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  • Plant Extracts
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  • 1
    Language: English
    In: Journal of agricultural and food chemistry, 14 September 2011, Vol.59(17), pp.9219-25
    Description: Recycling agricultural resources has become an important issue worldwide promoting the economical value of agricultural production processes. Desugared sugar cane extract (DSE) from Saccharum officinarum is a byproduct obtained during sugar production. Two new neolignan glucosides, saccharnan A (1) and saccharnan B (2), together with 10 known phenolics (3-12) were isolated from DSE, and their structures were elucidated on the basis of NMR spectral analysis. Compounds 3, 4, 8, and 9 showed good activity against DPPH radical (IC(50) ≤ 51.20 μM) and compounds 3-8 and 12 exhibited strong ABTS(+) free radical scavenging activity (IC(50) ≤ 51.57 μM) compared to those of the positive controls, ascorbic acid and Trolox. Moreover, compounds 7 and 12 acted as potent tyrosinase inhibitors (IC(50) ≤ 42.59 μM) compared to the positive control arbutin. Our results highlighted the economical value of recycling DSE for the future development of natural antioxidants and/or tyrosinase inhibitors.
    Keywords: Antioxidants -- Analysis ; Enzyme Inhibitors -- Analysis ; Monophenol Monooxygenase -- Antagonists & Inhibitors ; Plant Extracts -- Chemistry ; Saccharum -- Chemistry
    ISSN: 00218561
    E-ISSN: 1520-5118
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  • 2
    Language: English
    In: Phytochemistry, 2010, Vol.71(2), pp.271-279
    Description: Tricin-type flavonolignans ( – ), along with six known phenolic compounds ( – ), were isolated from the EtOAc extract of . Tricin-type flavonolignans, (2 )-dihydrotricin 4′- -( -β-guaiacylglyceryl) ether, (2 )-dihydrotricin 4′- -( -β-guaiacylglyceryl) ether, (2 )-dihydrotricin 4′- -( -β-4-hydroxyphenylglyceryl) ether, tricin 4′- -( -β-4-hydroxyphenylglyceryl) ether, tricin 4′- -( -β-4-hydroxylphenylglyceryl) ether, and (2 )-dihydrotricin 4′- -(β-6′′-methoxy-4′′-oxo-chroman-3′′-yloxy) ether namely calquiquelignan A–F, respectively, were isolated and characterized from the EtOAc extract of . Additionally, six known phenolic compounds, including dihydrotricin, tricin, salcolin A, -hydroxybenzoic acid, (2 , 3 )- -dihydrokapempferol and (2 )-naringenin, were also obtained and identified from the extract. Structures of the flavonolignans were assigned based on spectroscopic analyses that included 1D and 2D NMR spectroscopic techniques, such as HMQC, HMBC, and NOESY. Bioassay results showed that calquiquelignan A, dihydrotricin and (2 )-naringenin exhibited significant vasodilatory potencies, as indicated by 60.3%, 80.3% and 60.9% relaxations, respectively, at 100 μM. Salcolin A showed potent platelet aggregation inhibition, compared with aspirin. Most of the tricin-type derivatives (calquiquelignan A–B, dihydrotricin and tricin) also exhibited more potent hydroxyl radical ( OH) scavenging activity than trolox as characterized by the ultraweak chemiluminescence assay.
    Keywords: Calamus Quiquesetinervius ; Arecaceae ; Vasodilatory Potencies ; Platelet Aggregation ; Hydroxyl Radical ; Flavonolignan ; Calquiquelignan A–F ; Botany
    ISSN: 0031-9422
    E-ISSN: 1873-3700
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  • 3
    Language: English
    In: Food Chemistry, 01 September 2013, Vol.140(1-2), pp.305-314
    Description: roots showed oestrogenic and anti-platelet activities. ► Twenty-six compounds were isolated and divided into 10 different skeletons. ► The biosynthetic pathway of the isolated dihydrobenzofuroisocoumarins was proposed. can be used to develop nutritional dietary supplements. The ethanolic extract of (Liliaceae) roots showed potential oestrogenic and anti-platelet activities. Twenty-six compounds were isolated and classified as 10 skeletons, including two unusual new dihydrobenzofuroisocoumarins, (+)-platyphyllarin A ( ) and B ( ), one new butanoate, ethyltributanoate ( ), and two new homoisoflavanones, (−)-liriopein A ( ) and B ( ), along with 21 known compounds, including six homoisoflavonoids, one chalcone, six amides, one lignan, one fatty acid derivative, one alkaloid, three benzenoids, and two steroids. The biosynthetic pathway of compounds and was proposed in the current investigation. The oestrogenic activity of the isolates was evaluated utilising the pER8:GUS reporter assay system in transgenic plant as well as the SEAP reporter assay system in MCF-7 breast cancer cell-line; the anti-platelet activity was evaluated using the anti-platelet aggregation assay. Several components exhibited significant oestrogenic and anti-platelet activities; demonstrating for the first time the potential use of as a nutritional supplement for cardiovascular and endocrine diseases.
    Keywords: Liriope Platyphylla ; Dihydrobenzofuroisocoumarin ; Homoisoflavonoid ; Oestrogenic Activity ; Anti-Platelet Effect ; Arabidopsis Per8:Gus Reporter Assay ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
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  • 4
    Language: English
    In: Phytochemistry, November 2013, Vol.95, pp.315-321
    Description: Torvpregnanosides A and B ( – ), two pregnane glycosides, and torvoside Q ( ), a 23-keto-spirostanol glycoside, along with twelve known steroidal saponins were isolated from . All structures were identified from spectroscopic data, and the compounds were tested for anti-neutrophilic inflammation activity. Structure-activity relationships are discussed. Torvpregnanosides A and B, two pregnane glycosides, and torvoside Q, a 23-keto-spirostanol glycoside, along with twelve known steroidal saponins were isolated from aerial parts of . Of the latter, four of the 23-hydroxy-spirostanol glycosides, and, a yamogenin glycoside, were in this plant discovered. All structures were identified from spectroscopic data, and all the compounds were tested for anti-neutrophilic inflammatory activity. Two compounds showed selective inhibition against elastase release and superoxide anion generation, respectively, by human neutrophils with IC values of 5.66 and 3.59 μM, while two others inhibited both inflammatory mediators with IC values of 0.66–3.49 μM. Structure-activity relationships are discussed.
    Keywords: Solanum Torvum ; Solanaceae ; Steroidal Glycoside ; Anti-Neutrophilic Inflammation ; Botany
    ISSN: 0031-9422
    E-ISSN: 1873-3700
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  • 5
    Language: English
    In: Life Sciences, 13 June 2013, Vol.92(22), pp.1081-1092
    Description: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. In this study, we explored the anti-cancer activity of WYC02-9, a synthetic protoapigenone, on human HCT116 CRC cells. The anti-cancer activity of WYC02-9 and its underlying mechanisms were analyzed using XTT cell proliferation assays, colony formation assays, FACS analysis, annexin V staining, immunoblotting analysis, reactive oxygen species (ROS) generation assays, soft agar assays, a nude mice xenograft study and immunohistochemistry assays. Data showed that WYC02-9 suppressed CRC cell growth by arresting cells at G2/M and inducing cell death via apoptotic pathways. Further analysis demonstrated that WYC02-9-induced apoptosis was mediated by the activation of a ROS-mediated MAPK14 pathway. An in vivo xenograft study revealed that WYC02-9 enhanced MAP2K3/6 and MAPK14 phosphorylation, induced apoptosis, and suppressed CRC tumor growth. WYC02-9 exerts its anti-tumor effect via ROS/MAPK14-induced apoptosis and has the potential to be developed as a chemotherapeutic agent for CRC.
    Keywords: Flavonoid ; Wyc02-9 ; Mapk14 ; Colorectal Cancer ; Sciences (General) ; Biology
    ISSN: 0024-3205
    E-ISSN: 1879-0631
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  • 6
    In: PROTEOMICS, August 2013, Vol.13(15), pp.2297-2311
    Description: Hepatic ischemia‐reperfusion (IR) injury is a common clinical problem and ROS may be a contributing factor on IR injury. The current study evaluates the potential protective effect of saffron ethanol extract (SEE) in a rat model upon hepatic IR injury. Caspases 3 and terminal deoxynucleotidyl transferase‐mediated dUTP biotin nick end labeling (TUNEL) results showed increased cell death in the IR samples; reversely, minor apoptosis was detected in the SEE/IR group. Pretreatment with SEE significantly restored the content of antioxidant enzymes (SOD1 and catalase) and remarkably inhibited the intracellular ROS concentration in terms of reducing p47phox translocation. Proteome tools revealed that 20 proteins were significantly modulated in protein intensity between IR and SEE/IR groups. Particularly, SEE administration could attenuate the carbonylation level of several chaperone proteins. Network analysis suggested that saffron extract could alleviate IR‐induced ER stress and protein ubiquitination, which finally lead to cell apoptosis. Taken together, SEE could reduce hepatic IR injury through modulating protein oxidation and our results might help to develop novel therapeutic strategies against ROS‐caused diseases.
    Keywords: Animal Proteomics ; Antioxidant ; Ischemia‐Reperfusion Injury ; Redox Proteomics ; Saffron ; Valosin‐Containing Protein
    ISSN: 1615-9853
    E-ISSN: 1615-9861
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  • 7
    Language: English
    In: Progress in the chemistry of organic natural products, 2016, Vol.101, pp.113-230
    Description: In recent decades, annonaceous acetogenins have become highly studied plant secondary metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation, mechanism of action, and toxicity. The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics. The compounds are considered biologically in terms of their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities.
    Keywords: Acetogenin Mimics ; Acetogenins ; Annonaceae ; Anti-Cancer Activity ; Apoptosis ; Atypical Parkinsonism ; Ionophores ; Mitochondria Complex I Inhibition ; Neurotoxicity ; Pesticidal Activity ; Acetogenins -- Chemistry ; Annonaceae -- Chemistry ; Plant Extracts -- Chemistry
    ISSN: 2191-7043
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 8
    Language: English
    In: Planta medica, 2010, Vol.76(13), pp.1390-1404
    Description: Abstract Studies on the Annonaceous acetogenins began after the first cytotoxic acetogenin, uvaricin, was isolated in 1982. This attractive finding made many medicinal and natural product chemists direct their efforts on the isolation and identification of these classes of compounds. As more Annonaceous acetogenins were isolated, more information about them was uncovered. From their structural identification to the total synthesis of natural product analogues and from cell-based screening and molecular-based targeting to animal testing, the mechanisms of action of the Annonaceous acetogenins became clearer. The purpose of this review is to give an account of recent studies on this class of compounds and their analogues, which will aid us not only in clarifying how the Annonaceous acetogenins act but also in establishing principles for the further development of this class of compounds.
    Keywords: Annonaceae ; Acetogenins ; Mitochondria Complex I Inhibitor ; Pesticidal Activity ; Anticancer Activity ; Apoptosis ; Acetogenin Mimics
    ISSN: 0032-0943
    E-ISSN: 1439-0221
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  • 9
    Language: English
    In: Neuroscience Letters, 2006, Vol.404(1), pp.112-116
    Description: The plasma glucose lowering action of fruits of cornus ( ), the major active constituent of Die-Huang-Wan, has been documented to mediate acetylcholine (ACh) release, which in turn to stimulate muscarinic M receptors resulting in the enhancement of insulin secretion in rats with functional pancreatic β-cells. The present study was conducted to investigate the effect of oleanolic acid, one of the active principles of cornus fruit, on the release of insulin in rats. After an intraperitoneal injection into the fasting Wistar rats for 90 min, oleanolic acid decreased the plasma glucose in a dose-dependent manner in parallel to an increase of plasma levels of insulin as well as C-peptide. Moreover, disruption of synaptic ACh using an inhibitor of choline uptake, hemicholinium-3, or vesicular acetylcholine transport, vesamicol, abolished these actions of oleanolic acid. Also, physostigmine at concentration sufficient to inhibit acetylcholinesterase enhanced the actions of oleanolic acid. Both the plasma glucose lowering action and the raised plasma levels of insulin and C-peptide induced by oleanolic acid were also inhibited by 4-diphenylacetoxy- -methylpiperdine methiodide (4-DAMP), but not affected by the ganglionic nicotinic antagonist, pentolinium or hexamethonium. The results suggest that oleanolic acid has an ability to raise the release of ACh from nerve terminals, which in turn to stimulate muscarinic M receptors in the pancreatic cells and augment the insulin release to result in plasma glucose lowering action. Thus, oleanolic acid is one of the active principles responsible for the increase of plasma insulin produced by cornus fruit in rats.
    Keywords: Acetylcholine ; Cornus Fruit ; Muscarinic M 3 Receptors ; Wistar Rats ; Oleanolic Acid ; Medicine ; Anatomy & Physiology
    ISSN: 0304-3940
    E-ISSN: 1872-7972
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  • 10
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 15 September 2011, Vol.21(18), pp.5630-5632
    Description: One new phenanthrenedione, pterolinus K ( ), and one new chalcone, pterolinus L ( ) were isolated from the heartwood extract of The structures were elucidated by spectroscopic methods. Both and showed inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC value of 4.24 and 0.95 μM, and compound also inhibited superoxide anion generation with IC value of 0.99 μM. In addition, compound showed selective cytotoxicity against HepG2 with IC value of 10.86 μM, while compound showed a moderate cytotoxicity against KB with IC values of 17.18 μM.
    Keywords: Pterocarpus Santalinus ; Pterolinus K ; Pterolinus L ; Phenanthrenedione ; Chalcone ; Anti-Inflammatory ; Cytotoxicity ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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