Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Medicine
Type of Medium
Language
Year
  • 1
    In: JDDG: Journal der Deutschen Dermatologischen Gesellschaft, February 2006, Vol.4(2), pp.124-130
    Description: Radiotherapy plays an important role in the treatment of basal cell carcinoma of the face and head and achieves cure rates of 92‐96 %. Different fractionation concepts of radiotherapy have been described.This study investigates the efficacy, as well as acute and chronic toxicity, of a slightly hypofractionated radiotherapy schedule. 85 patients with 104 tumors underwent radiotherapy for basal cell carcinoma of the face and head. The radiotherapy schedule was 5×3 Gray/week up to a total dose of 57 Gray in 95 % of patients. Acute and late radiotherapy toxicity and cosmetic outcome were evaluated in long‐term follow‐up. No recurrence was observed. In 87 % of tumors, only low acute toxicity occurred at the end of radiotherapy. Late toxicity, if observed, was low in most patients. “Excellent” or “good” cosmesis was achieved in 94 % of tumors at last follow‐up. Our radiotherapy schedule achieves a very high local control rate and very good cosmetic and functional results.This fractionation can be recommended as a standardized radiotherapy treatment for basal cell carcinoma of the face and head. Die Radiotherapie spielt eine wichtige Rolle in der Behandlung des Basalzellkarzinoms des Gesichts‐/Kopfbereichs und erreicht Heilungsraten von 92‐96 %. Verschiedene Radiotherapie‐Fraktionierungsschemata sind beschrieben worden. Die vorliegende Arbeit untersucht die Wirksamkeit und (akute und chronische) Nebenwirkungen eines moderat hypofraktionierten Bestrahlungsschemas. 85 Patienten mit 104 Tumoren erhielten eine Radiotherapie bei einem Basalzellkarzinom des Gesichts‐/Kopfbereiches. In 95 % aller Patienten erfolgte eine Fraktionierung von 5x3 Gray/Woche bis zu einer Gesamtdosis von 57 Gray. Untersucht wurden akute und späte Radiotherapie‐Nebenwirkungen sowie das kosmetische Ergebnis. Es wurde kein Lokalrezidiv beobachtet. In 87 % aller Tumoren fanden sich zum Bestrahlungsende nur geringgradige akute Nebenwirkungen. Spätnebenwirkungen waren bei den meisten Patienten ebenfalls geringgradig ausgeprägt. In 94 % aller Tumoren konnte ein “exzellentes” oder “gutes” kosmetisches Ergebnis erreicht werden. Das verwendete Bestrahlungsschema erzielt eine sehr hohe lokale Kontrollrate und (“sehr”) “gute” kosmetische (und funktionelle) Ergebnisse. Die verwendete Fraktionierung kann insgesamt als standardisierte Behandlung für ein Basalzellkarzinom des Gesichts‐/Kopfbereiches empfohlen werden.
    Keywords: Basal Cell Carcinoma ; Radiotherapy ; Radiotherapy Dose Fractionation ; Treatment Outcome ; Basalzellkarzinom ; Radiotherapie ; Radiotherapie‐Fraktionierung ; Behandlungsergebnisse
    ISSN: 1610-0379
    E-ISSN: 1610-0387
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Child Development, May-June, 2002, Vol.73(3), p.752(16)
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/1467-8624.00436 Byline: Josef Perner, Birgit Lang, Daniela Kloo Abstract: This study tested the theory that advances on theory-of-mind tasks and on executive function tasks show a strong correlation because the typically used theory-of-mind tasks pose the same executive demands. In Experiment 1 with fifty-six 3- to 6-year-old children, performance on the dimensional change card-sorting task as an executive function task was correlated with performance on the usual false-belief prediction task, r= .65, and the false-belief explanation task, r= .65, as measures of theory-of-mind development. Because the explanation version of the false-belief test is supposed to be free of the alleged executive demands inherent in the prediction version, the equally strong correlation with the executive function task suggests that this correlation cannot be due to common executive demands. In Experiment 2, the basic finding of Experiment 1 was replicated on another sample of 73 children, ages 3 to 5.5 years. The need for new theories to explain the developmental link between theory of mind and executive function development is discussed, and some existing candidates are evaluated. Author Affiliation: (1)University of Salzburg
    Keywords: Cognitive Learning -- Causes Of ; Children -- Psychological Aspects ; Child Development -- Research ; Other Minds (Theory of knowledge) -- Research ; Belief And Doubt -- Psychological Aspects;
    ISSN: 0009-3920
    E-ISSN: 14678624
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: Child Development, May 2002, Vol.73(3), pp.752-767
    Description: This study tested the theory that advances on theory‐of‐mind tasks and on executive function tasks show a strong correlation because the typically used theory‐of‐mind tasks pose the same executive demands. In Experiment 1 with fifty‐six 3‐ to 6‐year‐old children, performance on the dimensional change card‐sorting task as an executive function task was correlated with performance on the usual false‐belief prediction task, = .65, and the false‐belief explanation task, = .65, as measures of theory‐of‐mind development. Because the explanation version of the false‐belief test is supposed to be free of the alleged executive demands inherent in the prediction version, the equally strong correlation with the executive function task suggests that this correlation cannot be due to common executive demands. In Experiment 2, the basic finding of Experiment 1 was replicated on another sample of 73 children, ages 3 to 5.5 years. The need for new theories to explain the developmental link between theory of mind and executive function development is discussed, and some existing candidates are evaluated.
    Keywords: Medicine ; Social Welfare & Social Work ; Sociology & Social History ; Psychology;
    ISSN: 0009-3920
    E-ISSN: 1467-8624
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Book
    Book
    Language: English
    Description: The case study has proved of enduring interest to all Western societies, particularly in relation to questions of subjectivity and the sexed self. This volume interrogates how case studies have been used by doctors, lawyers, psychoanalysts, and writers...
    Description: Foreword John Forrester Acknowledgments. Introduction: Case Studies and the Dissemination of Knowledge Joy Damousi, Birgit Lang and Katie Sutton Part I: Case Knowledge 1. The Case of the Archive Warwick Anderson 2. The Case Study as Representative Anecdote...
    Keywords: Knowledge, Sociology Of ; Knowledge, Sociology Of -- Case Studies ; Society
    ISBN: 9781138815339
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: German
    In: Strahlentherapie und Onkologie, 2001, Vol.177(5), pp.240-246
    Description: Das Basaliom oder Basalzellkarzinom ist ein im Alter häufig vorkommender Hauttumor, der chirurgisch gut behandelbar ist. Bei großen und rezidivierenden Tumoren und in kosmetisch ungünstiger Lokalisation stellt die perkutane Radiotherapie eine ebenso gute Therapieform dar. Von 1986 bis 1999 wurden 60 Frauen und 39 Männer mit 127 histologisch gesicherten Basaliomen primär bestrahlt. Die Tumoren lagen meistens im Gesichtsbereich an Schläfe, Nase und Stirn. Die Radiotherapie erfolgte am Orthovoltgerät mit Energien bis 100 kV. Die Einzeldosis schwankte zwischen 2 und 5 Gy bezogen auf die 80%-Isodosentiefe; die Wochendosis betrug 8–25 Gy und die Gesamtdosis 25–60 Gy. Die Nachbeobachtung des Kollektivs betrug im Mittel 36±21 Monate. Die akuten Nebenwirkungen wurden nach CTC-Kriterien und die radiogenen Spätfolgen als Einzelereignisse bezogen auf das Bestrahlungsfeld beurteilt. Bis auf einen Patienten erzielten alle (99%) 3 Monate nach Therapieabschluss eine komplette Tumorremission (CR). Bei allen Fällen wurde eine akute Strahlenreaktion im Bestrahlungsfeld beobachtet: CTC-Grad 1 in 100%, CTC-Grad 2 in 54% und CTC-Grad 3 in 30% der Fälle. Alle Nebenwirkungen heilten unter einfachen lokalen Maßnahmen komplikationslos ab. Spätfolgen traten nur in drei Fällen (3%) auf. Das kosmetische Gesamtergebnis war bei allen bis auf zwei Patienten (98%) gut bis ausgezeichnet. Bei zwei Fällen (2%) kam es zu einem Lokalrezidiv 6 bzw. 20 Monate nach Ende der Strahlentherapie. Die perkutane Radiotherapie erzielt sehr gute Tumorkontrollraten und ein gutes kosmetisches Ergebnis im Langzeitverlauf. Die von Dermatologen geprägte empirische Dosisverschreibung muss in Zukunft der strahlenphysikalischen ICRU-Dosisverschreibung und den neuen radiobiologischen Erkenntnissen zur Fraktionierung Rechnung tragen. The basal cell carcinoma which is often occurring in the elderly can be well treated by surgery. For large and recurrent lesions and in cosmetically difficult locations external beam radiotherapy provides an equally effective treatment alternative. From 1986 to 1999, 60 females and 39 males received primary radiotherapy for a total of 127 histologically verified basal cell carcinoma lesions. Tumors were mostly localized in the face at the temple, nose and forehead. Radiotherapy was applied with orthovoltage equipment and energies of up to 100 kV. Single doses ranged from 2 to 5 Gy related to the 80%-isodose depth. Weekly doses ranged from 8 to 25 Gy and total doses from 25 to 60 Gy. The mean follow-up period was 36±21 months. The acute sequelae were scored according to CTC criteria. Radiogenic late effects as single events were related to the radiation portal. 3 months after treatment all besides one patient (99%) experienced complete tumor remission (CR). In all cases, acute radiation reaction occurred within the radiation portal: CTC Grade 1 in 100%, CTC Grade 2 in 54% and CTC Grade 3 in 30% of the cases. All side effects regressed under simple local measures without further complications. Late sequelae were observed in three cases. Overall cosmetic outcome was good to excellent in almost all patients (98%). In two cases (2%) a local recurrence was observed 6 and 20 months after radiotherapy. External beam (orthovoltage) radiotherapy is very effective and yields high tumor control rates and good cosmetic results in long-term follow-up. Former dermatological treatment concepts should be replaced by an ICRU-based radiophysical dose prescription and should respect the newer radiobiological fractionation principles.
    Keywords: Key Words: Basal cell carcinoma ; Skin tumors ; Orthovoltage radiotherapy
    ISSN: 0179-7158
    E-ISSN: 1439099X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 15 November 2014, Vol.59(10), pp.1420-8
    Description: Faldaprevir is a potent, once-daily hepatitis C virus (HCV) NS3/4A protease inhibitor. Studies were performed to investigate potential drug interactions between faldaprevir and the commonly used antiretrovirals darunavir/ritonavir, efavirenz, and tenofovir to guide the coadministration of faldaprevir with these agents in human immunodeficiency virus/HCV-coinfected patients. In 3 open-label, phase 1 pharmacokinetic (PK) studies, healthy adult volunteers received (1) darunavir/ritonavir (800 mg/100 mg once daily) with and without faldaprevir (240 mg once daily); (2) faldaprevir (240 mg twice daily) with and without efavirenz (600 mg once daily); or (3) faldaprevir (240 mg twice daily) or tenofovir (300 mg once daily) alone and in combination. To assess potential drug interactions, geometric mean ratios and 90% confidence intervals for PK parameters were calculated. Safety was evaluated. Efavirenz decreased faldaprevir area under the concentration-time curve (AUC) by 35%, Cmax by 28%, and Cmin by 46%, consistent with induction of CYP3A by efavirenz. Tenofovir decreased faldaprevir AUC by 22%, which was not considered to be clinically relevant. Faldaprevir had no clinically relevant effects on darunavir or tenofovir PK (15% and 22% AUC increase, respectively). Adverse events were consistent with the known safety profiles of faldaprevir and the antiretrovirals being examined. No clinically significant interactions were observed between faldaprevir and darunavir/ritonavir or tenofovir. A potentially clinically relevant decrease in faldaprevir exposure was observed when coadministered with efavirenz; this decrease can be managed using the higher of the 2 faldaprevir doses tested in phase 3 trials (240 mg once daily as opposed to 120 mg once daily).
    Keywords: Hcv ; HIV ; Antiretrovirals ; Drug–Drug Interactions ; Faldaprevir ; Adenine -- Analogs & Derivatives ; Anti-HIV Agents -- Pharmacology ; Benzoxazines -- Pharmacology ; Oligopeptides -- Pharmacology ; Organophosphonates -- Pharmacology ; Protease Inhibitors -- Pharmacology ; Ritonavir -- Pharmacology ; Sulfonamides -- Pharmacology ; Thiazoles -- Pharmacology
    ISSN: 10584838
    E-ISSN: 1537-6591
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    In: Circulation, 2015, Vol.132(2), pp.82-92
    Description: BACKGROUND—: Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical challenge. Mechanism-based approaches to AF therapy are sought to increase effectiveness and to provide individualized patient care. K2P3.1 (TASK-1 [tandem of P domains in a weak inward-rectifying K channel–related acid-sensitive K channel-1]) 2-pore-domain K (K2P) channels have been implicated in action potential regulation in animal models. However, their role in the pathophysiology and treatment of paroxysmal and chronic patients with AF is unknown. METHODS AND RESULTS—: Right and left atrial tissue was obtained from patients with paroxysmal or chronic AF and from control subjects in sinus rhythm. Ion channel expression was analyzed by quantitative real-time polymerase chain reaction and Western blot. Membrane currents and action potentials were recorded using voltage- and current-clamp techniques. K2P3.1 subunits exhibited predominantly atrial expression, and atrial K2P3.1 transcript levels were highest among functional K2P channels. K2P3.1 mRNA and protein levels were increased in chronic AF. Enhancement of corresponding currents in the right atrium resulted in shortened action potential duration at 90% of repolarization (APD90) compared with patients in sinus rhythm. In contrast, K2P3.1 expression was not significantly affected in subjects with paroxysmal AF. Pharmacological K2P3.1 inhibition prolonged APD90 in atrial myocytes from patients with chronic AF to values observed among control subjects in sinus rhythm. CONCLUSIONS—: Enhancement of atrium-selective K2P3.1 currents contributes to APD shortening in patients with chronic AF, and K2P3.1 channel inhibition reverses AF-related APD shortening. These results highlight the potential of K2P3.1 as a novel drug target for mechanism-based AF therapy.
    Keywords: Medicine ; Anatomy & Physiology;
    ISSN: 0009-7322
    E-ISSN: 15244539
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Placenta, September 2017, Vol.57, pp.293-293
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.placenta.2017.07.220 Byline: Birgit Hirschmugl, Michael Gruber, Uwe Lang, Gernot Desoye, Christian Wadsack Author Affiliation: Medical University of Graz, Department of Obstetrics and Gynecology, Graz, Austria Article Note: (miscellaneous) P2.02
    Keywords: Medicine ; Anatomy & Physiology ; Zoology
    ISSN: 0143-4004
    E-ISSN: 1532-3102
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: The Journal of Allergy and Clinical Immunology, August 2017, Vol.140(2), pp.525-533.e10
    Description: Allergy vaccines should be easily applicable, safe, and efficacious. For Bet v 1–mediated birch pollen and associated food allergies, a single wild-type allergen does not provide a complete solution. We aimed to combine immunologically relevant epitopes of Bet v 1 and the 2 clinically most important related food allergens from apple and hazelnut to a single hybrid protein, termed MBC4. After identification of T cell epitope–containing parts on each of the 3 parental allergens, the hybrid molecule was designed to cover relevant epitopes and evaluated . Thereby a mutation was introduced into the hybrid sequence, which should alter the secondary structure without compromising the immunogenic properties of the molecule. MBC4 and the parental allergens were purified to homogeneity. Analyses of secondary structure elements revealed substantial changes rendering the hybrid nonreactive with patients' serum IgE. Nevertheless, the protein was monomeric in solution. MBC4 was able to activate T-cell lines from donors with birch pollen allergy and from mice immunized with the parental allergens. Moreover, on immunization of mice and rabbits, MBC4 induced cross-reactive IgG antibodies, which were able to block the binding of human serum IgE. Directed epitope rearrangements combined with a knowledge-based structural modification resulted in a protein unable to bind IgE from allergic patients. Still, properties to activate specific T cells or induce blocking antibodies were conserved. This suggests that MBC4 is a suitable vaccine candidate for the simultaneous treatment of Bet v 1 and associated food allergies.
    Keywords: Birch Pollen Allergy ; Bet V 1 ; Birch Pollen–Associated Food Allergy ; Allergy Vaccine Candidate ; Molecular Allergology ; Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    In: Movement Disorders, April 2016, Vol.31(4), pp.436-457
    Description: The system of assigning locus symbols to specify chromosomal regions that are associated with a familial disorder has a number of problems when used as a reference list of genetically determined disorders,including (I) erroneously assigned loci, (II) duplicated loci, (III) missing symbols or loci, (IV) unconfirmed loci and genes, (V) a combination of causative genes and risk factor genes in the same list, and (VI) discordance between phenotype and list assignment. In this article, we report on the recommendations of the International Parkinson and Movement Disorder Society Task Force for Nomenclature of Genetic Movement Disorders and present a system for naming genetically determined movement disorders that addresses these problems. We demonstrate how the system would be applied to currently known genetically determined parkinsonism, dystonia, dominantly inherited ataxia, spastic paraparesis, chorea, paroxysmal movement disorders, neurodegeneration with brain iron accumulation, and primary familial brain calcifications. This system provides a resource for clinicians and researchers that, unlike the previous system, can be considered an accurate and criterion‐based list of confirmed genetically determined movement disorders at the time it was last updated. © 2016 International Parkinson and Movement Disorder Society
    Keywords: Genetics ; Movement Disorders ; Nomenclature
    ISSN: 0885-3185
    E-ISSN: 1531-8257
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages