In:
Chirality, Wiley, Vol. 21, No. 2 ( 2009-02), p. 271-275
Abstract:
Enantiomers of 4‐(1,1,2‐trimethylhexyl)phenol, a chiral isomer of the endocrine disrupting chemical nonylphenol, have been resolved and isolated by preparative chiral HPLC. The absolute configurations of the enantiomers were then determined by an X‐ray crystallographic study of the (−)‐camphanoyl derivative of the first eluted enantiomer NP 35 E1. The first enantiomer (NP 35 E1) and the second enantiomer (NP 35 E2) eluted were found to have the S and R absolute configurations, respectively. The estrogenic potencies of the S and R enantiomers were tested by the E‐screen assay. A slight difference was observed in the relative proliferative effect between the S enantiomer and R enantiomer in the E‐screen assay. Chirality, 2009. © 2008 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0899-0042
,
1520-636X
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2001237-8
SSG:
12
SSG:
15,3
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