Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Medicine
Language
Year
  • 1
    In: Neurology, 2014, Vol.82(1), pp.77-79
    Description: Randomization is the standard means for addressing known and unknown confounders within the patient population in clinical trials. Although random assignment to treatment arms on a 1:1 basis has long been the norm, many 2-armed confirmatory trials now use unequal allocation schemes where the number of patients receiving investigational interventions exceeds those in the comparator arm. In what follows, we offer 3 arguments for why investigators, institutional review boards, and data and safety monitoring boards should exercise caution when planning or reviewing 2-armed confirmatory trials involving unequal allocation ratios. We close by laying out some of the conditions where uneven allocation can be justified ethically.
    Keywords: Medicine;
    ISSN: 0028-3878
    E-ISSN: 1526632X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Australian and New Zealand Journal of Psychiatry, February 2003, Vol.37(1), pp.1-4
    Keywords: Medicine
    ISSN: 0004-8674
    E-ISSN: 1440-1614
    Source: Sage Journals (Sage Publications)
    Source: SAGE Clinical Medicine (Sage Publications)
    Source: SAGE Health Sciences (Sage Publications)
    Source: SAGE STM (Sage Publications)
    Source: SAGE Neurology (Sage Publications)
    Source: SAGE Mental Health (Sage Publications)
    Source: SAGE Psychology (Sage Publications)
    Source: SAGE Communication and Media Studies (Sage Publications)
    Source: SAGE Journals (Sage Publications)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: The Journal of Allergy and Clinical Immunology, July 2013, Vol.132(1), pp.242-244
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jaci.2012.12.1571 Byline: Jonathan E. Phillips (a), Ruoqi Peng (a), Paul Harris (a), Lisa Burns (a), Lorena Renteria (a), Lennart K.A. Lundblad (b), Jay S. Fine (a), Carla M.T. Bauer (a), Christopher S. Stevenson (a) Author Affiliation: (a) Inflammation Discovery, pRED, Hoffmann-La Roche, Inc, Nutley, NJ (b) Vermont Lung Center, University of Vermont, Burlington, Vt Article Note: (footnote) Disclosure of potential conflict of interest: C. S. Stevenson, J. E. Phillips, R. Peng, P. Harris, L. Burns, L. Renteria, and C. M. T. Bauer are employed by Hoffmann-La Roche. L. K. A. Lundblad has received grants from Hoffman-La Roche and Merck, has consultant arrangements with Pfizer, is employed by the University of Vermont, and has received payment for the development of educational presentations from Jackson Labs. J. S. Fine is Executive Vice President of Boehringer Ingelheim Corporation.
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: BMJ (Clinical research ed.), 30 September 2014, Vol.349, pp.g5894
    Description: Nieuwenhuijse and colleagues’ article on the evidence base for introducing new implants in joint replacement along with Kesselheim and Rajan’s accompanying editorial on regulating incremental innovation in medical devices may engender concern in the wider medical community that new orthopaedic devices lack regulation.1 2 However, steps have already been taken in …
    Keywords: Orthopedic Procedures -- Instrumentation ; Orthopedics -- Legislation & Jurisprudence
    E-ISSN: 1756-1833
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: International Urogynecology Journal, 2013, Vol.24(9), pp.1547-1551
    Description: Byline: Ilias Giarenis (1), Jonathan Phillips (2), Heleni Mastoroudes (1), Sushma Srikrishna (1), Dudley Robinson (1), Cornelius Lewis (2), Linda Cardozo (1) Keywords: Effective dose; Radiation exposure; Urinary incontinence; Videourodynamics; Videocystourethrography Abstract: Introduction and hypothesis Our aim was to calculate the total radiation exposure and the dose absorbed by specific organs during videourodynamics (VUDS) in women. Methods This was a retrospective study of consecutive women attending for VUDS in a tertiary referral urodynamics unit. Tests with missing data and those that were terminated during the filling phase of the cystometry were excluded from the study. The VUDS examination was tailored according to the indication for the test and the urodynamic question to be answered. The PCXMC simulation program (version 2.0) was utilised to calculate the effective dose and the dose absorbed by individual organs. Results Out of 345 consecutive VUDS, 264 were included in the study. The mean effective dose was 0.34 mSv (SD: 0.15) and the mean fluoroscopic time was 63.15 s (SD: 21.81). Multivariate linear regression analysis of factors affecting the radiation dose showed that BMI (p=0.009) and fluoroscopy time (p〈0.001) were the only statistically significant factors. The final linear regression model for the estimation of the effective dose was Eff. Dose (mSv)=-0.049+0.003*BMI (kg/m.sup.2)+0.005*fluoroscopy time (s). Conclusions This study reveals that women are exposed to relatively small amounts of radiation during VUDS. The use of fluoroscopy only without additional static radiographic images minimises exposure to a level consistent with the "as low as reasonably achievable" radiological principle. Author Affiliation: (1) Department of Urogynaecology, King's College Hospital, London, SE5 9RS, UK (2) Department of Medical Engineering and Physics, King's College Hospital, London, UK Article History: Registration Date: 27/01/2013 Received Date: 12/10/2012 Accepted Date: 26/01/2013 Online Date: 22/02/2013
    Keywords: Effective dose ; Radiation exposure ; Urinary incontinence ; Videourodynamics ; Videocystourethrography
    ISSN: 0937-3462
    E-ISSN: 1433-3023
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: Journal of Pediatric Orthopaedics, 2012, Vol.32 Suppl 1 Supplement, pp.S32-S39
    Description: Although non-operative strategies remain a viable option for the management of some childrenʼs femur fractures, surgical management has become more popular and predictable, with potential complications better recognized and thus more easily avoided. This paper addresses the operative management of childrenʼs femur fractures highlighting the multiple techniques available to treat the spectrum of pediatric femur fractures. We present the applications of Elastic Stable Intramedullary Nailing and Locked intramedullary nailing, sub-muscular or open plating, and external fixation, and discuss the relative advantages and shortcomings of each technique. Cases are presented for illustration.
    Keywords: Medicine;
    ISSN: 0271-6798
    ISSN: 15392570
    E-ISSN: 15392570
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Journal of visualized experiments : JoVE, 06 April 2017(122)
    Description: Obstructive respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) are currently treated by inhaled anti-inflammatory and bronchodilator drugs. Despite the availability of multiple treatments, both diseases are growing public health concerns. The majority of asthma patients are well controlled on current inhaled therapies but a substantial number of patients with severe asthma are not. Asthma affects an estimated 300 million people worldwide and approximately 20 percent have a severe form of the disease. In contrast to asthma, there are few effective therapies for COPD. An estimated 10% of the population has COPD and the trend in death rates is increasing for COPD while decreasing for other major diseases. Although developing drugs for inhaled delivery is challenging, the nose-only inhalation unit enables direct delivery of novel drugs to the lung of rodents for pre-clinical efficacy and safety/toxicology studies. Inhaled drug delivery has multiple advantages for respiratory diseases, where high concentration in the lung improves efficacy and minimizes systemic side effects. Inhaled corticosteroids and bronchodilators benefit from these advantages and inhaled delivery may also hold potential for future biologic therapies. The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs of rodents, key data required before initiating clinical development.
    Keywords: Equipment Design ; Nose ; Bronchodilator Agents -- Administration & Dosage ; Drug Delivery Systems -- Instrumentation
    E-ISSN: 1940-087X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Disease Models & Mechanisms, 01 February 2015, Vol.8(2), pp.147-156
    Description: Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available. Children with NCL show a progressive decline in movement, vision and mental abilities, and an accumulation of autofluorescent...
    Keywords: Neuronal Ceroid Lipofuscinosis ; Batten Disease ; Tpp1 ; Tripeptidyl Peptidase 1 ; Dictyostelium ; Medicine ; Biology
    ISSN: 1754-8403
    E-ISSN: 1754-8411
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Clinical cancer research : an official journal of the American Association for Cancer Research, 01 July 2011, Vol.17(13), pp.4531-40
    Description: This study was designed to determine whether DNA methylation biomarkers are associated with recurrence and survival in colon cancer patients. A retrospective analysis of 82 patients who received curative surgical resection for American Joint Committee on Cancer (AJCC) high-risk stage II or III colon cancer (1999-2007) was conducted. DNA methylation status was quantitatively evaluated by the pyrosequencing method. We preselected three tumor suppressor genes and one locus of interest; CHFR, ID4, RECK, and MINT1. Mean methylation levels of multiple CpG sites in the promoter regions were used for analysis; 15% or more was defined as methylation positive. The association of recurrence-free survival (RFS) and overall survival (OS) with methylation status was analyzed by the log-rank test, Kaplan-Meier method, and Cox proportional hazards model. Methylation levels of ID4, MINT1, and RECK did not correlate with RFS or OS. CHFR was methylation positive in 63% patients. When methylation status was dichotomized (negative or low: 〈30%, high: ≥30%), patients with CHFR methylation-high (44%) had worse RFS (P = 0.006) and reduced OS (P = 0.069). When stratified by stage, CHFR methylation-high was associated with reduced RFS (P = 0.004) and OS (P = 0.010) in stage III patients. CHFR methylation-high was commonly associated with N2 disease (P = 0.04) and proximal tumors (P = 0.002). Multivariate analysis indicated AJCC T4 disease and CHFR methylation-high (P = 0.001 and P = 0.015, respectively) were independent predictors for recurrence. The extent of CHFR promoter methylation correlates with RFS, indicating it is a promising epigenetic marker for recurrence.
    Keywords: Cell Cycle Proteins -- Genetics ; Colonic Neoplasms -- Genetics ; DNA Methylation -- Genetics ; Neoplasm Proteins -- Genetics ; Promoter Regions, Genetic -- Genetics
    ISSN: 1078-0432
    E-ISSN: 15573265
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Physica Medica, September 2016, Vol.32, pp.324-324
    Description: IntroductionMulti-modal magnetic resonance imaging (MRI) combining T2-weighted imaging with advanced techniques such as diffusion-weighted imaging (DWI), dynamic contrast and proton spectroscopy is a promising tool for prostate cancer screening, staging and treatment planning. PurposeEvaluation and optimization of multi-modal MRI techniques for prostate cancer screening, staging and treatment planning. Materials and methodsParticipants at high risk of prostate cancer underwent MRI scans including T2-weighted imaging, DWI using echo planar readout, 3D chemical shift imaging (CSI) and dynamic contrast enhanced imaging on a 3T Siemens scanner with data acquisition using spine and surface coils only. The results were analyzed using vendor-supplied and in-house software and scored according to the “Prostate imaging reporting and data system (PI-RADS)” scoring system. ResultsDespite the promise of spectroscopic biomarkers as a diagnostic tool, the CSI spectra acquired using standard sequences proved generally of insufficient quality for reliable biomarker estimation. Scanner produced metabolite maps proved highly variable and prone to misidentification of metabolites due to poorly resolved peaks. Apparent diffusion coefficient (ADC) maps appeared diagnostically more useful although low signal and noise floor issues at higher b-values also affected the estimation of ADCs and apparent kurtosis observed at low b-values, casting some doubt on the reliability of high kurtosis values reported in the literature for prostate diffusion kurtosis imaging (DKI). ConclusionReliable quantification of spectroscopic biomarkers for prostate cancer requires improved protocols for CSI and spectroscopy. Apparent kurtosis observed for diffusion weighted images acquired at low maximum b-values are require further validation.
    Keywords: Medicine
    ISSN: 1120-1797
    E-ISSN: 1724-191X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages