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  • 1
    In: Analyst, 2016, Vol.141(4), pp.1226-1232
    Description: Platinum-based drugs are commonly used in cancer treatment. The biological activity of a metallodrug is obviously closely related to its chemical and stereochemical characteristics. An overlooked aspect is the effect of the ligand to the electronic structure of the metal atom (coordinated atom). We report herein a Resonant X-ray Emission Spectroscopy (RXES) study on the chemical speciation of chiral platinum complexes in which diastereomers are distinguished on the basis of their metal electronic configuration. This demonstrates RXES high chemical speciation capabilities, a necessary property to further investigate the reactivity of the Pt atom towards nucleophiles or bionucleophiles, and an important complement the previously reported RXES abilities, namely that it can be employed for in situ studies at physiological concentrations.
    Keywords: Spectrometry, X-Ray Emission ; Antineoplastic Agents -- Chemistry ; Organoplatinum Compounds -- Chemistry;
    ISSN: 0003-2654
    E-ISSN: 1364-5528
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  • 2
    Language: English
    In: Drug Discovery Today: Technologies, September 2015, Vol.16, pp.1-6
    Description: This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum and . The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells.
    Keywords: Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1740-6749
    E-ISSN: 1740-6749
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