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  • 1
    Language: English
    In: Journal of Ethnopharmacology, 2008, Vol.120(1), pp.108-111
    Description: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Only TSL-1, the extract from tender leaf of Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. This paper reports for the first time that extract from a vegetable, the tender leaf of Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Roem may be an important resource agninst SARS-CoV.
    Keywords: Sars ; Herb ; Traditional Chinese Medicine (Tcm) ; Toona Sinensis Roem ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0378-8741
    E-ISSN: 1872-7573
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  • 2
    Language: English
    In: Chemistry & Biodiversity, March 2008, Vol.5(3), pp.461-470
    Description: The chemical composition of the essential oils of ssp. ssp. , and was determined by GC/MS analysis. Essential oils have been evaluated for their inhibitory activity against SARS‐CoV and HSV‐1 replication by visually scoring of the virus‐induced cytopathogenic effect post‐infection. oil exerted an interesting activity against SARS‐CoV with an value of 120 μg/ml and a selectivity index (SI) of 4.16. This oil was characterized by the presence of ‐ocimene, 1,8‐cineole, ‐pinene, and ‐pinene as the main constituents. ssp. oil, in which ‐pinene and ‐myrcene were the major constituents, revealed antiviral activity against HSV‐1 with an value of 200 μg/ml and a SI of 5.
    Keywords: Severe Acute Respiratory Syndrome Sars ; Antiviral Activity ; Cytotoxic Activity ; Essential Oils ; Laurus Nobilis ; Ssp. ; Thuja Orientalis ; Ssp. ; Pistacia Palaestina ; Salvia Officinalis ; Satureja Thymbra
    ISSN: 1612-1872
    E-ISSN: 1612-1880
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