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  • 1
    Language: English
    In: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, April 2014, Vol.20(4), pp.299-304
    Description: To establish the prevalence of reliable self-monitored blood glucose (r-SMBG) data at office visits for diabetes and to determine whether r-SMBG is associated with changes in glycemic control and other clinical parameters. We conducted a chart review of 500 patients followed in an Endocrinology Faculty/Commercial Insurance Practice (FP) or a Managed Medicare/Medicaid Diabetes Clinic (MDC). Follow-up visits for patients with type 1 or type 2 diabetes from January 1, 2012 to June 30, 2012 were analyzed for anthropometric data, creatinine (Cr), glomerular filtration rate (GFR), low-density lipoprotein cholesterol (LDL-C), medications, hemoglobin A1C (A1C), change in A1C from the previous visit (ΔA1C), and availability of r-SMBG data at the visit. Our sample was composed of 215 MDC patients (43%) and 285 FP patients (57%). Overall, 151 patients (30%) provided r-SMBG data at their visit, with no difference between MDC or FP patients. Mean A1C at MDC was 9.1%, while mean A1C at FP was 7.9% (P8.0% demonstrated an A1C reduction of 1.2% if they provided r-SMBG, compared to an increase of 0.1% for MDC patients who did not (P〈.05). Providing r-SMBG did not affect A1C in FP patients in any A1C range. Only a minority of diabetes patients, mostly insulin-treated, made r-SMBG data available to their providers. Insulin-requiring Managed Medicare/Medicaid patients with poorly controlled diabetes had an A1c reduction associated with r-SMBG. Prospective studies are needed to determine whether this patient population may be more likely to benefit from r-SMBG at their visits.
    Keywords: Blood Glucose Self-Monitoring ; Blood Glucose -- Analysis ; Diabetes Mellitus -- Blood
    ISSN: 1530-891X
    E-ISSN: 19342403
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  • 2
    Language: English
    In: International Journal of Environmental Research and Public Health, 01 August 2016, Vol.13(8), p.809
    Description: The objective of our study was to measure the impact of transportation-related noise and total environmental noise on sleep disturbance for the residents of Montreal, Canada. A telephone-based survey on noise-related sleep disturbance among 4336 persons aged 18 years and over was conducted. LNight for each study participant was estimated using a land use regression (LUR) model. Distance of the respondent’s residence to the nearest transportation noise source was also used as an indicator of noise exposure. The proportion of the population whose sleep was disturbed by outdoor environmental noise in the past 4 weeks was 12.4%. The proportion of those affected by road traffic, airplane and railway noise was 4.2%, 1.5% and 1.1%, respectively. We observed an increased prevalence in sleep disturbance for those exposed to both rail and road noise when compared for those exposed to road only. We did not observe an increased prevalence in sleep disturbance for those that were both exposed to road and planes when compared to those exposed to road or planes only. We developed regression models to assess the marginal proportion of sleep disturbance as a function of estimated LNight and distance to transportation noise sources. In our models, sleep disturbance increased with proximity to transportation noise sources (railway, airplane and road traffic) and with increasing LNight values. Our study provides a quantitative estimate of the association between total environmental noise levels estimated using an LUR model and sleep disturbance from transportation noise.
    Keywords: Transportation Noise ; Sleep Disturbance ; Land Use Regression ; Public Health
    ISSN: 16617827
    E-ISSN: 1660-4601
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  • 3
    Language: English
    In: Environmental health perspectives, November 2016, Vol.124(11), pp.1694-1699
    Description: The impact of heat waves on mortality and health inequalities is well documented. Very few studies have assessed the effectiveness of heat action plans (HAPs) on health, and none has used quasi-experimental methods to estimate causal effects of such programs. We developed a quasi-experimental method to estimate the causal effects associated with HAPs that allows the identification of heterogeneity across subpopulations, and to apply this method specifically to the case of the Montreal (Quebec, Canada) HAP. A difference-in-differences approach was undertaken using Montreal death registry data for the summers of 2000-2007 to assess the effectiveness of the Montreal HAP, implemented in 2004, on mortality. To study equity in the effect of HAP implementation, we assessed whether the program effects were heterogeneous across sex (male vs. female), age (≥ 65 years vs. 〈 65 years), and neighborhood education levels (first vs. third tertile). We conducted sensitivity analyses to assess the validity of the estimated causal effect of the HAP program. We found evidence that the HAP contributed to reducing mortality on hot days, and that the mortality reduction attributable to the program was greater for elderly people and people living in low-education neighborhoods. These findings show promise for programs aimed at reducing the impact of extreme temperatures and health inequities. We propose a new quasi-experimental approach that can be easily applied to evaluate the impact of any program or intervention triggered when daily thresholds are reached. Citation: Benmarhnia T, Bailey Z, Kaiser D, Auger N, King N, Kaufman J. 2016. A difference-in-differences approach to assess the effect of a heat action plan on heat-related mortality, and differences in effectiveness according to sex, age, and socioeconomic status (Montreal, Quebec). Environ Health Perspect 124:1694-1699; http://dx.doi.org/10.1289/EHP203.
    Keywords: Program Evaluation ; Socioeconomic Factors ; Heat Stress Disorders -- Mortality
    E-ISSN: 1552-9924
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 4
    Language: English
    In: Physiotherapy Theory and Practice, 01 January 2010, Vol.26(3), pp.167-172
    Description: Many trigger point therapies, such as deep pressure massage and injection, are painful. Thermal ultrasound might be a comfortable procedure used to soften trigger points. Our objective was to compare thermal ultrasound with sham ultrasound in...
    Keywords: Physical Therapy
    ISSN: 0959-3985
    E-ISSN: 1532-5040
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  • 5
    Language: English
    In: The American Journal of Drug and Alcohol Abuse, 01 January 2005, Vol.31(3), pp.455-469
    Description: This study examined whether an EEG biofeedback protocol could improve outcome measures for a mixed substance abusing inpatient population. Method: One hundred twenty-one volunteers undergoing an inpatient substance abuse program were randomly...
    Keywords: EEG ; Biofeedback ; EEG Biofeedback ; Addiction Treatment ; Chemical Dependency ; Alpha-Theta ; Tova ; Mmpi ; Social Welfare & Social Work
    ISSN: 0095-2990
    E-ISSN: 1097-9891
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  • 6
    Language: English
    In: American Journal of Health Promotion, May 2018, Vol.32(4), pp.963-970
    Description: Purpose: To estimate the effects of a workplace initiative to reduce work–family conflict on employee performance. Design: A group-randomized multisite controlled experimental study with longitudinal follow-up. Setting: An information technology firm. Participants: Employees randomized...
    Keywords: Work–Family Conflict ; Workplace Intervention ; Workplace Flexibility ; Supervisor Support ; Field Experiment ; Performance ; Productivity ; Well-Being ; Public Health
    ISSN: 0890-1171
    E-ISSN: 2168-6602
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  • 7
    In: Archives of Ophthalmology, May, 2001, Vol.119(5), p.667
    Description: Objective: To assess, the course of change of visual function outcome variables in 5 patients with gyrate atrophy before a gene replacement therapy clinical trial. Methods: The outcome variables selected were visual field sensitivity and electroretinogram amplitude. The course of change of these outcome variables was determined by calculation of their half-lives. Results: In the 4 to 6 years during which each patient was followed up for this study, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). Conclusions: The course of the decline of visual function outcome variables is frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function. Arch Ophthalmol. 2001;119:667-669
    Keywords: Retinal Diseases -- Care And Treatment ; Gene Therapy -- Usage
    ISSN: 0003-9950
    E-ISSN: 15383601
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  • 8
    Language: English
    In: Journal of Pharmaceutical Sciences, February 1974, Vol.63(2), pp.219-221
    Description: To evaluate the pharmacokinetics and drug availability from various dosage formulations, a method for the determination of ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] in human plasma was required. A simple, rapid, sensitive, and specific procedure, based on a benzene extraction of the acidified specimen and subsequent GLC analysis of the methyl esters of the extract residue, was developed. The method is sensitive to 0.5 μg ibuprofen/ml plasma. Statistical analyses indicate an average recovery of 94.8 ±6.6% (SD), which is adequate to differentiate assay error from normal biological variation. Mass spectrometric analysis, in conjunction with GLC, confirmed the specificity of the method for intact drug. The procedure was successfully applied to drug absorption studies in humans.
    Keywords: Ibuprofen—Glc Analysis in Human Plasma ; (±)- 2-(P-Isobutylphenyl)Propionic Acid (Ibuprofen)—Glc Analysis in Human Plasma ; Glc—Analysis, Ibuprofen in Human Plasma ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0022-3549
    E-ISSN: 1520-6017
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  • 9
    Language: English
    In: Journal of Pharmaceutical Sciences, May 1975, Vol.64(5), pp.798-801
    Description: To study the behavior of the d- and l-isomers of ibuprofen in humans, a method for the determination of the individual enantiomers in plasma and urine was required. A specific procedure was developed based on (a) benzene extraction of the acidified specimens, (b) TLC of the benzene extract residue, (c) formation of the l-alpha-methylbenzylamides of the materials eluted from the chromatograms, and (d) quantification of the resulting diastereoisomeric amides by GLC in conjunction with flame-ionization detection. When using a 1-ml aliquot of the specimen, the method is sensitive to 1 mug of each enantiomer/ml of plasma or urine. As compared to simple aqueous solutions, the average recoveries of the enantiomers from plasma and urine ranged from 94 to96%. Mass spectrometric analyses, in conjunction with GLC, confirmed the specificity of the method for the intact enantiomers. The procedure was applied successfully to drug absorption studies in humans. After oral administration of the racemic mixture, the predominant enantiomer in peripheral circulation and excreted in urine was of the d-configuration.
    Keywords: Ibuprofen—Glc Determination of Enantiomers in Biological Specimens ; Glc-Determination, Ibuprofen Enantiomers in Biological Specimens ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0022-3549
    E-ISSN: 1520-6017
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  • 10
    In: British Journal of Haematology, August 2013, Vol.162(3), pp.348-359
    Description: Multiple myeloma () is a heterogeneous disease. International Staging System/fluorescence hybridization (/)‐based model and gene expression profiles () are effective approaches to define clinical outcome, although yet to be improved. The discovery of a class of small non‐coding s (micro s, mis) has revealed a new level of biological complexity underlying the regulation of gene expression. In this work, 163 presenting samples from patients were analysed by global mi profiling, and distinct mi expression characteristics in molecular subgroups with prognostic relevance (4p16, and 11q13 translocations) were identified. Furthermore we developed an “outcome classifier”, based on the expression of two mis (17 and 886‐5p), which is able to stratify patients into three risk groups (median 19·4, 40·6 and 65·3 months, =0·001). The mi‐based classifier significantly improved the predictive power of the / approach (=0·0004), and was independent of ‐derived prognostic signatures (〈0·002). Through integrative genomics analysis, we outlined the potential biological relevance of the mis included in the classifier and their putative roles in regulating a large number of genes involved in biology. This is the first report showing that mis can be built into molecular diagnostic strategies for risk stratification in .
    Keywords: Myeloma ; Micro ; Risk Stratification ; Outcome Classifier ; Genomic Profiling
    ISSN: 0007-1048
    E-ISSN: 1365-2141
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