, Cardiac -- Drug Therapy ; Disopyramide -- Blood;
    ISSN: 01675273
    E-ISSN: 18741754
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  • 3
    Language: English
    In: American Journal of Transplantation, 04/2007, Vol.7(4), pp.1003-1009
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1600-6143.2006.01702.x Byline: S.R. Johnson (a), S. Alexopoulos (a), M. Curry (a), D.W. Hanto (a) Keywords: Graft failure; liver transplant; outcome; primary nonfunction Abstract: PNF following liver transplantation (LT) is an infrequent but life-threatening complication. Liver allocation under MELD is based upon recipient severity of illness, a known risk factor for the occurrence of PNF. The incidence of PNF since the application of MELD has not previously been reported. The SRTR database was studied since inception of MELD until September 2004 for all adult recipients of deceased donor LT. PNF was defined as graft loss or death within 14 days of LT secondary to PNF or without defined cause. A total of 10545 transplants met inclusion criteria and PNF occurred in 613 (5.81%) of recipients. Univariate analysis demonstrated donor age, serum creatinine 〉1.5 mg/mL, hypertension and CVA as risk factors for PNF. Recipient factors included life support, mechanical ventilation, use of inotropes, hemodialysis, initial status 1 and use of a shared transplant. In the multivariate model only donor age and recipient serum creatinine, bilirubin, on life support and status 1 at transplant were significant risk factors for PNF. In this analysis of PNF in the MELD era the incidence of PNF does not appear to have increased from prior reports. Risk factors for PNF are related to donor age and severity of recipient illness. Author Affiliation: (a)The Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts Article History: Received 12 August 2006, revised 21 November 2006 and accepted for publication 6 December 2006 Article note: (*) Corresponding author: S. R. Johnson, srjohnso@bidmc.harvard.edu
    Keywords: Databases -- Analysis ; Organ Transplantation -- Analysis;
    ISSN: 1600-6135
    E-ISSN: 1600-6143
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  • 4
    Language: English
    In: European Heart Journal, 12/1988, 12/01/1988, Vol.9(12), pp.1284-1290
    Description: We treated 22 children, aged 3 days to 16 years 6 months (median 11 years 1 month), with flecainide for a variety of arrhythmias where a Class I agent was indicated. In 16, conventional antiarrhythmic treatment had failed. Structural heart disease was present in nine. The arrhythmia was paroxysmal re-entry atrioventricular tachycardia in nine; paroxysmal atrial tachycardia, flutter or fibrillation in five; paroxysmal ventricular tachycardia in five and frequent ventricular extrasystoles (with couplets) in three. Sinus rhythm was achieved in all four children who received flecainide during tachycardia (three received intravenous flecainide, one oral). During follow-up of 3-24 months (median 12 months), arrhythmia control was obtained in 13 children (59%). Combination therapy was used in seven of these; with digoxin in four and a beta blocker in three. Flecainide doses used in this study ranged from 1-11 mg kg-1 day-1 (median 4 mg kg-1 day-1), 25-297 mg m-2 day-1 (median 113 mg m-2 day-1). The median, pre-dose flecainide concentration in those responding to therapy was 225 micrograms l-1 and in those failing to respond was 417 micrograms l-1. An arrhythmogenic effect occurred in one child.
    Keywords: Medicine;
    ISSN: 0195-668X
    E-ISSN: 1522-9645
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