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  • 1
    In: International Journal of Urology, June 2013, Vol.20(6), pp.585-592
    Description: Byline: Sandra Steffens, Kristina I Ringe, Katharina Schroeer, Rieke Lehmann, Julia Rustemeier, Gerd Wegener, Mark Schrader, Rainer Hofmann, Markus A Kuczyk, Andres J Schrader, Keywords: body mass index; body surface area; obesity; prognosis; renal cell carcinoma; risk factors; visceral fat Objectives To assess the impact of overweight on prognosis of renal cell carcinoma patients. Patients And Methods A total of 2030 patients who underwent surgery for renal cell carcinoma from 1990 to 2011 in three University Medical Centers were included in this retrospective analysis. For all patients, height and weight measurements at the time of diagnosis were available for review. The median (mean) follow up was 56.6 months (66.0 months). Results A low body mass index was significantly associated with poor tumor differentiation, histology, microscopic vascular invasion and metastatic disease at the time of diagnosis. A lower-than-average body surface area - stratified according to the European average for men (1.98m.sub.2) and women (1.74m.sub.2) - was significantly related to older age, poor tumor differentiation, the histological subtype and microscopic vascular invasion. In addition, a low visceral fat area calculated in a subgroup of 133 evaluable patients was associated with a higher risk of advanced disease (pT3-4 and/or N/M+) at diagnosis. The tumor-specific 5-year survival rate was 71.3, 78.7 and 80.1%, for patients with a body mass index of, 〈25, 25-30 and a[yen]30. Multivariate analysis confirmed body mass index as an independent prognostic factor. Conclusion Our findings suggest that overweight represents an independent prognostic factor in renal cell carcinoma patients. Further research should address the question of why obese people have a higher incidence of renal cell carcinoma, but at the same time a significantly better prognosis than other patients, particularly in the case of localized disease. Author Affiliation:
    Keywords: Body Mass Index ; Body Surface Area ; Obesity ; Prognosis ; Renal Cell Carcinoma ; Risk Factors ; Visceral Fat
    ISSN: 0919-8172
    E-ISSN: 1442-2042
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  • 2
    Language: English
    In: BMC medical education, 17 April 2014, Vol.14, pp.82
    Description: Nursing staff are often involved in counseling patients with regard to health behavior. Although care promoting healthy lifestyle choices is included in the curriculum of nursing students in Germany, several studies of nursing students have reported a high prevalence of unhealthy behavior. This paper focuses on the behavior of female nursing students with regard to body mass index (BMI), physical activity, and cigarette and alcohol consumption. It describes trends through the comparison of results from 2008 and 2013. Data was collected in two waves at a regional medical training college. First, 301 nursing students were asked to fill out a 12 page questionnaire on health behavior in 2008. The questioning was repeated in 2013 with 316 participating nursing students using the previous questionnaire. 259 female nursing students completed the questionnaire in 2013. 31.6% of them were either overweight or obese, 28.5% exercised less than once a week, 42.9% smoked between 10 and 20 cigarettes a day and 72.6% drank alcohol, wherefrom 19.7% consumed alcohol in risky quantities. In comparison to the data of 266 female nursing students from 2008, there were significant differences in the BMI and alcohol consumption: The percentage of overweight and obese students and the percentage of alcohol consumers at risk increased significantly. Health behavior of female nursing students is often inadequate especially in regard to weight and cigarette and alcohol consumption. Strategies are required to promote healthy lifestyle choices.
    Keywords: Body Mass Index ; Sedentary Behavior ; Alcohol Drinking -- Epidemiology ; Smoking -- Epidemiology ; Students, Nursing -- Statistics & Numerical Data
    E-ISSN: 1472-6920
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  • 3
    In: International Wound Journal, December 2011, Vol.8(6), pp.578-584
    Description: We analysed the effect of different body features on contact area, interface pressure and pressure distribution of three different mattresses. Thirty‐eight volunteers (age ranged from 17 to 73 years, 23 females) were asked to lie on three different mattresses in a random order: I, standard hospital foam mattresses; II, higher specification foam mattresses (Viscorelax Sure); III, constant low pressure devices (CareMedx, AirSystems). Measurements were performed in supine position and in a 90° left‐ and right‐sided position, respectively, using a full‐body mat (pressure mapping device Xsensor X2‐Modell). Outcome variables were contact area (CA) in cm, mean interface pressure (IP) in mmHg and pressure distribution (PD) estimated as rate of low pressures between 5 and 33 mmHg on each mattress in percent. Mean CA was lowest in the standard hospital foam mattresses and increased in the higher specification foam mattresses and was highest in the constant low pressure device (supine position: 491 ± 86 cm, 615 ± 95 cm, 685 ± 116 cm). Mean IP was highest in the standard hospital foam mattresses and lower but similar in the higher specification foam mattresses and the constant low pressure devices (supine position: 22·3 ± 1·5 mmHg, 17·6 ± 1·7 mmHg, 17·6 ± 2·2 mmHg). Models were estimated for CA, IP and PD including the independent variables height, weight and waist‐to‐hip‐ratio (WHR). They show that body morphology seems to play a minor role for CA, IP and PD, but very thin and tall patients and very small and obese people might benefit from different mattresses. Our data show that CA increases with increasing specification of mattresses. Higher specification foam mattresses and constant low pressure devices show similar IP, but constant low pressure devices show a wider pressure distribution. Body morphology should be considered to optimise prevention for single patients.
    Keywords: Interface Pressure ; Mattresses ; Pressure Ulcer ; Waist‐To‐Hip‐Ratio
    ISSN: 1742-4801
    E-ISSN: 1742-481X
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  • 4
    Language: English
    In: Clinical Research in Cardiology, 2013, Vol.102(8), pp.607-614
    Description: Byline: Undine Pittl (1), Alexandra Schratter (2), Steffen Desch (1), Raluca Diosteanu (1), Denise Lehmann (1), Katharina Demmin (1), Jacqueline Horig (3), Gerhard Schuler (1), Thorsten Klemm (4), Meinhard Mende (5), Holger Thiele (1) Keywords: Resuscitation; Cardiac arrest; Hypothermia; Neuron-specific enolase; Outcome; Cooling-associated complications Abstract: Introduction Mild induced hypothermia (MIH) is indicated for comatose survivors of sudden cardiac arrest (SCA) to improve clinical outcome. In this study, we compared the efficacy of two different cooling devices for temperature management in SCA survivors. Methods Between April 2008 and August 2009, 80 patients after survived in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA) were included in this prospective, randomized, single center study. Hypothermia was induced after randomization by either invasive Coolgard.sup.(r) cooling or non-invasive ArcticSun.sup.(r) surface cooling at 33.0 degC core body temperature for 24 h followed by active rewarming. The primary endpoint was defined as the efficacy of both cooling systems, measured by neuron-specific enolase (NSE) levels as a surrogate parameter for brain damage. Secondary efficacy endpoints were the clinical and neurological outcome, time to start of cooling and reaching the target temperature, target temperature-maintenance and hypothermia-associated complications. Results NSE at 72 h did not differ significantly between the 2 groups with 16.5 ng/ml, interquartile range 11.8--46.5 in surface-cooled patients versus 19.0 ng/ml, interquartile range 11.0--42.0 in invasive-cooled patients, p = 0.99. Neurological and clinical outcome was similar in both groups. Target temperature of 33.0 degC was maintained more stable in the invasive group (33.0 versus 32.7 degC, p 〈 0.001). Bleeding complications were more frequent with invasive cooling (n = 17 [43.6 %] versus n = 7 [17.9 %] p = 0.03). Conclusion Invasive cooling has advantages with respect to temperature management over surface cooling however, did not result in different outcome as measured by NSE release in SCA survivors. Bleeding complications were more frequently encountered by invasive cooling. Author Affiliation: (1) Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, Strumpellstr. 39, 04289, Leipzig, Germany (2) Hospital Hietzing, Vienna, Austria (3) Hospital Freudenstadt, Freudenstadt, Germany (4) MVZ Laboratory Dr. Reising-Ackermann and Colleagues, Leipzig, Germany (5) University of Leipzig, Coordination Centre for Clinical Trials, Leipzig, Germany Article History: Registration Date: 17/04/2013 Received Date: 09/03/2013 Accepted Date: 17/04/2013 Online Date: 05/05/2013 Article note: Trial registration: ClinicalTrials.gov NCT: 00843297.
    Keywords: Resuscitation ; Cardiac arrest ; Hypothermia ; Neuron-specific enolase ; Outcome ; Cooling-associated complications
    ISSN: 1861-0684
    E-ISSN: 1861-0692
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  • 5
    Language: English
    In: Cell and Tissue Research, 2018, Vol.374(1), pp.121-136
    Description: Diseases associated with the accumulation of lipid droplets are increasing in western countries. Lipid droplet biogenesis, structure and degradation are regulated by proteins of the perilipin family. Perilipin 5 has been shown to regulate basal lipolysis in oxidative tissues. We examine perilipin 5 in normal human tissues and in diseases using protein biochemical and microscopic techniques. Perilipin 5 was constitutively located at small lipid droplets in skeletal myocytes, cardiomyocytes and brown adipocytes. In addition, perilipin 5 was detected in the epithelia of the gastrointestinal and urogenital tract, especially in hepatocytes, the mitochondria-rich parietal cells of the stomach, tubular kidney cells and ductal cells of the salivary gland and pancreas. Granular cytoplasmic expression, without a lipid droplet-bound localization was detected elsewhere. In cardiomyopathies, in skeletal muscle diseases and during hepatocyte steatogenesis, perilipin 5 was upregulated and localized to larger and more numerous lipid droplets. In steatotic human hepatocytes, perilipin 5 was moderately increased and colocalized with perilipins 1 and 2 but not with perilipin 3 at lipid droplets. In liver diseases implicated in alterations of mitochondria, such as mitochondriopathies, alcoholic liver disease, Wilson’s disease and acute liver injury, perilipin 5 was frequently localized to small lipid droplets and less in the cytoplasm. In tumorigenesis, perilipin 5 was especially upregulated in lipo-, leio- and rhabdomyosarcoma and hepatocellular and renal cell carcinoma. In summary, our study provides evidence that perilipin 5 is not restricted to certain cell types but localizes to distinct lipid droplet subpopulations reflecting a possible function in oxidative energy supply in normal tissues and in diseases.
    Keywords: Cardiomyopathy ; Hepatic steatogenesis ; Lipid droplets ; Perilipin 5 ; Tumorigenesis
    ISSN: 0302-766X
    E-ISSN: 1432-0878
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  • 6
    Language: English
    In: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, August 2013, Vol.11(8), pp.768-80; 768-79
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/ddg.12101/abstract Byline: Markus Reinholz, Julia K. Tietze, Katharina Kilian, Martin Schaller, Helmut Schofer, Percy Lehmann, Manfred Zierhut, Winfried Klovekorn, Thomas Ruzicka, Jurgen Schauber ***** No abstract is available for this article. ***** Author Affiliation: Article Note: Last update: 01.02.2013; Valid until: 01.02.2017; the guidelines were updated by an "informal expert panel for consensus-finding." A[c] German Society of Dermatology; authorized for electronic publication: AWMF online Supporting information: Additional Supporting Information may be found in the online version of this article Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
    Keywords: Practice Guidelines As Topic ; Dermatologic Agents -- Therapeutic Use ; Dermatology -- Standards ; Rosacea -- Diagnosis ; Ultraviolet Therapy -- Methods
    ISSN: 16100379
    E-ISSN: 1610-0387
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  • 7
    Language: English
    In: Virchows Archiv, 2010, Vol.457(3), pp.369-380
    Description: Obliterative airway remodelling is a morphological sequence in a variety of pulmonary diseases. Notably, bronchiolitis obliterans represents one of the key complications of lung transplantation, induced by (immigrating) myofibroblasts. A comparative expression analysis of obliterative airway remodelling in transplanted and non-transplanted patients has not been reported so far. Obliterated and unremodelled airways from explanted lungs ( n  = 19) from patients suffering from chronic allograft dysfunction, infection, graft-versus-host disease and toxic exposure were isolated by laser-assisted microdissection. Airways from lung allografts harvested shortly before and after transplantation ( n  = 4) as well as fibroblastic foci from lungs with interstitial pulmonary fibrosis ( n  = 4) served as references. Pre-amplified cDNA was analysed by quantitative real-time RT-PCR for expression of fibrosis, inflammation and apoptosis-associated genes. Composition of infiltrating cells and protein expression were assessed by conventional histology and immunohistochemistry. Bronchiolitis obliterans in transplanted patients showed a significant increase of BMP-7 expression ( p  = 0.0141 compared with controls), while TGF-β1 and FGF-2 as well as BMP-4 and BMP-7 were up-regulated in fibroblastic foci in interstitial pulmonary fibrosis ( p  〈 0.0424 compared with controls). Regarding other fibrosis-associated genes (BMP-6, SMAD-3, CASP-3 and CASP-9, FASLG, NF-KB1, IL-1 and IL-2) as well as cellularity and cellular composition, no significant differences between obliterative airway remodelling in transplanted and non-transplanted patients could be shown. Obliterative airway remodelling in lung allografts and in non-transplanted patients share many morphological and genetic traits. BMPs, especially BMP-7, warrant further investigation as possible markers for the aggravation of airway remodelling.
    Keywords: Bronchiolitis obliterans ; Lung transplantation ; Fibrosis ; Airway remodelling
    ISSN: 0945-6317
    E-ISSN: 1432-2307
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  • 8
    Language: English
    In: PLoS ONE, April 12, 2017, Vol.12(4), p.e0175563
    Description: VEGFA is an angiogenic factor secreted by tumors, in particular those with VEGFA amplification, as well as by macrophages and lymphocytes in the tumor microenvironment. Here we sought to define the presence of M1/M2 macrophages, PD-1-positive lymphocytes and PD-L1 tumoral and stromal expression in colorectal cancers harboring VEGFA amplification or chromosome 6 polysomy. 38 CRCs of which 13 harbored VEGFA amplification, 6 with Chr6 polysomy and 19 with neutral VEGFA copy number were assessed by immunohistochemistry for CD68 (marker for M1/M2 macrophages), CD163 (M2 macrophages), programmed death 1(PD-1)- tumor infiltrating and stromal lymphocytes as well as tumoral and stromal PD-1 ligand (PD-L1) expression. CRCs with VEGFA amplification or Chr6 polysomy were associated with decreased M1/M2 macrophages, reduced PD-1-expressing lymphocyte infiltration, as well as reduced stromal expression of PD-L1 at the tumor front. Compared to intermediate-grade CRCs, high-grade CRCs were associated with increased M1/M2 macrophages and increased tumoral expression of PD-L1. Our results suggest that VEGFA amplification or Chr6 polysomy is associated with an altered tumor immune microenvironment.
    Keywords: Tumors -- Genetic Aspects ; Colorectal Cancer -- Genetic Aspects ; Vascular Endothelial Growth Factor ; B Cells ; Immunohistochemistry ; Macrophages
    ISSN: 1932-6203
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  • 9
    In: Circulation, 2017, Vol.135(9), pp.881-897
    Description: BACKGROUND:: Chronic heart failure (HF) is associated with altered signal transduction via β-adrenoceptors and G proteins and with reduced cAMP formation. Nucleoside diphosphate kinases (NDPKs) are enriched at the plasma membrane of patients with end-stage HF, but the functional consequences of this are largely unknown, particularly for NDPK-C. Here, we investigated the potential role of NDPK-C in cardiac cAMP formation and contractility. METHODS:: Real-time polymerase chain reaction, (far) Western blot, immunoprecipitation, and immunocytochemistry were used to study the expression, interaction with G proteins, and localization of NDPKs. cAMP levels were determined with immunoassays or fluorescent resonance energy transfer, and contractility was determined in cardiomyocytes (cell shortening) and in vivo (fractional shortening). RESULTS:: NDPK-C was essential for the formation of an NDPK-B/G protein complex. Protein and mRNA levels of NDPK-C were upregulated in end-stage human HF, in rats after long-term isoprenaline stimulation through osmotic minipumps, and after incubation of rat neonatal cardiomyocytes with isoprenaline. Isoprenaline also promoted translocation of NDPK-C to the plasma membrane. Overexpression of NDPK-C in cardiomyocytes increased cAMP levels and sensitized cardiomyocytes to isoprenaline-induced augmentation of contractility, whereas NDPK-C knockdown decreased cAMP levels. In vivo, depletion of NDPK-C in zebrafish embryos caused cardiac edema and ventricular dysfunction. NDPK-B knockout mice had unaltered NDPK-C expression but showed contractile dysfunction and exacerbated cardiac remodeling during long-term isoprenaline stimulation. In human end-stage HF, the complex formation between NDPK-C and Gαi2 was increased whereas the NDPK-C/Gαs interaction was decreased, producing a switch that may contribute to an NDPK-C–dependent cAMP reduction in HF. CONCLUSIONS:: Our findings identify NDPK-C as an essential requirement for both the interaction between NDPK isoforms and between NDPK isoforms and G proteins. NDPK-C is a novel critical regulator of β-adrenoceptor/cAMP signaling and cardiac contractility. By switching from Gαs to Gαi2 activation, NDPK-C may contribute to lower cAMP levels and the related contractile dysfunction in HF.
    Keywords: Heart Failure ; Myocardial Contraction ; Receptors, Adrenergic, Beta ; Signal Transduction ; Cyclic Amp -- Analysis ; Heart Failure -- Pathology ; Nm23 Nucleoside Diphosphate Kinases -- Analysis;
    ISSN: 0009-7322
    E-ISSN: 15244539
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  • 10
    In: Journal of Computer Assisted Tomography, 2017, Vol.41(1), pp.121-124
    Description: OBJECTIVE: The aims were to study the acromion parameters in the population and to assess the extremity or sex variation in the acromion morphology. METHODS: The lateral acromion angle (LAA) and the acromion index (AI) were assessed in a computed tomographic scan database of 250 individuals in the age group of 20 to 49 years. For the analysis of LAA and AI, 286 and 234 shoulders were available, respectively. RESULTS: The LAA was 73.6 ± 6.6 degrees; 73.7 ± 6.9 and 72.5 ± 6.1 degrees for the right and left shoulder, respectively. The AI was 0.755 ± 0.12; 0.82 ± 0.12 and 0.69 ± 0.12 for the left and the right shoulder, respectively. The AI of the right shoulder was significantly different between the 2 sexes (P = 0.04). The difference in the AI and the LAA of the right and left shoulders was significant (P 〈 0.0001, P = 0.04). CONCLUSIONS: The morphology of the acromion differs between the right and the left shoulders as well as between sexes.
    Keywords: Acromion–Anatomy & Histology ; Adult–Diagnostic Imaging ; Female–Epidemiology ; Germany–Statistics & Numerical Data ; Humans–Statistics & Numerical Data ; Male–Statistics & Numerical Data ; Middle Aged–Statistics & Numerical Data ; Reproducibility of Results–Statistics & Numerical Data ; Sensitivity and Specificity–Statistics & Numerical Data ; Sex Distribution–Statistics & Numerical Data ; Sex Factors–Statistics & Numerical Data ; Tomography, X-Ray Computed–Statistics & Numerical Data;
    ISSN: 0363-8715
    E-ISSN: 15323145
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