In:
Cardiology, S. Karger AG, Vol. 134, No. 2 ( 2016), p. 101-106
Abstract:
〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Previous studies investigating the prognostic value of HbA 〈 sub 〉 1c 〈 /sub 〉 in patients undergoing coronary angiography reported a mixed pattern of results. Therefore, we aimed to better define the prognostic power of HbA 〈 sub 〉 1c 〈 /sub 〉 among coronary catheterized patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients undergoing coronary angiography (n = 3,749) were divided into four groups according to HbA 〈 sub 〉 1c 〈 /sub 〉 levels ( 〈 5, 5-6, 6-7 and 〉 7%). Cox regression models assessed long-term mortality after adjusting for multiple covariates. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Baseline clinical profiles differed in HbA 〈 sub 〉 1c 〈 /sub 〉 groups, with a higher prevalence of comorbidities in the groups with higher HbA 〈 sub 〉 1c 〈 /sub 〉 levels. Median follow-up was 1,745 days (interquartile range 1,007-2,171). A J-shaped association curve was observed between HbA 〈 sub 〉 1c 〈 /sub 〉 levels and all-cause mortality rates, with patients in the lowest and highest HbA 〈 sub 〉 1c 〈 /sub 〉 groups suffering from significantly higher mortality rates compared to in-between groups (hazard ratio 1.9, 95% CI 1.32-2.74, p = 0.001, and hazard ratio 1.58, 95% CI 1.29-1.95, p 〈 0.001, for the lowest and highest HbA 〈 sub 〉 1c 〈 /sub 〉 groups, respectively). This association persisted after adjustment for anemia, nutritional status, renal function, cardiovascular risk factors and inflammatory biomarkers. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 HbA 〈 sub 〉 1c 〈 /sub 〉 levels 〈 5 or 〉 7% are predictors of all-cause mortality in patients undergoing coronary angiography.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
2016
detail.hit.zdb_id:
1482041-9
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