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  • Pregnancy
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  • 1
    Language: German
    In: Klinikarzt – Medizin im Krankenhaus, 2012, Vol.41(4), pp.176-179
    Description: Der Gestationsdiabetes (GDM) ist eine Glukosetoleranzstörung, die erstmals in der Schwangerschaft diagnostiziert wird. Es ist eine der häufigsten Schwangerschaftskomplikation mit möglichen schwerwiegenden Akut- und Langzeitfolgen für Mutter und Kind. Der aktuelle Stand zu Diagnostik und Therapie wird im Folgenden beschrieben.
    Keywords: Gestational diabetes mellitus ; Pregnancy ; Consequences for mother and baby
    ISSN: 0341-2350
    E-ISSN: 1439-3859
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  • 2
    Language: English
    In: Journal of Psychiatric Research, September 2012, Vol.46(9), pp.1109-1117
    Description: A number of studies indicate that altered serotonergic transmission may be a risk factor for depression in the peripartum period. The aim of this study was to investigate whether genetic polymorphisms in the gene, the gene product of which is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system, are associated with depressive symptoms in pregnancy and the postpartum period. In a cohort of 361 Caucasians, the severity of depression was assessed prospectively during pregnancy (third trimester) and the postpartum period (2–3 days and 6–8 months) using the Edinburgh Postnatal Depression Scale (EPDS). Tagging single nucleotide polymorphisms (SNPs) in and SNPs that are known to be of functional relevance were genotyped. For each haplotype block or SNP, a multifactorial linear mixed model was performed to analyse the EPDS values over time. The haplotype block in the promoter region of showed significant associations with depression values during pregnancy and 6–8 months afterwards. Additionally, a haplotype block in intron 8 had an influence on depression values during pregnancy, but not after birth. There was a significant interaction between time and haplotypes and the severity of depression. The effect of haplotypes on EPDS values was strongest during pregnancy and 6 months after birth, with a low depression rating in the first few days after delivery for all women. In this cohort, haplotypes known to be of functional relevance were found to be associated with different EPDS values during and after pregnancy. These haplotypes were associated with depressive symptoms both before and after delivery and were thus not specific for postpartum-onset depression. This underlines the relevance of these functional polymorphisms for depression in general and the importance of longitudinal assessments in research on postpartum depression.
    Keywords: Depression ; Pregnancy ; Serotonin ; Polymorphisms ; Genetics ; Medicine
    ISSN: 0022-3956
    E-ISSN: 1879-1379
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  • 3
    Language: German
    In: Klinikarzt – Medizin im Krankenhaus, 2012, Vol.41(4), pp.171-175
    Description: Hypertensive Erkrankungen in der Schwangerschaft haben in Deutschland eine Prävalenz von ca. 8 %. Damit sind sie die häufigsten Erkrankungen in der Schwangerschaft und sind für bis zu 25 % der perinatalen Mortalität von Müttern und Kindern verantwortlich. Daher sollten medizinische Mitarbeiter aller Berufsgruppen sehr gut informiert sein, um bei Kontakt mit Schwangeren frühe Symptome oder Risikofaktoren zu erkennen.
    Keywords: Pregnancy ; Hypertonic disease ; Mortality of mother and baby
    ISSN: 0341-2350
    E-ISSN: 1439-3859
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  • 4
    Language: English
    In: BioMed Research International, 2014
    Description: Aim. Identification of women with moderate alcohol abuse during pregnancy is difficult. We correlated self-reported alcohol consumption during pregnancy and patient characteristics with objective alcohol indicators measured in fetal meconium. Methods. A total of 557 women singleton births and available psychological tests, obstetric data and meconium samples were included in statistical analysis. Alcohol metabolites (fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG)), were determined from meconium and correlated with patient characteristics. Results. We found that 21.2% of the 557 participants admitted low-tomoderate alcohol consumption during pregnancy. Of the parameters analyzed from meconium, only EtG showed an association with alcohol history (P 〈 0.01). This association was inverse in cases with EtG value above 120 ng/g. These values indicate women with most severe alcohol consumption, who obviously denied having consumed alcohol during pregnancy. No other associations between socioeconomic or psychological characteristics and the drinking status (via meconium alcohol metabolites) could be found. Conclusion. Women who drink higher doses of ethanol during pregnancy, according to metabolite measures in meconium, might be less likely to admit alcohol consumption. No profile of socioeconomic or psychological characteristics of those women positively tested via meconium could be established.
    Keywords: Alcoholism – Analysis ; Metabolites – Analysis ; Fatty Acids – Analysis ; Pregnant Women – Analysis ; Esters – Analysis ; Pregnancy – Analysis ; Drinking (Alcoholic Beverages) – Analysis
    ISSN: 2314-6133
    Source: Cengage Learning, Inc.
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  • 5
    In: Cardiovascular Research, 2010, Vol. 85(4), pp.681-690
    Description: AIMS: Proliferation of mammalian cardiomyocytes stops during the first weeks after birth, preventing the heart from regenerating after injury. Recently, several studies have indicated that induction of cardiomyocyte proliferation can be utilized to regenerate the mammalian heart. Thus, it is important to identify novel factors that can induce proliferation of cardiomyocytes. Here, we determine the effect of TNF-related weak inducer of apoptosis (TWEAK) on cardiomyocytes, a cytokine known to regulate proliferation in several other cell types.METHODS AND RESULTS: Stimulation of neonatal rat cardiomyocytes with TWEAK resulted in increased DNA synthesis, increased expression of the proliferative markers Cyclin D2 and Ki67, and downregulation of the cell cycle inhibitor p27KIP1. Importantly, TWEAK stimulation resulted also in mitosis (H3P), cytokinesis (Aurora B), and increased cardiomyocyte numbers. Loss of function experiments revealed that re-induction of proliferation was dependent on tumour necrosis factor receptor superfamily member 12A (FN14) signalling. Downstream signalling was mediated through activation of extracellular signal-regulated kinases and phosphatidylinositol 3-kinase as well as inhibition of glycogen synthase kinase-3beta. In contrast to neonatal cardiomyocytes, TWEAK had no effect on adult rat cardiomyocytes due to developmental downregulation of its receptor FN14. However, adenoviral expression of FN14 enabled efficient induction of cell cycle re-entry in adult cardiomyocytes after TWEAK stimulation.CONCLUSION: Our data establish TWEAK as a positive regulator of cardiomyocyte proliferation.
    Keywords: Tweak ; Fn14 ; Heart ; Cardiomyocytes ; Proliferation ; Signalling
    ISSN: 0008-6363
    E-ISSN: 1755-3245
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  • 6
    Language: English
    In: BioMed Research International, 01 January 2014, Vol.2014
    Description: Aim. Identification of women with moderate alcohol abuse during pregnancy is difficult. We correlated self-reported alcohol consumption during pregnancy and patient characteristics with objective alcohol indicators measured in fetal meconium. Methods. A total of 557 women singleton births and available psychological tests, obstetric data and meconium samples were included in statistical analysis. Alcohol metabolites (fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG)), were determined from meconium and correlated with patient characteristics. Results. We found that 21.2% of the 557 participants admitted low-to-moderate alcohol consumption during pregnancy. Of the parameters analyzed from meconium, only EtG showed an association with alcohol history (P〈0.01). This association was inverse in cases with EtG value above 120 ng/g. These values indicate women with most severe alcohol consumption, who obviously denied having consumed alcohol during pregnancy. No other associations between socioeconomic or psychological characteristics and the drinking status (via meconium alcohol metabolites) could be found. Conclusion. Women who drink higher doses of ethanol during pregnancy, according to metabolite measures in meconium, might be less likely to admit alcohol consumption. No profile of socioeconomic or psychological characteristics of those women positively tested via meconium could be established.
    Keywords: Medicine
    ISSN: 2314-6133
    E-ISSN: 2314-6141
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  • 7
    Language: English
    In: Archives of Gynecology and Obstetrics, 2014, Vol.289(4), pp.755-763
    Description: Purpose Depression during and after pregnancy can have a negative impact on women’s quality of life and on the development of the newborn child. Interventions have been shown to have a positive influence on both mothers and children. Predictive factors for depressive symptoms might possibly be able to identify groups that are at high risk. The aim of this study was to investigate the value of socioeconomic factors in predicting depressive symptoms during and after pregnancy. Methods Depressiveness was measured using the German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) at three time-points, in a prospective cohort study (n = 1,100). Visit 1 (Q1) was at study entry in the third trimester of the pregnancy, visit 2 (Q2) was shortly after birth, and visit 3 (Q3) was 6–8 months after birth. Depression scores were associated with socioeconomic factors and time in linear mixed models. Results Parity status, education status, monthly income, residential property status, and partnership status, as well as interactions between them, were found to be predictive factors for EPDS scores. The strongest factor influencing depressive symptoms was partnership status. Women who did not have an intact partnership had EPDS scores that were on average four points higher than in women with a partner at all three study visits (P 〈 0.000001). Conclusions Socioeconomic factors define subgroups that have different depression scores during and after pregnancy. Partnership status appears to be one of the most important influencing factors and could be useful for identifying women who should be offered an intervention to prevent possible negative effects on the mother or child.
    Keywords: Pregnancy ; Depression ; Socioeconomic factors ; Prediction
    ISSN: 0932-0067
    E-ISSN: 1432-0711
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  • 8
    Language: English
    In: Archives of Gynecology and Obstetrics, 2014, Vol.289(4), p.755(9)
    Description: Byline: Alexander Hein (1), Claudia Rauh (1), Anne Engel (1), Lothar Haberle (1), Ulf Dammer (1), Franziska Voigt (1,2), Peter A. Fasching (1), Florian Faschingbauer (1), Pascal Burger (3), Matthias W. Beckmann (1), Johannes Kornhuber (3), Tamme W. Goecke (1,2) Keywords: Pregnancy; Depression; Socioeconomic factors; Prediction Abstract: Purpose Depression during and after pregnancy can have a negative impact on women's quality of life and on the development of the newborn child. Interventions have been shown to have a positive influence on both mothers and children. Predictive factors for depressive symptoms might possibly be able to identify groups that are at high risk. The aim of this study was to investigate the value of socioeconomic factors in predicting depressive symptoms during and after pregnancy. Methods Depressiveness was measured using the German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) at three time-points, in a prospective cohort study (n = 1,100). Visit 1 (Q1) was at study entry in the third trimester of the pregnancy, visit 2 (Q2) was shortly after birth, and visit 3 (Q3) was 6--8 months after birth. Depression scores were associated with socioeconomic factors and time in linear mixed models. Results Parity status, education status, monthly income, residential property status, and partnership status, as well as interactions between them, were found to be predictive factors for EPDS scores. The strongest factor influencing depressive symptoms was partnership status. Women who did not have an intact partnership had EPDS scores that were on average four points higher than in women with a partner at all three study visits (P 〈 0.000001). Conclusions Socioeconomic factors define subgroups that have different depression scores during and after pregnancy. Partnership status appears to be one of the most important influencing factors and could be useful for identifying women who should be offered an intervention to prevent possible negative effects on the mother or child. Author Affiliation: (1) Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nuremberg, Universitaetsstrasse 21--23, 91054, Erlangen, Germany (2) Department of Gynecology and Obstetrics, Medical Faculty, University of Technology Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany (3) Department of Psychiatry and Psychotherapy, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany Article History: Registration Date: 27/09/2013 Received Date: 14/01/2013 Accepted Date: 27/09/2013 Online Date: 12/10/2013
    Keywords: Pregnant Women – Analysis ; Pregnancy – Analysis ; Depression (Mood Disorder) – Analysis ; Real Estate Industry – Analysis
    ISSN: 0932-0067
    E-ISSN: 14320711
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  • 9
    Language: English
    In: Archives of Gynecology and Obstetrics, 2012, Vol.286(6), pp.1407-1412
    Description: To compare depressiveness scores, both during and after pregnancy, with the delivery mode (DM).In a longitudinal, prospective study, standardized questionnaires for the Edinburgh Postnatal Depression Scale were presented to 1,100 women and used to assess the presence and severity of depressiveness at three time points: prenatal, from the 30th gestational week (Q1); 48–72 h postnatal (Q2); and 6–8 months postnatal (Q3). The patients were divided into four groups relative to DM: spontaneous delivery, primary cesarean section (CS), secondary CS, and assisted vaginal delivery. The final number of participating women with both delivery mode and depression information for all three time points was 753.There was a significant difference of the mean EPDS values between the spontaneous delivery and primary CS groups (P = 0.04) at Q1 (5.1 vs. 6.3). None of the other comparisons was significant. Significant differences relative to DM were seen at Q2 (P 〈 0.0001), but there were no significant differences between the patient groups at Q3 (P = 0.54).DM only showed coherence with the extent of depression briefly during the peripartal period. A relationship was found between depressiveness during pregnancy and DM, with higher depressiveness scores in the group of patients undergoing primary CS. This should be taken into account when patients requesting an elective cesarean section are being counseled.
    Keywords: Depression ; Delivery mode ; Cesarean section ; Assisted vaginal delivery
    ISSN: 0932-0067
    E-ISSN: 1432-0711
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  • 10
    Language: English
    In: BioMed Research International, 01 January 2014, Vol.2014
    Description: Purpose. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes of the stress hormone signaling pathway, specifically FKBP5, NR3C1, and CRHR1, are associated with depressive symptoms during and after pregnancy. Methods. The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for the assessment of maternal and fetal health including the assessment of depressiveness. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of the pregnancy, visit 2 was shortly after birth, and visit 3 was 6–8 months after birth. Germline DNA was collected from 361 pregnant women. Nine SNPs in the above mentioned genes were genotyped. After construction of haplotypes for each gene, a multifactorial linear mixed model was performed to analyse the depression values over time. Results. EPDS values were within expected ranges and comparable to previously published studies. Neither did the depression scores differ for comparisons among haplotypes at fixed time points nor did the change over time differ among haplotypes for the examined genes. No haplotype showed significant associations with depressive symptoms severity during pregnancy or the postpartum period. Conclusion. The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.
    Keywords: Medicine
    ISSN: 2314-6133
    E-ISSN: 2314-6141
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