In:
European Journal of Immunology, Wiley, Vol. 17, No. 11 ( 1987-01), p. 1593-1597
Kurzfassung:
The status of immunoglobulin and T cell receptor genes in acute lymphoblastic leukemia (ALL) of T and B lineage has been studied. Our data indicate that illegitimate gene rearrangements at immunoglobulin heavy chain (in T cell ALL), and T cell receptor β chain (in pre‐B ALL) genes are only rarely found (2 out of 30 patients). In contrast, T cell receptor γ chain gene rearrangements, characteristically found in T‐ALL, are also present in 7 of 18 patients with pre‐B ALL. Several features distinguish these illegitimate T cell receptor γ chain gene rearrangements from those in normal and leukemic T cells. V γ genes located far upstream of the J γ /C γ complexes (V γ 2, V γ 3, V γ 4, V γ 5) appear to be preferentially used in normal adult peripheral blood T cells. In contrast, V γ genes located immediately 5′ to the J γ /C γ complexes (V γ 8, V γ 9, V γ 10, V γ 11) predominate in V γ ‐J γ recombinations observed in T‐ALL and pre‐B ALL. Whereas the J γ 2 region is primarily used in T cell receptor γ gene rearrangements observed in T‐ALL, those in pre‐B ALL are confined mostly to the J γ 1 region. These data suggest a limited accessibility of the T cell receptor γ chain gene locus for recombination processes in early stages of B cell differentiation.
Materialart:
Online-Ressource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.1830171111
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1987
ZDB Id:
1491907-2
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