Format:
1 Online-Ressource (552 p)
ISBN:
9780128036198
Series Statement:
International Review of Neurobiology v.128
Content:
Front Cover -- Big on BK: Current Insights into the Function of Large Conductance Voltage- and Ca2+-Activated K+ Channels at the Molecular ... -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Biophysics of BK Channel Gating -- 1. Introduction -- 2. Voltage-Dependent Gating in BK Channels -- 2.1. Our Current Understanding of Voltage-Dependent Channel Gating -- 2.2. Operation of the Noncanonical BK Channel VSD -- 2.3. Modulation of BK Voltage-Dependent Gating -- 3. Ligand-Dependent Gating in BK Channels -- 3.1. Ca2+-Dependent Gating -- 3.2. Mg2+-Dependent Gating
Content:
4. The BK Allosteric Gating Mechanism -- 4.1. The HCA and HA Models of Allosteric BK Channel Activation -- 4.2. Electromechanical Coupling -- 4.3. Modulation of Electromechanical Coupling -- 4.4. Coupling Between the Ca2+ Sensors and the Gate -- 4.5. Modulation of BK Ca2+ Sensitivity -- 4.6. Coupling Between Voltage and Ca2+ Sensors -- 4.7. Coupling Between RCK1 and RCK2 Ca2+ Sensors -- 5. The Extraordinary Conductance of BK Channels -- 6. Concluding Remarks: The BK Channel as a Rebel and a Model -- Acknowledgments -- References
Content:
Chapter Two: Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits -- 1. Introduction -- 2. Discovery -- 3. Structural Characteristics -- 4. Modulation of the BK Channel´s Biophysical Properties by β Subunits -- 5. Modulation of the BK Channel´s Biophysical Properties by γ Subunits -- 6. Modulation of the BK Channel´s Pharmacological Properties by β and γ Subunits -- 7. Stoichiometry -- 8. Physiological and Pathological Relevance or Roles -- 9. Perspectives -- Acknowledgment -- References -- Chapter Three: Posttranscriptional and Posttranslational Regulation of BK Channels
Content:
1. Introduction -- 1.1. Spatiotemporal Control of BK Channel Number and Activity -- 2. Posttranscriptional Regulation -- 2.1. Alternative Pre-mRNA Splicing -- 2.1.1. Control of Alternative Splicing of the Pore-Forming α-Subunit -- 2.1.2. Alternative Splicing Controls the Biophysical Properties of BK Channels and Their Regulation by PTMs, Accessory Su ... -- 2.1.3. Splicing and Control of BK Channel Trafficking -- 2.1.4. Splicing and the Control of Regulatory β-Subunits -- 2.2. miRNA Control of Abundance and Diversity -- 2.3. RNA Editing -- 3. Posttranslational Modification
Content:
3.1. Reversible Protein Phosphorylation -- 3.1.1. Regulation by Reversible Serine-Threonine Protein Phosphorylation -- 3.1.1.1. Control of Channel Activity via Regulation of Pore-Forming α-Subunits -- 3.1.1.2. Control of Regulatory Subunits by Serine/Threonine Phosphorylation -- 3.1.1.3. Control of Channel Trafficking -- 3.1.1.4. Protein Serine/Threonine Dephosphorylation -- 3.1.2. Reversible Tyrosine Phosphorylation -- 3.2. Lipidation -- 3.2.1. Reversible S-Acylation -- 3.2.2. Atypical Internal Protein Myristoylation -- 3.3. N-Linked Glycosylation -- 3.4. Ubiquitination
Content:
4. Conclusions and Perspectives
Note:
Description based upon print version of record
Additional Edition:
9780128036471
Additional Edition:
9780128036198
Additional Edition:
Print version Contet, Candice Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels : Elsevier Science,c2016 9780128036198
Language:
English
Keywords:
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