In:
Annual Review of Neuroscience, Annual Reviews, Vol. 41, No. 1 ( 2018-07-08), p. 207-232
Abstract:
Brain tumors are the leading cause of cancer-related death in children, and medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in surgery, radiation, and chemotherapy have improved the survival of MB patients. But despite these advances, 25–30% of patients still die from the disease, and survivors suffer severe long-term side effects from the aggressive therapies they receive. Although MB is often considered a single disease, molecular profiling has revealed a significant degree of heterogeneity, and there is a growing consensus that MB consists of multiple subgroups with distinct driver mutations, cells of origin, and prognosis. Here, we review recent progress in MB research, with a focus on the genes and pathways that drive tumorigenesis, the animal models that have been developed to study tumor biology, and the advances in conventional and targeted therapy.
Type of Medium:
Online Resource
ISSN:
0147-006X
,
1545-4126
DOI:
10.1146/neuro.2018.41.issue-1
DOI:
10.1146/annurev-neuro-070815-013838
Language:
English
Publisher:
Annual Reviews
Publication Date:
2018
detail.hit.zdb_id:
1470452-3
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