In:
Molecular Systems Biology, EMBO, Vol. 11, No. 3 ( 2015-03)
Abstract:
image Analysis of the mechanisms controlling liver regeneration in response to hepatocyte growth factor ( HGF ), using single cell and population data combined with mathematical modeling, reveals that CDK 2 phosphorylated at T160 acts as gate‐keeper for hepatocyte proliferation. Primary mouse hepatocytes cross the restriction point after 32 h of HGF stimulation. A hepatocyte‐specific mathematical model of G1/S transition was developed based on time‐resolved quantitative immunoblotting and DNA content data. Single cell experiments demonstrate a linear relationship between CDK 2 T160 phosphorylation and hepatocytes in S/G2/M phase. Phosphorylation of CDK 2 on T160 constitutes the gate‐keeping mechanism for G1/S transition in hepatocytes.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
DOI:
10.15252/msb.20156032
Language:
English
Publisher:
EMBO
Publication Date:
2015
detail.hit.zdb_id:
2193510-5
SSG:
12
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