Format:
Online-Ressource
ISSN:
1460-2075
Content:
PDGF may be involved in the pathogenesis of a variety of disorders including atherosclerosis and certain types of cancer. There is currently little understanding of the molecular structure of PDGF and of the critical amino acid residues involved in receptor binding and cell activation. Two such PDGF‐B chain residues, arginine 27 and isoleucine 30, have been identified by a site‐directed mutagenesis programme. Substitutions in these positions can lead to PDGF mutants defective in both receptor affinity and cell activation as judged by displacement of [125I]PDGF‐BB, mitogenic assay and inositol lipid turnover. Circular dichroism and fluorescence spectroscopy show that such mutations do not disrupt the structure of PDGF.
In:
volume:10
In:
number:13
In:
year:1991
In:
pages:4113-4120
In:
extent:8
In:
European Molecular Biology Organization, The EMBO journal, Heidelberg : EMBO Press, 1982-, 10, Heft 13 (1991), 4113-4120 (gesamt 8), 1460-2075
Language:
English
DOI:
10.1002/j.1460-2075.1991.tb04988.x
URN:
urn:nbn:de:101:1-2024012604362103100864
URL:
https://doi.org/10.1002/j.1460-2075.1991.tb04988.x
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2024012604362103100864
URL:
https://d-nb.info/1317292197/34
URL:
https://doi.org/10.1002/j.1460-2075.1991.tb04988.x
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