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  • 1
    In: Bone Marrow Transplantation, 2017
    Keywords: Allografts–Blood ; Bone Marrow Transplantation–Blood ; Donor Selection–Therapy ; Female–Therapy ; HLA Antigens–Therapy ; Humans–Therapy ; Isoantibodies–Therapy ; Leukemia, Myelogenous, Chronic, BCR-Abl Positive–Therapy ; Middle Aged–Therapy ; Tissue Donors–Therapy ; HLA Antigens ; Isoantibodies;
    ISSN: 0268-3369
    E-ISSN: 1476-5365
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  • 2
    In: British Journal of Dermatology, September 2006, Vol.155(3), pp.600-607
    Description: In previous studies, distinct immunological abnormalities have been reported in localized scleroderma (LS). Several pro‐inflammatory cytokines have been demonstrated at increased levels in sera of patients with LS in parallel with disease activity. Human ‐defensins (hBDs) are peptides with antimicrobial activity, but have been also shown to be implicated in tissue injury, scarring and wound healing. hBD expression in LS, a condition resembling pathological scarring due to excessive stimulation of matrix synthesis and fibroblast activation, has so far not been investigated. Ultraviolet (UV) A1 phototherapy, the most recent advance in the treatment of LS, targets T‐cell dermal inflammatory infiltrates via induction of various cytokines and soluble factors besides well‐known effects on collagen metabolism. We sought to investigate the effects of UVA1 on the expression and modulation of hBDs and several pro‐inflammatory cytokines in LS. UVA1 phototherapy was performed five times weekly for 8 weeks resulting in a total of 40 treatment sessions (single dose 20 J cm, cumulative dose 800 J cm). hBD‐1, hBD‐2 and hBD‐3 mRNA as well as tumour necrosis factor‐, transforming growth factor‐, interleukin (IL) ‐2, IL‐4, IL‐6 and IL‐8 mRNA expression were determined by quantitative real‐time reverse transcription‐polymerase chain reaction in lesional and unaffected skin of patients with LS. Skin status markedly improved in all 14 patients, resulting in a significant reduction of the clinical score from baseline to the end of treatment. hBD‐1, hBD‐2 and hBD‐3 mRNA levels were higher in lesional skin compared with unaffected skin and skin from healthy volunteers. Following UVA1 phototherapy, hBD‐1 mRNA decreased in lesional, but not in unaffected skin. hBD‐3 mRNA levels significantly decreased after UVA1 in lesional skin, whereas an increase of hBD‐3 was observed in unaffected skin. IL‐6 and IL‐8 mRNA levels were significantly elevated in lesional skin and significantly decreased after UVA1 irradiation, whereas mRNA for both cytokines remained unchanged in irradiated unaffected skin. The decrease of hBD‐1, hBD‐3, IL‐6 and IL‐8 mRNA paralleled the extent of disease and response to UVA1 phototherapy. hBDs and IL‐6 and IL‐8, cytokines with pivotal importance in sclerotic skin diseases, are downregulated by UVA1 in the lesional skin of patients with LS. Their pathogenetic relevance with respect to clinical improvement needs further investigation.
    Keywords: Human Beta Defensins ; Interleukin‐6 ; Interleukin‐8 ; Localized Scleroderma ; Ultraviolet‐A1 Irradiation
    ISSN: 0007-0963
    E-ISSN: 1365-2133
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  • 3
    Language: English
    In: Acta dermato-venereologica, 2000, Vol.80(5), pp.390-1
    Keywords: Ultraviolet Therapy ; Parapsoriasis -- Radiotherapy
    ISSN: 0001-5555
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 4
    Language: German
    In: Deutsche Medizinische Wochenschrift, 2009, Vol.134(11), pp.517-518
    Description: Was sehen Sie? Die 58-jährige Patientin war bis vor 3 Jahren starke Raucherin gewesen (insgesamt 40 Packungsjahre). Das Röntgen-Thoraxbild zeigt zwei auffällige Befunde. Welche sind das? Erlauben diese Befunde eine Diagnose? Wenn ja, welche? Sind Differenzialdiagnosen möglich? Wenn ja, welche? Auflösung
    Keywords: Bronchoscopy–Methods ; Diagnosis, Differential–Diagnostic Imaging ; Female–Etiology ; Humans–Surgery ; Middle Aged–Diagnostic Imaging ; Pulmonary Disease, Chronic Obstructive–Etiology ; Pulmonary Emphysema–Surgery ; Radiography, Thoracic–Methods ; Smoking–Adverse Effects;
    ISSN: 0012-0472
    E-ISSN: 14394413
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  • 5
    Language: English
    In: Psychopharmacology, 1982, Vol.76(3), pp.236-239
    Description: Twenty-nine inpatients with primary affective disorder were treated with 150 mg amitriptyline (AT) daily for 28 days. Pretreatment urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was measured in two or three 24-h urine samples. Plasma levels of AT and nortriptyline (NT) were determined after 14, 21, and 28 days of treatment. MHPG excretion was significantly correlated with clinical response to treatment. Responders defined by two different methods showed higher pretreatment MHPG excretion than nonresponders. Correspondingly, high MHPG excretors (median split) showed significantly more improvement than low excretors. These relationships were even more apparent when possibly incomplete urine samples (creatinine excretion below 1000 mg/24 h) were excluded. The high and low MHPG subgroups did not significantly differ from each other in their plasma levels of AT, NT, or AT plus NT. A significant rank correlation between clinical response and plasma levels of AT and/or NT did not exist, but there was a trend towards lower levels in responders.
    Keywords: Methoxy-4-hydroxyphenylglycol ; MHPG ; Amitriptyline ; Plasma drug level ; Drug response
    ISSN: 0033-3158
    E-ISSN: 1432-2072
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  • 6
    Language: German
    In: Deutsche Medizinische Wochenschrift, 2009, Vol.134(11), pp.506-510
    Description: Zusammenfassung Hintergrund und Fragestellung: Bei Patienten mit heterogenem Lungenemphysem kann eine bronchoskopische Lungenvolumenreduktion (LVR) Lungenfunktion und Belastbarkeit verbessern. Untersucht wurden Durchführbarkeit und Sicherheit einer endoskopischen Ventilimplantation bei Patienten mit schwerem homogenem Emphysem. Patienten und Methoden: Zehn Patienten (5 Frauen, 5 Männer; mittleres Alter 60 [54 – 71] Jahre) wurden prospektiv in die Pilotstudie eingeschlossen. Die Homogenität des Emphysems wurde durch eine Computeranalyse der Computertomographie des Thorax bestätigt. Alle endobronchialen Ventile (EBV) wurden mit einem flexiblen Bronchoskop in Vollnarkose platziert; jeweils der Lungenlappen mit der szintigraphisch geringsten Perfusion wurde verschlossen. Endpunkte der Studie waren Lungenfunktion, Lebensqualität und die Gehstrecke im 6-Minuten-Gehtest (6-MWT) an Tag 30 und Tag 90 sowie die Sicherheit dieses Verfahrens. Ergebnisse: Vor Intervention lagen die forcierte Einsekundenkapazität (FEV1) bei 0,93 l (0,55 – 1,35 l), das Residualvolumen (RV) bei 5,23 l (3,55 – 8,24 l) und die Gehstrecke im 6-MWT bei 325 Metern (150 – 480 m). Nach bronchoskopischer EBV-Implantation wurde eine klinische Verbesserung der Dyspnoe und der Belastbarkeit bei 7 von 10 Patienten gesehen. In der Lungenfunktion zeigte sich keine signifikante Verbesserung an Tag 30 und 90, aber ein Trend zur Verbesserung der Gehstrecke (ΔMW + 10,4 ± 9,8 %). Ein Pneumothorax wurde beobachtet, in einem Fall mussten die Ventile aufgrund rezidivierender Infekte nach 90 Tagen explantiert werden. Folgerung: Eine bronchoskopische LVR ist auch bei Patienten mit einem schweren homogenen Lungenemphysem machbar und erscheint sicher. Möglicherweise ergibt sich – im Gegensatz zur chirurgischen LVR – für diese Patientengruppe ein neuer Therapieansatz. Größere klinische Studien sind zur Bestimmung der Auswahlkriterien und der Effektivität notwendig.
    Description: SummaryBackground and objective: After bronchoscopic lung-volume reduction (LVR) improvement in pulmonary function and exercising tolerance can be achieved in patients with severe heterogeneous lung emphysema. Feasibility and safety for one-way valve placement in homogeneous emphysema were evaluated.Patients and methods: Ten patients entered this prospective study. In all cases a homogeneous distribution was confirmed by computer analysis of the CT-scans. We performed unilateral LVR and occluded the lobe with the lowest perfusion, measured by nuclear scintigraphy. Endpoints of the study were changes in lung function test, quality of life and 6-minutes-walk-test (6-MWT) at day 30 and 90 and the safety of the procedure.Results: Preoperative mean forced expiratory volume in 1 second (FEV1) was 0.93 l (range 0.55 – 1.35 l), mean residual volume was 5.23 l (3.55 – 8.24 l) and 6-MWT was 325 m ( 150 – 480 m). Improvement of dyspnoe and exercising tolerance was reported in 7 cases. No major changes in lung function were evident at days 30 and 90. A trend towards improvement was observed in 6-MWT (ΔMW + 10.4 ± 9.8 %). One pneumothorax was noticed, in one case the valves were removed after 90 days because of recurrent infections.Conclusions: This study shows that bronchoscopic LVR in patients with severe homogeneous emphysema is feasible and seems to be safe. In contrast to surgical LVR patients may have a cinical benefit by bronchoscopic treatment. Longtime follow –up and patient selection criteria have to be examined in larger trials.
    Keywords: Homogenes Lungenemphysem ; Bronchoskopische Lungenvolumenreduktion (Blvr) ; Endobronchiales Ventil (Ebv) ; Endoskopische Ventilimplantation ; Homogeneous Lung Emphysema ; Bronchoscopic Lung Volume Reduction (Blvr) ; Endobronchial Valve (Ebv) ; Endoscopic Valve Placement
    ISSN: 0012-0472
    E-ISSN: 14394413
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  • 7
    Language: English
    In: Health Education Research, 12/01/2011, Vol.26(6), pp.937-947
    Description: News stories reporting race-specific health information commonly emphasize disparities between racial groups. But recent research suggests this focus on disparities has unintended effects on African American audiences, generating negative emotions and less interest in preventive behaviors (Nicholson RA, Kreuter MW, Lapka C et al. Unintended effects of emphasizing disparities in cancer communication to African-Americans. Cancer Epidemiol Biomarkers Prev 2008; 17: 2946-52). They found that black adults are more interested in cancer screening after reading about the progress African Americans have made in fighting cancer than after reading stories emphasizing disparities between blacks and whites. This study builds on past findings by (i) examining how health journalists judge the newsworthiness of stories that report race-specific health information by emphasizing disparities versus progress and (ii) determining whether these judgments can be changed by informing journalists of audience reactions to disparity versus progress framing. In a double-blind-randomized experiment, 175 health journalists read either a disparity- or progress-framed story on colon cancer, preceded by either an inoculation about audience effects of such framing or an unrelated (i.e. control) information stimuli. Journalists rated the disparity-frame story more favorably than the progress-frame story in every category of news values. However, the inoculation significantly increased positive reactions to the progress-frame story. Informing journalists of audience reactions to race-specific health information could influence how health news stories are framed. Adapted from the source document.
    Keywords: Health Inequalities ; Journalists ; Cancer ; Black American People ; Framing ; News ; Article;
    ISSN: 0268-1153
    E-ISSN: 1465-3648
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  • 8
    Language: English
    In: Rheumatology, 04/01/2012, Vol.51(4), pp.735-742
    Description: OBJECTIVES: To assess the prevalence and risk factors of ulnar artery occlusion (UAO) in an unselected SSc patient cohort and to determine whether UAO is associated with digital ulcers (DUs).METHODS: A total of 79 SSc patients and 40 'healthy' controls underwent colour duplex sonography of the radial and ulnar artery to compare blood flow velocity, resistive indices (RIs) and presence of occlusion and were followed for a mean of 53 months.RESULTS: In both, radial and ulnar arteries, peak systolic velocity (PSV) and end-diastolic velocity (EDV) were significantly lower and RI higher in SSc patients compared with controls (PSVrad: 40.1 vs 48.6 cm/s; PSVuln 38.2 vs 56.6 cm/s; EDVrad 3.8 vs 10.4 cm/s; EDVuln 3.0 vs 13.0 cm/s; RIrad 0.91 vs 0.82; RIuln 0.92 vs 0.80; all P 〈 0.01). Seventeen (21.5%) SSc patients had UAO (11 patients bilateral) compared with none in the control subjects. Patients with UAO had a significantly longer disease duration (170 vs 66 months, P 〈 0.001). At baseline, the prevalence of DU was not different in upper extremities with UAO [8/28 (28.6%)] compared with upper extremities without UAO [36/129 (27.9%)]. However, during follow-up new or recurrent DU occurred more often in upper extremities with UAO than in those without UAO [14/28 (50%) vs 24/113 (21.2%); relative risk (RR) = 2.4; 95% CI 1.4, 3.7; P = 0.002].CONCLUSION: Blood flow is significantly decreased in radial and ulnar arteries in SSc. UAO is frequent and an important risk factor for the development of DUs in patients with SSc.
    Keywords: Medicine;
    ISSN: 1462-0324
    E-ISSN: 1462-0332
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  • 9
    In: Health Education Research, 2015, Vol. 30(1), pp.107-120
    Description: Blue-collar workers, particularly those in the construction trades, are more likely to smoke and have less success in quitting when compared with white-collar workers. Little is known about health communication strategies that might influence this priority population. This article describes our formative work to develop targeted messages to increase participation in an existing smoking cessation program among construction workers. Using an iterative and sequential mixed-methods approach, we explored the culture, health attitudes and smoking behaviors of unionized construction workers. We used focus group and survey data to inform message development, and applied audience segmentation methods to identify potential subgroups. Among 144 current smokers, 65% reported wanting to quit smoking in the next 6 months and only 15% had heard of a union-sponsored smoking cessation program, despite widespread advertising. We tested 12 message concepts and 26 images with the target audience to evaluate perceived relevance and effectiveness. Participants responded most favorably to messages and images that emphasized family and work, although responses varied by audience segments based on age and parental status. This study is an important step towards integrating the culture of a high-risk group into targeted messages to increase participation in smoking cessation activities.
    Keywords: Public Health;
    ISSN: 0268-1153
    E-ISSN: 1465-3648
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  • 10
    In: Health Education Research, 2018, Vol. 33(3), pp.256-259
    Description: The aim of this study was to assess the effect of a creating a smoke-free home (SFH) on cessation and reduction of cigarette smoking on low-income smokers. This secondary data analysis uses data from study participants who were originally recruited through 2-1-1 information and referral call centers in Atlanta (Georgia, 2013), North Carolina (2014) and the Texas Gulf Coast (2015) across three randomized controlled trials testing an intervention aimed at creating SFHs, pooling data from 941 smokers. Participants who reported adopting a SFH were more likely to report quitting smoking than those who did not adopt a SFH. This was true at 3-month follow-up and even more pronounced at 6-month follow-up and persisted when considering only those who consistently reported no smoking at 3 and 6 months. Among those who did not stop smoking, the number of cigarettes per day declined significantly more and quit attempts were more frequent for those who created a SFH compared with those who did not. Findings suggest that creating a SFH facilitates cessation, reduces cigarette consumption and increases quit attempts. Future studies should assess the long-term impact of SFHs on sustaining cessation.
    Keywords: Public Health;
    ISSN: 0268-1153
    E-ISSN: 1465-3648
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