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Berlin Brandenburg

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  • Infections  (4)
  • Chlamydia Trachomatis
  • 1
    Language: English
    In: PLoS ONE, 2012, Vol.7(5), p.e36298
    Description: Lactobacillus- dominated vaginal microbiotas are associated with reproductive health and STI resistance in women, whereas altered microbiotas are associated with bacterial vaginosis (BV), STI risk and poor reproductive outcomes. Putative vaginal taxa have been observed in male first-catch urine, urethral swab and coronal sulcus (CS) specimens but the significance of these observations is unclear. We used 16 S rRNA sequencing to characterize the microbiota of the CS and urine collected from 18 adolescent men over three consecutive months. CS microbiotas of most participants were more stable than their urine microbiotas and the composition of CS microbiotas were strongly influenced by circumcision. BV-associated taxa, including Atopobium , Megasphaera , Mobiluncus , Prevotella and Gemella , were detected in CS specimens from sexually experienced and inexperienced participants. In contrast, urine primarily contained taxa that were not abundant in CS specimens. Lactobacilllus and Streptococcus were major urine taxa but their abundance was inversely correlated. In contrast, Sneathia , Mycoplasma and Ureaplasma were only found in urine from sexually active participants. Thus, the CS and urine support stable and distinct bacterial communities. Finally, our results suggest that the penis and the urethra can be colonized by a variety of BV-associated taxa and that some of these colonizations result from partnered sexual activity.
    Keywords: Research Article ; Biology ; Medicine ; Public Health And Epidemiology ; Infectious Diseases ; Microbiology ; Urology
    E-ISSN: 1932-6203
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  • 2
    Language: English
    In: The Journal of Pediatrics, 1996, Vol.128(2), pp.288-295
    Description: To determine whether condom use among high-risk female adolescents could be increased by a behavioral intervention, with the use of infection with as a biomarker of condom practices. Prospective, randomized, controlled intervention. Urban family planning and sexually transmitted disease clinics. Two hundred nine female adolescents, aged 15 through 19 years, who were treated for genitourinary infection, were randomly assigned to standard (control) or experimental (behavioral intervention) groups. One hundred twelve subjects returned for follow-up 5 to 7 months after enrollment and comprise the study subjects. Subjects completed a multiinstrument questionnaire measuring sexual behavior, condom practices, attitudes and beliefs, cognitive complexity, sociodemographics, and motivation at enrollment and follow-up. Endourethral and endocervical sites were sampled for . Among the 112 subjects who returned for repeated examination, those who had received the experimental intervention reported increased use of condoms by their sexual partners for protection against sexually transmitted diseases (odds ratio = 2.4; = 0.02) and for vaginal intercourse (odds ratio = 3.1; = 0.005) at the 6-month follow-up. Multivariable logistic regression analysis controlling for condom use at enrollment demonstrated that the experimental intervention (odds ratio = 2.8; = 0.03) and the higher cognitive complexity (odds ratio = 4.6; = 0.02) independently contributed to greater condom use at follow-up. Despite greater use of condoms among the group who had received the intervention, use remained inconsistent and rates of reinfection with were not significantly different (26% vs 17%; = 0.3). Although a brief behavioral intervention among high-risk female adolescents can increase condom use by their sexual partners, incident infection does not appear to be reduced, because condom use remained inconsistent. (J P 1996;128:288-95 )
    Keywords: Medicine
    ISSN: 0022-3476
    E-ISSN: 1097-6833
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  • 3
    In: Sexually Transmitted Diseases, 1999, Vol.26(1), pp.26-32
    Description: OBJECTIVE:: To identify factors associated with subsequent sexually transmitted infection (STI) (within 1 year of initial infection) due to Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis. DESIGN:: SETTING:: PARTICIPANTS:: MAIN OUTCOME MEASURES:: RESULTS:: CONCLUSIONS::
    Keywords: Chlamydia ; Demographic Aspects ; Trichomonas Vaginalis ; Gonorrhea ; Teenage Girls ; Sexual Behavior ; Sexually Transmitted Diseases ; Risk Factors ; Medicine;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 4
    Language: English
    In: Sexually transmitted diseases, July 2019, Vol.46(7), pp.440-445
    Description: Rectal infection with Chlamydia trachomatis (CT) is frequent in women who deny receptive anal sex and is thought to arise from autoinoculation of the rectum from vaginal secretions. An alternate hypothesis is that oral sex inoculates and establishes gastrointestinal tract infection. Distinguishing these... We enrolled high-risk men with and without nongonococcal urethritis who presented to a sexually transmitted infection clinic in Indianapolis, Indiana. Urine and rectal swabs were collected and tested for urogenital and rectal CT, Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG). Men completed... Rectal CT was detected in 2/84 (2.4%) heterosexual men who reported cunnilingus, but no lifetime receptive anal behaviors. All of the men who denied receptive anal behaviors were negative for rectal NG and MG. In homosexual and bisexual men, rectal CT prevalence was high (9.7%), and rectal NG (4.8%)... We detected rectal CT infections in heterosexual men who reported cunnilingus but denied receptive anal behaviors. Oral sex may be a risk factor for rectal CT infection via oral inoculation of the gastrointestinal tract.
    Keywords: Chlamydia Trachomatis ; Infections ; Vagina ; Detection ; Urethritis ; Urine ; Sex ; Chlamydia Trachomatis ; Gastrointestinal Tract ; Chlamydia ; Inoculation ; Gastrointestinal Tract ; Secretions ; Sexual Behavior ; Women ; Urine ; Chlamydia Trachomatis ; Inoculation ; Rectum ; Risk Groups;
    ISSN: 01485717
    E-ISSN: 1537-4521
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