Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • 1
    Language: English
    In: Emerging infectious diseases, February 2017, Vol.23(2), pp.336-339
    Description: At a clinic in Indianapolis, Indiana, USA, we observed an increase in Neisseria gonorrhoeae-negative men with suspected gonococcal urethritis who had urethral cultures positive for N. meningitidis. We describe genomes of 2 of these N. meningitidis sequence type 11 complex urethritis isolates. Clinical evidence suggests these isolates may represent an emerging urethrotropic clade.
    Keywords: Neisseria ; Neisseria Gonorrhoeae ; Neisseria Meningitidis ; Bacteria ; Genome ; Meningitis ; Sexually Transmitted Disease ; Sexually Transmitted Infections ; Urethra ; Urethritis ; Neisseria Meningitidis -- Classification ; Urethritis -- Epidemiology
    ISSN: 10806040
    E-ISSN: 1080-6059
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  • 2
    Language: English
    In: Sexually Transmitted Infections, 14 July 2019, Vol.95(Suppl 1), p.A338
    Description: Persistent NGU occurs when symptoms persist after empiric NGU treatment and has been associated with (MG) infection. The prevalence and etiology of persistent NGU in men remains largely unknown.
    Keywords: Urethritis ; Antimicrobial Resistance
    ISSN: 1368-4973
    ISSN: 13684973
    E-ISSN: 1472-3263
    E-ISSN: 14723263
    Source: BMJ Journals (BMJ Publishing Group)
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  • 3
    Language: English
    In: Sexually Transmitted Infections, 14 July 2019, Vol.95(Suppl 1), p.A338
    Description: Syndromic management remains the standard nongonococcal urethritis (NGU) treatment approach. Whether pathogen-specific signs/symptoms inform treatment decisions remains unclear. We identified men with single- and mixed-pathogen NGU and assessed for the presence of pathogen-specific signs or symptoms to improve syndromic management.
    Keywords: Urethritis
    ISSN: 1368-4973
    ISSN: 13684973
    E-ISSN: 1472-3263
    E-ISSN: 14723263
    Source: BMJ Journals (BMJ Publishing Group)
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  • 4
    Language: English
    In: Sexually Transmitted Infections, 14 July 2019, Vol.95(Suppl 1), p.A228
    Description: The ability to quantify the organism load of (CT) using a commercial assay could expand insights from epidemiological studies. This approach can be applied to routine diagnostic testing, and multiple specimen types. Approximate CT organism load was determined in urine from men with NGU, with and without co-infections, by comparing the results from each positive sample to a set of CT standards using the Abbott Real2000 (2000) platform.
    Keywords: Chlamydia ; Urethritis ; Bacterial Load
    ISSN: 1368-4973
    ISSN: 13684973
    E-ISSN: 1472-3263
    E-ISSN: 14723263
    Source: BMJ Journals (BMJ Publishing Group)
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  • 5
    Language: English
    In: Molecular microbiology, January 2019, Vol.111(1), pp.254-268
    Description: Clusters of Neisseria meningitidis (Nm) urethritis among primarily heterosexual males in multiple US cities have been attributed to a unique non-encapsulated meningococcal clade (the US Nm urethritis clade, US_NmUC) within the hypervirulent clonal complex 11. Resistance to antimicrobial peptides (AMPs) is a key feature of urogenital pathogenesis of the closely related species, Neisseria gonorrhoeae. The US_NmUC isolates were found to be highly resistant to the model AMP, polymyxin B (PmB, MICs 64-256 µg ml ). The isolates also demonstrated stable subpopulations of heteroresistant colonies that showed near total resistant to PmB (MICs 384-1024 µg ml ) and colistin (MIC 256 µg ml ) as well as enhanced LL-37 resistance. This is the first observation of heteroresistance in N. meningitidis. Consistent with previous findings, overall PmB resistance in US_NmUC isolates was due to active Mtr efflux and LptA-mediated lipid A modification. However, whole genome sequencing, variant analyses and directed mutagenesis revealed that the heteroresistance phenotypes and very high-level AMP resistance were the result of point mutations and IS1655 element movement in the pilMNOPQ operon, encoding the type IV pilin biogenesis apparatus. Cross-resistance to other classes of antibiotics was also observed in the heteroresistant colonies. High-level resistance to AMPs may contribute to the pathogenesis of US_NmUC.
    Keywords: Peptides – Analysis ; Chromosomes – Analysis ; Urethritis – Genetic Aspects ; Urethritis – Analysis ; Microbial Drug Resistance – Genetic Aspects ; Microbial Drug Resistance – Analysis;
    ISSN: 0950382X
    E-ISSN: 1365-2958
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  • 6
    Language: English
    In: Sexually Transmitted Infections, 12 September 2019
    Description: (CT) and (MG) cause the majority of non-gonococcal urethritis (NGU). The role of (UU) in NGU is unclear. Prior case–control studies that examined the association of UU and NGU may have been confounded by mixed infections and less stringent criteria for controls. The objective of this case–control study was to determine the prevalence and aetiology of mixed infections in men and assess if UU monoinfection is associated with NGU.
    Keywords: Urethritis ; Chlamydia Trachomatis ; Chlamydia Infection ; Mycoplasma ; Epidemiology (General)
    ISSN: 1368-4973
    ISSN: 13684973
    E-ISSN: 1472-3263
    E-ISSN: 14723263
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  • 7
    In: Sexually Transmitted Diseases, 2019, Vol.46(7), pp.440-445
    Description: BACKGROUND: Rectal infection with Chlamydia trachomatis (CT) is frequent in women who deny receptive anal sex and is thought to arise from autoinoculation of the rectum from vaginal secretions. An alternate hypothesis is that oral sex inoculates and establishes gastrointestinal tract infection. Distinguishing these hypotheses is difficult in women. In men, autoinoculation is unlikely and heterosexual men frequently perform oral sex, but rarely participate in receptive anal exposure behaviors. METHODS: We enrolled high-risk men with and without nongonococcal urethritis who presented to a sexually transmitted infection clinic in Indianapolis, Indiana. Urine and rectal swabs were collected and tested for urogenital and rectal CT, Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG). Men completed surveys concerning symptoms, sexual orientation, and detailed recent and lifetime oral and anal sexual behaviors. RESULTS: Rectal CT was detected in 2/84 (2.4%) heterosexual men who reported cunnilingus, but no lifetime receptive anal behaviors. All of the men who denied receptive anal behaviors were negative for rectal NG and MG. In homosexual and bisexual men, rectal CT prevalence was high (9.7%), and rectal NG (4.8%) and MG (4.8%) were also detected. CONCLUSIONS: We detected rectal CT infections in heterosexual men who reported cunnilingus but denied receptive anal behaviors. Oral sex may be a risk factor for rectal CT infection via oral inoculation of the gastrointestinal tract.
    Keywords: Chlamydia Trachomatis ; Infections ; Vagina ; Detection ; Urethritis ; Urine ; Sex ; Chlamydia Trachomatis ; Gastrointestinal Tract ; Chlamydia ; Inoculation ; Bisexuals ; Gastrointestinal Tract ; Secretions ; Sexual Behavior ; Women ; Urine ; Chlamydia Trachomatis ; Inoculation ; Rectum ; Risk Groups ; Risk Analysis ; Secretions ; Oral Sex ; Urine ; Gonorrhoea ; Infection ; Sexually Transmitted Diseases–STD ; Men ; Anal Sex ; Bisexual ; Urethritis ; Infections ; Gays & Lesbians ; Sexual Behavior ; Risk Factors ; Sexual Orientation ; Condoms ; High Risk ; Sex ; Bisexuality ; Risk Factors ; Anal Intercourse ; Urine ; Rectum ; Gastrointestinal System ; Health Risks ; Sexually Transmitted Diseases–STD;
    ISSN: 0148-5717
    E-ISSN: 15374521
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