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  • 1
    Article
    Article
    Language: English
    In: The Journal of Urology, March 2017, Vol.197(3), pp.595-595
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.11.105 Byline: Deborah L. Jacobson, Emilie K. Johnson Author Affiliation: Division of Urology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 2
    Language: English
    In: The Journal of Urology, January 2013, Vol.189(1), pp.17-24
    Description: Penile carcinoma is rare in the developed world and treatment guidelines are often based on marginal clinical data. Prospective controlled studies are virtually absent and meta-analyses are rare. Vulvar carcinoma, on the other hand, has many parallels to penile carcinoma, and the level of evidence for diagnosis and treatment is more robust. Therefore, we assessed the body of literature on vulvar carcinoma to identify potential improvements in the care of patients with penile carcinoma. A literature review was performed on vulvar carcinoma and direct comparisons were made to a similar review of the literature on penile carcinoma. Several aspects of vulvar carcinoma management are clearly established and deserve closer evaluation in penile carcinoma. For example, human papillomavirus is identified in a high percentage of patients with vulvar carcinoma but is understudied in penile carcinoma. Further study is of potential clinical value, especially with the development of human papillomavirus vaccines for prevention. Penile carcinoma TNM staging does not adequately stratify survival or risk of advanced disease. Staging of vulvar carcinoma is dependent on tumor size and depth of invasion measured in millimeters, as opposed to the invasion of underlying structures in penile carcinoma. Management of the inguinal nodes is more refined for vulvar carcinoma, where lymphatic mapping has been conducted and sentinel node biopsy has proven to be highly effective in multicenter trials. Finally, the efficacy of adjuvant radiation and chemotherapy has been tested in controlled trials or reported in meta-analyses for vulvar carcinoma, which are both lacking for penile carcinoma. Radiation after inguinal node dissection, for example, has been shown to enhance survival in patients with defined risk factors. Neoadjuvant chemoradiation is recommended before surgery for advanced vulvar carcinoma. Evidence derived from studies on vulvar carcinoma can be extrapolated to penile carcinoma to help guide clinical trials and future research directions to enhance the treatment of these patients.
    Keywords: Penile Neoplasms ; Vulvar Neoplasms ; Carcinoma, Squamous Cell ; Neoplasm Staging ; Disease Management ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 3
    In: PLoS ONE, 2014, Vol.9(3)
    Description: Introduction Adaptation to living with a stoma is complex, and studies have shown that stoma creation has a great impact on patients' health related quality of life. The objective was to explore the effect of a structured patient education program on health related quality of life. Therefore, we implemented interventions aimed at increasing health related quality of life during and after hospital admission. Materials and Methods We designed a case/control study aimed at adult patients admitted to the surgical ward for stoma creation, irrespective of type of stoma or reason for creation of stoma. We included 50 patients in the study. Health related quality of life was measured before hospital discharge, three months and six months after stoma creation. The program included educational interventions involving lay-teachers, alongside health professional teachers. Results We found a significant rise in health related quality of life in the intervention group (P〈0.001) and no significant change in the control group (P = 0.144). However, we found no significant differences when comparing between groups at 3 and 6 months ( p  = 0.12 and p  =  0.63, respective). Additionally, there were differences in scores in health related quality of life baseline ( p = 0.045 ) with lower scores in the intervention group compared with the intervention group. However, there were no significant differences in the demographic variables at baseline Conclusions Educational activities aimed at increase in knowledge and focusing on patients' psychosocial needs may lead to a rise in patients' health related quality of life. When patients with a stoma attend a structured patient education program it is possible to improve their health related quality of life compared with patients with a stoma, who do not attend the program. Trial Registration ClinicalTrials.gov NCT01154725
    Keywords: Research Article ; Medicine ; Social And Behavioral Sciences
    E-ISSN: 1932-6203
    Source: U.S. National Library of Medicine (NIH/NLM)
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  • 4
    Language: English
    In: Urology, June 2017, Vol.104, pp.5-6
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.urology.2017.03.021 Byline: Werner J. Struss, Peter C. Black Article Note: (footnote) Shipley W.U., Seiferheld W., Lukka H.R., et al. N Engl J Med 2017; 376:417-428.
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
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  • 5
    Language: English
    In: Urology, March 2016, Vol.89, pp.10-11
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.urology.2015.12.002 Byline: Edmund C.P. Chedgy, Peter C. Black Article Note: (footnote) Mateo J., Carreira S., Sandhu S., et al., N Engl J Med 2015;373:1697-1708.
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
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  • 6
    Language: English
    In: Urology, March 2016, Vol.89, pp.8-9
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.urology.2015.12.003 Byline: Edmund C.P. Chedgy, Peter C. Black Article Note: (footnote) Motzer R.J., Escudier B., McDermott D.F., et al., N Engl J Med 2015;373:1803-1813.
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
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  • 7
    Language: English
    In: Urology, June 2017, Vol.104, pp.7-8
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
    Source: ScienceDirect Journals (Elsevier)
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  • 8
    Language: English
    In: European Urology, May 2013, Vol.63(5), pp.830-831
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.eururo.2012.12.061 Byline: Peter C. Black Author Affiliation: Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
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  • 9
    Language: English
    In: The Journal of Urology, January 2015, Vol.193(1), pp.302-312
    Description: To provide unencumbered real-time ultrasound image guidance during robot-assisted laparoscopic radical prostatectomy, we developed a robotic transrectal ultrasound system that tracks the da Vinci® Surgical System instruments. We describe our initial clinical experience with this system. After an evaluation in a canine model, 20 patients were enrolled in the study. During each procedure the transrectal ultrasound transducer was manually positioned using a brachytherapy stabilizer to provide good imaging of the prostate. Then the transrectal ultrasound was registered to the da Vinci robot by a previously validated procedure. Finally, automatic rotation of the transrectal ultrasound was enabled such that the transrectal ultrasound imaging plane safely tracked the tip of the da Vinci instrument controlled by the surgeon, while real-time transrectal ultrasound images were relayed to the surgeon at the da Vinci console. Tracking was activated during all critical stages of the surgery. The transrectal ultrasound robot was easy to set up and use, adding 7 minutes (range 5 to 14) to the procedure. It did not require an assistant or additional control devices. Qualitative feedback was acquired from the surgeons, who found transrectal ultrasound useful in identifying the urethra while passing the dorsal venous complex suture, defining the prostate-bladder interface during bladder neck dissection, identifying the seminal vesicles and their location with respect to the rectal wall, and identifying the distal prostate boundary at the apex. Real-time, registered robotic transrectal ultrasound guidance with automatic instrument tracking during robot-assisted laparoscopic radical prostatectomy is feasible and potentially useful. The results justify further studies to establish whether the approach can improve procedure outcomes.
    Keywords: Robotics ; Ultrasonography ; Prostatectomy ; Laparoscopy ; Prostatic Neoplasms ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 10
    In: PLoS ONE, 2014, Vol.9(3)
    Description: Background The results of prostate specific antigen (PSA) and digital rectal examination (DRE) screenings lead to both under and over treatment of prostate cancer (PCa). As such, there is an urgent need for the identification and evaluation of new markers for early diagnosis and disease prognosis. Studies have shown a link between PCa, lipids and lipid metabolism. Therefore, the aim of this study was to examine the concentrations and distribution of serum lipids in patients with PCa as compared with serum from controls. Method Using Electrospray ionization mass spectrometry (ESI-MS/MS) lipid profiling, we analyzed serum phospholipids from age-matched subjects who were either newly diagnosed with PCa or healthy (normal). Results We found that cholester (CE), dihydrosphingomyelin (DSM), phosphatidylcholine (PC), egg phosphatidylcholine (ePC) and egg phoshphatidylethanolamine (ePE) are the 5 major lipid groups that varied between normal and cancer serums. ePC 38:5, PC 40:3, and PC 42:4 represent the lipids species most prevalent in PCa as compared with normal serum. Further analysis revealed that serum ePC 38:5 ≥0.015 nmoles, PC 40.3 ≤0.001 nmoles and PC 42:4 ≤0.0001 nmoles correlated with the absence of PCa at 94% prediction. Conversely, serum ePC 38:5 ≤0.015 nmoles, PC 40:3 ≥0.001 nmoles, and PC 42:4 ≥0.0001 nmoles correlated with the presence of PCa. Conclusion In summary, we have demonstrated that ePC 38:5, PC 40:3, and PC 42:4 may serve as early predictive serum markers for the presence of PCa.
    Keywords: Research Article ; Biology ; Medicine
    E-ISSN: 1932-6203
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