X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Sport nutrition: the role of macronutrients and minerals in endurance exercises
    Kemerovo State University ; 2018
    In:  Foods and Raw Materials Vol. 6, No. 2 ( 2018-12-20), p. 403-412
    Details
    In: Foods and Raw Materials, Kemerovo State University, Vol. 6, No. 2 ( 2018-12-20), p. 403-412
    Abstract: Athletes’ nutrition optimization is very important for the nutritional support in all sport specializations. Macronutrients, as well as minerals and vitamins, are functionally active components that play an important role in nutrition of athletes especially in endurance sport. Optimal use of diets, including specialized sport nutrition, normalizes biochemical, immune, endocrine functions and restores athletes’ energy balance at different stages of sport exercises. Non-optimal athletes’ nutrition of different age groups, inadequate to their physiological needs, and no personalized approach to athletes’ diets, violate their right to adequate safe nutrition, according to international standards and criteria. Nutritional factors are one of the most important key factors in the risk prevention measures for a large number of diet-dependent diseases (e.g. digestive, liver, pancreas, cardiovascular system, endocrine system, and kidney diseases). The review presents the information on energy requirements, balance and availability, types and content of functional products for athletes. It also gives an overview of the specialized food market in Russia.
    Type of Medium: Online Resource
    ISSN: 2308-4057 , 2310-9599
    Uniform Title: Sport nutrition: the role of macronutrients and minerals in endurance exercises
    URL: Issue
    URL: Article
    DOI: 10.21603/issue_5c230496217325.50262728
    DOI: 10.21603/2308-4057-2018-2-403-412
    Language: English , Russian
    Publisher: Kemerovo State University
    Publication Date: 2018
    detail.hit.zdb_id: 2812885-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 2
    Online Resource
    Online Resource
    Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)
    Wiley ; 2017
    In:  Clinical and Translational Allergy Vol. 7, No. S3 ( 2017-8)
    Details
    In: Clinical and Translational Allergy, Wiley, Vol. 7, No. S3 ( 2017-8)
    Type of Medium: Online Resource
    ISSN: 2045-7022
    URL: Article
    DOI: 10.1186/s13601-017-0163-x
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2630865-4
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 3
    Online Resource
    Online Resource
    Infection with Rhinovirus Facilitates Allergen Penetration Across a Respiratory Epithelial Cell Layer
    S. Karger AG ; 2015
    In:  International Archives of Allergy and Immunology Vol. 166, No. 4 ( 2015), p. 291-296
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 166, No. 4 ( 2015), p. 291-296
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Rhinovirus infections are a major risk factor for asthma exacerbations. We sought to investigate in an in vitro system whether infection with human rhinovirus reduces the integrity and barrier function of a respiratory epithelial cell layer and thus may influence allergen penetration. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We cultured the human bronchial epithelial cell line 16HBE14o- in a transwell culture system as a surrogate of respiratory epithelium. The cell monolayer was infected with human rhinovirus 14 at 2 different doses. The extent and effects of transepithelial allergen penetration were assessed using transepithelial resistance measurements and a panel of 〈 sup 〉 125 〈 /sup 〉 I-labeled purified recombinant respiratory allergens (rBet v 1, rBet v 2, and rPhl p 5). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Infection of respiratory cell monolayers with human rhinovirus decreased transepithelial resistance and induced a pronounced increase in allergen penetration. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our results indicate that infection with rhinovirus damages the respiratory epithelial barrier and allows allergens to penetrate more efficiently into the subepithelial tissues where they may cause increased allergic inflammation.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000430441
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 4
    Online Resource
    Online Resource
    HIV-Specific Antibody Responses in HIV-Infected Patients: From a Monoclonal to a Polyclonal View
    S. Karger AG ; 2015
    In:  International Archives of Allergy and Immunology Vol. 167, No. 4 ( 2015), p. 223-241
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 167, No. 4 ( 2015), p. 223-241
    Abstract: HIV infections represent a major global health threat, affecting more than 35 million individuals worldwide. High infection rates and problems associated with lifelong antiretroviral treatment emphasize the need for the development of prophylactic and therapeutic immune intervention strategies. It is conceivable that insights for the design of new immunogens capable of eliciting protective immune responses may come from the analysis of HIV-specific antibody responses in infected patients. Using sophisticated technologies, several monoclonal neutralizing antibodies were isolated from HIV-infected individuals. However, the majority of polyclonal antibody responses found in infected patients are nonneutralizing. Comprehensive analyses of the molecular targets of HIV-specific antibody responses identified that during natural infection antibodies are mainly misdirected towards gp120 epitopes outside of the CD4-binding site and against regions and proteins that are not exposed on the surface of the virus. We therefore argue that vaccines aiming to induce protective responses should include engineered immunogens, which are capable of focusing the immune response towards protective epitopes.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000438484
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 5
    Online Resource
    Online Resource
    Greater Real-Life Diagnostic Efficacy of Allergen Molecule-Based Diagnosis for Prescription of Immunotherapy in an Area with Multiple Pollen Exposure
    S. Karger AG ; 2017
    In:  International Archives of Allergy and Immunology Vol. 173, No. 2 ( 2017), p. 93-98
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 173, No. 2 ( 2017), p. 93-98
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing for the identification of the disease-causing allergen sources. The study was conducted in an area where patients are exposed to pollen from multiple sources (trees, grasses, and weeds) at the same time to compare the diagnostic efficiency of the 2 forms of diagnosis. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients from Astana, Kazakhstan, who suffered from pollen-induced allergy ( 〈 i 〉 n 〈 /i 〉 = 95) were subjected to skin prick testing (SPT) with a local panel of tree pollen, grass pollen, and weed pollen allergen extracts and IgE antibodies specific for marker allergen molecules (nArt v 1, nArt v 3, rAmb a 1, rPhl p 1, rPhl p 5, rBet v 1) were measured by ImmunoCAP. Direct and indirect costs for diagnosis based on SPT and marker allergen-based IgE serology as well as direct costs for immunotherapy depending on SPT and serological test results were calculated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The costs for SPT-based diagnosis per patient were lower than the costs for allergen molecule-based IgE serology. However, allergen molecule-based serology was more precise in detecting the disease-causing allergen sources. A lower number of immunotherapy treatments ( 〈 i 〉 n 〈 /i 〉 = 119) was needed according to molecular diagnosis as compared to extract-based diagnosis ( 〈 i 〉 n 〈 /i 〉 = 275), which considerably reduced the total costs for diagnosis and for a 3-year treatment from EUR 1,112.30 to 521.77 per patient. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The results from this real-life study show that SPT is less expensive than allergen molecule-based diagnostic testing, but molecular diagnosis allowed more precise prescription of immunotherapy which substantially reduced treatment costs and combined costs for diagnosis and treatment.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000477442
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 6
    Online Resource
    Online Resource
    Protein Biomarkers in Asthma
    S. Karger AG ; 2018
    In:  International Archives of Allergy and Immunology Vol. 175, No. 4 ( 2018), p. 189-208
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 175, No. 4 ( 2018), p. 189-208
    Abstract: Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000486856
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 7
    Online Resource
    Online Resource
    Real-Life Study for the Diagnosis of House Dust Mite Allergy - The Value of Recombinant Allergen-Based IgE Serology
    S. Karger AG ; 2016
    In:  International Archives of Allergy and Immunology Vol. 170, No. 2 ( 2016), p. 132-137
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 170, No. 2 ( 2016), p. 132-137
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 〈 i 〉 Dermatophagoides pteronyssinus 〈 /i 〉 is one of the most important perennial allergen sources worldwide. Molecular diagnostics using the commercially available major allergens (Der p 1 and Der p 2) in combination with Der p 10 do not detect house dust mite (HDM) sensitization in a number of cases when used alone. The objective was to evaluate the IgE reactivity profiles of these patients using an experimental immunoassay biochip. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Sera of HDM-allergic patients (positive skin prick test, CAP class ≥1 for allergen extract, and positive intranasal provocation) were tested for IgE antibodies against Der p 1, Der p 2, and Der p 10 by ImmunoCAP fluorescence enzyme immunoassay. Negatively tested sera were examined by an experimental chip containing 13 microarrayed HDM allergens. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of 97 patients tested, 16 showed negative results to Der p 1, Der p 2, and Der p 10. MeDALL chip evaluation revealed 5 patients monosensitized to Der p 23, and 11 patients were negative for all HDM MeDALL chip components. Seven sera were available for further testing, and 3 of them showed IgE reactivity to dot-blotted nDer p 1, and 2 reacted with high-molecular weight components ( 〉 100 kDa) in nitrocellulose-blotted HDM extract when tested with 〈 sup 〉 125 〈 /sup 〉 I-labeled anti-IgE in a RAST-based assay. The HDM extract-specific IgE levels of the 11 patients were 〈 3.9 kU/l. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Recombinant allergen-based IgE serology is of great value when conventional IgE diagnostics fails. Der p 23 is an important HDM allergen, especially when major allergens are negative. Therefore, it would be desirable to have Der p 23 commercially available. Further research concerning the prevalence and clinical significance of different HDM allergens is needed.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000447694
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 8
    Online Resource
    Online Resource
    Specific Antibodies for the Detection of 〈b〉〈i〉Alternaria〈/i〉〈/b〉 Allergens and the Identification of Cross-Reactive Antigens in Other Fungi
    S. Karger AG ; 2016
    In:  International Archives of Allergy and Immunology Vol. 170, No. 4 ( 2016), p. 269-278
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 170, No. 4 ( 2016), p. 269-278
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The mould 〈 i 〉 Alternaria alternata 〈 /i 〉 is an important source of respiratory allergens. 〈 i 〉 A. alternata 〈 /i 〉 extracts show great variations regarding allergenic potency. The aim of this study was to generate antibody probes specific for important 〈 i 〉 Alternaria 〈 /i 〉 allergens and to use them to study allergen expression, depending on different culture conditions, as well as to search for cross-reactive allergens in other mould species. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Synthetic peptides from antigenic regions of 〈 i 〉 A. alternata 〈 /i 〉 allergens (Alt a 1, Alt a 2, Alt a 3, Alt a 6 and Alt a 8) were used to raise highly specific rabbit antibodies. These antibodies and IgE from allergic patients were used to detect allergens by immunoblotting in extracts of 4 〈 i 〉 A. alternata 〈 /i 〉 strains grown under varying culturing conditions, in commercial skin-prick extracts and in closely ( 〈 i 〉 Cladosporium herbarum 〈 /i 〉 and 〈 i 〉 Aureobasidium pullulans 〈 /i 〉 ) or distantly related ( 〈 i 〉 Aspergillus niger 〈 /i 〉 and 〈 i 〉 Penicillium chrysogenum 〈 /i 〉 ) mould species. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There was a wide variation of expression of the individual 〈 i 〉 A. Alternata 〈 /i 〉 allergens, depending on the strain and culture conditions, but the antibody probes allowed us to distinguish strains and culture conditions with low and high allergen expression. In the commercial skin-prick solutions, varying levels of Alt a 1 were found, but no other allergens were detectable. Alt a 1 was identified as species-specific 〈 i 〉 A. Alternata 〈 /i 〉 allergen, whereas Alt a 3, 6- and Alt a 8-cross-reactive antigens were found in 〈 i 〉 C. 〈 /i 〉 〈 i 〉 herbarum 〈 /i 〉 and/or 〈 i 〉 A. pullulans 〈 /i 〉 . 〈 b 〉 〈 i 〉 Conclusions and Clinical Relevance: 〈 /i 〉 〈 /b 〉 Peptide-specific antibodies are useful to analyze diagnostic and therapeutic mould extracts, to study the presence of 〈 i 〉 A. Alternata 〈 /i 〉 allergens in biological samples and to search for cross-reactive allergens in other mould species.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000449415
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 9
    Online Resource
    Online Resource
    Grass-Allergic Children Frequently Show Asymptomatic Low-Level IgE Co-Sensitization and Cross-Reactivity to Wheat
    S. Karger AG ; 2018
    In:  International Archives of Allergy and Immunology Vol. 177, No. 2 ( 2018), p. 135-144
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 177, No. 2 ( 2018), p. 135-144
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Specific immunoglobulin E (IgE) sensitization to wheat is more common than a doctor’s confirmed wheat allergy and is also frequently observed in grass pollen-allergic patients (pollinosis patients). Thus, the objective of this study was to investigate the level and feature of serological IgE cross-reactivity between grass pollen and wheat in a cohort of pollinosis subjects with no diagnosis of wheat allergy. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Seventy-two children, aged 5–17 years, with a doctor’s diagnosis of pollinosis, IgE towards grass pollen, and currently eating wheat were recruited. Serum samples were analyzed for IgE against wheat, timothy grass/wheat-specific allergen components, Pru p 3, and cross-reactive carbohydrate determinants (CCD) and specific IgE-binding inhibition experiments were performed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Sixty percent of the grass pollen subjects were sensitized to wheat with a median of 0.5 kU 〈 sub 〉 A 〈 /sub 〉 /L. Wheat-sensitized subjects were more often sensitized to the two allergens, Phl p 12 and CCD, known to be cross-reactive between grass and wheat. Sensitizations to seven wheat-specific allergens derived from the gluten fraction were, with the exception of one individual, only found in wheat-sensitized subjects. These subjects also more often reported current and past history of allergy to staple foods (milk, egg, wheat, soy, and fish). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Wheat sensitization caused by cross-reactivity but also by sensitization to wheat-specific allergens was common in the grass-allergic children and also associated with allergy to staple foods other than wheat. The results indicate the presence of a subgroup of pollinosis patients with simultaneous sensitization to wheat and food allergy not only caused by cross-reactions.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000489610
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482722-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 10
    Online Resource
    Online Resource
    Tracing IgE-Producing Cells in Allergic Patients
    MDPI AG ; 2019
    In:  Cells Vol. 8, No. 9 ( 2019-08-28), p. 994-
    Details
    In: Cells, MDPI AG, Vol. 8, No. 9 ( 2019-08-28), p. 994-
    Abstract: Immunoglobulin E (IgE) is the key immunoglobulin in the pathogenesis of IgE associated allergic diseases affecting 30% of the world population. Recent data suggest that allergen-specific IgE levels in serum of allergic patients are sustained by two different mechanisms: inducible IgE production through allergen exposure, and continuous IgE production occurring even in the absence of allergen stimulus that maintains IgE levels. This assumption is supported by two observations. First, allergen exposure induces transient increases of systemic IgE production. Second, reduction in IgE levels upon depletion of IgE from the blood of allergic patients using immunoapheresis is only temporary and IgE levels quickly return to pre-treatment levels even in the absence of allergen exposure. Though IgE production has been observed in the peripheral blood and locally in various human tissues (e.g., nose, lung, spleen, bone marrow), the origin and main sites of IgE production in humans remain unknown. Furthermore, IgE-producing cells in humans have yet to be fully characterized. Capturing IgE-producing cells is challenging not only because current staining technologies are inadequate, but also because the cells are rare, they are difficult to discriminate from cells bearing IgE bound to IgE-receptors, and plasma cells express little IgE on their surface. However, due to the central role in mediating both the early and late phases of allergy, free IgE, IgE-bearing effector cells and IgE-producing cells are important therapeutic targets. Here, we discuss current knowledge and unanswered questions regarding IgE production in allergic patients as well as possible therapeutic approaches targeting IgE.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells8090994
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2661518-6
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages