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  • 1
    In: International Journal of Urology, June 2013, Vol.20(6), pp.585-592
    Description: Byline: Sandra Steffens, Kristina I Ringe, Katharina Schroeer, Rieke Lehmann, Julia Rustemeier, Gerd Wegener, Mark Schrader, Rainer Hofmann, Markus A Kuczyk, Andres J Schrader, Keywords: body mass index; body surface area; obesity; prognosis; renal cell carcinoma; risk factors; visceral fat Objectives To assess the impact of overweight on prognosis of renal cell carcinoma patients. Patients And Methods A total of 2030 patients who underwent surgery for renal cell carcinoma from 1990 to 2011 in three University Medical Centers were included in this retrospective analysis. For all patients, height and weight measurements at the time of diagnosis were available for review. The median (mean) follow up was 56.6 months (66.0 months). Results A low body mass index was significantly associated with poor tumor differentiation, histology, microscopic vascular invasion and metastatic disease at the time of diagnosis. A lower-than-average body surface area - stratified according to the European average for men (1.98m.sub.2) and women (1.74m.sub.2) - was significantly related to older age, poor tumor differentiation, the histological subtype and microscopic vascular invasion. In addition, a low visceral fat area calculated in a subgroup of 133 evaluable patients was associated with a higher risk of advanced disease (pT3-4 and/or N/M+) at diagnosis. The tumor-specific 5-year survival rate was 71.3, 78.7 and 80.1%, for patients with a body mass index of, 〈25, 25-30 and a[yen]30. Multivariate analysis confirmed body mass index as an independent prognostic factor. Conclusion Our findings suggest that overweight represents an independent prognostic factor in renal cell carcinoma patients. Further research should address the question of why obese people have a higher incidence of renal cell carcinoma, but at the same time a significantly better prognosis than other patients, particularly in the case of localized disease. Author Affiliation:
    Keywords: Body Mass Index ; Body Surface Area ; Obesity ; Prognosis ; Renal Cell Carcinoma ; Risk Factors ; Visceral Fat
    ISSN: 0919-8172
    E-ISSN: 1442-2042
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  • 2
    Language: English
    In: BMC medical education, 17 April 2014, Vol.14, pp.82
    Description: Nursing staff are often involved in counseling patients with regard to health behavior. Although care promoting healthy lifestyle choices is included in the curriculum of nursing students in Germany, several studies of nursing students have reported a high prevalence of unhealthy behavior. This paper focuses on the behavior of female nursing students with regard to body mass index (BMI), physical activity, and cigarette and alcohol consumption. It describes trends through the comparison of results from 2008 and 2013. Data was collected in two waves at a regional medical training college. First, 301 nursing students were asked to fill out a 12 page questionnaire on health behavior in 2008. The questioning was repeated in 2013 with 316 participating nursing students using the previous questionnaire. 259 female nursing students completed the questionnaire in 2013. 31.6% of them were either overweight or obese, 28.5% exercised less than once a week, 42.9% smoked between 10 and 20 cigarettes a day and 72.6% drank alcohol, wherefrom 19.7% consumed alcohol in risky quantities. In comparison to the data of 266 female nursing students from 2008, there were significant differences in the BMI and alcohol consumption: The percentage of overweight and obese students and the percentage of alcohol consumers at risk increased significantly. Health behavior of female nursing students is often inadequate especially in regard to weight and cigarette and alcohol consumption. Strategies are required to promote healthy lifestyle choices.
    Keywords: Body Mass Index ; Sedentary Behavior ; Alcohol Drinking -- Epidemiology ; Smoking -- Epidemiology ; Students, Nursing -- Statistics & Numerical Data
    E-ISSN: 1472-6920
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  • 3
    Language: English
    In: Clinical Research in Cardiology, 2013, Vol.102(8), pp.607-614
    Description: Byline: Undine Pittl (1), Alexandra Schratter (2), Steffen Desch (1), Raluca Diosteanu (1), Denise Lehmann (1), Katharina Demmin (1), Jacqueline Horig (3), Gerhard Schuler (1), Thorsten Klemm (4), Meinhard Mende (5), Holger Thiele (1) Keywords: Resuscitation; Cardiac arrest; Hypothermia; Neuron-specific enolase; Outcome; Cooling-associated complications Abstract: Introduction Mild induced hypothermia (MIH) is indicated for comatose survivors of sudden cardiac arrest (SCA) to improve clinical outcome. In this study, we compared the efficacy of two different cooling devices for temperature management in SCA survivors. Methods Between April 2008 and August 2009, 80 patients after survived in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA) were included in this prospective, randomized, single center study. Hypothermia was induced after randomization by either invasive Coolgard.sup.(r) cooling or non-invasive ArcticSun.sup.(r) surface cooling at 33.0 degC core body temperature for 24 h followed by active rewarming. The primary endpoint was defined as the efficacy of both cooling systems, measured by neuron-specific enolase (NSE) levels as a surrogate parameter for brain damage. Secondary efficacy endpoints were the clinical and neurological outcome, time to start of cooling and reaching the target temperature, target temperature-maintenance and hypothermia-associated complications. Results NSE at 72 h did not differ significantly between the 2 groups with 16.5 ng/ml, interquartile range 11.8--46.5 in surface-cooled patients versus 19.0 ng/ml, interquartile range 11.0--42.0 in invasive-cooled patients, p = 0.99. Neurological and clinical outcome was similar in both groups. Target temperature of 33.0 degC was maintained more stable in the invasive group (33.0 versus 32.7 degC, p 〈 0.001). Bleeding complications were more frequent with invasive cooling (n = 17 [43.6 %] versus n = 7 [17.9 %] p = 0.03). Conclusion Invasive cooling has advantages with respect to temperature management over surface cooling however, did not result in different outcome as measured by NSE release in SCA survivors. Bleeding complications were more frequently encountered by invasive cooling. Author Affiliation: (1) Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, Strumpellstr. 39, 04289, Leipzig, Germany (2) Hospital Hietzing, Vienna, Austria (3) Hospital Freudenstadt, Freudenstadt, Germany (4) MVZ Laboratory Dr. Reising-Ackermann and Colleagues, Leipzig, Germany (5) University of Leipzig, Coordination Centre for Clinical Trials, Leipzig, Germany Article History: Registration Date: 17/04/2013 Received Date: 09/03/2013 Accepted Date: 17/04/2013 Online Date: 05/05/2013 Article note: Trial registration: ClinicalTrials.gov NCT: 00843297.
    Keywords: Resuscitation ; Cardiac arrest ; Hypothermia ; Neuron-specific enolase ; Outcome ; Cooling-associated complications
    ISSN: 1861-0684
    E-ISSN: 1861-0692
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  • 4
    Language: English
    In: Virchows Archiv, 2010, Vol.457(3), pp.369-380
    Description: Obliterative airway remodelling is a morphological sequence in a variety of pulmonary diseases. Notably, bronchiolitis obliterans represents one of the key complications of lung transplantation, induced by (immigrating) myofibroblasts. A comparative expression analysis of obliterative airway remodelling in transplanted and non-transplanted patients has not been reported so far. Obliterated and unremodelled airways from explanted lungs ( n  = 19) from patients suffering from chronic allograft dysfunction, infection, graft-versus-host disease and toxic exposure were isolated by laser-assisted microdissection. Airways from lung allografts harvested shortly before and after transplantation ( n  = 4) as well as fibroblastic foci from lungs with interstitial pulmonary fibrosis ( n  = 4) served as references. Pre-amplified cDNA was analysed by quantitative real-time RT-PCR for expression of fibrosis, inflammation and apoptosis-associated genes. Composition of infiltrating cells and protein expression were assessed by conventional histology and immunohistochemistry. Bronchiolitis obliterans in transplanted patients showed a significant increase of BMP-7 expression ( p  = 0.0141 compared with controls), while TGF-β1 and FGF-2 as well as BMP-4 and BMP-7 were up-regulated in fibroblastic foci in interstitial pulmonary fibrosis ( p  〈 0.0424 compared with controls). Regarding other fibrosis-associated genes (BMP-6, SMAD-3, CASP-3 and CASP-9, FASLG, NF-KB1, IL-1 and IL-2) as well as cellularity and cellular composition, no significant differences between obliterative airway remodelling in transplanted and non-transplanted patients could be shown. Obliterative airway remodelling in lung allografts and in non-transplanted patients share many morphological and genetic traits. BMPs, especially BMP-7, warrant further investigation as possible markers for the aggravation of airway remodelling.
    Keywords: Bronchiolitis obliterans ; Lung transplantation ; Fibrosis ; Airway remodelling
    ISSN: 0945-6317
    E-ISSN: 1432-2307
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  • 5
    Language: English
    In: J Neruology Research, 2013, Vol.3(2), pp.62-67
    Description: Background: Walking speed tests are common means to screen physical ability and are usually performed in an institutional setting. Little additional information is normally given about the environmental circumstances. This study aimed to evaluate the effect of different environments on walking speed....
    Keywords: Neurologi ; Neurology ; Sjukgymnastik ; Physiotherapy ; Polio; Mobility; Environment
    ISSN: 1923-2845
    E-ISSN: 19232853
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  • 6
    Language: English
    In: Developmental and Comparative Immunology, December 2014, Vol.47(2), pp.254-263
    Description: Polymorph-nuclear neutrophils (PMN) in cattle exhibit unique features when compared to human or murine PMN and are of particular interest concerning the risk of post-partum mammary gland or extra-mammary infections related to the periparturient suppression of neutrophil functions. Former studies could show that effects of IL-2 on innate immune cells such as PMN were mediated by the interleukin-2 receptor (IL-2R) β and γ chains. In the current study we could detect IL-2Rα (CD25) expression on bovine PMN using flow-cytometric analysis. CD25 was detected on granulocytes from post-partum and early lactating cows with different inflammatory conditions. The expression of CD25 on PMN in blood and raw milk increased with disease severity. Our results suggest CD25 expression on PMN as a potential biomarker for acute infections in cattle. Furthermore, our data provide a basis to better understanding of the periparturient functional suppressions of PMN that might reveal new molecular targets for therapy or prevention of disease.
    Keywords: Cd25 ; Interleukin-2 Receptor ; Pmn ; Bovine Neutrophil ; Biomarker ; Medicine ; Biology
    ISSN: 0145-305X
    E-ISSN: 1879-0089
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  • 7
    Language: English
    In: Clinical chemistry, November 2018, Vol.64(11), pp.1646-1656
    Description: Measurements of plasma or urinary metanephrines are recommended for diagnosis of pheochromocytoma and paraganglioma (PPGL). What test offers optimal diagnostic accuracy for patients at high and low risk of disease, whether urinary free metanephrines offer advantages over deconjugated metanephrines, and what advantages are offered by including methoxytyramine in panels all remain unclear. A population of 2056 patients with suspected PPGLs underwent prospective screening for disease using mass spectrometric-based measurements of plasma free, urinary deconjugated, and urinary free metanephrines and methoxytyramine. PPGLs were confirmed in 236 patients and were excluded in others on follow-up evaluation. Measurements of plasma free metabolites offered higher ( 〈 0.01) diagnostic sensitivity (97.9%) than urinary free (93.4%) and deconjugated (92.9%) metabolites at identical specificities for plasma and urinary free metabolites (94.2%) but at a lower ( 〈 0.005) specificity for deconjugated metabolites (92.1%). The addition of methoxytyramine offered little value for urinary panels but provided higher ( 〈 0.005) diagnostic performance for plasma measurements than either urinary panel according to areas under ROC curves (0.991 vs 0.972 and 0.964). Diagnostic performance of urinary and plasma tests was similar for patients at low risk of disease, whereas plasma measurements were superior to both urinary panels for high-risk patients. Diagnosis of PPGLs using plasma or urinary free metabolites provides advantages of fewer false-positive results compared with commonly measured deconjugated metabolites. The plasma panel offers better diagnostic performance than either urinary panel for patients at high risk of disease and, with appropriate preanalytics, provides the test of choice. Measurements of methoxytyramine in urine show limited diagnostic utility compared with plasma.
    Keywords: Metanephrine ; Adrenal Gland Neoplasms -- Diagnosis ; Chromaffin Cells -- Metabolism ; Dopamine -- Analogs & Derivatives ; Paraganglioma -- Diagnosis
    ISSN: 00099147
    E-ISSN: 1530-8561
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  • 8
    In: Laryngoscope Investigative Otolaryngology, October 2017, Vol.2(5), pp.325-330
    Description: Objectives/Hypothesis: The time course of the reinnervation of the paralyzed face after hypoglossal-facial jump nerve suture using electromyography (EMG) was assessed. The relation to the clinical outcome was analyzed.Study Design: Retrospective single-center cohort study.Methods: Reestablishment of motor units was studied by quantitative EMG and motor unit potential (MUP) analysis in 11 patients after hypoglossal-facial jump nerve suture. Functional recovery was evaluated using the Stennert index (0 = normal; 10 = maximal palsy).Results: Clinically, first movements were seen between 6 and 〉10 months after surgery in individual patients. Maximal improvement was achieved at 18 months. The Stennert index decreased from 7.9 ± 2.0 preoperatively to a final postoperative score of 5.8 ± 2.4. EMG monitoring performed for 2.8 to 60 months after surgery revealed that pathological spontaneous activity disappeared within 2 weeks. MUPs were first recorded after the 2nd month and present in all 11 patients 8-10 months post-surgery. Polyphasic regeneration potentials first appeared at 4-10 months post-surgery. The MUP amplitudes increased between the 3rd and 15th months after surgery to values of control muscles. The MUP duration was significantly increased above normal values between the 3rd and 24th months after surgery.Conclusion: Reinnervation can be detected at least 2 months earlier by EMG than by clinical evaluation. Changes should be followed for at least 18 months to assess outcome. EMG changes reflected the remodeling of motor units due to axonal regeneration and collateral sprouting by hypoglossal nerve fibers into the reinnervated facial muscle fibers.Level of Evidence: 3b.
    Keywords: Facial Nerve ; Hypoglossal Nerve ; Cross‐Nerve Suture ; Nerve Repair ; Muscle Reinnervation ; Motor Unit Potential ; Emg ; Regeneration
    ISSN: 2378-8038
    ISSN: 0023852X
    E-ISSN: 2378-8038
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  • 9
    Language: English
    In: Journal for ImmunoTherapy of Cancer, 2014, Vol.2(Suppl 3), p.P21
    Description: Adoptive immunotherapy using gene-modified T cells redirected against cancer has proven clinical efficacy and tremendous potential in several medical fields. However, such personalized medicine faces several challenges in the complexity associated with the current clinical manufacturing methods, which hampers dissemination.
    Keywords: Medicine;
    ISSN: 2051-1426
    Source: CrossRef
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  • 10
    Language: English
    In: Familial Cancer, 2017, Vol.16(1), pp.67-71
    Description: In a 14-year-old boy with polyposis and rectosigmoid carcinoma, we identified a novel POLE germline mutation, p.(Val411Leu), previously found as recurrent somatic mutation in ‘ultramutated’ sporadic cancers. This is the youngest reported cancer patient with polymerase proofreading-associated polyposis indicating that POLE mutation p.(Val411Leu) may confer a more severe phenotype than previously reported POLE and POLD1 germline mutations. The patient had multiple café-au-lait macules and a pilomatricoma mimicking the clinical phenotype of constitutional mismatch repair deficiency. We hypothesize that these skin features may be common to different types of constitutional DNA repair defects associated with polyposis and early-onset cancer.
    Keywords: Polymerase proofreading-associated polyposis ; Constitutional mismatch repair deficiency ; Café-au-lait macule ; Pilomatricoma ; Colon cancer
    ISSN: 1389-9600
    E-ISSN: 1573-7292
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