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Berlin Brandenburg

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  • 1
    Language: English
    In: Therapeutic Advances in Urology, June 2012, Vol.4(3), pp.133-138
    Description: Penile cancer is an aggressive disease and after systemic progression it is virtually incurable. While this squamous cell cancer responds to chemotherapy, successful treatment of lymphatic metastases can only be achieved with aggressive surgical treatment in combination with chemotherapy. However, because penile carcinoma is relatively rare there is a paucity of clinical data on the chemotherapy for this aggressive disease. Recent advances have included the establishment of less toxic regimens incorporating taxanes, while cisplatinum remains central to all regimens. Multi-institutional studies are urgently needed to advance the multimodal care for patients with penile cancer.
    Keywords: Penis ; Neoplasm ; Penile Cancer ; Lymph Node ; Metastasis ; Chemotherapy ; Medicine
    ISSN: 1756-2872
    E-ISSN: 1756-2880
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  • 2
    In: BJU International, March 2018, Vol.121(3), pp.393-398
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/bju.14037/abstract Byline: Juan Chipollini, Sylvia Yan, Sarah R. Ottenhof, Yao Zhu, Desiree Draeger, Adam S. Baumgarten, Dominic H. Tang, Chris Protzel, Ding-wei Ye, Oliver W. Hakenberg, Simon Horenblas, Nicholas A. Watkin, Philippe E. Spiess Keywords: carcinoma in situ; recurrence; #PenileCancer Objectives To evaluate recurrence after penile-sparing surgery (PSS) in the management of carcinoma in situ (CIS) of the penis in a large multicentre cohort of patients. Patients and Methods We identified consecutive patients from five major academic centres, treated between June 1986 and November 2014, who underwent PSS for pathologically proven penile CIS. The primary outcome was local recurrence-free survival (RFS), which was estimated using the Kaplan-Meier method. Results A total of 205 patients were identified. Treatment methods included circumcision, glansectomy, wide local excision, laser therapy and total glans resurfacing. Over a median (interquartile range [IQR]) follow-up of 40 (26-65.6) months, there were 48 local recurrences, with 45.8% occurring in the first year and 81.3% occurring by year 5. The majority of recurrences were observed in the laser group (58.3%). The median (IQR) time to local recurrence was 15.9 (5.66-26.14) months. The 1- 2- and 5-year RFS rates were 88.4, 85.6 and 75%, respectively, and the median (IQR) RFS time was 106.5 (80.2-132.2) months. Conclusions Among patients with penile CIS selected for surgical management, durable responses at intermediate- to long-term follow-up were noted. For those with glandular CIS, glans resurfacing offered the best outcomes. CAPTION(S): Fig. S1 Overall survival based on recurrence status. Table S1 Univariable and multivariable Cox proportional hazard ratio (HR) for factors associated with local recurrence. Table S2 Management of local and regional recurrences.
    Keywords: Carcinoma In Situ ; Recurrence ; #Penilecancer
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 3
    Language: English
    In: Urology, November 2017, Vol.109, pp.140-144
    Description: To analyze the recurrence and survival outcomes of glansectomy in patients with penile squamous cell carcinoma. We performed a retrospective review of 410 patients across 5 international tertiary referral centers between 1999 and 2016. All patients had tumors involving the glans penis and underwent glansectomy as primary treatment. The Kaplan-Meier method and log-rank test were used to calculate survival and recurrence. Median follow-up was 42 months (interquartile range [IQR] 29-56). The median age was 64 years (IQR 53-72). Median tumor size was 2.2 cm (IQR 1.5-3.0). A total of 240 patients (58.5%) had pT2 disease, whereas only 43 patients (10.5%) had pT3 or pT4 disease. The majority of the cohort had poorly differentiated tumors (43.7%). Most recurrences were local at 7.6% (31 patients). Only 14 patients (3.4%) had regional recurrence and 9 patients (2.2%) had distant recurrence. When stratified by pathologic stage, tumors that were pT2 or higher were (  〈 .001) and were more likely to be poorly differentiated (  〈 .001). There were no differences in recurrence location among pathologic stages (  = .15). The 1-, 2-, and 5-year recurrence-free survival were 98%, 94%, and 78%, respectively. There were no differences in overall survival when stratified by stage (  = .67). Glansectomy is an oncologically safe treatment modality for squamous cell carcinoma of the glans in appropriately selected invasive tumors.
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
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  • 4
    Language: English
    In: Virchows Archiv, 2011, Vol.458(2), pp.221-229
    Description: Alterations in the p16/cyclinD1/Rb and ARF/Mdm2/p53 pathways are frequent events in the pathogenesis of squamous cell carcinomas. Different mechanisms of p16 regulation have been described for penile carcinomas so far. Therefore, expression of p16 and p53 was immunohistochemically detected with monoclonal antibodies in 52 primary invasive penile squamous cell carcinomas. The carcinomas were analyzed for allelic loss (LOH) in p16 INK4A and p53 , as well as for mutations in the p16 INK4A and the p53 gene. In addition, we examined the promoter status of p16 INK4A by methylation-specific PCR. The presence of human papilloma virus (HPV) 6/11, HPV 16 and HPV 18 DNA was analyzed by PCR. Data were compared to clinical data. Concerning p16, 26 (50%) tumors showed positive immunohistochemistry, 32 (62%) tumors showed allelic loss and 22 tumors (42%) showed promoter hypermethylation. All tumors with negative p16 immunohistochemistry showed LOH near the p16 INK4A locus and/or hypermethylation of the p16 INK4A promoter. HPV 16 DNA was detected in 17 tumors, ten of them with positive p16 immunostaining. The remaining seven tumors with negative p16 staining showed allelic loss and/or promoter hypermethylation. Evidence of lymph node metastasis was significantly associated with negative p16 immunohistochemistry as well as with combined LOH and promoter hypermethylation ( p  = 0.003 and p  = 0.018, respectively). Allelic loss around p53 was found in 22 tumors (42%), and seven mutations of the p53 gene could be demonstrated in our tumors. No correlations could be found between any p53 alteration and clinical parameters.
    Keywords: Penile carcinoma ; Metastasis ; p16 ; HPV ; LOH
    ISSN: 0945-6317
    E-ISSN: 1432-2307
    Source: Springer Science & Business Media B.V.
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  • 5
    Language: English
    In: Human Pathology, 2011, Vol.42(8), pp.1078-1088
    Description: Acquired chromosomal aberrations, including gene copy number alterations, are involved in the development and progression of human malignancies. , a transcription factor–coding gene located at 3q26.33, is known to be recurrently and specifically amplified in squamous cell carcinomas of the lung, the esophagus, and the oral cavity. In these organs, the SOX2 protein plays an important role in tumorigenesis and tumor survival. The aim of this study was to determine whether amplification is also found in squamous cell carcinomas in other organs commonly affected by this tumor entity. In addition, we examined a large spectrum of lung cancer entities with neuroendocrine differentiation (ie, small cell cancers, large cell cancers, typical and atypical carcinoids) for and copy number gains to reveal potential molecular ties to squamous cell carcinomas or adenocarcinomas of the lung. Applying fluorescence in situ hybridization, we assessed squamous cell carcinomas of the cervix uteri (n = 47), the skin (n = 57), and the penis (n = 53) for copy number alterations and detected amplifications in 28%, 28%, and 32% of tumors, respectively. Furthermore, we performed immunohistochemical SOX2 staining and found that amplification is significantly associated with overexpression of the corresponding protein in squamous cell carcinomas ( 〈 .001). Of the lung cancer entities with neuroendocrine differentiation, only small cell cancers and large cell cancers exhibited or amplifications at significant frequencies, indicating that at least a subset of these might be dedifferentiated forms of squamous cell carcinomas or adenocarcinomas of the lung. We conclude that amplification and consequent SOX2 protein overexpression may represent important mechanisms of tumor initiation and progression in a considerable subset of squamous cell carcinomas.
    Keywords: Sox2 ; Squamous Cell Carcinoma ; Skin ; Penis ; Uterine Cervix ; Medicine
    ISSN: 0046-8177
    E-ISSN: 1532-8392
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