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  • 1
    Language: English
    In: Radiology, December 2012, Vol.265(3), pp.651-3
    Description: Liu et al (1) have shown that iodinated contrast medium preferentially vasoconstricts the glomerular afferent arterioles by depleting endothelial nitric oxide bioavailability. This potentiates an exaggerated afferent arteriolar vasoconstricting response to angiotensin II and opens possibilities for new methods to prevent or treat nephrotoxicity after contrast medium administration.
    Keywords: Arterioles -- Drug Effects ; Contrast Media -- Pharmacology ; Glomerular Filtration Rate -- Drug Effects ; Triiodobenzoic Acids -- Pharmacology
    ISSN: 00338419
    E-ISSN: 1527-1315
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  • 2
    Language: English
    In: Diagnostic Pathology, 01 June 2012, Vol.7(1), p.77
    Description: Abstract Paragangliomas are rare neoplasms arising from undifferentiated cells of the primitive neural crest. We report a case of a 57-year-old patient with renal pigmented paraganglioma that was an incidental finding. Histopathological examination showed typical morphology of paraganglioma, as well as the unusual feature of large amounts of pigment in the cytoplasm of the tumor cells which was confirmed by bleached Fontana-Masson. Electron microscopy showed abundant, pleomorphic electron-dense granules consistent with neuromelanin. The tumor cells were positive for CD56 and chromogranin A, negative for HMB-45. The unique morphologic appearance represents divergent differentiation from neural crest. To our knowledge, the present case represents the first example of pigmented paraganglioma of the kidney. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2017147293711495.
    Keywords: Pigmented Paraganglioma ; Kidney ; Differential Diagnosis
    ISSN: 1746-1596
    E-ISSN: 1746-1596
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  • 3
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(11), p.e110773
    Description: Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was to assess whether BDNF promoter methylation in peripheral blood was able to predict the risk of AD. A total of 44 AD patients and 62 age- and gender-matched controls were recruited in the current case-control study. Using the bisulphite pyrosequencing technology, we evaluated four CpG sites in the promoter of the BDNF. Our results showed that BDNF methylation was significantly higher in AD cases than in the controls (CpG1: p = 10.021; CpG2: p = 0.002; CpG3: p = 0.007; CpG4: p = 0.005; average methylation: p = 0.004). In addition, BDNF promoter methylation was shown to be significantly correlated with the levels of alkaline phosphatase (ALP), glucose, Lp(a), ApoE and ApoA in males (ALP: r = -0.308, p = 0.042; glucose: r = -0.383, p = 0.010; Lp(a): r = 0.333, p = 0.027; ApoE: r = -0.345, p = 0.032;), ApoA levels in females (r = 0.362, p = 0.033), and C Reactive Protein (CRP) levels in both genders (males: r = -0.373, p = 0.016; females: r = -0.399, p = 0.021). Our work suggested that peripheral BDNF promoter methylation might be a diagnostic marker of AD risk, although its underlying function remains to be elaborated in the future.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: International Orthopaedics, 2016, Vol.40(1), pp.191-195
    Description: Background: Medial posterior horn meniscal tear is difficult to visualise during arthroscopy and is occasionally undetected by preoperative magnetic resonance imaging (MRI). Consequently, attention should be paid to performing a thorough examination and to some characteristic signs that indicate occult meniscal tear. The purpose of this study was to assess an indicative correlation between arthroscopic features of cartilage injury and a concomitant occult meniscal tear. Methods: We performed a retrospective clinical and radiographic study of a consecutive series of patients between January 2013 and December 2014. Of 1,596 patients, all 78 with wave-like chondral injury of the medial femoral condyle diagnosed at arthroscopy were included in the study. The occurrence, pattern, location and concomitant pathology of medial meniscal injury were analysed. Results: The characteristic wave sign associated with chondral injury in the medial femoral condyle was detected by MRI preoperatively in two cases only; all others were discovered intraoperatively at arthroscopy. Cartilage injury was rated as Outerbridge type II in 53 patients, type III in 24, and type IV in one. Wave sign defects were all characterised by their transverse orientation in the load-bearing femoral condyle. The occult longitudinal peripheral meniscus tear of the posterior horn was seen in all patients with a positive wave sign visualised under arthroscopy. The wave sign was positively correlated with medial peripheral meniscal injury of the posterior horn (P 〈 0.01). Conclusion: Wave sign chondral injury in the medial femoral condyle seen at arthroscopy is a characteristic indicator for concomitant occult medial longitudinal peripheral meniscus tears of the posterior horn. Level of evidence Case series, Level IV.
    Keywords: Cartilage injury ; Meniscal tear ; Arthroscopy ; Knee
    ISSN: 0341-2695
    E-ISSN: 1432-5195
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  • 5
    Language: English
    In: Scientific reports, 23 August 2018, Vol.8(1), pp.12698
    Description: This clinical retrospective study explored factors associated with distal tibiofibular syndesmosis ossification (TFSO) after ankle fracture fixation. Between August 2012 and January 2015, 172 patients with ankle fractures (121 men) with an average age of 46.6 years (range, 22-71 years) were treated surgically...
    Keywords: Fracture Fixation, Internal ; Ankle Fractures -- Surgery ; Ankle Joint -- Pathology ; Osteogenesis -- Physiology
    E-ISSN: 2045-2322
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  • 6
    Language: English
    In: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, April 2014, Vol.34(2), pp.173-7
    Description: To investigate how the pretreatment of mice with Ganoderma spores affected the apoptosis of their splenic lymphocytes induced by dexamethasone after 19 days treatment. Sixty Kunming mice were randomly divided into six groups: blank control groupdrenched with normal saline; a drug control group drenched with 150 mg/mL Ganoderma spores; a model group treated with saline; a low dose group with 50 mg/mL Ganoderma spores; a moderate dose group with 100 mg/mL Ganoderma spores; and a high dose group with 150 mg/mL Ganoderma spores. The effect of Ganoderma spores on apoptosis in spleen lymphocytes was analyzed. All groups were treated for 19 days. On day 20, the model group and the 3 treatment groups were intraperitoneally injected dexamethasone to induce apoptosis. Splenic index and apoptosis indes were employed to measure cell apoptosis. The results showed that Ganoderma spores reduced the splenic index to different degrees in each group and the best effect was seen in the high dose group (P 〈 0.05).Terminal dexynucleotidyl transferase (TdT)-mediated 2'-Deoxyuridine 5'-Triphosphate nick end labeling staining revealed that the apoptotic index in all groups administered Ganoderma spores differed significantly from the model group, and a dose-response was observed. Flow cytometric analysis indicated that spleen lymphocyte apoptosis in the model group was extensive. Each dose of Ganoderma spores inhibited dexamethasone-induced apoptosis in spleen lymphocytes, and a dose-response was observed as well. The highest dose of Ganoderma spores decreased Malondialdehyde content in serum induced by dexamethasone (P 〈 0.05). The findings imply that the pretreatment of the mice with Ganoderma spores could reduce the apoptosis rate induced by dexamethasone in their splenic lymphocytes.
    Keywords: Apoptosis -- Drug Effects ; Drugs, Chinese Herbal -- Pharmacology ; Lymphocytes -- Cytology ; Protective Agents -- Pharmacology ; Reishi -- Chemistry ; Spleen -- Cytology ; Spores, Fungal -- Chemistry
    ISSN: 0255-2922
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  • 7
    Language: English
    In: Connective Tissue Research, 02 January 2015, Vol.56(1), pp.9-17
    Description: Purpose of the study: Gluteal muscle contracture (GMC) is a chronic fibrotic disease of gluteal muscles which is characterized by excessive deposition of collagen in the extracellular matrix. Transforming growth factor (TGF)-βs have been shown to play an important role in the progression of...
    Keywords: Gluteal Muscle Contracture ; Pai-1 ; Smad2/3 ; Smad7 ; Tgf-Β/Smad Pathway ; Biology ; Anatomy & Physiology
    ISSN: 0300-8207
    E-ISSN: 1607-8438
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  • 8
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(3), p.e92322
    Description: OBJECTIVE: To examine the relationship between the HW phenotype and risk for CKD in a community population aged 40 years and older. METHODS: A cross-sectional study was conducted in Zhuhai from June to October 2012. The participants were divided into three groups: Group 1, Waist circumference 〉90 cm in men or 〉85 cm in women and triglycerides ≥2 mmol/l; Group 3, Waist circumference ≤90 cm in men or ≤85 cm in women and triglycerides 〈2 mmol/l; Group 2, The remaining participants. The prevalence of the three subgroups and CKD were determined. The association between HW phenotype and CKD was then analyzed using SPSS (version 13.0). RESULTS: After adjusting for age and sex, Group 1 was associated with CKD (OR 3.08, 95% CI 2.01, 4.73, P〈0.001), when compared with Group 3. Further adjustment for factors which were potential confounders and unlikely to be in the causal pathway between the HW phenotype and CKD, Group 1 was still significantly associated with CKD. The OR for CKD was 2.65 (95% CI 1.65, 4.26, P〈0.001). When adjusted for diabetes and hypertension, the association of Group 1 and CKD was still significant (OR 2.09, 95% CI 1.26, 3.45, P = 0.004). Group 2 was associated with CKD (OR 1.81, 95% CI 1.29, 2.53, P = 0.001), when compared with Group 3. Further adjustment for factors which were potential confounders, Group 2 was still significantly associated with CKD. The OR for CKD was 1.75 (95% CI 1.22, 2.51, P = 0.002). When adjusted for diabetes and hypertension, the association between Group 2 and CKD still existed. The OR for CKD was 1.48 (95% CI 1.01, 2.16, P = 0.046). CONCLUSION: Our results showed that HW phenotype was associated with CKD in the population aged 40 years and older.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: International journal of molecular medicine, January 2019, Vol.43(1), pp.127-142
    Description: Accumulating evidence has suggested that circular RNAs (circRNAs), a novel class of non‑coding RNAs, have crucial roles in tumor progression. However, the significance of circRNAs in hypopharyngeal cancer (HCa) remains to be investigated. The present study has identified aberrantly expressed circRNAs by performing circRNA sequencing analyses of three pairs of tumor and adjacent normal samples from patients with HCa. The results demonstrated that 173 circRNAs were differentially expressed (DE), including 71 upregulated and 102 downregulated circRNAs (FDR〈0.05 and fold changes of ≥2 or ≤0.5 by Mann‑Whitney U test followed by Benjamini‑Hochberg correction for multiple testing). Pathway analyses of the genes producing DE circRNAs revealed that many of them were involved in cancer‑related pathways. To further illustrate the roles of circRNAs in HCa progression, a competing endogenous RNA (ceRNAs) network was constructed, consisting of circRNAs, miRNA, and miRNA targeted genes. The results demonstrated that multiple cancer‑related pathways were affected by performing enrichment analyses of the targeted genes. Of note, a ceRNA subnetwork was isolated, consisting of two circRNAs (hsa_circ_0008287 and hsa_circ_0005027) and one miRNA (hsa‑miR‑548c‑3p), which significantly affect both ErbB and Hippo signaling pathways. In conclusion, the present study identified a set of circRNAs that are potentially implicated in the tumorigenesis of HCa and may serve as potential biomarkers for the diagnosis of HCa.
    Keywords: Rna -- Research ; Cellular Signal Transduction -- Research ; Pharyngeal Cancer -- Development And Progression ; Pharyngeal Cancer -- Research ; Pharyngeal Cancer -- Genetic Aspects;
    ISSN: 11073756
    E-ISSN: 1791-244X
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  • 10
    In: American Journal of Epidemiology, 2003, Vol.157(11), pp.1007-1014
    Description: Previous epidemiologic studies have generated inconsistent results regarding the associations between fat intakes and risk of Parkinsons disease. The authors investigated these associations in two large, prospective US cohorts. They documented 191 incident cases of Parkinsons disease in men (19861998) and 168 in women (19801998) during the follow-up. Overall, intakes of total fat or major types of fat were not significantly associated with the risk. The relative risks comparing the highest quintile of animal fat intake with the lowest were 1.42 for men (95 confidence interval (CI): 0.91, 2.20; p for trend 0.1) and 0.65 for women (95 CI: 0.36, 1.16; p for trend 0.3). For men, but not women, replacement of polyunsaturated fat with saturated fat was associated with a significantly increased risk (5 of energy intake, relative risk (RR) 1.83, 95 CI: 1.10, 3.03). Of the individual polyunsaturated fatty acids, arachidonic acid tended to be inversely associated with the risk (pooled RR between extreme quintiles 0.65, 95 CI: 0.46, 0.91; p for trend 0.05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinsons disease, but a possible adverse effect of saturated fat for men could not be excluded.
    Keywords: Dietary Fats -- Adverse Effects ; Parkinson Disease -- Etiology;
    ISSN: 0002-9262
    E-ISSN: 1476-6256
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