In:
Therapeutic Apheresis and Dialysis, Wiley, Vol. 22, No. 2 ( 2018-04), p. 189-195
Abstract:
Technical problems during clinical lipid apheresis interfere with fractionator performance. Therefore, a large animal model was established to characterize a new plasma fractionation membrane. Four sheep were randomized, controlled, and crossover subjected to double ofiltration lipoprotein apheresis with three specimens of FractioPES R having slightly different HDL sieving coefficients ( S K ) (FPESa, 0.30, FPESb, 0.26, and FPESc, 0.22) versus a control fractionator (EVAL). S K and reduction ratios were determined for LDL, HDL, fibrinogen, IgG, and albumin. Compared to EVAL (0.42 ± 0.04 to 0.74 ± 0.08) and FPESa (0.36 ± 0.06 to 0.64 ± 0.04), S K for HDL were lower ( P 〈 0.05) with FPESc (0.30 ± 0.04 to 0.49 ± 0.10). Fibrinogen S K were higher ( P 〈 0.05) with EVAL (0.02 ± 0.01 to 0.40 ± 0.08) compared to FPESb (0.05 ± 0.02 to 0.26 ± 0.34) and FPESc (0.01 ± 0.01 to 0.21 ± 0.16). No further differences were determined. The animal model distinguished between minor differences in fractionation membrane permeability, demonstrating equivalent sieving of FPESa and EVAL and slightly inferior permeability of FPESb and FPESc.
Type of Medium:
Online Resource
ISSN:
1744-9979
,
1744-9987
DOI:
10.1111/tap.2018.22.issue-2
DOI:
10.1111/1744-9987.12649
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2010864-3
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