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  • Obesity
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  • 1
    In: International Journal of Urology, June 2013, Vol.20(6), pp.585-592
    Description: Byline: Sandra Steffens, Kristina I Ringe, Katharina Schroeer, Rieke Lehmann, Julia Rustemeier, Gerd Wegener, Mark Schrader, Rainer Hofmann, Markus A Kuczyk, Andres J Schrader, Keywords: body mass index; body surface area; obesity; prognosis; renal cell carcinoma; risk factors; visceral fat Objectives To assess the impact of overweight on prognosis of renal cell carcinoma patients. Patients And Methods A total of 2030 patients who underwent surgery for renal cell carcinoma from 1990 to 2011 in three University Medical Centers were included in this retrospective analysis. For all patients, height and weight measurements at the time of diagnosis were available for review. The median (mean) follow up was 56.6 months (66.0 months). Results A low body mass index was significantly associated with poor tumor differentiation, histology, microscopic vascular invasion and metastatic disease at the time of diagnosis. A lower-than-average body surface area - stratified according to the European average for men (1.98m.sub.2) and women (1.74m.sub.2) - was significantly related to older age, poor tumor differentiation, the histological subtype and microscopic vascular invasion. In addition, a low visceral fat area calculated in a subgroup of 133 evaluable patients was associated with a higher risk of advanced disease (pT3-4 and/or N/M+) at diagnosis. The tumor-specific 5-year survival rate was 71.3, 78.7 and 80.1%, for patients with a body mass index of, 〈25, 25-30 and a[yen]30. Multivariate analysis confirmed body mass index as an independent prognostic factor. Conclusion Our findings suggest that overweight represents an independent prognostic factor in renal cell carcinoma patients. Further research should address the question of why obese people have a higher incidence of renal cell carcinoma, but at the same time a significantly better prognosis than other patients, particularly in the case of localized disease. Author Affiliation:
    Keywords: Body Mass Index ; Body Surface Area ; Obesity ; Prognosis ; Renal Cell Carcinoma ; Risk Factors ; Visceral Fat
    ISSN: 0919-8172
    E-ISSN: 1442-2042
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  • 2
    Language: English
    In: BMC medical education, 17 April 2014, Vol.14, pp.82
    Description: Nursing staff are often involved in counseling patients with regard to health behavior. Although care promoting healthy lifestyle choices is included in the curriculum of nursing students in Germany, several studies of nursing students have reported a high prevalence of unhealthy behavior. This paper focuses on the behavior of female nursing students with regard to body mass index (BMI), physical activity, and cigarette and alcohol consumption. It describes trends through the comparison of results from 2008 and 2013. Data was collected in two waves at a regional medical training college. First, 301 nursing students were asked to fill out a 12 page questionnaire on health behavior in 2008. The questioning was repeated in 2013 with 316 participating nursing students using the previous questionnaire. 259 female nursing students completed the questionnaire in 2013. 31.6% of them were either overweight or obese, 28.5% exercised less than once a week, 42.9% smoked between 10 and 20 cigarettes a day and 72.6% drank alcohol, wherefrom 19.7% consumed alcohol in risky quantities. In comparison to the data of 266 female nursing students from 2008, there were significant differences in the BMI and alcohol consumption: The percentage of overweight and obese students and the percentage of alcohol consumers at risk increased significantly. Health behavior of female nursing students is often inadequate especially in regard to weight and cigarette and alcohol consumption. Strategies are required to promote healthy lifestyle choices.
    Keywords: Body Mass Index ; Sedentary Behavior ; Alcohol Drinking -- Epidemiology ; Smoking -- Epidemiology ; Students, Nursing -- Statistics & Numerical Data
    E-ISSN: 1472-6920
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  • 3
    Language: German
    In: PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie, 2016, Vol.66(12), pp.465-472
    Keywords: Bindungsstil ; Bariatrische operation ; Adipositas ; Gewichtsverlust ; Operationsergebnis ; Attachment style ; Bariatric surgery ; Obesity ; Weight loss ; Outcome of surgery
    ISSN: 0937-2032
    E-ISSN: 1439-1058
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  • 4
    Language: English
    In: Obesity Facts, October 2010, Vol.3(5), pp.328-331
    Description: Elevated visceral adipose tissue-derived serpin (vaspin) serum concentrations are associated with impaired insulin sensitivity, but increase unexpectedly after long-term physical training. We therefore investigated the effect of an acute exercise bout and the effects of vitamin supplementation on chronic exercise effect and on serum vaspin concentrations. We measured serum vaspin and thiobarbituric acid-reactive substances (TBARS) concentrations in 80 individuals before and after a 1-hour acute exercise bout and independently in 40 healthy young men who were randomly assigned to either antioxidant (vitamin C (1,000 mg/day) and vitamin E (400 IU/day)) or to no supplementation after a standardized 4-week physical training program as a post hoc analysis. Serum vaspin concentrations significantly decreased after acute physical exercise as well as after 4 weeks of training in individuals without antioxidants. Changes in vaspin serum concentration correlate with increased TBARS serum concentrations both in response to a 1-hour exercise bout (r = –0.42, p 〈 0.01) and to the 4-week training (r = –0.31, p 〈 0.05). Interestingly, supplementation with antioxidants rather increased circulating vaspin levels in response to 4 weeks of exercise. In conclusion, vaspin serum concentrations are decreased by exercise-induced oxidative stress, but not by exercise-associated improvement in insulin sensitivity.
    Keywords: Short Communication ; Obesity ; Type 2 Diabetes ; Vaspin ; Exercise ; Antioxidants ; Oxidative Stress ; Insulin Sensitivity ; Medicine
    ISSN: 1662-4025
    E-ISSN: 1662-4033
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  • 5
    Language: English
    In: Cardiovascular Revascularization Medicine, March 2016, Vol.17(2), pp.88-94
    Description: Obesity with its worldwide growing prevalence is an established cardiovascular risk factor with increased morbidity and mortality. However, the phenomenon, that mild to moderate obesity seems to represent a protective effect on diseases has been termed the “obesity paradox”. We retrospectively assessed 529 patients (72.6% male, mean age 59.7 ± 12.7 years) admitted with ST-elevation myocardial infarction (STEMI). The female and male study populations were separated into four body mass index (BMI) groups: ≤ 24.9 kg/m , 25.0–29.9 kg/m , 30.0–34.9 kg/m and ≥ 35.0 kg/m . Blood samples of high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were analyzed. With increasing BMI group the rate of major adverse cardiac events (MACE) decreased in all patients (test for trend = 0.041). No gender difference between MACE and BMI could be noticed ( = 0.16). A higher risk for MACE was indicated in group BMI ≤ 18.5 kg/m in comparison to group BMI 25.0–29.9 kg/m (OR: 7.93; 95% CI: 1.75–35.89; = 0.0091), whereas group BMI 30.0–34.9 kg/m was significant associated with a lower risk in comparison to group BMI 25.0–29.9 kg/m (OR: 0.65; 95% CI: 0.21–1.96; = 0.044). An association between HDL-c ( = 0.55) or LDL-c ( = 0.10) and MACE could not be detected. The study demonstrates that patients with STEMI and a BMI of 30.0–34.9 kg/m have a decreased risk for MACE compared to patients with normal BMI. No gender related differences were indicated. An association between MACE and lipoproteins could not be detected.
    Keywords: Body Mass Index ; Major Adverse Cardiac Events ; Obesity ; St-Segment Elevation Myocardial Infarction ; Medicine
    ISSN: 1553-8389
    E-ISSN: 1878-0938
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  • 6
    Language: English
    In: International journal of obesity (2005), February 2019, Vol.43(2), pp.263-275
    Description: Obesity-associated activation of sympathetic nervous outflow is well documented, whereas involvement of dysregulated adrenomedullary hormonal function in obesity is less clear. This study assessed relationships of sympathoadrenal function with indices of obesity and influences of circulating catecholamines on body mass. Anthropometric and clinical data along with plasma and 24-h urine samples were collected from 590 volunteers and 1368 patients tested for phaeochromocytoma and paraganglioma (PPGL), among whom tumours were diagnosed in 210 individuals. Among patients tested for PPGL, those with tumours less often had a body mass index (BMI) above 30 kg/m (12 vs. 31%) and more often a BMI under 25 kg/m (56 vs. 32%) than those without tumours (P 〈 0.0001). Urinary outputs of catecholamines in patients with PPGL were negatively related to BMI (r = -0.175, P = 0.0133). Post-operative weight gain (P 〈 0.0001) after resection of PPGL was positively related to presurgical tumoural catecholamine output (r = 0.257, P = 0.0101). Higher BMI in men and women and percent body fat in women of the volunteer group were associated with lower plasma concentrations and urinary outputs of adrenaline and metanephrine, the former indicating obesity-related reduced adrenaline secretion and the latter obesity-related reduced adrenomedullary adrenaline stores. Daytime activity was associated with substantial increases in urinary adrenaline and noradrenaline excretion, with blunted responses in obese subjects. The findings in patients with PPGL support an influence of high circulating catecholamines on body weight. Additional associations of adrenomedullary dysfunction with obesity raise the possibility of a permissive influence of the adrenal medulla on the regulation of body weight.
    Keywords: Tumors ; Anthropometry ; Body Mass Index ; Noradrenaline ; Obesity ; Outflow ; Adrenal Glands ; Patients ; Norepinephrine ; Adrenal Glands ; Outflow ; Tumors ; Excretion ; Excretion ; Paraganglioma ; Urine ; Catecholamine ; Body Mass Index ; Adrenal Medulla ; Body Weight ; Urine ; Secretion ; Catecholamines ; Cell Activation ; Excretion ; Tumors ; Sympathetic Nervous System ; Epinephrine ; Body Mass ; Body Weight ; Obesity ; Body Size ; Body Weight ; Obesity ; Urine ; Tumors ; Obesity ; Phaeochromocytoma ; Body Fat;
    ISSN: 03070565
    E-ISSN: 1476-5497
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