In:
Science, American Association for the Advancement of Science (AAAS), Vol. 343, No. 6169 ( 2014-01-24), p. 416-419
Abstract:
The vascular endothelium is increasingly being recognized to play a role during organogenesis and tissue regeneration. Hu et al. (p. 416 ) found that rapid down-regulation of endothelial-derived Angiopoietin-2 following partial hepatectomy releases an endogenous transforming growth factor β1–driven paracrine proliferative brake on hepatocytes. Later, recovery of endothelial Angiopoetin-2 expression facilitates angiogenesis in the regenerating liver in a vascular endothelial growth factor receptor 2–dependent manner. Thus, the vascular endothelium may help to orchestrate tissue regeneration through the control of inhibitory and stimulatory pathways in parenchymal and nonparenchymal cells.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1244880
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2014
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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