Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Yaws
Type of Medium
Language
Year
  • 1
    Language: English
    In: Emerging infectious diseases, December 2013, Vol.19(12), pp.2058-60
    Description: To the Editor: In 2012, the World Health Organization launched plans for a second campaign to eradicate the neglected tropical disease, yaws (1). The first campaign, conducted during the mid-20th century, was tremendously successful in terms of treatment and reduced the number of cases by 95%. However, it failed to eradicate the disease, and when local efforts to prevent new cases proved insufficient, yaws resurged in some areas. Comments on the new yaws eradication campaign have emphasized the need for sustained support and resources. Here we draw attention to an additional concern that could impede yaws eradication efforts.
    Keywords: Africa ; World Health Organization ; Bacteria ; Eradication ; Nonhuman Primates ; Pallidum ; Pertenue ; Syphilis ; Treponeme ; Yaws ; Zoonoses ; Disease Reservoirs ; Monkey Diseases -- Transmission ; Primates -- Microbiology ; Treponemal Infections -- Veterinary ; Yaws -- Transmission
    ISSN: 10806040
    E-ISSN: 1080-6059
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: PLoS ONE, 01 January 2015, Vol.10(11), p.e0143100
    Description: The bacterium Treponema pallidum is known to cause syphilis (ssp. pallidum), yaws (ssp. pertenue), and endemic syphilis (ssp. endemicum) in humans. Nonhuman primates have also been reported to be infected with the bacterium with equally versatile clinical manifestations, from severe skin ulcerations to asymptomatic. At present all simian strains are closely related to human yaws-causing strains, an important consideration for yaws eradication. We tested clinically healthy Guinea baboons (Papio papio) at Parc National Niokolo Koba in south eastern Senegal for the presence of anti-T. pallidum antibodies. Since T. pallidum infection in this species was identified 50 years ago, and there has been no attempt to treat non-human primates for infection, it was hypothesized that a large number of West African baboons are still infected with simian strains of the yaws-bacterium. All animals were without clinical signs of treponematoses, but 18 of 20 (90%) baboons tested positive for antibodies against T. pallidum based on treponemal tests. Yet, Guinea baboons seem to develop no clinical symptoms, though it must be assumed that infection is chronic or comparable to the latent stage in human yaws infection. The non-active character is supported by the low anti-T. pallidum serum titers in Guinea baboons (median = 1:2,560) versus serum titers that are found in genital-ulcerated olive baboons with active infection in Tanzania (range of medians among the groups of initial, moderate, and severe infected animals = 1:15,360 to 1:2.097e+7). Our findings provide evidence for simian infection with T. pallidum in wild Senegalese baboons. Potentially, Guinea baboons in West Africa serve as a natural reservoir for human infection, as the West African simian strain has been shown to cause sustainable yaws infection when inoculated into humans. The present study pinpoints an area where further research is needed to support the currently on-going second WHO led yaws eradication campaign with its goal to eradicate yaws by 2020.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: 2015, Vol.9(3), p.e0003637
    Description: There is evidence to suggest that the yaws bacterium ( Treponema pallidum ssp. pertenue ) may exist in non-human primate populations residing in regions where yaws is endemic in humans. Especially in light of the fact that the World Health Organizaiton (WHO) recently launched its second yaws eradication campaign, there is a considerable need for reliable tools to identify treponemal infection in our closest relatives, African monkeys and great apes. It was hypothesized that commercially available serological tests detect simian anti- T . pallidum antibody in serum samples of baboons, with comparable sensitivity and specificity to their results on human sera. Test performances of five different treponemal tests (TTs) and two non-treponemal tests (NTTs) were evaluated using serum samples of 57 naturally T . pallidum -infected olive baboons ( Papio anubis ) from Lake Manyara National Park in Tanzania. The T . pallidum particle agglutination assay (TP-PA) was used as a gold standard for comparison. In addition, the overall infection status of the animals was used to further validate test performances. For most accurate results, only samples that originated from baboons of known infection status, as verified in a previous study by clinical inspection, PCR and immunohistochemistry, were included. All tests, TTs and NTTs, used in this study were able to reliably detect antibodies against T . pallidum in serum samples of infected baboons. The sensitivity of TTs ranged from 97.7-100%, while specificity was between 88.0-100.0%. The two NTTs detected anti-lipoidal antibodies in serum samples of infected baboons with a sensitivity of 83.3% whereas specificity was 100%. For screening purposes, the TT Espline TP provided the highest sensitivity and specificity and at the same time provided the most suitable format for use in the field. The enzyme immune assay Mastblot TP (IgG), however, could be considered as a confirmatory test. ; The success of any disease eradication campaign depends on considering possible non-human reservoirs of the disease. Although the first report of . infection in baboons was published in the 1970’s and the zoonotic potential was demonstrated by inoculation of a West African simian strain into humans, nonhuman primates have not yet been considered as a possible reservoir for re-emerging yaws in Africa. Simian strains are genetically most closely related to the strains that cause yaws in humans. The identification of baboons as a reservoir for human infection in Africa would be revolutionary and aid important aspects to yaws eradication programs. Reliable serological tests and a useful standardized test algorithm for the screening of wild baboon populations are essential for studying potential transmission events between monkeys and humans.
    Keywords: Research Article
    ISSN: 19352727
    E-ISSN: 1935-2735
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: PLoS Neglected Tropical Diseases, 01 April 2018, Vol.12(4), p.e0006396
    Description: We show proof of concept for gene targets (polA, tprL, and TP_0619) that can be used in loop-mediated isothermal amplification (LAMP) assays to rapidly differentiate infection with any of the three Treponema pallidum subspecies (pallidum (TPA), pertenue (TPE), and endemicum (TEN)) and which are known to infect humans and nonhuman primates (NHPs). Four TPA, six human, and two NHP TPE strains, as well as two human TEN strains were used to establish and validate the LAMP assays. All three LAMP assays were highly specific for the target DNA. Amplification was rapid (5-15 min) and within a range of 10E+6 to 10E+2 of target DNA molecules. Performance in NHP clinical samples was similar to the one seen in human TPE strains. The newly designed LAMP assays provide proof of concept for a diagnostic tool that enhances yaws clinical diagnosis. It is highly specific for the target DNA and does not require expensive laboratory equipment. Test results can potentially be interpreted with the naked eye, which makes it suitable for the use in remote clinical settings.
    Keywords: Medicine
    ISSN: 1935-2727
    E-ISSN: 1935-2735
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Emerging infectious diseases, May 2017, Vol.23(5), pp.816-819
    Description: Survey results showed treponemal infection among pet macaques in Southeast Asia, a region with a high prevalence of human yaws. This finding, along with studies showing treponemal infection in nonhuman primates in Africa, should encourage a One Health approach to yaws eradication and surveillance activities, possibly including monitoring of nonhuman primates in yaws-endemic regions.
    Keywords: Asia ; Indonesia ; Macaca Spp. ; One Health ; Southeast Asia ; Sulawesi ; Treponema Pallidum ; Treponema Pallidum Subsp. Pertenue ; Bacteria ; Eradication ; Macaques ; Mammalian Host Reservoirs ; Nonhuman Primates ; Nontreponemal ; Pets ; Surveillance ; Yaws ; Monkey Diseases -- Epidemiology ; Treponemal Infections -- Veterinary
    ISSN: 10806040
    E-ISSN: 1080-6059
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Emerging infectious diseases, June 2018, Vol.24(6), pp.1002-1009
    Description: We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys). We found the bacterium at 11 of 14 investigated geographic locations. Anogenital ulceration was the most common clinical manifestation; orofacial lesions also were observed. Molecular data show that nonhuman primates in Tanzania are most likely infected with T. pallidum subsp. pertenue-like strains, which could have implications for human yaws eradication.
    Keywords: Africa ; One Health ; Tanzania ; Treponema Pallidum ; Bacteria ; Eradication ; Infection ; Nonhuman Primates ; Spirochetes ; Yaws ; Treponema Pallidum ; Primate Diseases -- Epidemiology ; Yaws -- Veterinary
    ISSN: 10806040
    E-ISSN: 1080-6059
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: PLoS neglected tropical diseases, 2018, Vol.12(10), pp.urn:issn:1935-2727
    Description: BACKGROUND: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multistage disease endemic in tropical regions in Africa, Asia, Oceania, and South America. To date, seven TPE strains have been completely sequenced and analyzed including five TPE strains of human origin (CDC-2, CDC 2575, Gauthier, Ghana-051, and Samoa D) and two TPE strains isolated from the baboons (Fribourg-Blanc and LMNP-1). This study revealed the complete genome sequences of two TPE strains, Kampung Dalan K363 and Sei Geringging K403, isolated in 1990 from villages in the Pariaman region of Sumatra, Indonesia and compared these genome sequences with other known TPE genomes.
    Keywords: Research Article ; Biology And Life Sciences ; Biology And Life Sciences ; Research And Analysis Methods ; Research And Analysis Methods ; Research And Analysis Methods ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Medicine And Health Sciences;
    ISSN: 1935-2727
    ISSN: 1935-2735
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Houinei, W., C. Godornes, A. Kapa, S. Knauf, E. Q. Mooring, C. González-Beiras, R. Watup, et al. 2017. “Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.” PLoS Neglected Tropical Diseases 11 (5): e0004958. doi:10.1371/journal.pntd.0004958. http://dx.doi.org/10.1371/journal.pntd.0004958.
    Description: Background: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. Methodology/Principal findings We performed a cross-sectional study in rural villages of Lihir Island, Papua New Guinea during a yaws elimination campaign. Participants were asymptomatic subjects recruited from households with cases of leg ulcers, and from households without cases of leg ulcers. We rubbed swabs on the intact skin of the leg of asymptomatic individuals, and collected flies and swabs of environmental surfaces. All specimens were tested by PCR for H. ducreyi and T. p. pertenue DNA. Of 78 asymptomatic participants that had an adequate specimen for DNA detection, H. ducreyi-PCR positivity was identified in 16 (21%) and T. p. pertenue-PCR positivity in 1 (1%). In subgroup analyses, H. ducreyi-PCR positivity did not differ in participants exposed or not exposed to a case of H. ducreyi ulcer in the household (24% vs 18%; p = 0.76). Of 17 cultures obtained from asymptomatic participants, 2 (12%) yielded a definitive diagnosis of H. ducreyi, proving skin colonization. Of 10 flies tested, 9 (90%) had H. ducreyi DNA and 5 (50%) had T. p. pertenue DNA. Of 6 bed sheets sampled, 2 (33%) had H. ducreyi DNA and 1 (17%) had T. p. pertenue DNA. Conclusions/Significance: This is the first time that H. ducreyi DNA and colonization has been demonstrated on the skin of asymptomatic children and that H. ducreyi DNA and T. p. pertenue DNA has been identified in flies and on fomites. The ubiquity of H. ducreyi in the environment is a contributing factor to the spread of the organism.
    Keywords: Medicine And Health Sciences ; Diagnostic Medicine ; Signs And Symptoms ; Ulcers ; Pathology And Laboratory Medicine ; Biology And Life Sciences ; Molecular Biology ; Molecular Biology Techniques ; Artificial Gene Amplification And Extension ; Polymerase Chain Reaction ; Infectious Diseases ; Bacterial Diseases ; Treponematoses ; Yaws ; Tropical Diseases ; Neglected Tropical Diseases ; Dermatology ; Skin Infections ; Microbiology ; Medical Microbiology ; Microbial Pathogens ; Bacterial Pathogens ; Treponema Pallidum ; Pathogens ; Bacteriology ; Gram Negative Bacteria ; Extraction Techniques ; Dna Extraction ; Organisms ; Bacteria ; Haemophilus
    ISSN: 19352727
    E-ISSN: 19352735
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
  • 10
    Language: English
    In: The Lancet Infectious Diseases, October 2015, Vol.15(10), pp.1220-1225
    Description: Yaws is endemic in west Africa, southeast Asia, and the Pacific region. To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. Progress has been made towards achievement of this ambitious goal, including the validation of point-of-care and molecular diagnostic tests and piloting of the strategy in several countries, including Ghana, Vanuatu, and Papua New Guinea. Gaps in knowledge need to be addressed to allow refinement of the eradication strategy. Studies exploring determinants of the spatial distribution of yaws are needed to help with the completion of baseline mapping. The finding that causes lesions similar to yaws is particularly important and further work is needed to assess the effect of azithromycin on these lesions. The integration of diagnostic tests into different stages of the eradication campaign needs investigation. Finally, studies must be done to inform the optimum mass-treatment strategy for sustainable interruption of transmission.
    Keywords: Medicine ; Public Health
    ISSN: 1473-3099
    E-ISSN: 1474-4457
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages